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Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy.

Springer SU, Chen CH, Rodriguez Pena MDC, Li L, Douville C, Wang Y, Cohen JD, Taheri D, Silliman N, Schaefer J, Ptak J, Dobbyn L, Papoli M, Kinde I, Afsari B, Tregnago AC, Bezerra SM, VandenBussche C, Fujita K, Ertoy D, Cunha IW, Yu L, Bivalacqua TJ, Grollman AP, Diaz LA, Karchin R, Danilova L, Huang CY, Shun CT, Turesky RJ, Yun BH, Rosenquist TA, Pu YS, Hruban RH, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Dickman KG, Netto GJ.

Elife. 2018 Mar 20;7. pii: e32143. doi: 10.7554/eLife.32143.


Relapse in dermatofibrosarcoma protuberans: A histological and molecular analysis.

Molina AS, Duprat Neto JP, Bertolli E, da Cunha IW, Fregnani JHTG, Figueiredo PHM, Soares FA, Macedo MP, Pinto Lopes CA, de Abranches Oliveira Santos Filho ID.

J Surg Oncol. 2018 Apr;117(5):845-850. doi: 10.1002/jso.25039. Epub 2018 Mar 6.


Prognostic impact of concomitant loss of PBRM1 and BAP1 protein expression in early stages of clear cell renal cell carcinoma.

da Costa WH, da Cunha IW, Fares AF, Bezerra SM, Shultz L, Clavijo DA, da Silva DV, Netto GJ, Guimaraes GC, Cassio Zequi S.

Urol Oncol. 2018 May;36(5):243.e1-243.e8. doi: 10.1016/j.urolonc.2018.01.002. Epub 2018 Feb 14.


Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival.

Machado LE, Alvarenga AW, da Silva FF, Roffé M, Begnami MD, Torres LFB, da Cunha IW, Martins VR, Hajj GNM.

J Histochem Cytochem. 2018 Jun;66(6):403-414. doi: 10.1369/0022155417750838. Epub 2018 Jan 12.


DNA methylation landscape of hepatoblastomas reveals arrest at early stages of liver differentiation and cancer-related alterations.

Maschietto M, Rodrigues TC, Kashiwabara AY, de Araujo ÉSS, Marques Aguiar TF, da Costa CML, da Cunha IW, Dos Reis Vasques L, Cypriano M, Brentani H, de Toledo SRC, Pearson PL, Carraro DM, Rosenberg C, Krepischi ACV.

Oncotarget. 2016 Dec 25;8(58):97871-97889. doi: 10.18632/oncotarget.14208. eCollection 2017 Nov 17.


Tissue-based molecular markers in upper tract urothelial carcinoma and their prognostic implications.

Favaretto RL, Zequi SC, Oliveira RAR, Santana T, Costa WH, Cunha IW, Guimarães GC.

Int Braz J Urol. 2018 Jan-Feb;44(1):22-37. doi: 10.1590/S1677-5538.IBJU.2017.0204. Review.


KRAS mutation status is highly homogeneous between areas of the primary tumor and the corresponding metastasis of colorectal adenocarcinomas: one less problem in patient care.

Petaccia de Macedo M, Melo FM, Ribeiro HSC, Marques MC, Kagohara LT, Begnami MD, Neto JC, Ribeiro JS, Soares FA, Carraro DM, Cunha IW.

Am J Cancer Res. 2017 Sep 1;7(9):1978-1989. eCollection 2017.


Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype.

Bovolim G, da Costa WH, Guimaraes GC, Soares FA, da Cunha IW.

Virchows Arch. 2017 Dec;471(6):815-818. doi: 10.1007/s00428-017-2191-2. Epub 2017 Jul 8.


Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder.

Rodriguez Pena MDC, Tregnago AC, Eich ML, Springer S, Wang Y, Taheri D, Ertoy D, Fujita K, Bezerra SM, Cunha IW, Raspollini MR, Yu L, Bivalacqua TJ, Papadopoulos N, Kinzler KW, Vogelstein B, Netto GJ.

Virchows Arch. 2017 Dec;471(6):761-767. doi: 10.1007/s00428-017-2164-5. Epub 2017 Jun 8.


Pericytic tumors of the kidney-a clinicopathologic analysis of 17 cases.

