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Items: 15


Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors.

Holden JK, Cunningham CN.

Cancers (Basel). 2018 Mar 20;10(3). pii: E81. doi: 10.3390/cancers10030081. Review.


Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.

Arunagiri A, Haataja L, Cunningham CN, Shrestha N, Tsai B, Qi L, Liu M, Arvan P.

Ann N Y Acad Sci. 2018 Apr;1418(1):5-19. doi: 10.1111/nyas.13531. Epub 2018 Jan 28. Review.


Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.

Biel JT, Thompson MC, Cunningham CN, Corn JE, Fraser JS.

Structure. 2017 May 2;25(5):739-749.e3. doi: 10.1016/j.str.2017.03.009. Epub 2017 Apr 13.


Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.

Cunningham CN, He K, Arunagiri A, Paton AW, Paton JC, Arvan P, Tsai B.

Diabetes. 2017 Mar;66(3):741-753. doi: 10.2337/db16-1338. Epub 2016 Dec 27.


Opportunistic intruders: how viruses orchestrate ER functions to infect cells.

Ravindran MS, Bagchi P, Cunningham CN, Tsai B.

Nat Rev Microbiol. 2016 Jul;14(7):407-420. doi: 10.1038/nrmicro.2016.60. Epub 2016 Jun 6. Review.


Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.

Noland CL, Gierke S, Schnier PD, Murray J, Sandoval WN, Sagolla M, Dey A, Hannoush RN, Fairbrother WJ, Cunningham CN.

Structure. 2016 Jan 5;24(1):179-186. doi: 10.1016/j.str.2015.11.005. Epub 2015 Dec 24.


PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.

He K, Cunningham CN, Manickam N, Liu M, Arvan P, Tsai B.

Mol Biol Cell. 2015 Oct 1;26(19):3413-23. doi: 10.1091/mbc.E15-01-0034. Epub 2015 Aug 12.


USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.

Cunningham CN, Baughman JM, Phu L, Tea JS, Yu C, Coons M, Kirkpatrick DS, Bingol B, Corn JE.

Nat Cell Biol. 2015 Feb;17(2):160-9. doi: 10.1038/ncb3097. Epub 2015 Jan 26.


Human TREX2 components PCID2 and centrin 2, but not ENY2, have distinct functions in protein export and co-localize to the centrosome.

Cunningham CN, Schmidt CA, Schramm NJ, Gaylord MR, Resendes KK.

Exp Cell Res. 2014 Jan 15;320(2):209-18. doi: 10.1016/j.yexcr.2013.11.015. Epub 2013 Dec 1.


Decoding a chain letter for degradation.

Cunningham CN, Corn JE.

Structure. 2013 Jul 2;21(7):1068-70. doi: 10.1016/j.str.2013.06.009.


Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling.

Phillips AH, Zhang Y, Cunningham CN, Zhou L, Forrest WF, Liu PS, Steffek M, Lee J, Tam C, Helgason E, Murray JM, Kirkpatrick DS, Fairbrother WJ, Corn JE.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11379-84. doi: 10.1073/pnas.1302407110. Epub 2013 Jun 25.


The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis.

Cunningham CN, Southworth DR, Krukenberg KA, Agard DA.

Protein Sci. 2012 Aug;21(8):1162-71. doi: 10.1002/pro.2103.


Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.

Vasko RC, Rodriguez RA, Cunningham CN, Ardi VC, Agard DA, McAlpine SR.

ACS Med Chem Lett. 2010 Jan 1;1(1):4-8.


Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.

Cunningham CN, Krukenberg KA, Agard DA.

J Biol Chem. 2008 Jul 25;283(30):21170-8. doi: 10.1074/jbc.M800046200. Epub 2008 May 20.


Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.

Costello PS, Turner M, Walters AE, Cunningham CN, Bauer PH, Downward J, Tybulewicz VL.

Oncogene. 1996 Dec 19;13(12):2595-605.


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