Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 133

1.

Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells.

Thompson K, Chen J, Luo Q, Xiao Y, Cummins TR, Bhatwadekar AD.

PLoS One. 2018 Feb 23;13(2):e0193280. doi: 10.1371/journal.pone.0193280. eCollection 2018.

2.

Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation.

Shugg T, Johnson DE, Shao M, Lai X, Witzmann F, Cummins TR, Rubart-Von-der Lohe M, Hudmon A, Overholser BR.

Heart Rhythm. 2018 Jun;15(6):895-904. doi: 10.1016/j.hrthm.2018.01.024. Epub 2018 Feb 2.

PMID:
29410121
3.

Characterization of Membrane Patch-Ion Channel Probes for Scanning Ion Conductance Microscopy.

Shi W, Zeng Y, Zhu C, Xiao Y, Cummins TR, Hou J, Baker LA.

Small. 2018 May;14(18):e1702945. doi: 10.1002/smll.201702945. Epub 2017 Dec 11.

PMID:
29226633
4.

Posttranslational Modification of Sodium Channels.

Pei Z, Pan Y, Cummins TR.

Handb Exp Pharmacol. 2018;246:101-124. doi: 10.1007/164_2017_69.

PMID:
29071507
5.

FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons.

Barbosa C, Xiao Y, Johnson AJ, Xie W, Strong JA, Zhang JM, Cummins TR.

Pflugers Arch. 2017 Feb;469(2):195-212. doi: 10.1007/s00424-016-1911-9. Epub 2016 Dec 20.

6.

Membrane patches as ion channel probes for scanning ion conductance microscopy.

Shi W, Zeng Y, Zhou L, Xiao Y, Cummins TR, Baker LA.

Faraday Discuss. 2016 Dec 12;193:81-97.

PMID:
27711908
7.

Unusual Voltage-Gated Sodium Currents as Targets for Pain.

Barbosa C, Cummins TR.

Curr Top Membr. 2016;78:599-638. doi: 10.1016/bs.ctm.2015.12.005. Epub 2016 Feb 2. Review.

PMID:
27586296
8.

Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation.

Pei Z, Xiao Y, Meng J, Hudmon A, Cummins TR.

Nat Commun. 2016 Jun 23;7:12035. doi: 10.1038/ncomms12035.

9.

t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy.

Thapa P, Cabalteja CC, Philips EE 3rd, Espiritu MJ, Peigneur S, Mille BG, Tytgat J, Cummins TR, Bingham JP.

Biopolymers. 2016 Sep;106(5):737-45. doi: 10.1002/bip.22887.

10.

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol.

Patel RR, Barbosa C, Brustovetsky T, Brustovetsky N, Cummins TR.

Brain. 2016 Aug;139(Pt 8):2164-81. doi: 10.1093/brain/aww129. Epub 2016 Jun 5.

11.

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration.

Ohlemacher SK, Sridhar A, Xiao Y, Hochstetler AE, Sarfarazi M, Cummins TR, Meyer JS.

Stem Cells. 2016 Jun;34(6):1553-62. doi: 10.1002/stem.2356. Epub 2016 Mar 21.

13.

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons.

Barbosa C, Tan ZY, Wang R, Xie W, Strong JA, Patel RR, Vasko MR, Zhang JM, Cummins TR.

Mol Pain. 2015 Sep 25;11:60. doi: 10.1186/s12990-015-0063-9.

14.

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.

Patel RR, Barbosa C, Xiao Y, Cummins TR.

PLoS One. 2015 Jul 16;10(7):e0133485. doi: 10.1371/journal.pone.0133485. eCollection 2015.

15.

Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.

Torregrosa R, Yang XF, Dustrude ET, Cummins TR, Khanna R, Kohn H.

Bioorg Med Chem. 2015 Jul 1;23(13):3655-66. doi: 10.1016/j.bmc.2015.04.014. Epub 2015 Apr 11.

16.

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker.

Tan ZY, Priest BT, Krajewski JL, Knopp KL, Nisenbaum ES, Cummins TR.

FEBS Lett. 2014 Nov 3;588(21):3964-9. doi: 10.1016/j.febslet.2014.09.011. Epub 2014 Sep 19.

17.

Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.

Lee H, Park KD, Torregrosa R, Yang XF, Dustrude ET, Wang Y, Wilson SM, Barbosa C, Xiao Y, Cummins TR, Khanna R, Kohn H.

J Med Chem. 2014 Jul 24;57(14):6165-82. doi: 10.1021/jm500707r. Epub 2014 Jul 15.

