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Central Application of Aliskiren, a Renin Inhibitor, Improves Outcome After Experimental Stroke Independent of Its Blood Pressure Lowering Effect.

Panahpour H, Terpolilli NA, Schaffert D, Culmsee C, Plesnila N.

Front Neurol. 2019 Sep 4;10:942. doi: 10.3389/fneur.2019.00942. eCollection 2019.


A new approach on assessing clinical pharmacists' impact on prescribing errors in a surgical intensive care unit.

Kessemeier N, Meyn D, Hoeckel M, Reitze J, Culmsee C, Tryba M.

Int J Clin Pharm. 2019 Oct;41(5):1184-1192. doi: 10.1007/s11096-019-00874-8. Epub 2019 Jul 22.


Actin(g) on mitochondria - a role for cofilin1 in neuronal cell death pathways.

Hoffmann L, Rust MB, Culmsee C.

Biol Chem. 2019 Aug 27;400(9):1089-1097. doi: 10.1515/hsz-2019-0120. Review.


Sex differences in neonatal mouse brain injury after hypoxia-ischemia and adaptaquin treatment.

Li K, Li T, Wang Y, Xu Y, Zhang S, Culmsee C, Wang X, Zhu C.

J Neurochem. 2019 Sep;150(6):759-775. doi: 10.1111/jnc.14790. Epub 2019 Jul 28.


Protamine Sulfate Induces Mitochondrial Hyperpolarization and a Subsequent Increase in Reactive Oxygen Species Production.

Ramzan R, Michels S, Weber P, Rhiel A, Irqsusi M, Rastan AJ, Culmsee C, Vogt S.

J Pharmacol Exp Ther. 2019 Aug;370(2):308-317. doi: 10.1124/jpet.119.257725. Epub 2019 Jun 3.


The Potential Role of Ferroptosis in Neonatal Brain Injury.

Wu Y, Song J, Wang Y, Wang X, Culmsee C, Zhu C.

Front Neurosci. 2019 Feb 14;13:115. doi: 10.3389/fnins.2019.00115. eCollection 2019. Review.


Mitochondria, Microglia, and the Immune System-How Are They Linked in Affective Disorders?

Culmsee C, Michels S, Scheu S, Arolt V, Dannlowski U, Alferink J.

Front Psychiatry. 2019 Jan 9;9:739. doi: 10.3389/fpsyt.2018.00739. eCollection 2018. Review.


Metabolic switch induced by Cimicifuga racemosa extract prevents mitochondrial damage and oxidative cell death.

Rabenau M, Unger M, Drewe J, Culmsee C.

Phytomedicine. 2019 Jan;52:107-116. doi: 10.1016/j.phymed.2018.09.177. Epub 2018 Sep 17.


Sex-dependent effects of Cacna1c haploinsufficiency on juvenile social play behavior and pro-social 50-kHz ultrasonic communication in rats.

Kisko TM, Braun MD, Michels S, Witt SH, Rietschel M, Culmsee C, Schwarting RKW, Wöhr M.

Genes Brain Behav. 2018 Dec 27:e12552. doi: 10.1111/gbb.12552. [Epub ahead of print]


Effects of Cimicifuga racemosa extract Ze450 on mitochondria in models of oxidative stress in neuronal cells.

Rabenau M, Unger M, Drewe J, Culmsee C.

Data Brief. 2018 Oct 26;21:1872-1879. doi: 10.1016/j.dib.2018.10.092. eCollection 2018 Dec.


Neurobiology of the major psychoses: a translational perspective on brain structure and function-the FOR2107 consortium.

Kircher T, Wöhr M, Nenadic I, Schwarting R, Schratt G, Alferink J, Culmsee C, Garn H, Hahn T, Müller-Myhsok B, Dempfle A, Hahmann M, Jansen A, Pfefferle P, Renz H, Rietschel M, Witt SH, Nöthen M, Krug A, Dannlowski U.

Eur Arch Psychiatry Clin Neurosci. 2018 Sep 28. doi: 10.1007/s00406-018-0943-x. [Epub ahead of print]


The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.

Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N.

FASEB J. 2018 Nov;32(11):6159-6173. doi: 10.1096/fj.201800246R. Epub 2018 Jun 7.


Psychiatric risk gene Cacna1c determines mitochondrial resilience against oxidative stress in neurons.

Michels S, Wöhr M, Schwarting RK, Culmsee C.

Cell Death Dis. 2018 May 29;9(6):645. doi: 10.1038/s41419-018-0676-9. No abstract available.


SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling.

Honrath B, Krabbendam IE, IJsebaart C, Pegoretti V, Bendridi N, Rieusset J, Schmidt M, Culmsee C, Dolga AM.

Cell Death Dis. 2018 May 22;9(6):593. doi: 10.1038/s41419-018-0590-1.


