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Items: 7


L445P mutation on heavy chain stabilizes IgG4 under acidic conditions.

Xu CA, Feng AZ, Ramineni CK, Wallace MR, Culyba EK, Guay KP, Mehta K, Mabry R, Farrand S, Xu J, Feng J.

MAbs. 2019 Oct;11(7):1289-1299. doi: 10.1080/19420862.2019.1631116. Epub 2019 Jul 11.


Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor.

Garvie CW, Fraley CV, Elowe NH, Culyba EK, Lemke CT, Hubbard BK, Kaushik VK, Daniels DS.

Protein Sci. 2016 Nov;25(11):2018-2027. doi: 10.1002/pro.3019. Epub 2016 Oct 15.


A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein.

Pop MS, Stransky N, Garvie CW, Theurillat JP, Hartman EC, Lewis TA, Zhong C, Culyba EK, Lin F, Daniels DS, Pagliarini R, Ronco L, Koehler AN, Garraway LA.

Mol Cancer Ther. 2014 Jun;13(6):1492-502. doi: 10.1158/1535-7163.MCT-13-0689. Epub 2014 Apr 15.


N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability.

Price JL, Culyba EK, Chen W, Murray AN, Hanson SR, Wong CH, Powers ET, Kelly JW.

Biopolymers. 2012;98(3):195-211. doi: 10.1002/bip.22030. Epub 2012 Feb 3.


Amyloid-β forms fibrils by nucleated conformational conversion of oligomers.

Lee J, Culyba EK, Powers ET, Kelly JW.

Nat Chem Biol. 2011 Jul 31;7(9):602-9. doi: 10.1038/nchembio.624.


Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns.

Culyba EK, Price JL, Hanson SR, Dhar A, Wong CH, Gruebele M, Powers ET, Kelly JW.

Science. 2011 Feb 4;331(6017):571-5. doi: 10.1126/science.1198461. Erratum in: Science. 2012 Mar 2;335(6072):1042.


The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability.

Hanson SR, Culyba EK, Hsu TL, Wong CH, Kelly JW, Powers ET.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3131-6. doi: 10.1073/pnas.0810318105. Epub 2009 Feb 9.

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