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Items: 17


Dual Blockade of Interleukin-1β and Interleukin-17A Reduces Murine Arthritis Pathogenesis but Also Leads to Spontaneous Skin Infections in Nonhuman Primates.

Ruzek MC, Huang L, Zhang TT, Bryant S, Slivka PF, Cuff CA, Tripp C, Blaich G.

J Pharmacol Exp Ther. 2018 Mar;364(3):474-484. doi: 10.1124/jpet.117.243493. Epub 2018 Jan 8.


Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage.

Goedken ER, O'Brien RF, Xiang T, Banach DL, Marchie SC, Barlow EH, Hubbard S, Mankovich JA, Jiang J, Richardson PL, Cuff CA, Cherniack AD.

Protein Expr Purif. 2011 Jan;75(1):55-62. doi: 10.1016/j.pep.2010.08.013. Epub 2010 Sep 6.


In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties.

Strakhova MI, Cuff CA, Manelli AM, Carr TL, Witte DG, Baranowski JL, Vortherms TA, Miller TR, Rundell L, McPherson MJ, Adair RM, Brito AA, Bettencourt BM, Yao BB, Wetter JM, Marsh KC, Liu H, Cowart MD, Brioni JD, Esbenshade TA.

Br J Pharmacol. 2009 May;157(1):44-54. doi: 10.1111/j.1476-5381.2009.00236.x.


(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.

Ahmad S, Madsen CS, Stein PD, Janovitz E, Huang C, Ngu K, Bisaha S, Kennedy LJ, Chen BC, Zhao R, Sitkoff D, Monshizadegan H, Yin X, Ryan CS, Zhang R, Giancarli M, Bird E, Chang M, Chen X, Setters R, Search D, Zhuang S, Nguyen-Tran V, Cuff CA, Harrity T, Darienzo CJ, Li T, Reeves RA, Blanar MA, Barrish JC, Zahler R, Robl JA.

J Med Chem. 2008 May 8;51(9):2722-33. doi: 10.1021/jm800001n. Epub 2008 Apr 15.


The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.

Madsen CS, Janovitz E, Zhang R, Nguyen-Tran V, Ryan CS, Yin X, Monshizadegan H, Chang M, D'Arienzo C, Scheer S, Setters R, Search D, Chen X, Zhuang S, Kunselman L, Peters A, Harrity T, Apedo A, Huang C, Cuff CA, Kowala MC, Blanar MA, Sun CQ, Robl JA, Stein PD.

J Pharmacol Exp Ther. 2008 Feb;324(2):576-86. Epub 2007 Nov 6.


Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.

Zhao L, Cuff CA, Moss E, Wille U, Cyrus T, Klein EA, Praticò D, Rader DJ, Hunter CA, Puré E, Funk CD.

J Biol Chem. 2002 Sep 20;277(38):35350-6. Epub 2002 Jul 16.


The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation.

Cuff CA, Kothapalli D, Azonobi I, Chun S, Zhang Y, Belkin R, Yeh C, Secreto A, Assoian RK, Rader DJ, Puré E.

J Clin Invest. 2001 Oct;108(7):1031-40.


A crucial role for CD44 in inflammation.

Puré E, Cuff CA.

Trends Mol Med. 2001 May;7(5):213-21. Review.


Lymphoid tissue homing chemokines are expressed in chronic inflammation.

Hjelmström P, Fjell J, Nakagawa T, Sacca R, Cuff CA, Ruddle NH.

Am J Pathol. 2000 Apr;156(4):1133-8.


Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development.

Cuff CA, Schwartz J, Bergman CM, Russell KS, Bender JR, Ruddle NH.

J Immunol. 1998 Dec 15;161(12):6853-60.


Mediators of inflammation.

Sacca R, Cuff CA, Ruddle NH.

Curr Opin Immunol. 1997 Dec;9(6):851-7. Review.


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