Sirohi D, Smith SC, Epstein JI, Balzer BL, Simko JP, Balitzer D, Benhamida J, Kryvenko ON, Gupta NS, Paluru S, da Cunha IW, Leal DN, Williamson SR, de Peralta-Venturina M, Amin MB.

Hum Pathol. 2017 Jun;64:106-117. doi: 10.1016/j.humpath.2017.04.005. Epub 2017 Apr 21.


Double-hit lymphomas: clinical, morphological, immunohistochemical and cytogenetic study in a series of Brazilian patients with high-grade non-Hodgkin lymphoma.

Oliveira CC, Maciel-Guerra H, Kucko L, Hirama EJ, Brilhante AD, Quevedo FC, da Cunha IW, Soares FA, Niero-Melo L, Dos Reis PP, Domingues MA.

Diagn Pathol. 2017 Jan 7;12(1):3. doi: 10.1186/s13000-016-0593-0.


Infections with multiple high-risk HPV types are associated with high-grade and persistent low-grade intraepithelial lesions of the cervix.

De Brot L, Pellegrini B, Moretti ST, Carraro DM, Soares FA, Rocha RM, Baiocchi G, da Cunha IW, de Andrade VP.

Cancer Cytopathol. 2017 Feb;125(2):138-143. doi: 10.1002/cncy.21789. Epub 2016 Nov 21.


Epidermal growth factor receptor as an adverse survival predictor in squamous cell carcinoma of the penis.

Silva Amancio AM, Cunha IW, Neves JI, Quetz JD, Carraro DM, Rocha RM, Zequi SC, Cubilla AL, da Fonseca FP, Lopes A, Cunha MD, Lima MV, Vassallo J, Guimarães GC, Soares FA.

Hum Pathol. 2017 Mar;61:97-104. doi: 10.1016/j.humpath.2016.07.041. Epub 2016 Nov 15.


A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease.

Ferreira EN, Barros BD, de Souza JE, Almeida RV, Torrezan GT, Garcia S, Krepischi AC, Mello CA, Cunha IW, Pinto CA, Soares FA, Dias-Neto E, Lopes A, de Souza SJ, Carraro DM.

Hum Genomics. 2016 Nov 18;10(1):36.


Urological cancer related to familial syndromes.

Costa WH, Jabboure G Netto, Cunha IW.

Int Braz J Urol. 2017 Mar-Apr;43(2):192-201. doi: 10.1590/S1677-5538.IBJU.2016.0125. Review.


Evaluation of Akt and RICTOR Expression Levels in Astrocytomas of All Grades.

Alvarenga AW, Machado LE, Rodrigues BR, Lupinacci FC, Sanemastu P, Matta E, Roffé M, Torres LF, da Cunha IW, Martins VR, Hajj GN.

J Histochem Cytochem. 2017 Feb;65(2):93-103. doi: 10.1369/0022155416675850. Epub 2016 Oct 28.


GATA3 expression in primary vulvar Paget disease: a potential pitfall leading to misdiagnosis of pagetoid urothelial intraepithelial neoplasia.

Morbeck D, Tregnago AC, Baiocchi G, Sacomani C, Peresi PM, Osório CT, Schutz L, Bezerra SM, de Brot L, Cunha IW.

Histopathology. 2017 Feb;70(3):435-441. doi: 10.1111/his.13086. Epub 2016 Nov 21. Erratum in: Histopathology. 2017 May;70(6):1016.


Epithelial-mesenchymal transition (EMT) phenotype at invasion front of squamous cell carcinoma of the penis influences oncological outcomes.

da Cunha IW, Souza MJ, da Costa WH, Amâncio AM, Fonseca FP, Zequi Sde C, Lopes A, Guimarães GC, Soares F.

Urol Oncol. 2016 Oct;34(10):433.e19-26. doi: 10.1016/j.urolonc.2016.05.015. Epub 2016 Jul 2.


Ulceration in bladder cancer associates with extravesical disease, independent of cell cycle, or hypoxia pathways status: Integrating gross morphology and expression profiles in cystectomies.

Schultz L, Spagnul SJT, Damm GR, da Cunha IW, Bezerra SM, da Costa WH, Guimaraes GC, Zequi SD, Soares FA.

Urol Oncol. 2016 Nov;34(11):484.e9-484.e17. doi: 10.1016/j.urolonc.2016.05.031. Epub 2016 Jul 1.


Prognostic role of decreased E-cadherin expression in patients with upper tract urothelial carcinoma: a multi-institutional study.

