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Items: 1 to 50 of 93

1.

The Hypothalamic-Pituitary-Adrenal Axis and Serotonin Metabolism in Individual Brain Nuclei of Mice with Genetic Disruption of the NK1 Receptor Exposed to Acute Stress.

Culman J, Mühlenhoff S, Blume A, Hedderich J, Lützen U, Hunt SP, Rupniak NMJ, Zhao Y.

Cell Mol Neurobiol. 2018 Aug;38(6):1271-1281. doi: 10.1007/s10571-018-0594-5. Epub 2018 Jun 15.

PMID:
29948553
2.

Neuroprotective effects of AT1 receptor antagonists after experimental ischemic stroke: what is important?

Culman J, Jacob T, Schuster SO, Brolund-Spaether K, Brolund L, Cascorbi I, Zhao Y, Gohlke P.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Sep;390(9):949-959. doi: 10.1007/s00210-017-1395-y. Epub 2017 Jul 2.

PMID:
28669009
3.

Activation of the cell membrane angiotensin AT2 receptors in human leiomyosarcoma cells induces differentiation and apoptosis by a PPARγ - dependent mechanism.

LÜtzen U, Zhao Y, Lucht K, Zuhayra M, Hedderich J, Cascorbi I, Culman J.

Neoplasma. 2017;64(3):395-405. doi: 10.4149/neo_2017_310.

PMID:
28253719
4.

Pioglitazone induces cell growth arrest and activates mitochondrial apoptosis in human uterine leiomyosarcoma cells by a peroxisome proliferator-activated receptor γ-independent mechanism.

Lützen U, Zhao Y, Lucht K, Zuhayra M, Marx M, Cascorbi I, Culman J.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan;390(1):37-48. doi: 10.1007/s00210-016-1291-x. Epub 2016 Sep 23.

PMID:
27664035
5.

Effective method of measuring the radioactivity of [ 131I]-capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff.

Lützen U, Zhao Y, Marx M, Imme T, Assam I, Siebert FA, Culman J, Zuhayra M.

J Appl Clin Med Phys. 2016 Jul 8;17(4):59-72. doi: 10.1120/jacmp.v17i4.5942.

6.

Biodistribution and pharmacokinetics of the (99m)Tc labeled human elastase inhibitor, elafin, in rats.

Kaschwich M, Lützen U, Zhao Y, Tjiong A, Marx M, Haenisch S, Wiedow O, Preuss S, Culman J, Zuhayra M.

Drug Metab Pharmacokinet. 2016 Apr;31(2):146-55. doi: 10.1016/j.dmpk.2016.01.004. Epub 2016 Feb 5.

PMID:
26948953
7.

Omapatrilat: penetration across the blood-brain barrier and effects on ischaemic stroke in rats.

Schmedt Auf der Günne W, Zhao Y, Hedderich J, Gohlke P, Culman J.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Sep;388(9):939-51. doi: 10.1007/s00210-015-1126-1. Epub 2015 May 8.

PMID:
25953200
8.

Activation of intracellular angiotensin AT₂ receptors induces rapid cell death in human uterine leiomyosarcoma cells.

Zhao Y, Lützen U, Fritsch J, Zuhayra M, Schütze S, Steckelings UM, Recanti C, Namsoleck P, Unger T, Culman J.

Clin Sci (Lond). 2015 May;128(9):567-78. doi: 10.1042/CS20140627.

PMID:
25487516
9.

In vivo SPECT imaging of [¹²³I]-labeled pentamidine pro-drugs for the treatment of human African trypanosomiasis, pharmacokinetics, and bioavailability studies in rats.

Cohrs B, Zhao Y, Lützen U, Culman J, Clement B, Zuhayra M.

Int J Pharm. 2014 Dec 30;477(1-2):167-75. doi: 10.1016/j.ijpharm.2014.10.032. Epub 2014 Oct 16.

PMID:
25455769
10.

Treatment of rats with pioglitazone in the reperfusion phase of focal cerebral ischemia: a preclinical stroke trial.

Culman J, Nguyen-Ngoc M, Glatz T, Gohlke P, Herdegen T, Zhao Y.

Exp Neurol. 2012 Dec;238(2):243-53. doi: 10.1016/j.expneurol.2012.09.003. Epub 2012 Sep 17.

PMID:
22995601
11.

Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?

Tauer U, Zhao Y, Hunt SP, Culman J.

Neuropharmacology. 2012 Nov;63(6):958-65. doi: 10.1016/j.neuropharm.2012.06.041. Epub 2012 Jul 6.

PMID:
22771977
12.

The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria.

Zhao Y, Spigolon G, Bonny C, Culman J, Vercelli A, Herdegen T.

Mol Cell Neurosci. 2012 Mar;49(3):300-10. doi: 10.1016/j.mcn.2011.12.005. Epub 2011 Dec 21.

PMID:
22206897
13.

