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Items: 1 to 50 of 78

1.

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties.

Mills RD, Liang LY, Lio DS, Mok YF, Mulhern TD, Cao G, Griffin M, Kenche VB, Culvenor JG, Cheng HC.

J Neurochem. 2018 Nov;147(3):409-428. doi: 10.1111/jnc.14566.

2.

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice.

Finkelstein DI, Hare DJ, Billings JL, Sedjahtera A, Nurjono M, Arthofer E, George S, Culvenor JG, Bush AI, Adlard PA.

ACS Chem Neurosci. 2016 Jan 20;7(1):119-29. doi: 10.1021/acschemneuro.5b00253. Epub 2015 Oct 30.

PMID:
26481462
3.

Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).

Mills RD, Mulhern TD, Liu F, Culvenor JG, Cheng HC.

Hum Mutat. 2014 Apr;35(4):395-412. doi: 10.1002/humu.22515. Epub 2014 Feb 24. Review.

PMID:
24470158
4.

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.

Tan JL, Li QX, Ciccotosto GD, Crouch PJ, Culvenor JG, White AR, Evin G.

PLoS One. 2013 Apr 17;8(4):e61246. doi: 10.1371/journal.pone.0061246. Print 2013.

5.

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations.

Mills RD, Mulhern TD, Cheng HC, Culvenor JG.

Biochem Soc Trans. 2012 Oct;40(5):1086-9. Review.

PMID:
22988870
6.

Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1).

Sim CH, Gabriel K, Mills RD, Culvenor JG, Cheng HC.

Hum Mutat. 2012 Oct;33(10):1408-22. doi: 10.1002/humu.22127. Epub 2012 Jul 5. Review.

PMID:
22644621
7.

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.

Hung LW, Villemagne VL, Cheng L, Sherratt NA, Ayton S, White AR, Crouch PJ, Lim S, Leong SL, Wilkins S, George J, Roberts BR, Pham CL, Liu X, Chiu FC, Shackleford DM, Powell AK, Masters CL, Bush AI, O'Keefe G, Culvenor JG, Cappai R, Cherny RA, Donnelly PS, Hill AF, Finkelstein DI, Barnham KJ.

J Exp Med. 2012 Apr 9;209(4):837-54. doi: 10.1084/jem.20112285. Epub 2012 Apr 2.

8.

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.

Soon CP, Donnelly PS, Turner BJ, Hung LW, Crouch PJ, Sherratt NA, Tan JL, Lim NK, Lam L, Bica L, Lim S, Hickey JL, Morizzi J, Powell A, Finkelstein DI, Culvenor JG, Masters CL, Duce J, White AR, Barnham KJ, Li QX.

J Biol Chem. 2011 Dec 23;286(51):44035-44. doi: 10.1074/jbc.M111.274407. Epub 2011 Oct 27.

9.

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.

Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC.

Biochemistry. 2011 Aug 9;50(31):6667-77. doi: 10.1021/bi2001938. Epub 2011 Jul 18.

10.

Changes in acetylcholinesterase expression are associated with altered presenilin-1 levels.

Silveyra MX, García-Ayllón MS, Serra-Basante C, Mazzoni V, García-Gutierrez MS, Manzanares J, Culvenor JG, Sáez-Valero J.

Neurobiol Aging. 2012 Mar;33(3):627.e27-37. doi: 10.1016/j.neurobiolaging.2011.04.006. Epub 2011 May 28.

PMID:
21621296
11.

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate.

Ho M, Hoke DE, Chua YJ, Li QX, Culvenor JG, Masters C, White AR, Evin G.

Int J Alzheimers Dis. 2010 Dec 28;2011:950932. doi: 10.4061/2011/950932.

12.

Both the p33 and p55 subunits of the Helicobacter pylori VacA toxin are targeted to mammalian mitochondria.

Foo JH, Culvenor JG, Ferrero RL, Kwok T, Lithgow T, Gabriel K.

J Mol Biol. 2010 Sep 3;401(5):792-8. doi: 10.1016/j.jmb.2010.06.065. Epub 2010 Jul 6.

PMID:
20615415
13.

α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.

George S, Mok SS, Nurjono M, Ayton S, Finkelstein DI, Masters CL, Li QX, Culvenor JG.

J Mol Neurosci. 2010 Oct;42(2):243-54. doi: 10.1007/s12031-010-9378-1. Epub 2010 May 13.

PMID:
20464527
14.

Dopamine D2 receptor knockout mice develop features of Parkinson disease.

Tinsley RB, Bye CR, Parish CL, Tziotis-Vais A, George S, Culvenor JG, Li QX, Masters CL, Finkelstein DI, Horne MK.

Ann Neurol. 2009 Oct;66(4):472-84. doi: 10.1002/ana.21716. Erratum in: Ann Neurol. 2009 Dec;66(6):869.

