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Items: 1 to 50 of 266

1.

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions.

Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, Köfalvi A, Agostinho P, Cunha RA.

eNeuro. 2018 Dec 26;5(6). pii: ENEURO.0385-18.2018. doi: 10.1523/ENEURO.0385-18.2018. eCollection 2018 Nov-Dec.

2.

Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making.

Leffa DT, Pandolfo P, Gonçalves N, Machado NJ, de Souza CM, Real JI, Silva AC, Silva HB, Köfalvi A, Cunha RA, Ferreira SG.

Front Mol Neurosci. 2018 Dec 20;11:475. doi: 10.3389/fnmol.2018.00475. eCollection 2018.

3.

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD in GPR37 deficient mice.

Morató X, Gonçalves FQ, Lopes JP, Jauregui O, Soler C, Fernández-Dueñas V, Cunha RA, Ciruela F.

J Neurochem. 2018 Dec 22. doi: 10.1111/jnc.14653. [Epub ahead of print]

PMID:
30578680
4.

Purinergic signalling and brain development.

Rodrigues RJ, Marques JM, Cunha RA.

Semin Cell Dev Biol. 2018 Dec 4. pii: S1084-9521(18)30065-X. doi: 10.1016/j.semcdb.2018.12.001. [Epub ahead of print] Review.

PMID:
30529149
5.

Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats.

Duarte JM, Gaspar R, Caetano L, Patrício P, Soares-Cunha C, Mateus-Pinheiro A, Alves ND, Santos AR, Ferreira SG, Sardinha V, Oliveira JF, Fontes-Ribeiro C, Sousa N, Cunha RA, Ambrósio AF, Pinto L, Rodrigues AJ, Gomes CA.

Glia. 2019 Jan;67(1):182-192. doi: 10.1002/glia.23476. Epub 2018 Nov 21.

PMID:
30461068
6.

Anandamide Effects in a Streptozotocin-Induced Alzheimer's Disease-Like Sporadic Dementia in Rats.

Moreira-Silva D, Carrettiero DC, Oliveira ASA, Rodrigues S, Dos Santos-Lopes J, Canas PM, Cunha RA, Almeida MC, Ferreira TL.

Front Neurosci. 2018 Sep 21;12:653. doi: 10.3389/fnins.2018.00653. eCollection 2018.

7.

Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors.

Dobrachinski F, Gerbatin RR, Sartori G, Golombieski RM, Antoniazzi A, Nogueira CW, Royes LF, Fighera MR, Porciúncula LO, Cunha RA, Soares FAA.

Mol Neurobiol. 2018 Aug 13. doi: 10.1007/s12035-018-1296-1. [Epub ahead of print]

PMID:
30105669
8.

Treadmill Exercise Attenuates L-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice.

Speck AE, Schamne MG, S Aguiar A Jr, Cunha RA, Prediger RD.

Mol Neurobiol. 2018 Aug 2. doi: 10.1007/s12035-018-1278-3. [Epub ahead of print]

PMID:
30073506
9.

The exercise sex gap and the impact of the estrous cycle on exercise performance in mice.

Aguiar AS Jr, Speck AE, Amaral IM, Canas PM, Cunha RA.

Sci Rep. 2018 Jul 16;8(1):10742. doi: 10.1038/s41598-018-29050-0.

10.

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation.

Morató X, Luján R, Gonçalves N, Watanabe M, Altafaj X, Carvalho AL, Fernández-Dueñas V, Cunha RA, Ciruela F.

Hum Mol Genet. 2018 Oct 15;27(20):3528-3541. doi: 10.1093/hmg/ddy264.

PMID:
30010864
11.

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.

Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print]

PMID:
29950682
12.

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease.

Silva AC, Lemos C, Gonçalves FQ, Pliássova AV, Machado NJ, Silva HB, Canas PM, Cunha RA, Lopes JP, Agostinho P.

Neurobiol Dis. 2018 Sep;117:72-81. doi: 10.1016/j.nbd.2018.05.024. Epub 2018 May 31.

PMID:
29859867
13.

Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats.

Fernandes LMP, Cartágenes SC, Barros MA, Carvalheiro TCVS, Castro NCF, Schamne MG, Lima RR, Prediger RD, Monteiro MC, Fontes-Júnior EA, Cunha RA, Maia CSF.

Behav Brain Res. 2018 Sep 17;350:99-108. doi: 10.1016/j.bbr.2018.05.007. Epub 2018 May 9.