Activation of cerebral peroxisome proliferator-activated receptors γ (PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat.

Zuhayra M, Zhao Y, von Forstner C, Henze E, Gohlke P, Culman J, Lützen U.

Neuropathol Appl Neurobiol. 2011 Dec;37(7):738-52. doi: 10.1111/j.1365-2990.2011.01169.x.

PMID:
21366664
14.

Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes.

Schmerbach K, Pfab T, Zhao Y, Culman J, Mueller S, Villringer A, Muller DN, Hocher B, Unger T, Thoene-Reineke C.

PLoS One. 2010 Nov 29;5(11):e15052. doi: 10.1371/journal.pone.0015052.

15.

Peroxisome-proliferator-activated receptors gamma and peroxisome-proliferator-activated receptors beta/delta and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain.

Glatz T, Stöck I, Nguyen-Ngoc M, Gohlke P, Herdegen T, Culman J, Zhao Y.

J Hypertens. 2010 Jul;28(7):1488-97. doi: 10.1097/HJH.0b013e3283396e4e.

PMID:
20410836
16.

Blockade of tachykinin NK1/NK2 receptors in the brain attenuates the activation of corticotrophin-releasing hormone neurones in the hypothalamic paraventricular nucleus and the sympathoadrenal and pituitary-adrenal responses to formalin-induced pain in the rat.

Culman J, Das G, Ohlendorf C, Haass M, Maser-Gluth C, Zuhayra M, Zhao Y, Itoi K.

J Neuroendocrinol. 2010 May;22(5):467-76. doi: 10.1111/j.1365-2826.2010.01987.x. Epub 2010 Feb 20.

PMID:
20210847
17.

The c-Jun N-terminal kinase (JNK) inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats.

Liu JR, Zhao Y, Patzer A, Staak N, Boehm R, Deuschl G, Culman J, Bonny C, Herdegen T, Eschenfelder C.

Neuropathol Appl Neurobiol. 2010 Apr;36(3):211-24. doi: 10.1111/j.1365-2990.2009.01047.x. Epub 2009 Oct 22.

PMID:
19849792
18.

Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia.

Patzer A, Zhao Y, Stöck I, Gohlke P, Herdegen T, Culman J.

Eur J Neurosci. 2008 Nov;28(9):1786-94. doi: 10.1111/j.1460-9568.2008.06478.x.

PMID:
18973594
19.

PPAR-gamma: therapeutic target for ischemic stroke.

Culman J, Zhao Y, Gohlke P, Herdegen T.

Trends Pharmacol Sci. 2007 May;28(5):244-9. Epub 2007 Apr 9. Review.

PMID:
17416424
20.

Comparison between early and delayed systemic treatment with candesartan of rats after ischaemic stroke.

Brdon J, Kaiser S, Hagemann F, Zhao Y, Culman J, Gohlke P.

J Hypertens. 2007 Jan;25(1):187-96.

PMID:
17143191
22.

Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats.

Xu J, Scholz A, Rösch N, Blume A, Unger T, Kreutz R, Culman J, Gohlke P.

J Hypertens. 2005 Dec;23(12):2277-85.

PMID:
16269970
23.

The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain.

Zhao Y, Patzer A, Gohlke P, Herdegen T, Culman J.

Eur J Neurosci. 2005 Jul;22(1):278-82.

PMID:
16029218
24.

Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation.

Zhao Y, Foryst-Ludwig A, Bruemmer D, Culman J, Bader M, Unger T, Kintscher U.

J Neurochem. 2005 Sep;94(5):1395-401. Epub 2005 Jun 30.

25.

ANG III induces expression of inducible transcription factors of AP-1 and Krox families in rat brain.

Blume A, Undeutsch C, Zhao Y, Kaschina E, Culman J, Unger T.

Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R845-50. Epub 2005 May 5.

26.

Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury.

Li J, Culman J, Hörtnagl H, Zhao Y, Gerova N, Timm M, Blume A, Zimmermann M, Seidel K, Dirnagl U, Unger T.

FASEB J. 2005 Apr;19(6):617-9. Epub 2005 Jan 21.

PMID:
15665034
27.
28.

Antisense targeting of oxytocinergic hypothalamus neurons induces cytoplasmic triple helix-like immunoreactivity.

Jirikowski GF, Culman J, Lee JS, Celeda D, Prüfer K.

Cell Mol Biol (Noisy-le-grand). 2003;49 Online Pub:OL481-6.

PMID:
14995079
29.

Chronic pretreatment with candesartan improves recovery from focal cerebral ischaemia in rats.

Groth W, Blume A, Gohlke P, Unger T, Culman J.

J Hypertens. 2003 Nov;21(11):2175-82.

PMID:
14597862
30.

Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells.

Zhao Y, Biermann T, Luther C, Unger T, Culman J, Gohlke P.

J Neurochem. 2003 May;85(3):759-67.

31.

Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death.