Downregulation of the psychiatric susceptibility gene Cacna1c promotes mitochondrial resilience to oxidative stress in neuronal cells.

Michels S, Ganjam GK, Martins H, Schratt GM, Wöhr M, Schwarting RKW, Culmsee C.

Cell Death Discov. 2018 May 10;4:54. doi: 10.1038/s41420-018-0061-6. eCollection 2018.


Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats.

Kisko TM, Braun MD, Michels S, Witt SH, Rietschel M, Culmsee C, Schwarting RKW, Wöhr M.

Dis Model Mech. 2018 Jun 20;11(6). pii: dmm034116. doi: 10.1242/dmm.034116.


Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson's Disease Etiopathology.

Wilkaniec A, Lenkiewicz AM, Czapski GA, Jęśko HM, Hilgier W, Brodzik R, Gąssowska-Dobrowolska M, Culmsee C, Adamczyk A.

Mol Neurobiol. 2019 Jan;56(1):125-140. doi: 10.1007/s12035-018-1082-0. Epub 2018 Apr 21.


Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis.

Jelinek A, Heyder L, Daude M, Plessner M, Krippner S, Grosse R, Diederich WE, Culmsee C.

Free Radic Biol Med. 2018 Mar;117:45-57. doi: 10.1016/j.freeradbiomed.2018.01.019. Epub 2018 Jan 31.


Glucose-regulated protein 75 determines ER-mitochondrial coupling and sensitivity to oxidative stress in neuronal cells.

Honrath B, Metz I, Bendridi N, Rieusset J, Culmsee C, Dolga AM.

Cell Death Discov. 2017 Nov 6;3:17076. doi: 10.1038/cddiscovery.2017.76. eCollection 2017.


Cylindromatosis mediates neuronal cell death in vitro and in vivo.

Ganjam GK, Terpolilli NA, Diemert S, Eisenbach I, Hoffmann L, Reuther C, Herden C, Roth J, Plesnila N, Culmsee C.

Cell Death Differ. 2018 Aug;25(8):1394-1407. doi: 10.1038/s41418-017-0046-7. Epub 2018 Jan 19.


One protein, different cell fate: the differential outcome of depleting GRP75 during oxidative stress in neurons.

Honrath B, Culmsee C, Dolga AM.

Cell Death Dis. 2018 Jan 18;9(2):32. doi: 10.1038/s41419-017-0148-7. No abstract available.


Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.


Drug Safety Analysis in a Real-Life Cohort of Parkinson's Disease Patients with Polypharmacy.

Müller-Rebstein S, Trenkwalder C, Ebentheuer J, Oertel WH, Culmsee C, Höglinger GU.

CNS Drugs. 2017 Dec;31(12):1093-1102. doi: 10.1007/s40263-017-0478-0.


Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission.

Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, Culmsee C, Rust MB.

Cell Death Dis. 2017 Oct 5;8(10):e3063. doi: 10.1038/cddis.2017.448.


Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways.

Krabbendam IE, Honrath B, Culmsee C, Dolga AM.

Cell Calcium. 2018 Jan;69:101-111. doi: 10.1016/j.ceca.2017.07.005. Epub 2017 Jul 22. Review.


Small conductance Ca2+-activated K+ channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases.

Honrath B, Krabbendam IE, Culmsee C, Dolga AM.

Neurochem Int. 2017 Oct;109:13-23. doi: 10.1016/j.neuint.2017.05.005. Epub 2017 May 13. Review.


[Pharmacotherapy of Parkinson's disease : Aspects of drug safety].

Müller-Rebstein S, Trenkwalder C, Oertel WH, Culmsee C, Eckermann G, Höglinger GU.

Nervenarzt. 2017 Aug;88(8):888-894. doi: 10.1007/s00115-017-0345-8. Review. German.


Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain.

Zhou K, Xie C, Wickström M, Dolga AM, Zhang Y, Li T, Xu Y, Culmsee C, Kogner P, Zhu C, Blomgren K.

Oncotarget. 2017 May 23;8(21):34111-34127. doi: 10.18632/oncotarget.16292.


A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

Niu X, Brahmbhatt H, Mergenthaler P, Zhang Z, Sang J, Daude M, Ehlert FGR, Diederich WE, Wong E, Zhu W, Pogmore J, Nandy JP, Satyanarayana M, Jimmidi RK, Arya P, Leber B, Lin J, Culmsee C, Yi J, Andrews DW.

Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5. doi: 10.1016/j.chembiol.2017.03.011. Epub 2017 Apr 6.


BID links ferroptosis to mitochondrial cell death pathways.

Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R, Ganjam GK, Dolga AM, Oppermann S, Culmsee C.

Redox Biol. 2017 Aug;12:558-570. doi: 10.1016/j.redox.2017.03.007. Epub 2017 Mar 9.


SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake.

Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N, Culmsee C, Dolga AM.