Favaretto RL, Bahadori A, Mathieu R, Haitel A, Grubmüller B, Margulis V, Karam JA, Rouprêt M, Seitz C, Karakiewicz PI, Cunha IW, Zequi SC, Wood CG, Weizer AZ, Raman JD, Remzi M, Rioux-Leclercq N, Jacquet-Kammerer S, Bensalah K, Lotan Y, Bachmann A, Rink M, Briganti A, Shariat SF.

World J Urol. 2017 Jan;35(1):113-120. doi: 10.1007/s00345-016-1835-1. Epub 2016 Apr 29.


Nuclear unphosphorylated STAT3 correlates with a worse prognosis in human glioblastoma.

Rodrigues BR, Queiroz-Hazarbassanov N, Lopes MH, Bleggi-Torres LF, Suzuki S, Cunha IW, Sanematsu P, Martins VR.

Pathol Res Pract. 2016 Jun;212(6):517-23. doi: 10.1016/j.prp.2016.03.001. Epub 2016 Mar 14.


May Sonic Hedgehog proteins be markers for malignancy in uterine smooth muscle tumors?

Garcia N, Bozzini N, Baiocchi G, da Cunha IW, Maciel GA, Soares Junior JM, Soares FA, Baracat EC, Carvalho KC.

Hum Pathol. 2016 Apr;50:43-50. doi: 10.1016/j.humpath.2015.08.026. Epub 2015 Nov 24.


TOP2A copy number and TOP2A expression in uterine benign smooth muscle tumours and leiomyosarcoma.

Baiocchi G, Poliseli FL, De Brot L, Mantoan H, Schiavon BN, Faloppa CC, Vassallo J, Soares FA, Cunha IW.

J Clin Pathol. 2016 Oct;69(10):884-9. doi: 10.1136/jclinpath-2015-203561. Epub 2016 Mar 18.


Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors.

Krepischi ACV, Maschietto M, Ferreira EN, Silva AG, Costa SS, da Cunha IW, Barros BDF, Grundy PE, Rosenberg C, Carraro DM.

Mol Cytogenet. 2016 Feb 24;9:20. doi: 10.1186/s13039-016-0227-y. eCollection 2016.


Cyclooxygenase-2 (COX2) and p53 protein expression are interdependent in breast cancer but not associated with clinico-pathological surrogate subtypes, tumor aggressiveness and patient survival.

Serra KP, Peres RM, Sarian LO, Vassallo J, Pinto GA, Silva GR, Soares FA, da Cunha IW, Espinola J, Bento AM, Del Corso LM, Derchain S.

Acta Histochem. 2016 Mar;118(2):176-82. doi: 10.1016/j.acthis.2015.12.009. Epub 2016 Jan 11.


Prognostic Significance of Apoptosis-related Markers in Patients With Soft-Tissue Sarcomas of Extremities.

Mühlbeier DF, Saddi VA, de Paula ÉC, Cunha IW, Fregnani JH, Barbosa MA, Manoel WJ.

Appl Immunohistochem Mol Morphol. 2016 Apr;24(4):268-74. doi: 10.1097/PAI.0000000000000185.


RAS mutations vary between lesions in synchronous primary colorectal cancer: testing only one lesion is not sufficient to guide anti-EGFR treatment decisions.

de Macedo MP, de Melo FM, Ribeiro Jda S, de Mello CA, de Souza Begnami MD, Soares FA, Carraro DM, da Cunha IW.

Oncoscience. 2015 Feb 9;2(2):125-30. eCollection 2015.


KRAS gene mutation in a series of unselected colorectal carcinoma patients with prognostic morphological correlations: a pyrosequencing method improved by nested PCR.

de Macêdo MP, de Melo FM, Lisboa BC, Andrade LD, de Souza Begnami MD, Junior SA, Ribeiro HS, Soares FA, Carraro DM, da Cunha IW.

Exp Mol Pathol. 2015 Jun;98(3):563-7. doi: 10.1016/j.yexmp.2015.03.038. Epub 2015 Mar 31.


Prognostic factors in patients with penile carcinoma and inguinal lymph node metastasis.

da Costa WH, Rosa de Oliveira RA, Santana TB, Benigno BS, da Cunha IW, de Cássio Zequi S, Guimaraes GC, Lopes A.

Int J Urol. 2015 Jul;22(7):669-73. doi: 10.1111/iju.12759. Epub 2015 Mar 31.