PMID:
19847912
15.

Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: implications for disease-associated kinases.

Cheng HC, Johnson TM, Mills RD, Chong YP, Chan KC, Culvenor JG.

Clin Exp Pharmacol Physiol. 2010 Jan;37(1):93-101. doi: 10.1111/j.1440-1681.2009.05237.x. Epub 2009 Jun 29. Review.

PMID:
19566834
16.

Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease.

Hung YH, Robb EL, Volitakis I, Ho M, Evin G, Li QX, Culvenor JG, Masters CL, Cherny RA, Bush AI.

J Biol Chem. 2009 Aug 14;284(33):21899-907. doi: 10.1074/jbc.M109.019521. Epub 2009 Jun 19.

17.

SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.

Smidt K, Jessen N, Petersen AB, Larsen A, Magnusson N, Jeppesen JB, Stoltenberg M, Culvenor JG, Tsatsanis A, Brock B, Schmitz O, Wogensen L, Bush AI, Rungby J.

PLoS One. 2009 May 25;4(5):e5684. doi: 10.1371/journal.pone.0005684.

18.

Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease.

Dutescu RM, Li QX, Crowston J, Masters CL, Baird PN, Culvenor JG.

Graefes Arch Clin Exp Ophthalmol. 2009 Sep;247(9):1213-21. doi: 10.1007/s00417-009-1060-3. Epub 2009 Mar 7.

PMID:
19271231
19.

Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation.

Silveyra MX, Evin G, Montenegro MF, Vidal CJ, Martínez S, Culvenor JG, Sáez-Valero J.

Mol Cell Biol. 2008 May;28(9):2908-19. doi: 10.1128/MCB.02065-07. Epub 2008 Feb 25.

20.

Alpha-synuclein transgenic mice exhibit reduced anxiety-like behaviour.

George S, van den Buuse M, San Mok S, Masters CL, Li QX, Culvenor JG.

Exp Neurol. 2008 Apr;210(2):788-92. doi: 10.1016/j.expneurol.2007.12.017. Epub 2008 Jan 4.

PMID:
18295208
21.

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1).

Mills RD, Sim CH, Mok SS, Mulhern TD, Culvenor JG, Cheng HC.

J Neurochem. 2008 Apr;105(1):18-33. doi: 10.1111/j.1471-4159.2008.05249.x. Epub 2008 Jan 23. Review.

22.

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.

Fodero-Tavoletti MT, Smith DP, McLean CA, Adlard PA, Barnham KJ, Foster LE, Leone L, Perez K, Cortés M, Culvenor JG, Li QX, Laughton KM, Rowe CC, Masters CL, Cappai R, Villemagne VL.

J Neurosci. 2007 Sep 26;27(39):10365-71.

23.

Not so senile.

Culvenor JG.

Trends Cell Biol. 1997 Nov;7(11):421. No abstract available.

PMID:
17708995
24.

A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.

Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, Delldonne A, Dickson DW, Farrer MJ.

Neuroscience. 2007 Jul 29;147(4):1047-58. Epub 2007 Jul 3.

PMID:
17611037
25.

Plasma alpha-synuclein is decreased in subjects with Parkinson's disease.

Li QX, Mok SS, Laughton KM, McLean CA, Cappai R, Masters CL, Culvenor JG, Horne MK.

Exp Neurol. 2007 Apr;204(2):583-8. Epub 2006 Dec 19.

PMID:
17258710
26.

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

Sim CH, Lio DS, Mok SS, Masters CL, Hill AF, Culvenor JG, Cheng HC.

Hum Mol Genet. 2006 Nov 1;15(21):3251-62. Epub 2006 Sep 25.

PMID:
17000703
27.

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.

Hoke DE, Tan JL, Ilaya NT, Culvenor JG, Smith SJ, White AR, Masters CL, Evin GM.

FEBS J. 2005 Nov;272(21):5544-57.

28.

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.

Cappai R, Leck SL, Tew DJ, Williamson NA, Smith DP, Galatis D, Sharples RA, Curtain CC, Ali FE, Cherny RA, Culvenor JG, Bottomley SP, Masters CL, Barnham KJ, Hill AF.

FASEB J. 2005 Aug;19(10):1377-9. Epub 2005 Jun 9.

PMID:
15946991
29.

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

Evin G, Canterford LD, Hoke DE, Sharples RA, Culvenor JG, Masters CL.

Biochemistry. 2005 Mar 22;44(11):4332-41.

PMID:
15766262
30.

Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle.

Ilaya NT, Evin G, Masters CL, Culvenor JG.

J Neurochem. 2004 Oct;91(1):230-7.

31.

Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex.

Smith MJ, Sharples RA, Evin G, McLean CA, Dean B, Pavey G, Fantino E, Cotton RG, Imaizumi K, Masters CL, Cappai R, Culvenor JG.

Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):128-35.

PMID:
15306129
32.
33.

Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte.

Wickham ME, Culvenor JG, Cowman AF.

J Biol Chem. 2003 Sep 26;278(39):37658-63. Epub 2003 Jul 11.

34.

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

Beher D, Fricker M, Nadin A, Clarke EE, Wrigley JD, Li YM, Culvenor JG, Masters CL, Harrison T, Shearman MS.

Biochemistry. 2003 Jul 15;42(27):8133-42.

PMID:
12846562
35.

alpha-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy.

Gai WP, Pountney DL, Power JH, Li QX, Culvenor JG, McLean CA, Jensen PH, Blumbergs PC.

Exp Neurol. 2003 May;181(1):68-78.

PMID:
12710935
36.

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage.

Sernee MF, Evin G, Culvenor JG, Villadangos JA, Beyreuther K, Masters CL, Cappai R.

Eur J Biochem. 2003 Feb;270(3):495-506.

37.

Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects.

Li QX, Campbell BC, McLean CA, Thyagarajan D, Gai WP, Kapsa RM, Beyreuther K, Masters CL, Culvenor JG.

J Alzheimers Dis. 2002 Aug;4(4):309-15.

PMID:
12446933
38.

Oligodendrocytes from neural stem cells express alpha-synuclein: increased numbers from presenilin 1 deficient mice.

Culvenor JG, Rietze RL, Bartlett PF, Masters CL, Li QX.

Neuroreport. 2002 Jul 19;13(10):1305-8.

PMID:
12151792
39.

Alternative transcripts of presenilin-1 associated with frontotemporal dementia.

Evin G, Smith MJ, Tziotis A, McLean C, Canterford L, Sharples RA, Cappai R, Weidemann A, Beyreuther K, Cotton RG, Masters CL, Culvenor JG.

Neuroreport. 2002 May 7;13(6):917-21.

PMID:
11997713
40.

Alternative transcripts of presenilin-1 associated with frontotemporal dementia.

Evin G, Smith MJ, Tziotis A, McLean C, Canterford L, Sharples RA, Cappai R, Weidemann A, Beyreuther K, Cotton RG, Masters CL, Culvenor JG.

Neuroreport. 2002 Apr 16;13(5):719-23.

PMID:
11973477
41.

Duck hepatitis B virus replication in primary bile duct epithelial cells.

Lee JY, Culvenor JG, Angus P, Smallwood R, Nicoll A, Locarnini S.

J Virol. 2001 Aug;75(16):7651-61.

42.

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

Evin G, Sharples RA, Weidemann A, Reinhard FB, Carbone V, Culvenor JG, Holsinger RM, Sernee MF, Beyreuther K, Masters CL.

Biochemistry. 2001 Jul 27;40(28):8359-68.

PMID:
11444983
43.

The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease.

Campbell BC, McLean CA, Culvenor JG, Gai WP, Blumbergs PC, Jäkälä P, Beyreuther K, Masters CL, Li QX.

J Neurochem. 2001 Jan;76(1):87-96.

44.

Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies.

Campbell BC, Li QX, Culvenor JG, Jäkälä P, Cappai R, Beyreuther K, Masters CL, McLean CA.

Neurobiol Dis. 2000 Jun;7(3):192-200.

PMID:
10860784
45.

Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells.

Waterkeyn JG, Wickham ME, Davern KM, Cooke BM, Coppel RL, Reeder JC, Culvenor JG, Waller RF, Cowman AF.

EMBO J. 2000 Jun 15;19(12):2813-23.

46.

Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.

Culvenor JG, Evin G, Cooney MA, Wardan H, Sharples RA, Maher F, Reed G, Diehlmann A, Weidemann A, Beyreuther K, Masters CL.

Exp Cell Res. 2000 Mar 15;255(2):192-206.

PMID:
10694435
47.

Presenilin I expression in yeast lowers secretion of the amyloid precursor protein.

Evin G, Le Brocque D, Culvenor JG, Galatis D, Weidemann A, Beyreuther K, Masters CL, Cappai R.

Neuroreport. 2000 Feb 7;11(2):405-8.

PMID:
10674495
48.

Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components.

Gai WP, Power JH, Blumbergs PC, Culvenor JG, Jensen PH.

J Neurochem. 1999 Nov;73(5):2093-100.

49.

Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.

Culvenor JG, McLean CA, Cutt S, Campbell BC, Maher F, Jäkälä P, Hartmann T, Beyreuther K, Masters CL, Li QX.

Am J Pathol. 1999 Oct;155(4):1173-81.

50.

Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.

Bayer TA, Jäkälä P, Hartmann T, Havas L, McLean C, Culvenor JG, Li QX, Masters CL, Falkai P, Beyreuther K.

Neurosci Lett. 1999 May 14;266(3):213-6.

PMID:
10465711

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