Cell Death Differ. 2017 May;24(5):761-773. doi: 10.1038/cdd.2017.2. Epub 2017 Mar 10.


[In process].

Culmsee C.

Med Monatsschr Pharm. 2017 Mar;40(3):109. German. No abstract available.


Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H.

J Allergy Clin Immunol. 2016 Jul;138(1):47-56. doi: 10.1016/j.jaci.2016.02.046. Review.


Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.

Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C.

Cell Death Dis. 2016 May 5;7:e2214. doi: 10.1038/cddis.2016.107.


Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR.

Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008.


Activation of SK2 channels preserves ER Ca²⁺ homeostasis and protects against ER stress-induced cell death.

Richter M, Vidovic N, Honrath B, Mahavadi P, Dodel R, Dolga AM, Culmsee C.

Cell Death Differ. 2016 May;23(5):814-27. doi: 10.1038/cdd.2015.146. Epub 2015 Nov 20.


The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.

Dong F, Eibach M, Bartsch JW, Dolga AM, Schlomann U, Conrad C, Schieber S, Schilling O, Biniossek ML, Culmsee C, Strik H, Koller G, Carl B, Nimsky C.

Neuro Oncol. 2015 Nov;17(11):1474-85. doi: 10.1093/neuonc/nov042. Epub 2015 Mar 29.


Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance.

Benzler J, Ganjam GK, Pretz D, Oelkrug R, Koch CE, Legler K, Stöhr S, Culmsee C, Williams LM, Tups A.

Diabetes. 2015 Jun;64(6):2015-27. doi: 10.2337/db14-0093. Epub 2015 Jan 27.


SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2.

Richter M, Nickel C, Apel L, Kaas A, Dodel R, Culmsee C, Dolga AM.

Neurochem Int. 2015 Feb;81:63-75. doi: 10.1016/j.neuint.2014.12.007. Epub 2015 Jan 6.


Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition.

Neitemeier S, Ganjam GK, Diemert S, Culmsee C.

Apoptosis. 2014 Dec;19(12):1665-77. doi: 10.1007/s10495-014-1048-2.


α1-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity.

Gold M, Dolga AM, Koepke J, Mengel D, Culmsee C, Dodel R, Koczulla AR, Bach JP.

J Neuroinflammation. 2014 Sep 23;11:165. doi: 10.1186/s12974-014-0165-8.


The serine protease inhibitor TLCK attenuates intrinsic death pathways in neurons upstream of mitochondrial demise.

Reuther C, Ganjam GK, Dolga AM, Culmsee C.

Apoptosis. 2014 Nov;19(11):1545-58. doi: 10.1007/s10495-014-1027-7.


N-acyl derivatives of 4-phenoxyaniline as neuroprotective agents.

Barho MT, Oppermann S, Schrader FC, Degenhardt I, Elsässer K, Wegscheid-Gerlach C, Culmsee C, Schlitzer M.

ChemMedChem. 2014 Oct;9(10):2260-73. doi: 10.1002/cmdc.201402195. Epub 2014 Jul 17.


Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity.

Oppermann S, Schrader FC, Elsässer K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C.

J Pharmacol Exp Ther. 2014 Aug;350(2):273-89. doi: 10.1124/jpet.114.213777. Epub 2014 May 21.


Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity.

Höllerhage M, Goebel JN, de Andrade A, Hildebrandt T, Dolga A, Culmsee C, Oertel WH, Hengerer B, Höglinger GU.

Neurobiol Aging. 2014 Jul;35(7):1700-11. doi: 10.1016/j.neurobiolaging.2014.01.027. Epub 2014 Jan 28.


Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.

Dolga AM, de Andrade A, Meissner L, Knaus HG, Höllerhage M, Christophersen P, Zischka H, Plesnila N, Höglinger GU, Culmsee C.

Cell Death Dis. 2014 Jan 16;5:e999. doi: 10.1038/cddis.2013.530.


Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress.

Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C.

Cell Death Dis. 2014 Jan 16;5:e993. doi: 10.1038/cddis.2013.518.


Overexpression of suppressor of cytokine signaling 3 in the arcuate nucleus of juvenile Phodopus sungorus alters seasonal body weight changes.

Ganjam GK, Benzler J, Pinkenburg O, Boucsein A, Stöhr S, Steger J, Culmsee C, Barrett P, Tups A.

J Comp Physiol B. 2013 Dec;183(8):1101-11. doi: 10.1007/s00360-013-0772-1. Epub 2013 Jul 17.


Oxidative stress and neurodegeneration.

White A, Culmsee C, Beart P.

Neurochem Int. 2013 Apr;62(5):521. doi: 10.1016/j.neuint.2013.03.006. No abstract available.


Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.

Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C.

J Biol Chem. 2013 Apr 12;288(15):10792-804. doi: 10.1074/jbc.M113.453522. Epub 2013 Feb 19.

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