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Items: 1 to 50 of 69

1.

α11β1 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration.

Zeltz C, Alam J, Liu H, Erusappan PM, Hoschuetzky H, Molven A, Parajuli H, Cukierman E, Costea DE, Lu N, Gullberg D.

Cancers (Basel). 2019 Jun 1;11(6). pii: E765. doi: 10.3390/cancers11060765.

2.

Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland.

Jones CE, Hammer AM, Cho Y, Sizemore GM, Cukierman E, Yee LD, Ghadiali SN, Ostrowski MC, Leight JL.

Neoplasia. 2019 Jan;21(1):132-145. doi: 10.1016/j.neo.2018.10.010. Epub 2018 Dec 12.

3.

Patient-derived Models Reveal Impact of the Tumor Microenvironment on Therapeutic Response.

Shafi AA, Schiewer MJ, de Leeuw R, Dylgjeri E, McCue PA, Shah N, Gomella LG, Lallas CD, Trabulsi EJ, Centenera MM, Hickey TE, Butler LM, Raj G, Tilley WD, Cukierman E, Knudsen KE.

Eur Urol Oncol. 2018 Sep;1(4):325-337. doi: 10.1016/j.euo.2018.04.019. Epub 2018 Jun 6.

PMID:
30467556
4.

Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2.

Malik R, Luong T, Cao X, Han B, Shah N, Franco-Barraza J, Han L, Shenoy VB, Lelkes PI, Cukierman E.

Matrix Biol. 2018 Nov 7. pii: S0945-053X(18)30284-1. doi: 10.1016/j.matbio.2018.11.001. [Epub ahead of print]

PMID:
30412725
5.

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility.

Kaur A, Ecker BL, Douglass SM, Kugel CH 3rd, Webster MR, Almeida FV, Somasundaram R, Hayden J, Ban E, Ahmadzadeh H, Franco-Barraza J, Shah N, Mellis IA, Keeney F, Kossenkov A, Tang HY, Yin X, Liu Q, Xu X, Fane M, Brafford P, Herlyn M, Speicher DW, Wargo JA, Tetzlaff MT, Haydu LE, Raj A, Shenoy V, Cukierman E, Weeraratna AT.

Cancer Discov. 2019 Jan;9(1):64-81. doi: 10.1158/2159-8290.CD-18-0193. Epub 2018 Oct 2.

PMID:
30279173
6.

Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells.

Fragoso MF, Romualdo GR, Vanderveer LA, Franco-Barraza J, Cukierman E, Clapper ML, Carvalho RF, Barbisan LF.

Food Chem Toxicol. 2018 Nov;121:237-245. doi: 10.1016/j.fct.2018.08.078. Epub 2018 Sep 6.

PMID:
30194994
7.

Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence.

Franco-Barraza J, Francescone R, Luong T, Shah N, Madhani R, Cukierman G, Dulaimi E, Devarajan K, Egleston BL, Nicolas E, Katherine Alpaugh R, Malik R, Uzzo RG, Hoffman JP, Golemis EA, Cukierman E.

Elife. 2017 Jan 31;6. pii: e20600. doi: 10.7554/eLife.20600.

8.

Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma.

Roy I, Boyle KA, Vonderhaar EP, Zimmerman NP, Gorse E, Mackinnon AC, Hwang RF, Franco-Barraza J, Cukierman E, Tsai S, Evans DB, Dwinell MB.

Lab Invest. 2017 Mar;97(3):302-317. doi: 10.1038/labinvest.2016.146. Epub 2017 Jan 16.

9.

Preparation of Extracellular Matrices Produced by Cultured and Primary Fibroblasts.

Franco-Barraza J, Beacham DA, Amatangelo MD, Cukierman E.

Curr Protoc Cell Biol. 2016 Jun 1;71:10.9.1-10.9.34. doi: 10.1002/cpcb.2.

10.

Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions.

Alexander J, Cukierman E.

Curr Opin Cell Biol. 2016 Oct;42:80-93. doi: 10.1016/j.ceb.2016.05.002. Epub 2016 May 20. Review.

11.

A Chemomechanical Model of Matrix and Nuclear Rigidity Regulation of Focal Adhesion Size.

Cao X, Lin Y, Driscoll TP, Franco-Barraza J, Cukierman E, Mauck RL, Shenoy VB.

Biophys J. 2015 Nov 3;109(9):1807-17. doi: 10.1016/j.bpj.2015.08.048.

12.

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer.

Malik R, Lelkes PI, Cukierman E.

