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Items: 42


The Role of the BCL-2 Family of Proteins in HIV-1 Pathogenesis and Persistence.

Chandrasekar AP, Cummins NW, Badley AD.

Clin Microbiol Rev. 2019 Oct 30;33(1). pii: e00107-19. doi: 10.1128/CMR.00107-19. Print 2019 Dec 18. Review.


Mechanisms of Human Immunodeficiency Virus-Associated Lymphocyte Regulated Cell Death.

Paim AC, Badley AD, Cummins NW.

AIDS Res Hum Retroviruses. 2019 Dec 10. doi: 10.1089/AID.2019.0213. [Epub ahead of print]


TRAILshort Protects against CD4 T Cell Death during Acute HIV Infection.

Natesampillai S, Paim AC, Cummins NW, Chandrasekar AP, Bren GD, Lewin SR, Kiem HP, Badley AD.

J Immunol. 2019 Aug 1;203(3):718-724. doi: 10.4049/jimmunol.1900271. Epub 2019 Jun 12.


HIV elite control is associated with reduced TRAILshort expression.

Paim AC, Cummins NW, Natesampillai S, Garcia-Rivera E, Kogan N, Neogi U, Sönnerborg A, Sperk M, Bren GD, Deeks S, Polley E, Badley AD.

AIDS. 2019 Sep 1;33(11):1757-1763. doi: 10.1097/QAD.0000000000002279.


Risks and Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Hematologic Malignancies in Patients with HIV Infection.

Arslan S, Litzow MR, Cummins NW, Rizza SA, Badley AD, Navarro W, Hashmi SK.

Biol Blood Marrow Transplant. 2019 Aug;25(8):e260-e267. doi: 10.1016/j.bbmt.2019.03.021. Epub 2019 Mar 26. Review.


Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.

Nie Z, Aboulnasr F, Natesampillai S, Burke SP, Krogman A, Bren GD, Chung TDY, Anderson JR, Smart MK, Katzmann DJ, Rajagopalan G, Cummins NW, Badley AD.

J Immunol. 2018 Sep 1;201(5):1599. doi: 10.4049/jimmunol.1800867. Epub 2018 Jul 13. No abstract available.


Transient Loss of HIV-1 DNA in an HIV-1 Positive Patient After Kidney Transplantation: A Case Report.

Paim AC, Rizza SA, Badley AD, Prieto M, Taler SJ, Chong PP, Cummins NW.

Am J Med. 2018 Oct;131(10):e423-e424. doi: 10.1016/j.amjmed.2018.04.022. Epub 2018 May 3. No abstract available.


HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome.

Natesampillai S, Cummins NW, Nie Z, Sampath R, Baker JV, Henry K, Pinzone M, O'Doherty U, Polley EC, Bren GD, Katzmann DJ, Badley AD.

J Virol. 2018 Jun 13;92(13). pii: e00037-18. doi: 10.1128/JVI.00037-18. Print 2018 Jul 1.


Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.

Nie Z, Aboulnasr F, Natesampillai S, Burke SP, Krogman A, Bren GD, Chung TDY, Anderson JR, Smart MK, Katzmann DJ, Rajagopalan G, Cummins NW, Badley AD.

J Immunol. 2018 Feb 1;200(3):1110-1123. doi: 10.4049/jimmunol.1701113. Epub 2017 Dec 20. Erratum in: J Immunol. 2018 Sep 1;201(5):1599.


Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study.

Cummins NW, Rizza S, Litzow MR, Hua S, Lee GQ, Einkauf K, Chun TW, Rhame F, Baker JV, Busch MP, Chomont N, Dean PG, Fromentin R, Haase AT, Hampton D, Keating SM, Lada SM, Lee TH, Natesampillai S, Richman DD, Schacker TW, Wietgrefe S, Yu XG, Yao JD, Zeuli J, Lichterfeld M, Badley AD.

PLoS Med. 2017 Nov 28;14(11):e1002461. doi: 10.1371/journal.pmed.1002461. eCollection 2017 Nov.


An advanced BLT-humanized mouse model for extended HIV-1 cure studies.

Lavender KJ, Pace C, Sutter K, Messer RJ, Pouncey DL, Cummins NW, Natesampillai S, Zheng J, Goldsmith J, Widera M, Van Dis ES, Phillips K, Race B, Dittmer U, Kukolj G, Hasenkrug KJ.

AIDS. 2018 Jan 2;32(1):1-10. doi: 10.1097/QAD.0000000000001674.


Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells.

Sampath R, Cummins NW, Natesampillai S, Bren GD, Chung TD, Baker J, Henry K, Pagliuzza A, Badley AD.

PLoS One. 2017 Jun 19;12(6):e0179327. doi: 10.1371/journal.pone.0179327. eCollection 2017.


