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Items: 1 to 50 of 79

1.

Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B.

Pippa S, Mannironi C, Licursi V, Bombardi L, Colotti G, Cundari E, Mollica A, Coluccia A, Naccarato V, La Regina G, Silvestri R, Negri R.

Molecules. 2019 May 4;24(9). pii: E1739. doi: 10.3390/molecules24091739.

2.

Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization.

Ferrara M, Sessa G, Fiore M, Bernard F, Asteriti IA, Cundari E, Colotti G, Ferla S, Desideri M, Buglioni S, Trisciuoglio D, Del Bufalo D, Brancale A, Degrassi F.

Oncogene. 2018 Jan 11;37(2):231-240. doi: 10.1038/onc.2017.320. Epub 2017 Sep 18.

3.

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.

Di Cesare E, Verrico A, Miele A, Giubettini M, Rovella P, Coluccia A, Famiglini V, La Regina G, Cundari E, Silvestri R, Lavia P.

Oncotarget. 2017 Mar 21;8(12):19738-19759. doi: 10.18632/oncotarget.14980.

4.

Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin.

Sánchez-Lamar A, Piloto-Ferrer J, Fiore M, Stano P, Cozzi R, Tofani D, Cundari E, Francisco M, Romero A, González ML, Degrassi F.

J Ethnopharmacol. 2016 Dec 24;194:781-788. doi: 10.1016/j.jep.2016.11.006. Epub 2016 Nov 11.

PMID:
27840259
5.

Towards a New Paradigm in Nano-Genotoxicology: Facing Complexity of Nanomaterials' Cellular Interactions and Effects.

Gonzalez L, Cundari E, Leyns L, Kirsch-Volders M.

Basic Clin Pharmacol Toxicol. 2017 Sep;121 Suppl 3:23-29. doi: 10.1111/bcpt.12698. Epub 2017 Mar 15. Review.

6.

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.

Burla R, Carcuro M, Torre ML, Fratini F, Crescenzi M, D'Apice MR, Spitalieri P, Raffa GD, Astrologo L, Lattanzi G, Cundari E, Raimondo D, Biroccio A, Gatti M, Saggio I.

Open Biol. 2016 Aug;6(8). pii: 160103. doi: 10.1098/rsob.160103.

7.

Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replication.

De Santis Puzzonia M, Gonzalez L, Ascenzi S, Cundari E, Degrassi F.

Cell Cycle. 2016;15(2):274-82. doi: 10.1080/15384101.2015.1127469.

8.

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.

Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, La Torre M, Micheli E, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M, Saggio I.

PLoS Genet. 2015 Jun 25;11(6):e1005167. doi: 10.1371/journal.pgen.1005167. eCollection 2015 Jun.

9.

Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability.

Stellas D, Souliotis VL, Bekyrou M, Smirlis D, Kirsch-Volders M, Degrassi F, Cundari E, Kyrtopoulos SA.

Mutat Res. 2014 Nov;769:59-68. doi: 10.1016/j.mrfmmm.2014.07.004. Epub 2014 Jul 19.

PMID:
25771725
10.

Amorphous silica nanoparticles alter microtubule dynamics and cell migration.

Gonzalez L, De Santis Puzzonia M, Ricci R, Aureli F, Guarguaglini G, Cubadda F, Leyns L, Cundari E, Kirsch-Volders M.

Nanotoxicology. 2015;9(6):729-36. doi: 10.3109/17435390.2014.969791. Epub 2014 Oct 17.

PMID:
25325157
11.

The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy.

Asteriti IA, Di Cesare E, De Mattia F, Hilsenstein V, Neumann B, Cundari E, Lavia P, Guarguaglini G.

Oncotarget. 2014 Aug 15;5(15):6229-42.

12.

An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors.

Mannironi C, Proietto M, Bufalieri F, Cundari E, Alagia A, Danovska S, Rinaldi T, Famiglini V, Coluccia A, La Regina G, Silvestri R, Negri R.

PLoS One. 2014 Jan 29;9(1):e86002. doi: 10.1371/journal.pone.0086002. eCollection 2014.

13.

Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization.

Sorino C, Bruno T, Desantis A, Di Certo MG, Iezzi S, De Nicola F, Catena V, Floridi A, Chessa L, Passananti C, Cundari E, Fanciulli M.

J Biol Chem. 2013 Aug 9;288(32):23348-57. doi: 10.1074/jbc.M113.465302. Epub 2013 Jun 24.

14.

p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.

Prodosmo A, De Amicis A, Nisticò C, Gabriele M, Di Rocco G, Monteonofrio L, Piane M, Cundari E, Chessa L, Soddu S.

J Clin Invest. 2013 Mar;123(3):1335-42. doi: 10.1172/JCI67289. Epub 2013 Feb 1.

15.

Hard-metal (WC-Co) particles trigger a signaling cascade involving p38 MAPK, HIF-1α, HMOX1, and p53 activation in human PBMC.

Lombaert N, Castrucci E, Decordier I, Van Hummelen P, Kirsch-Volders M, Cundari E, Lison D.

