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Ring substituents on substituted benzamide ligands indirectly mediate interactions with position 7.39 of transmembrane helix 7 of the D4 dopamine receptor.

Ericksen SS, Cummings DF, Teer ME, Amdani S, Schetz JA.

J Pharmacol Exp Ther. 2012 Aug;342(2):472-85. doi: 10.1124/jpet.112.193979. Epub 2012 May 15.


Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes.

Cummings DF, Canseco DC, Sheth P, Johnson JE, Schetz JA.

Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. doi: 10.1016/j.bmc.2010.05.017. Epub 2010 May 15.


Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548.

Cummings DF, Ericksen SS, Goetz A, Schetz JA.

J Pharmacol Exp Ther. 2010 Jun;333(3):682-95. doi: 10.1124/jpet.109.164962. Epub 2010 Mar 9. Erratum in: J Pharmacol Exp Ther. 2010 Nov;335(2):518.


Three amino acids in the D2 dopamine receptor regulate selective ligand function and affinity.

Cummings DF, Ericksen SS, Schetz JA.

J Neurochem. 2009 Jul;110(1):45-57. doi: 10.1111/j.1471-4159.2009.06103.x. Epub 2009 Apr 16.


Ligand selectivity of D2 dopamine receptors is modulated by changes in local dynamics produced by sodium binding.

Ericksen SS, Cummings DF, Weinstein H, Schetz JA.

J Pharmacol Exp Ther. 2009 Jan;328(1):40-54. doi: 10.1124/jpet.108.141531. Epub 2008 Oct 10.

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