Lysinibacillus massiliensis Panniculitis Masquerading as Erythema Nodosum: A Case Report.

Jin JJ, Keith PJ, Cummins NW, Kane SV, Pritt BS, Sanchez JL.

Open Forum Infect Dis. 2017 Apr 6;4(2):ofx072. doi: 10.1093/ofid/ofx072. eCollection 2017 Spring.


Epidemiology, risk factors, and outcomes of infections in patients undergoing liver transplantation for hilar cholangiocarcinoma.

Ramanan P, Cummins NW, Wilhelm MP, Heimbach JK, Dierkhising R, Kremers WK, Rosen CB, Gores GJ, Razonable RR.

Clin Transplant. 2017 Aug;31(8). doi: 10.1111/ctr.13023. Epub 2017 Jul 5.


Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition.

Cummins NW, Sainski-Nguyen AM, Natesampillai S, Aboulnasr F, Kaufmann S, Badley AD.

J Virol. 2017 May 12;91(11). pii: e00012-17. doi: 10.1128/JVI.00012-17. Print 2017 Jun 1.


Casp8p41: The Protean Mediator of Death in CD4 T-cells that Replicate HIV.

Sampath R, Cummins NW, Badley AD.

J Cell Death. 2016 Sep 27;9:9-17. eCollection 2016. Review.


Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future.

Cummins NW, Badley AD, Kasten MJ, Sampath R, Temesgen Z, Whitaker JA, Wilson JW, Yao JD, Zeuli J, Rizza SA.

World J Virol. 2016 May 12;5(2):63-7. doi: 10.5501/wjv.v5.i2.63. Review.


Is Abnormal Urine Protein/Osmolality Ratio Associated with Abnormal Renal Function in Patients Receiving Tenofovir Disoproxil Fumarate?

Marcelin JR, Berg ML, Tan EM, Amer H, Cummins NW, Rizza SA.

PLoS One. 2016 Feb 12;11(2):e0149562. doi: 10.1371/journal.pone.0149562. eCollection 2016.


Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size.

Cummins NW, Sainski AM, Dai H, Natesampillai S, Pang YP, Bren GD, de Araujo Correia MCM, Sampath R, Rizza SA, O'Brien D, Yao JD, Kaufmann SH, Badley AD.

J Virol. 2016 Mar 28;90(8):4032-4048. doi: 10.1128/JVI.03179-15. Print 2016 Apr.


Fever and Cardiac Arrest in a Patient With a Left Ventricular Assist Device.

Tan EM, Marcelin JR, Tande AJ, Rizza SA, Cummins NW.

Open Forum Infect Dis. 2015 Mar 5;2(2):ofv033. doi: 10.1093/ofid/ofv033. eCollection 2015 Apr.


Casp8p41 and HIV.

Cummins NW, Badley AD.

Oncotarget. 2015 Sep 15;6(27):23042-3. No abstract available.


Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis.

Cummins NW, Neuhaus J, Chu H, Neaton J, Wyen C, Rockstroh JK, Skiest DJ, Boyd MA, Khoo S, Rotger M, Telenti A, Weinshilboum R, Badley AD; INSIGHT Study Group.

EBioMedicine. 2015 May 12;2(7):706-12. doi: 10.1016/j.ebiom.2015.05.012. eCollection 2015 Jul.


Can HIV Be Cured and Should We Try?

Cummins NW, Badley AD.

Mayo Clin Proc. 2015 Jun;90(6):705-9. doi: 10.1016/j.mayocp.2015.03.008. Epub 2015 May 2. No abstract available.


Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation.

Sainski AM, Dai H, Natesampillai S, Pang YP, Bren GD, Cummins NW, Correia C, Meng XW, Tarara JE, Ramirez-Alvarado M, Katzmann DJ, Ochsenbauer C, Kappes JC, Kaufmann SH, Badley AD.

J Cell Biol. 2014 Sep 29;206(7):867-76. doi: 10.1083/jcb.201405051. Epub 2014 Sep 22. Erratum in: J Cell Biol. 2014 Oct 13;207(1):159.


CORR Insights: Is synovial C-reactive protein a useful marker for periprosthetic joint infection?

Cummins NW.

Clin Orthop Relat Res. 2014 Dec;472(12):4004-5. doi: 10.1007/s11999-014-3882-5. Epub 2014 Aug 19. No abstract available.


Mucormycosis in patients with inflammatory bowel disease: case series and review of the literature.

Abidi MZ, Coelho-Prabhu N, Hargreaves J, Weiland T, Van Dyken I, Tande A, Tosh PK, Walker RC, Cummins NW.

Case Rep Med. 2014;2014:637492. doi: 10.1155/2014/637492. Epub 2014 Apr 27.