18.

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.

Xiao Y, Blumenthal K, Cummins TR.

Mol Pharmacol. 2014 Aug;86(2):159-67. doi: 10.1124/mol.114.092338. Epub 2014 Jun 4.

19.

Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.

Tan ZY, Piekarz AD, Priest BT, Knopp KL, Krajewski JL, McDermott JS, Nisenbaum ES, Cummins TR.

J Neurosci. 2014 May 21;34(21):7190-7. doi: 10.1523/JNEUROSCI.5011-13.2014.

20.

Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel.

Chen X, Sun W, Gianaris NG, Riley AM, Cummins TR, Fehrenbacher JC, Obukhov AG.

J Biol Chem. 2014 Apr 4;289(14):9600-10. doi: 10.1074/jbc.M113.536862. Epub 2014 Feb 25.

21.

Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin.

Rowe AH, Xiao Y, Rowe MP, Cummins TR, Zakon HH.

Science. 2013 Oct 25;342(6157):441-446. doi: 10.1126/science.1236451.

22.

Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1.6 by calmodulin.

Reddy Chichili VP, Xiao Y, Seetharaman J, Cummins TR, Sivaraman J.

Sci Rep. 2013;3:2435. doi: 10.1038/srep02435.

23.

Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation.

King AM, Yang XF, Wang Y, Dustrude ET, Barbosa C, Due MR, Piekarz AD, Wilson SM, White FA, Salomé C, Cummins TR, Khanna R, Kohn H.

ACS Chem Neurosci. 2012 Dec 19;3(12):1037-49. doi: 10.1021/cn300129d. Epub 2012 Sep 19.

24.

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.

Song W, Xiao Y, Chen H, Ashpole NM, Piekarz AD, Ma P, Hudmon A, Cummins TR, Shou W.

J Physiol. 2012 Oct 15;590(20):5123-39. doi: 10.1113/jphysiol.2012.235374. Epub 2012 Jul 23.

25.

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.

Brittain MK, Brustovetsky T, Brittain JM, Khanna R, Cummins TR, Brustovetsky N.

Neuropharmacology. 2012 Nov;63(6):974-82. doi: 10.1016/j.neuropharm.2012.07.012. Epub 2012 Jul 20.

26.

Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo.

Fu LY, Cummins TR, Moczydlowski EG.

Channels (Austin). 2012 Jan-Feb;6(1):41-9. doi: 10.4161/chan.19001. Epub 2012 Jan 1.

27.

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites.

Ashpole NM, Herren AW, Ginsburg KS, Brogan JD, Johnson DE, Cummins TR, Bers DM, Hudmon A.

J Biol Chem. 2012 Jun 8;287(24):19856-69. doi: 10.1074/jbc.M111.322537. Epub 2012 Apr 18.

28.

Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.

Ashpole NM, Song W, Brustovetsky T, Engleman EA, Brustovetsky N, Cummins TR, Hudmon A.

J Biol Chem. 2012 Mar 9;287(11):8495-506. doi: 10.1074/jbc.M111.323915. Epub 2012 Jan 17.

29.

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger.

Brittain MK, Brustovetsky T, Sheets PL, Brittain JM, Khanna R, Cummins TR, Brustovetsky N.

Neurobiol Dis. 2012 Apr;46(1):109-17. doi: 10.1016/j.nbd.2011.12.051. Epub 2012 Jan 10.

30.

Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes.

Theile JW, Cummins TR.

Front Pharmacol. 2011 Oct 4;2:54. doi: 10.3389/fphar.2011.00054. eCollection 2011.

31.

Isolation and characterization of CvIV4: a pain inducing α-scorpion toxin.

Rowe AH, Xiao Y, Scales J, Linse KD, Rowe MP, Cummins TR, Zakon HH.

PLoS One. 2011;6(8):e23520. doi: 10.1371/journal.pone.0023520. Epub 2011 Aug 24.

32.

Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells.

Koehler KR, Tropel P, Theile JW, Kondo T, Cummins TR, Viville S, Hashino E.

BMC Neurosci. 2011 Aug 10;12:82. doi: 10.1186/1471-2202-12-82.

33.

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex.

Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, Hurley JH, Khanna M, Hammes NM, Samuels BC, White FA, Khanna R.

Channels (Austin). 2011 Sep-Oct;5(5):449-56. doi: 10.4161/chan.5.5.17363. Epub 2011 Sep 1.

34.

Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.

Theile JW, Cummins TR.

Mol Pharmacol. 2011 Oct;80(4):724-34. doi: 10.1124/mol.111.072751. Epub 2011 Jul 25.