PMID:
29752970
14.

Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex.

Kerkhofs A, Canas PM, Timmerman AJ, Heistek TS, Real JI, Xavier C, Cunha RA, Mansvelder HD, Ferreira SG.

Front Pharmacol. 2018 Mar 20;9:133. doi: 10.3389/fphar.2018.00133. eCollection 2018.

15.

Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex.

Real JI, Simões AP, Cunha RA, Ferreira SG, Rial D.

Eur J Neurosci. 2018 May;47(9):1127-1134. doi: 10.1111/ejn.13912. Epub 2018 Apr 2.

PMID:
29570875
16.

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.

Simões AP, Silva CG, Marques JM, Pochmann D, Porciúncula LO, Ferreira S, Oses JP, Beleza RO, Real JI, Köfalvi A, Bahr BA, Lerma J, Cunha RA, Rodrigues RJ.

Cell Death Dis. 2018 Feb 20;9(3):297. doi: 10.1038/s41419-018-0351-1.

17.

Elevated Pressure Changes the Purinergic System of Microglial Cells.

Rodrigues-Neves AC, Aires ID, Vindeirinho J, Boia R, Madeira MH, Gonçalves FQ, Cunha RA, Santos PF, Ambrósio AF, Santiago AR.

Front Pharmacol. 2018 Jan 24;9:16. doi: 10.3389/fphar.2018.00016. eCollection 2018.

18.

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex.

Kerkhofs A, Xavier AC, da Silva BS, Canas PM, Idema S, Baayen JC, Ferreira SG, Cunha RA, Mansvelder HD.

Front Pharmacol. 2018 Jan 4;8:899. doi: 10.3389/fphar.2017.00899. eCollection 2017.

19.

RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.

Šponer J, Bussi G, Krepl M, Banáš P, Bottaro S, Cunha RA, Gil-Ley A, Pinamonti G, Poblete S, Jurečka P, Walter NG, Otyepka M.

Chem Rev. 2018 Apr 25;118(8):4177-4338. doi: 10.1021/acs.chemrev.7b00427. Epub 2018 Jan 3.

20.

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage.

Boia R, Elvas F, Madeira MH, Aires ID, Rodrigues-Neves AC, Tralhão P, Szabó EC, Baqi Y, Müller CE, Tomé ÂR, Cunha RA, Ambrósio AF, Santiago AR.

Cell Death Dis. 2017 Oct 5;8(10):e3065. doi: 10.1038/cddis.2017.451.

21.

Distinct sensitivity to caffeine-induced insomnia related to age.

Frozi J, de Carvalho HW, Ottoni GL, Cunha RA, Lara DR.

J Psychopharmacol. 2018 Jan;32(1):89-95. doi: 10.1177/0269881117722997. Epub 2017 Sep 7.

PMID:
28879806
22.

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease.

Amorim JA, Canas PM, Tomé AR, Rolo AP, Agostinho P, Palmeira CM, Cunha RA.

J Alzheimers Dis. 2017;60(2):525-536. doi: 10.3233/JAD-170356.

PMID:
28869472
23.

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo.

Morató X, Luján R, López-Cano M, Gandía J, Stagljar I, Watanabe M, Cunha RA, Fernández-Dueñas V, Ciruela F.

Sci Rep. 2017 Aug 25;7(1):9452. doi: 10.1038/s41598-017-10147-x.

24.

Excretory/secretory antigens of Strongyloides venezuelensis applied to IgG detection in human strongyloidosis.

Cunha RA, de Carvalho EFG, de Sousa JEN, Costa-Cruz JM.

Parasitol Int. 2017 Oct;66(5):671-676. doi: 10.1016/j.parint.2017.07.001. Epub 2017 Jul 10.

PMID:
28705595
25.

Chronic coffee consumption and respiratory disease: A systematic review.

Alfaro TM, Monteiro RA, Cunha RA, Cordeiro CR.

Clin Respir J. 2018 Mar;12(3):1283-1294. doi: 10.1111/crj.12662. Epub 2017 Jul 7. Review.

PMID:
28671769
26.

ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION (TDCS) INCREASES ISOMETRIC STRENGTH OF SHOULDER ROTATORS MUSCLES IN HANDBALL PLAYERS.

Hazime FA, da Cunha RA, Soliaman RR, Romancini ACB, Pochini AC, Ejnisman B, Baptista AF.