SOD2 immunoexpression predicts lymph node metastasis in penile cancer.

Termini L, Fregnani JH, Boccardo E, da Costa WH, Longatto-Filho A, Andreoli MA, Costa MC, Lopes A, da Cunha IW, Soares FA, Villa LL, Guimarães GC.

BMC Clin Pathol. 2015 Mar 3;15:3. doi: 10.1186/s12907-015-0003-7. eCollection 2015.


Pattern of invasion is the most important prognostic factor in patients with penile cancer submitted to lymph node dissection and pathological absence of lymph node metastasis.

Aita G, da Costa WH, de Cassio Zequi S, da Cunha IW, Soares F, Guimaraes GC, Lopes A.

BJU Int. 2015 Oct;116(4):584-9. doi: 10.1111/bju.13071. Epub 2015 Mar 28.


Immunohistochemical assessment of PTEN in vulvar cancer: best practices for tissue staining, evaluation, and clinical association.

Lavorato-Rocha AM, Anjos LG, Cunha IW, Vassallo J, Soares FA, Rocha RM.

Methods. 2015 May;77-78:20-4. doi: 10.1016/j.ymeth.2014.12.017. Epub 2015 Jan 3.


Pathologic and imunohistochemical characterization of tumoral inflammatory cell infiltrate in invasive penile squamous cell carcinomas: Fox-P3 expression is an independent predictor of recurrence.

Vassallo J, Rodrigues AF, Campos AH, Rocha RM, da Cunha IW, Zequi SC, Guimarães GC, da Fonseca FP, Lopes A, Cubilla A, Soares FA.

Tumour Biol. 2015 Apr;36(4):2509-16. doi: 10.1007/s13277-014-2864-2. Epub 2015 Jan 5.


Dermatofibrosarcoma protuberans of the vulva: margins assessment and reconstructive options - a report of two cases.

Bertolli E, Bretchbuhl ER, Camarço WR, Campagnari M, Molina AS, Baiocchi G, Macedo MP, Pinto CA, Cunha IW, Neto JP.

World J Surg Oncol. 2014 Dec 29;12(1):399. [Epub ahead of print]


Upregulated genes at 2q24 gains as candidate oncogenes in hepatoblastomas.

Rodrigues TC, Fidalgo F, da Costa CM, Ferreira EN, da Cunha IW, Carraro DM, Krepischi AC, Rosenberg C.

Future Oncol. 2014 Dec;10(15):2449-57. doi: 10.2217/fon.14.149.


Genomic screening of testicular germ cell tumors from monozygotic twins.

Silveira SM, da Cunha IW, Marchi FA, Busso AF, Lopes A, Rogatto SR.

Orphanet J Rare Dis. 2014 Nov 26;9:181. doi: 10.1186/s13023-014-0181-x.


Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival.

Lopes MH, Santos TG, Rodrigues BR, Queiroz-Hazarbassanov N, Cunha IW, Wasilewska-Sampaio AP, Costa-Silva B, Marchi FA, Bleggi-Torres LF, Sanematsu PI, Suzuki SH, Oba-Shinjo SM, Marie SK, Toulmin E, Hill AF, Martins VR.

Oncogene. 2015 Jun;34(25):3305-14. doi: 10.1038/onc.2014.261. Epub 2014 Aug 25.


Natural history and surgical treatment of chordoma: a retrospective cohort study.

Aguiar Júnior S, Andrade WP, Baiocchi G, Guimarães GC, Cunha IW, Estrada DA, Suzuki SH, Kowalski LP, Lopes A.

Sao Paulo Med J. 2014;132(5):297-302. Epub 2014 Jul 29.


Gene expression profiling in leiomyosarcomas and undifferentiated pleomorphic sarcomas: SRC as a new diagnostic marker.

Villacis RA, Silveira SM, Barros-Filho MC, Marchi FA, Domingues MA, Scapulatempo-Neto C, Aguiar S Jr, Lopes A, Cunha IW, Rogatto SR.

PLoS One. 2014 Jul 16;9(7):e102281. doi: 10.1371/journal.pone.0102281. eCollection 2014.


Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma.

Alves MR, Carneiro FC, Lavorato-Rocha AM, da Costa WH, da Cunha IW, de Cássio Zequi S, Guimaraes GC, Soares FA, Carraro DM, Rocha RM.