35.

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV.

Xiao Y, Jackson JO 2nd, Liang S, Cummins TR.

J Biol Chem. 2011 Aug 5;286(31):27301-10. doi: 10.1074/jbc.M111.246876. Epub 2011 Jun 9.

36.

Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels.

Sheets PL, Jarecki BW, Cummins TR.

Br J Pharmacol. 2011 Sep;164(2b):719-30. doi: 10.1111/j.1476-5381.2011.01209.x.

37.

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents.

Theile JW, Jarecki BW, Piekarz AD, Cummins TR.

J Physiol. 2011 Feb 1;589(Pt 3):597-608. doi: 10.1113/jphysiol.2010.200915. Epub 2010 Nov 29.

38.

Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel.

Gracias NG, Cummins TR, Kelley MR, Basile DP, Iqbal T, Vasko MR.

Neurotoxicology. 2011 Jan;32(1):140-9. doi: 10.1016/j.neuro.2010.09.006. Epub 2010 Oct 7.

39.

KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I.

Brustovetsky T, Brittain MK, Sheets PL, Cummins TR, Pinelis V, Brustovetsky N.

Br J Pharmacol. 2011 Jan;162(1):255-70. doi: 10.1111/j.1476-5381.2010.01054.x.

40.

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.

Xiao Y, Blumenthal K, Jackson JO 2nd, Liang S, Cummins TR.

Mol Pharmacol. 2010 Dec;78(6):1124-34. doi: 10.1124/mol.110.066332. Epub 2010 Sep 20.

41.

In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation.

Wang Y, Brittain JM, Jarecki BW, Park KD, Wilson SM, Wang B, Hale R, Meroueh SO, Cummins TR, Khanna R.

J Biol Chem. 2010 Aug 13;285(33):25296-307. doi: 10.1074/jbc.M110.128801. Epub 2010 Jun 9.

42.

Sodium channels in normal and pathological pain.

Dib-Hajj SD, Cummins TR, Black JA, Waxman SG.

Annu Rev Neurosci. 2010;33:325-47. doi: 10.1146/annurev-neuro-060909-153234. Review.

PMID:
20367448
43.

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

Jarecki BW, Piekarz AD, Jackson JO 2nd, Cummins TR.

J Clin Invest. 2010 Jan;120(1):369-78. doi: 10.1172/JCI40801. Epub 2009 Dec 28.

44.

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels.

Brittain JM, Piekarz AD, Wang Y, Kondo T, Cummins TR, Khanna R.

J Biol Chem. 2009 Nov 6;284(45):31375-90. doi: 10.1074/jbc.M109.009951. Epub 2009 Sep 15.

45.

Alternative splicing of Na(V)1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T.

Jarecki BW, Sheets PL, Xiao Y, Jackson JO 2nd, Cummins TR.

Channels (Austin). 2009 Jul-Aug;3(4):259-67. Epub 2009 Jul 23.

46.

Transfection of rat or mouse neurons by biolistics or electroporation.

Dib-Hajj SD, Choi JS, Macala LJ, Tyrrell L, Black JA, Cummins TR, Waxman SG.

Nat Protoc. 2009;4(8):1118-26. doi: 10.1038/nprot.2009.90. Epub 2009 Jul 9.

PMID:
19617884
47.

Voltage-clamp and current-clamp recordings from mammalian DRG neurons.

Cummins TR, Rush AM, Estacion M, Dib-Hajj SD, Waxman SG.

Nat Protoc. 2009;4(8):1103-12. doi: 10.1038/nprot.2009.91. Epub 2009 Jul 9.

PMID:
19617882
48.

Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment.

Dib-Hajj SD, Binshtok AM, Cummins TR, Jarvis MF, Samad T, Zimmermann K.

Brain Res Rev. 2009 Apr;60(1):65-83. doi: 10.1016/j.brainresrev.2008.12.005. Epub 2008 Dec 25. Review.

PMID:
19150627
49.

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable.

Dib-Hajj SD, Estacion M, Jarecki BW, Tyrrell L, Fischer TZ, Lawden M, Cummins TR, Waxman SG.

Mol Pain. 2008 Sep 19;4:37. doi: 10.1186/1744-8069-4-37.

50.

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.

Xiao Y, Bingham JP, Zhu W, Moczydlowski E, Liang S, Cummins TR.

J Biol Chem. 2008 Oct 3;283(40):27300-13. doi: 10.1074/jbc.M708447200. Epub 2008 Jul 14.

Supplemental Content

Loading ...
Support Center