Trends Biotechnol. 2015 Apr;33(4):230-6. doi: 10.1016/j.tibtech.2015.01.004. Epub 2015 Feb 20. Review.

13.

Structural and mechanistic insights into the recruitment of talin by RIAM in integrin signaling.

Chang YC, Zhang H, Franco-Barraza J, Brennan ML, Patel T, Cukierman E, Wu J.

Structure. 2014 Dec 2;22(12):1810-1820. doi: 10.1016/j.str.2014.09.020. Epub 2014 Nov 20.

14.

Engineering of tumor microenvironments.

Hutmacher DW, Cukierman E.

Adv Drug Deliv Rev. 2014 Dec 15;79-80:1-2. doi: 10.1016/j.addr.2014.11.001. Epub 2014 Nov 8. No abstract available.

PMID:
25446131
15.

Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6).

Bassi DE, Cenna J, Zhang J, Cukierman E, Klein-Szanto AJ.

Mol Carcinog. 2015 Oct;54(10):1122-31. doi: 10.1002/mc.22183. Epub 2014 May 21.

16.

3-D extracellular matrix from sectioned human tissues.

Campbell CB, Cukierman E, Artym VV.

Curr Protoc Cell Biol. 2014 Mar 3;62:Unit 19.16.1-20. doi: 10.1002/0471143030.cb1916s62.

17.

The wound healing, chronic fibrosis, and cancer progression triad.

Rybinski B, Franco-Barraza J, Cukierman E.

Physiol Genomics. 2014 Apr 1;46(7):223-44. doi: 10.1152/physiolgenomics.00158.2013. Epub 2014 Feb 11. Review.

18.

Miniaturized pre-clinical cancer models as research and diagnostic tools.

Håkanson M, Cukierman E, Charnley M.

Adv Drug Deliv Rev. 2014 Apr;69-70:52-66. doi: 10.1016/j.addr.2013.11.010. Epub 2013 Dec 1. Review.

19.

Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment.

Wong GS, Lee JS, Park YY, Klein-Szanto AJ, Waldron TJ, Cukierman E, Herlyn M, Gimotty P, Nakagawa H, Rustgi AK.

Oncogenesis. 2013 Aug 5;2:e59. doi: 10.1038/oncsis.2013.17.

20.

Controlled breast cancer microarrays for the deconvolution of cellular multilayering and density effects upon drug responses.

Håkanson M, Kobel S, Lutolf MP, Textor M, Cukierman E, Charnley M.

PLoS One. 2012;7(6):e40141. doi: 10.1371/journal.pone.0040141. Epub 2012 Jun 29.

21.

The mesenchymal tumor microenvironment: a drug-resistant niche.

Cukierman E, Bassi DE.

Cell Adh Migr. 2012 May-Jun;6(3):285-96. doi: 10.4161/cam.20210. Epub 2012 May 1. Review.

22.

Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma.

Gupta V, Bassi DE, Simons JD, Devarajan K, Al-Saleem T, Uzzo RG, Cukierman E.

PLoS One. 2011;6(6):e21494. doi: 10.1371/journal.pone.0021494. Epub 2011 Jun 28.

23.

Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis.

Goetz JG, Minguet S, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibáñez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, Sánchez-Mateos P, Cukierman E, Del Pozo MA.

Cell. 2011 Jul 8;146(1):148-63. doi: 10.1016/j.cell.2011.05.040.

24.

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells.

Lee HO, Mullins SR, Franco-Barraza J, Valianou M, Cukierman E, Cheng JD.

BMC Cancer. 2011 Jun 13;11:245. doi: 10.1186/1471-2407-11-245.

25.

Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.

Kwon Y, Cukierman E, Godwin AK.

PLoS One. 2011 Apr 19;6(4):e18872. doi: 10.1371/journal.pone.0018872.

26.

Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis.

Shatalova EG, Klein-Szanto AJ, Devarajan K, Cukierman E, Clapper ML.

Cancer Prev Res (Phila). 2011 Jan;4(1):107-15. doi: 10.1158/1940-6207.CAPR-10-0133. Epub 2012 Dec 31.

27.

Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.

Bassi DE, Zhang J, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ.

Neoplasia. 2010 Jul;12(7):516-26.

28.

Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors.

Cukierman E, Bassi DE.

Semin Cancer Biol. 2010 Jun;20(3):139-45. doi: 10.1016/j.semcancer.2010.04.004. Epub 2010 May 7. Review.

29.

Isoform-specific upregulation of palladin in human and murine pancreas tumors.