Xu J, Culman J, Blume A, Brecht S, Gohlke P.

Stroke. 2003 May;34(5):1287-92. Epub 2003 Apr 3.

PMID:
12677021
32.

The renin-angiotensin system in the brain: possible therapeutic implications for AT(1)-receptor blockers.

Culman J, Blume A, Gohlke P, Unger T.

J Hum Hypertens. 2002 Aug;16 Suppl 3:S64-70. Review.

33.

Peripherally applied candesartan inhibits central responses to angiotensin II in conscious rats.

Gohlke P, Kox T, Jürgensen T, von Kügelgen S, Rascher W, Unger T, Culman J.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Jun;365(6):477-83. Epub 2002 Apr 5.

PMID:
12070762
34.

Effects of orally applied candesartan cilexetil on central responses to angiotensin II in conscious rats.

Gohlke P, Von Kügelgen S, Jürgensen T, Kox T, Rascher W, Culman J, Unger T.

J Hypertens. 2002 May;20(5):909-18.

PMID:
12011652
35.

The renin-angiotensin system in the brain: an update.

Culman J, Baulmann J, Blume A, Unger T.

J Renin Angiotensin Aldosterone Syst. 2001 Jun;2(2):96-102. Review. No abstract available.

PMID:
11881106
36.

Involvement of adrenoceptors in the angiotensin II-induced expression of inducible transcription factors in the rat forebrain and hypothalamus.

Blume A, Neumann C, Dorenkamp M, Culman J, Unger T.

Neuropharmacology. 2002 Feb;42(2):281-8.

PMID:
11804625
37.

C-FOS expression in the rat brain in response to substance P and neurokinin B.

Spitznagel H, Baulmann J, Blume A, Unger T, Culman J.

Brain Res. 2001 Oct 19;916(1-2):11-21.

PMID:
11597586
38.

AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats.

Gohlke P, Weiss S, Jansen A, Wienen W, Stangier J, Rascher W, Culman J, Unger T.

J Pharmacol Exp Ther. 2001 Jul;298(1):62-70.

PMID:
11408526
39.

Effect of repetitive icv injections of ANG II on c-Fos and AT(1)-receptor expression in the rat brain.

Moellenhoff E, Blume A, Culman J, Chatterjee B, Herdegen T, Lebrun CJ, Unger T.

Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R1095-104.

40.
41.

Tachykinin receptor inhibition and c-Fos expression in the rat brain following formalin-induced pain.

Baulmann J, Spitznagel H, Herdegen T, Unger T, Culman J.

Neuroscience. 2000;95(3):813-20.

PMID:
10670449
42.
43.

Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin II in conscious, normotensive rats.

Culman J, von Heyer C, Piepenburg B, Rascher W, Unger T.

Eur J Pharmacol. 1999 Feb 19;367(2-3):255-65.

PMID:
10079000
44.

Effect of moxonidine on blood pressure and sympathetic tone in conscious spontaneously hypertensive rats.

Nurminen ML, Culman J, Haass M, Chung O, Unger T.

Eur J Pharmacol. 1998 Nov 27;362(1):61-7.

PMID:
9865531
45.

Angiotensin II receptor blockade and end-organ protection: pharmacological rationale and evidence.

Unger T, Culman J, Gohlke P.

J Hypertens Suppl. 1998 Sep;16(7):S3-9. Review.

PMID:
9855025
46.

Central angiotensin AT1 and muscarinic receptors in ITF expression on intracerebroventricular NaCl.

Moellenhoff E, Lebrun CJ, Blume A, Culman J, Herdegen T, Unger T.

Am J Physiol. 1998 Jul;275(1):R234-44. doi: 10.1152/ajpregu.1998.275.1.R234.

PMID:
9688984
47.

Angiotensin AT2 receptor degradation is prevented by ligand occupation.

Csikós T, Balmforth AJ, Grojec M, Gohlke P, Culman J, Unger T.

Biochem Biophys Res Commun. 1998 Feb 4;243(1):142-7.

PMID:
9473495
48.

A new formalin test allowing simultaneous evaluation of cardiovascular and nociceptive responses.

Culman J, Ritter S, Ohlendorf C, Haass M, Maser-Gluth C, Spitznagel H, Unger T.

Can J Physiol Pharmacol. 1997 Oct-Nov;75(10-11):1203-11.

PMID:
9431444
49.

Oxytocin pathways mediate the cardiovascular and behavioral responses to substance P in the rat brain.

Maier T, Dai WJ, Csikós T, Jirikowski GF, Unger T, Culman J.

Hypertension. 1998 Jan;31(1 Pt 2):480-6.

PMID:
9453349
50.

Effect of tachykinin receptor inhibition in the brain on cardiovascular and behavioral responses to stress.

Culman J, Klee S, Ohlendorf C, Unger T.

J Pharmacol Exp Ther. 1997 Jan;280(1):238-46.

PMID:
8996202

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