Arch Toxicol. 2013 Feb;87(2):259-68. doi: 10.1007/s00204-012-0943-y. Epub 2012 Sep 28.

PMID:
23052192
16.

HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.

Rinaldo C, Moncada A, Gradi A, Ciuffini L, D'Eliseo D, Siepi F, Prodosmo A, Giorgi A, Pierantoni GM, Trapasso F, Guarguaglini G, Bartolazzi A, Cundari E, Schininà ME, Fusco A, Soddu S.

Mol Cell. 2012 Jul 13;47(1):87-98. doi: 10.1016/j.molcel.2012.04.029. Epub 2012 May 31.

17.

Synchronous protein cycling in batch cultures of the yeast Saccharomyces cerevisiae at log growth phase.

Romagnoli G, Cundari E, Negri R, Crescenzi M, Farina L, Giuliani A, Bianchi MM.

Exp Cell Res. 2011 Dec 10;317(20):2958-68. doi: 10.1016/j.yexcr.2011.09.007. Epub 2011 Sep 24.

PMID:
21978910
18.

Methodological approaches influencing cellular uptake and cyto-(geno) toxic effects of nanoparticles.

Gonzalez L, Corradi S, Thomassen LC, Martens JA, Cundari E, Lison D, Kirsch-Volders M.

J Biomed Nanotechnol. 2011 Feb;7(1):3-5.

PMID:
21485774
19.

The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.

Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, Benihoud K, Saggio I, Rosselli F.

Nucleic Acids Res. 2011 Jul;39(13):5459-73. doi: 10.1093/nar/gkr084. Epub 2011 Mar 17.

20.

Yeast lsm pro-apoptotic mutants show defects in S-phase entry and progression.

Palermo V, Cundari E, Mangiapelo E, Falcone C, Mazzoni C.

Cell Cycle. 2010 Oct 1;9(19):3991-6. Epub 2010 Oct 29.

PMID:
20935467
21.

Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis.

Decordier I, Cundari E, Kirsch-Volders M.

Mutat Res. 2008 Mar 12;651(1-2):30-9. doi: 10.1016/j.mrgentox.2007.10.016. Epub 2007 Nov 9. Review.

PMID:
18242119
22.

Mitotic checkpoints and the maintenance of the chromosome karyotype.

Decordier I, Cundari E, Kirsch-Volders M.

Mutat Res. 2008 Mar 12;651(1-2):3-13. doi: 10.1016/j.mrgentox.2007.10.020. Epub 2007 Nov 12. Review.

PMID:
18242118
23.

Gcn5p plays an important role in centromere kinetochore function in budding yeast.

Vernarecci S, Ornaghi P, Bâgu A, Cundari E, Ballario P, Filetici P.

Mol Cell Biol. 2008 Feb;28(3):988-96. Epub 2007 Nov 26.

24.

Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts.

Sánchez-Lamar A, Fonseca G, Fuentes JL, Cozzi R, Cundari E, Fiore M, Ricordy R, Perticone P, Degrassi F, De Salvia R.

J Ethnopharmacol. 2008 Feb 12;115(3):416-22. Epub 2007 Oct 18.

PMID:
18036756
25.

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells.

Stagni V, di Bari MG, Cursi S, Condò I, Cencioni MT, Testi R, Lerenthal Y, Cundari E, Barilà D.

Blood. 2008 Jan 15;111(2):829-37. Epub 2007 Oct 11.

26.

E1B55K-deleted adenovirus (ONYX-015) overrides G1/S and G2/M checkpoints and causes mitotic catastrophe and endoreduplication in p53-proficient normal cells.

Cherubini G, Petouchoff T, Grossi M, Piersanti S, Cundari E, Saggio I.

Cell Cycle. 2006 Oct;5(19):2244-52. Epub 2006 Oct 1.

PMID:
16969092
27.

Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.

Foglietti C, Filocamo G, Cundari E, De Rinaldis E, Lahm A, Cortese R, Steinkühler C.

J Biol Chem. 2006 Jun 30;281(26):17968-76. Epub 2006 Apr 21.

28.

ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity.

Oricchio E, Saladino C, Iacovelli S, Soddu S, Cundari E.

Cell Cycle. 2006 Jan;5(1):88-92. Epub 2006 Jan 21.

PMID:
16319535
29.

Influence of caspase activity on micronuclei detection: a possible role for caspase-3 in micronucleation.

Decordier I, Cundari E, Kirsch-Volders M.

Mutagenesis. 2005 May;20(3):173-9. Epub 2005 Apr 7.

PMID:
15817572
30.

Evaluation of the apoptogenic potential of hard metal dust (WC-Co), tungsten carbide and metallic cobalt.

Lombaert N, De Boeck M, Decordier I, Cundari E, Lison D, Kirsch-Volders M.

Toxicol Lett. 2004 Dec 1;154(1-2):23-34.

PMID:
15475175
31.

p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.

Tritarelli A, Oricchio E, Ciciarello M, Mangiacasale R, Palena A, Lavia P, Soddu S, Cundari E.