Virchows Arch. 2014 Sep;465(3):321-30. doi: 10.1007/s00428-014-1629-z. Epub 2014 Jul 16.


Radical prostatectomy and positive surgical margins: relationship with prostate cancer outcome.

De La Roca RL, Da Cunha IW, Bezerra SM, Da Fonseca FP.

Int Braz J Urol. 2014 May-Jun;40(3):306-15. doi: 10.1590/S1677-5538.IBJU.2014.03.03.


Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.

Silva AR, Santos AC, Farfel JM, Grinberg LT, Ferretti RE, Campos AH, Cunha IW, Begnami MD, Rocha RM, Carraro DM, de Bragança Pereira CA, Jacob-Filho W, Brentani H.

PLoS One. 2014 Jun 17;9(6):e99897. doi: 10.1371/journal.pone.0099897. eCollection 2014.


Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour.

Torrezan GT, Ferreira EN, Nakahata AM, Barros BD, Castro MT, Correa BR, Krepischi AC, Olivieri EH, Cunha IW, Tabori U, Grundy PE, Costa CM, de Camargo B, Galante PA, Carraro DM.

Nat Commun. 2014 Jun 9;5:4039. doi: 10.1038/ncomms5039.


Training in molecular pathology during residency: the experience of a Brazilian hospital.

de Macedo MP, Andrade LD, Andrade VP, Vassallo J, Campos AH, Pinto CA, de Osório CA, Begnami MD, Carraro DM, Soares FA, da Cunha IW.

J Clin Pathol. 2014 Jul;67(7):647-8. doi: 10.1136/jclinpath-2014-202271. Epub 2014 Apr 24. No abstract available.


KRAS insertions in colorectal cancer: what do we know about unusual KRAS mutations?

de Macedo MP, de Lima LG, Begnami MD, de Melo FM, Andrade LD, Lisboa BC, Soares LM, Soares FA, Carraro DM, da Cunha IW.

Exp Mol Pathol. 2014 Apr;96(2):257-60. doi: 10.1016/j.yexmp.2014.02.014. Epub 2014 Mar 2.


Bannayan-Riley-Ruvalcaba syndrome with deforming lipomatous hamartomas in infant--case report.

Gontijo GM, Pinto CA, Rogatto SR, Cunha IW, Aguiar S Jr, Alves CA.

An Bras Dermatol. 2013 Nov-Dec;88(6):982-5. doi: 10.1590/abd1806-4841.20132730.


NF-κB and COX-2 expression in nonmalignant endometrial lesions and cancer.

Faloppa CC, Baiocchi G, Cunha IW, Fregnani JH, Osorio CA, Fukazawa EM, Kumagai LY, Badiglian-Filho L, Pinto GL, Soares FA.

Am J Clin Pathol. 2014 Feb;141(2):196-203. doi: 10.1309/AJCPV7U7PGHOWEQG.


Artificial dermis (Matriderm®) followed by skin graft as an option in dermatofibrosarcoma protuberans with complete circumferential and peripheral deep margin assessment.

Bertolli E, Campagnari M, Molina AS, Macedo MP, Pinto CA, Cunha IW, Duprat Neto JP.

Int Wound J. 2015 Oct;12(5):545-7. doi: 10.1111/iwj.12157. Epub 2013 Sep 19.


Polybromo-1 (PBRM1), a SWI/SNF complex subunit is a prognostic marker in clear cell renal cell carcinoma.

da Costa WH, Rezende M, Carneiro FC, Rocha RM, da Cunha IW, Carraro DM, Guimaraes GC, de Cassio Zequi S.

BJU Int. 2014 May;113(5b):E157-63. doi: 10.1111/bju.12426. Epub 2013 Dec 2.


Regulation of stress-inducible phosphoprotein 1 nuclear retention by protein inhibitor of activated STAT PIAS1.

Soares IN, Caetano FA, Pinder J, Rodrigues BR, Beraldo FH, Ostapchenko VG, Durette C, Pereira GS, Lopes MH, Queiroz-Hazarbassanov N, Cunha IW, Sanematsu PI, Suzuki S, Bleggi-Torres LF, Schild-Poulter C, Thibault P, Dellaire G, Martins VR, Prado VF, Prado MA.

Mol Cell Proteomics. 2013 Nov;12(11):3253-70. doi: 10.1074/mcp.M113.031005. Epub 2013 Aug 12.

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