Int J Sports Phys Ther. 2017 Jun;12(3):402-407.

27.

Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization.

Morató X, López-Cano M, Canas PM, Cunha RA, Ciruela F.

J Vis Exp. 2017 May 12;(123). doi: 10.3791/55661.

PMID:
28570537
28.

Adenosine A2A receptors are up-regulated and control the activation of human alveolar macrophages.

Alfaro TM, Rodrigues DI, Tomé ÂR, Cunha RA, Robalo Cordeiro C.

Pulm Pharmacol Ther. 2017 Aug;45:90-94. doi: 10.1016/j.pupt.2017.04.009. Epub 2017 May 9.

PMID:
28499635
29.

Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid β (Aβ1-40) administration in mice.

Santos VV, Stark R, Rial D, Silva HB, Bayliss JA, Lemus MB, Davies JS, Cunha RA, Prediger RD, Andrews ZB.

J Neuroendocrinol. 2017 May;29(5). doi: 10.1111/jne.12476.

PMID:
28380673
30.

Effects of crude extracts of a saxitoxin-producer strain of the cyanobacterium Cylindrospermopsis raciborskii on the swimming behavior of wild and laboratory reared guppy Poecilia vivipara.

Lopes KC, Ferrão-Filho AD, Dos Santos EG, Cunha RA, Santos CP.

Toxicon. 2017 Apr;129:44-51. doi: 10.1016/j.toxicon.2017.02.002. Epub 2017 Feb 12.

31.

Unraveling Mg2+-RNA binding with atomistic molecular dynamics.

Cunha RA, Bussi G.

RNA. 2017 May;23(5):628-638. doi: 10.1261/rna.060079.116. Epub 2017 Feb 1.

32.

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

Gonçalves N, Simões AT, Prediger RD, Hirai H, Cunha RA, Pereira de Almeida L.

Ann Neurol. 2017 Mar;81(3):407-418. doi: 10.1002/ana.24867. Epub 2017 Feb 17.

PMID:
28032667
33.

Central Ghrelin Resistance Permits the Overconsolidation of Fear Memory.

Harmatz ES, Stone L, Lim SH, Lee G, McGrath A, Gisabella B, Peng X, Kosoy E, Yao J, Liu E, Machado NJ, Weiner VS, Slocum W, Cunha RA, Goosens KA.

Biol Psychiatry. 2017 Jun 15;81(12):1003-1013. doi: 10.1016/j.biopsych.2016.11.009. Epub 2016 Nov 29.

34.

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Rial D, Morató X, Real JI, Gonçalves FQ, Stagljar I, Pereira FC, Fernández-Dueñas V, Cunha RA, Ciruela F.

Neurosci Lett. 2017 Jan 18;638:162-166. doi: 10.1016/j.neulet.2016.12.040. Epub 2016 Dec 19.

PMID:
28007645
35.

Change in the nose areas in children with mouth breathing after nasal cleansing and massage.

Melo AC, Gomes AO, Cunha DA, Lima SJ, Lima WR, Cunha RA, Silva HJ.

Codas. 2016 Nov-Dec;28(6):770-777. doi: 10.1590/2317-1782/20162015172. Portuguese, English.

36.

Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.

Duarte FV, Amorim JA, Varela AT, Teodoro JS, Gomes AP, Cunha RA, Palmeira CM, Rolo AP.

Purinergic Signal. 2017 Jun;13(2):179-190. doi: 10.1007/s11302-016-9548-x. Epub 2016 Nov 15.

37.

Translation, Cross-cultural Adaptation, and Clinimetric Testing of Instruments Used to Assess Patients With Ankle Sprain in the Brazilian Population.

da Cunha RA, Hazime FA, da Silva Martins MC, Ferreira M, de Castro Pochini A, Ejnisman B.

J Orthop Sports Phys Ther. 2016 Dec;46(12):1042-1050. Epub 2016 Nov 8.

PMID:
27825293
38.

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

Fonseca R, Carvalho RA, Lemos C, Sequeira AC, Pita IR, Carvalho F, Silva CD, Prediger RD, Jarak I, Cunha RA, Fontes Ribeiro CA, Köfalvi A, Pereira FC.

CNS Neurosci Ther. 2017 Feb;23(2):119-126. doi: 10.1111/cns.12649. Epub 2016 Oct 19.

PMID:
27762079
39.