Choice of antiretroviral therapy differentially impacts survival of HIV-infected CD4 T cells.

Cummins NW, Sainski AM, Natesampillai S, Bren GD, Badley AD.

Mol Cell Ther. 2014 Jan 3;2:1. doi: 10.1186/2052-8426-2-1. eCollection 2014.


Making sense of how HIV kills infected CD4 T cells: implications for HIV cure.

Cummins NW, Badley AD.

Mol Cell Ther. 2014 Jul 3;2:20. doi: 10.1186/2052-8426-2-20. eCollection 2014. Review.


Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of Casp8p41.

Cummins NW, Neuhaus J, Sainski AM, Strausbauch MA, Wettstein PJ, Lewin SR, Plana M, Rizza SA, Temesgen Z, Touloumi G, Freiberg M, Neaton J, Badley AD; INSIGHT SMART Study Group.

AIDS Res Hum Retroviruses. 2014 May;30(5):476-9. doi: 10.1089/AID.2013.0243. Epub 2014 Feb 14.


Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV.

Cummins NW, Badley AD.

Cell Mol Life Sci. 2013 Sep;70(18):3355-63. doi: 10.1007/s00018-012-1239-3. Epub 2012 Dec 30. Review.


Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice.

Cummins NW, Weaver EA, May SM, Croatt AJ, Foreman O, Kennedy RB, Poland GA, Barry MA, Nath KA, Badley AD.

FASEB J. 2012 Jul;26(7):2911-8. doi: 10.1096/fj.11-190017. Epub 2012 Apr 6.


Multiple Pyogenic Liver Abscesses Caused by Eggerthella lenta Treated with Ertapenem: A Case Report.

Elias RM, Khoo SY, Pupaibool J, Nienaber JH, Cummins NW.

Case Rep Med. 2012;2012:718130. doi: 10.1155/2012/718130. Epub 2012 Mar 5.


Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations.

Cummins NW, Klicpera A, Sainski AM, Bren GD, Khosla S, Westendorf JJ, Badley AD.

PLoS One. 2011;6(9):e24876. doi: 10.1371/journal.pone.0024876. Epub 2011 Sep 12.


Isolation of a TRAIL antagonist from the serum of HIV-infected patients.

Schnepple DJ, Shepard B, Bren GD, Cummins NW, Natesampillai S, Trushin S, Algeciras-Schimnich A, Meng XW, Sainski AM, Rizza SA, Kaufmann SH, Badley AD.

J Biol Chem. 2011 Oct 14;286(41):35742-54. doi: 10.1074/jbc.M111.274639. Epub 2011 Aug 22.


The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak.

Sainski AM, Natesampillai S, Cummins NW, Bren GD, Taylor J, Saenz DT, Poeschla EM, Badley AD.

J Virol. 2011 Aug;85(16):7965-75. doi: 10.1128/JVI.02515-10. Epub 2011 Jun 8.


Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells.

Natesampillai S, Nie Z, Cummins NW, Jochmans D, Bren GD, Angel JB, Badley AD.

PLoS Pathog. 2010 Nov 24;6(11):e1001213. doi: 10.1371/journal.ppat.1001213.


Intracellular Casp8p41 content is inversely associated with CD4 T cell count.

Cummins NW, Jiang W, McGinty J, Bren GD, Bosch RJ, Landay A, Deeks SG, Martin JN, Douek D, Lederman MM, Brenchley J, Badley AD.

J Infect Dis. 2010 Aug 15;202(3):386-91. doi: 10.1086/653705.


Casp8p41 expression in primary T cells induces a proinflammatory response.

Taylor JA, Cummins NW, Bren GD, Rizza SA, Kolbert CP, Behrens MD, Knutson KL, Kahl JC, Asmann YW, Badley AD.

AIDS. 2010 Jun 1;24(9):1251-8. doi: 10.1097/QAD.0b013e3283389e90.


How much gp120 is there?

Cummins NW, Rizza SA, Badley AD.

J Infect Dis. 2010 Apr 15;201(8):1273-4; author reply 1274-5. doi: 10.1086/651434. No abstract available.


Mechanisms of HIV-associated lymphocyte apoptosis: 2010.

Cummins NW, Badley AD.

Cell Death Dis. 2010 Nov 11;1:e99. doi: 10.1038/cddis.2010.77. Review.


Deficiency of cytomegalovirus (CMV)-specific CD8+ T cells in patients presenting with late-onset CMV disease several years after transplantation.

Cummins NW, Deziel PJ, Abraham RS, Razonable RR.

Transpl Infect Dis. 2009 Feb;11(1):20-7. doi: 10.1111/j.1399-3062.2008.00344.x. Epub 2008 Sep 21.


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