Mol Biol Cell. 2004 Aug;15(8):3751-7. Epub 2004 Jun 4.

32.

Mammalian cell transduction and internalization properties of lambda phages displaying the full-length adenoviral penton base or its central domain.

Piersanti S, Cherubini G, Martina Y, Salone B, Avitabile D, Grosso F, Cundari E, Di Zenzo G, Saggio I.

J Mol Med (Berl). 2004 Jul;82(7):467-76. Epub 2004 May 19.

PMID:
15150649
33.

Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5.

Salone B, Martina Y, Piersanti S, Cundari E, Cherubini G, Franqueville L, Failla CM, Boulanger P, Saggio I.

J Virol. 2003 Dec;77(24):13448-54.

34.

Mammalian RanBP1 regulates centrosome cohesion during mitosis.

Di Fiore B, Ciciarello M, Mangiacasale R, Palena A, Tassin AM, Cundari E, Lavia P.

J Cell Sci. 2003 Aug 15;116(Pt 16):3399-411. Epub 2003 Jul 2. Erratum in: J Cell Sci. 2003 Sep 1;116(Pt 17):3659.

35.

Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells.

Somma MP, Fasulo B, Cenci G, Cundari E, Gatti M.

Mol Biol Cell. 2002 Jul;13(7):2448-60.

36.

Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules.

Decordier I, Dillen L, Cundari E, Kirsch-Volders M.

Mutagenesis. 2002 Jul;17(4):337-44.

PMID:
12110631
37.

p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.

Ciciarello M, Mangiacasale R, Casenghi M, Zaira Limongi M, D'Angelo M, Soddu S, Lavia P, Cundari E.

J Biol Chem. 2001 Jun 1;276(22):19205-13. Epub 2001 Feb 28.

38.

Binding properties, cell delivery, and gene transfer of adenoviral penton base displaying bacteriophage.

Di Giovine M, Salone B, Martina Y, Amati V, Zambruno G, Cundari E, Failla CM, Saggio I.

Virology. 2001 Mar 30;282(1):102-12.

39.

Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields.

Mangiacasale R, Tritarelli A, Sciamanna I, Cannone M, Lavia P, Barberis MC, Lorenzini R, Cundari E.

FEBS Lett. 2001 Jan 5;487(3):397-403.

40.

Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo.

Guarguaglini G, Renzi L, D'Ottavio F, Di Fiore B, Casenghi M, Cundari E, Lavia P.

Cell Growth Differ. 2000 Aug;11(8):455-65.

41.

Engagement of CD4 before TCR triggering regulates both Bax- and Fas (CD95)-mediated apoptosis.

Somma F, Tuosto L, Gilardini Montani MS, Di Somma MM, Cundari E, Piccolella E.

J Immunol. 2000 May 15;164(10):5078-87.

42.

Phyllanthus orbicularis aqueous extract: cytotoxic, genotoxic, and antimutagenic effects in the CHO cell line.

Sànchez-Lamar A, Fiore M, Cundari E, Ricordy R, Cozzi R, De Salvia R.

Toxicol Appl Pharmacol. 1999 Dec 15;161(3):231-9.

PMID:
10620480
43.

Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole.

Verdoodt B, Decordier I, Geleyns K, Cunha M, Cundari E, Kirsch-Volders M.

Mutagenesis. 1999 Sep;14(5):513-20.

PMID:
10473656
44.

p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.

Casenghi M, Mangiacasale R, Tuynder M, Caillet-Fauquet P, Elhajouji A, Lavia P, Mousset S, Kirsch-Volders M, Cundari E.

Exp Cell Res. 1999 Aug 1;250(2):339-50.

PMID:
10413588
45.

TCR engagement regulates differential responsiveness of human memory T cells to Fas (CD95)-mediated apoptosis.

Di Somma MM, Somma F, Gilardini Montani MS, Mangiacasale R, Cundari E, Piccolella E.

J Immunol. 1999 Apr 1;162(7):3851-8.

46.

Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2.

Gilardini Montani MS, Tuosto L, Giliberti R, Stefanini L, Cundari E, Piccolella E.

Cell Death Differ. 1999 Jan;6(1):79-86.

47.

Towards a unifying model for the metaphase/anaphase transition.

Kirsch-Volders M, Cundari E, Verdoodt B.

Mutagenesis. 1998 Jul;13(4):321-35. Review.

PMID:
9717168
48.

DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition.

Vanni A, Fiore M, De Salvia R, Cundari E, Ricordy R, Ceccarelli R, Degrassi F.

Mutat Res. 1998 Jun 5;401(1-2):55-63.

PMID:
9639674
49.

Deregulated expression of the RanBP1 gene alters cell cycle progression in murine fibroblasts.

Battistoni A, Guarguaglini G, Degrassi F, Pittoggi C, Palena A, Di Matteo G, Pisano C, Cundari E, Lavia P.

J Cell Sci. 1997 Oct;110 ( Pt 19):2345-57.

50.

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