Goicoechea SM, Bednarski B, Stack C, Cowan DW, Volmar K, Thorne L, Cukierman E, Rustgi AK, Brentnall T, Hwang RF, McCulloch CA, Yeh JJ, Bentrem DJ, Hochwald SN, Hingorani SR, Kim HJ, Otey CA.

PLoS One. 2010 Apr 26;5(4):e10347. doi: 10.1371/journal.pone.0010347.

30.

The benefits and challenges associated with the use of drug delivery systems in cancer therapy.

Cukierman E, Khan DR.

Biochem Pharmacol. 2010 Sep 1;80(5):762-70. doi: 10.1016/j.bcp.2010.04.020. Epub 2010 Apr 22. Review.

31.

Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins.

Castelló-Cros R, Khan DR, Simons J, Valianou M, Cukierman E.

BMC Cancer. 2009 Mar 26;9:94. doi: 10.1186/1471-2407-9-94.

32.

Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices.

Castelló-Cros R, Cukierman E.

Methods Mol Biol. 2009;522:275-305. doi: 10.1007/978-1-59745-413-1_19.

33.

Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner.

Quiros RM, Valianou M, Kwon Y, Brown KM, Godwin AK, Cukierman E.

Gynecol Oncol. 2008 Jul;110(1):99-109. doi: 10.1016/j.ygyno.2008.03.006. Epub 2008 May 2.

34.

Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells.

Serebriiskii I, Castelló-Cros R, Lamb A, Golemis EA, Cukierman E.

Matrix Biol. 2008 Jul;27(6):573-585. doi: 10.1016/j.matbio.2008.02.008. Epub 2008 Mar 6.

35.

Preparation of extracellular matrices produced by cultured and primary fibroblasts.

Beacham DA, Amatangelo MD, Cukierman E.

Curr Protoc Cell Biol. 2007 Jan;Chapter 10:Unit 10.9. doi: 10.1002/0471143030.cb1009s33.

PMID:
18228495
36.

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.

Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK.

Genes Dev. 2007 Nov 1;21(21):2788-803.

37.

Three-dimensional matrix induces sustained activation of ERK1/2 via Src/Ras/Raf signaling pathway.

Damianova R, Stefanova N, Cukierman E, Momchilova A, Pankov R.

Cell Biol Int. 2008 Feb;32(2):229-34. Epub 2007 Sep 7.

PMID:
17933561
38.

Modeling tissue morphogenesis and cancer in 3D.

Yamada KM, Cukierman E.

Cell. 2007 Aug 24;130(4):601-10. Review.

39.

Tumour development due to stroma permissiveness.

Cukierman E.

J Biosci. 2005 Dec;30(5):551-2. No abstract available.

40.

A Rac switch regulates random versus directionally persistent cell migration.

Pankov R, Endo Y, Even-Ram S, Araki M, Clark K, Cukierman E, Matsumoto K, Yamada KM.

J Cell Biol. 2005 Aug 29;170(5):793-802.

41.

PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.

Bassi DE, Lopez De Cicco R, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ.

Cancer Res. 2005 Aug 15;65(16):7310-9.

42.

Multiple mechanisms of telomere maintenance exist in liposarcomas.

Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D.

Clin Cancer Res. 2005 Aug 1;11(15):5347-55.

43.
44.

Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression.

Beacham DA, Cukierman E.

Semin Cancer Biol. 2005 Oct;15(5):329-41. Review.

PMID:
15970443
45.

A visual-quantitative analysis of fibroblastic stromagenesis in breast cancer progression.

Cukierman E.

J Mammary Gland Biol Neoplasia. 2004 Oct;9(4):311-24. Review.

PMID:
15838602
46.

Cell migration analyses within fibroblast-derived 3-D matrices.

Cukierman E.

Methods Mol Biol. 2005;294:79-93.

PMID:
15576907
47.

Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis.

Einarson MB, Cukierman E, Compton DA, Golemis EA.

Mol Cell Biol. 2004 May;24(9):3957-71.

48.

Dimensions and dynamics in integrin function.

Yamada KM, Pankov R, Cukierman E.

Braz J Med Biol Res. 2003 Aug;36(8):959-66. Epub 2003 Jul 23. Review.

49.

Cell-matrix adhesions on poly(vinyl alcohol) hydrogels.

Zajaczkowski MB, Cukierman E, Galbraith CG, Yamada KM.

Tissue Eng. 2003 Jun;9(3):525-33.

PMID:
12857420
50.

Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases.

Katz BZ, Romer L, Miyamoto S, Volberg T, Matsumoto K, Cukierman E, Geiger B, Yamada KM.

J Biol Chem. 2003 Aug 1;278(31):29115-20. Epub 2003 May 16.

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