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety.

Caetano L, Pinheiro H, Patrício P, Mateus-Pinheiro A, Alves ND, Coimbra B, Baptista FI, Henriques SN, Cunha C, Santos AR, Ferreira SG, Sardinha VM, Oliveira JF, Ambrósio AF, Sousa N, Cunha RA, Rodrigues AJ, Pinto L, Gomes CA.

Mol Psychiatry. 2017 Jul;22(7):1035-1043. doi: 10.1038/mp.2016.173. Epub 2016 Oct 11.

PMID:
27725661
40.

Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.

Rodrigues L, Miranda IM, Andrade GM, Mota M, Cortes L, Rodrigues AG, Cunha RA, Gonçalves T.

Oncotarget. 2016 Sep 27;7(39):62862-62872. doi: 10.18632/oncotarget.11760.

41.

How does adenosine control neuronal dysfunction and neurodegeneration?

Cunha RA.

J Neurochem. 2016 Dec;139(6):1019-1055. doi: 10.1111/jnc.13724. Epub 2016 Aug 16. Review.

42.

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.

Viana da Silva S, Haberl MG, Zhang P, Bethge P, Lemos C, Gonçalves N, Gorlewicz A, Malezieux M, Gonçalves FQ, Grosjean N, Blanchet C, Frick A, Nägerl UV, Cunha RA, Mulle C.

Nat Commun. 2016 Jun 17;7:11915. doi: 10.1038/ncomms11915.

43.

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory.

Simões AP, Machado NJ, Gonçalves N, Kaster MP, Simões AT, Nunes A, Pereira de Almeida L, Goosens KA, Rial D, Cunha RA.

Neuropsychopharmacology. 2016 Nov;41(12):2862-2871. doi: 10.1038/npp.2016.98. Epub 2016 Jun 17.

44.

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.

Moidunny S, Matos M, Wesseling E, Banerjee S, Volsky DJ, Cunha RA, Agostinho P, Boddeke HW, Roy S.

J Neuroinflammation. 2016 Jun 10;13(1):144. doi: 10.1186/s12974-016-0613-8.

45.

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.

Pinheiro BS, Lemos C, Neutzling Kaufmann F, Marques JM, da Silva-Santos CS, Carvalho E, Mackie K, Rodrigues RJ, Cunha RA, Köfalvi A.

Brain Res Bull. 2016 Jun;124:222-30. doi: 10.1016/j.brainresbull.2016.05.009. Epub 2016 May 18.

PMID:
27208730
46.

Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors.

George J, Cunha RA, Mulle C, Amédée T.

Eur J Neurosci. 2016 May;43(10):1366-78. doi: 10.1111/ejn.13191. Epub 2016 Mar 1.

47.

Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex.

Pliássova A, Canas PM, Xavier AC, da Silva BS, Cunha RA, Agostinho P.

J Alzheimers Dis. 2016 Apr 18;52(4):1209-14. doi: 10.3233/JAD-160213.

PMID:
27104908
48.

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.

Köfalvi A, Lemos C, Martín-Moreno AM, Pinheiro BS, García-García L, Pozo MA, Valério-Fernandes Â, Beleza RO, Agostinho P, Rodrigues RJ, Pasquaré SJ, Cunha RA, de Ceballos ML.

Neuropharmacology. 2016 Nov;110(Pt A):519-529. doi: 10.1016/j.neuropharm.2016.03.015. Epub 2016 Mar 11.

49.

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.

Machado NJ, Simões AP, Silva HB, Ardais AP, Kaster MP, Garção P, Rodrigues DI, Pochmann D, Santos AI, Araújo IM, Porciúncula LO, Tomé ÂR, Köfalvi A, Vaugeois JM, Agostinho P, El Yacoubi M, Cunha RA, Gomes CA.

Mol Neurobiol. 2017 Mar;54(2):1552-1563. doi: 10.1007/s12035-016-9774-9. Epub 2016 Feb 9.

PMID:
26860412
50.

Depression as a Glial-Based Synaptic Dysfunction.

Rial D, Lemos C, Pinheiro H, Duarte JM, Gonçalves FQ, Real JI, Prediger RD, Gonçalves N, Gomes CA, Canas PM, Agostinho P, Cunha RA.

Front Cell Neurosci. 2016 Jan 22;9:521. doi: 10.3389/fncel.2015.00521. eCollection 2015. Review.

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