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Items: 1 to 50 of 274

1.

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy.

Bektas A, Schurman SH, Gonzalez-Freire M, Dunn CA, Singh AK, Macian F, Cuervo AM, Sen R, Ferrucci L.

Aging (Albany NY). 2019 Nov 9;11(21):9234-9263. doi: 10.18632/aging.102438. Epub 2019 Nov 9.

2.

Pros and Cons of Chaperone-Mediated Autophagy in Cancer Biology.

Arias E, Cuervo AM.

Trends Endocrinol Metab. 2019 Nov 4. pii: S1043-2760(19)30208-5. doi: 10.1016/j.tem.2019.09.007. [Epub ahead of print] Review.

PMID:
31699565
3.

Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy.

Valdor R, García-Bernal D, Riquelme D, Martinez CM, Moraleda JM, Cuervo AM, Macian F, Martinez S.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20655-20665. doi: 10.1073/pnas.1903542116. Epub 2019 Sep 23.

4.

Nanomechanical detection of Escherichia coli infection by bacteriophage T7 using cantilever sensors.

Mertens J, Cuervo A, Carrascosa JL.

Nanoscale. 2019 Oct 3;11(38):17689-17698. doi: 10.1039/c9nr05240b.

PMID:
31538998
5.

Atomic structure of the Epstein-Barr virus portal.

Machón C, Fàbrega-Ferrer M, Zhou D, Cuervo A, Carrascosa JL, Stuart DI, Coll M.

Nat Commun. 2019 Aug 29;10(1):3891. doi: 10.1038/s41467-019-11706-8.

6.

Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism.

Cuervo A, Fàbrega-Ferrer M, Machón C, Conesa JJ, Fernández FJ, Pérez-Luque R, Pérez-Ruiz M, Pous J, Vega MC, Carrascosa JL, Coll M.

Nat Commun. 2019 Aug 20;10(1):3746. doi: 10.1038/s41467-019-11705-9.

7.

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.

Butler VJ, Gao F, Corrales CI, Cortopassi WA, Caballero B, Vohra M, Ashrafi K, Cuervo AM, Jacobson MP, Coppola G, Kao AW.

PLoS Genet. 2019 Aug 9;15(8):e1008295. doi: 10.1371/journal.pgen.1008295. eCollection 2019 Aug.

8.

Rheumatoid Arthritis Initiating as Palindromic Rheumatism: A Distinct Clinical Phenotype?

Castellanos-Moreira R, Rodriguez-Garcia SC, Gómez-Puerta JA, Ruiz-Esquide V, Camacho O, Ramírez J, Cuervo A, Morla R, Cañete JD, Haro I, Sanmarti R.

J Rheumatol. 2019 Aug 1. pii: jrheum.190061. doi: 10.3899/jrheum.190061. [Epub ahead of print]

PMID:
31371648
9.

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs.

Kirchner P, Bourdenx M, Madrigal-Matute J, Tiano S, Diaz A, Bartholdy BA, Will B, Cuervo AM.

PLoS Biol. 2019 May 31;17(5):e3000301. doi: 10.1371/journal.pbio.3000301. eCollection 2019 May.

10.

Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99).

Jiang Y, Sato Y, Im E, Berg M, Bordi M, Darji S, Kumar A, Mohan PS, Bandyopadhyay U, Diaz A, Cuervo AM, Nixon RA.

J Neurosci. 2019 Jul 3;39(27):5255-5268. doi: 10.1523/JNEUROSCI.0578-19.2019. Epub 2019 May 1.

PMID:
31043483
11.

The negative effect of lipid challenge on autophagy inhibits T cell responses.

Guerrero-Ros I, Clement CC, Reynolds CA, Patel B, Santambrogio L, Cuervo AM, Macian F.

Autophagy. 2019 Apr 14:1-16. doi: 10.1080/15548627.2019.1606635. [Epub ahead of print]

PMID:
30982401
12.

Trypanosoma cruzi infection, discrete typing units and feeding sources among Psammolestes arthuri (Reduviidae: Triatominae) collected in eastern Colombia.

Velásquez-Ortiz N, Hernández C, Herrera G, Cruz-Saavedra L, Higuera A, Arias-Giraldo LM, Urbano P, Cuervo A, Teherán A, Ramírez JD.

Parasit Vectors. 2019 Apr 8;12(1):157. doi: 10.1186/s13071-019-3422-y.

13.

Earth history and the passerine superradiation.

Oliveros CH, Field DJ, Ksepka DT, Barker FK, Aleixo A, Andersen MJ, Alström P, Benz BW, Braun EL, Braun MJ, Bravo GA, Brumfield RT, Chesser RT, Claramunt S, Cracraft J, Cuervo AM, Derryberry EP, Glenn TC, Harvey MG, Hosner PA, Joseph L, Kimball RT, Mack AL, Miskelly CM, Peterson AT, Robbins MB, Sheldon FH, Silveira LF, Smith BT, White ND, Moyle RG, Faircloth BC.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7916-7925. doi: 10.1073/pnas.1813206116. Epub 2019 Apr 1.

14.

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaat3005. doi: 10.1126/scitranslmed.aat3005.

PMID:
30918111
15.

Psoriatic Synovitis: Singularity and Potential Clinical Implications.

Celis R, Cuervo A, Ramírez J, Cañete JD.

Front Med (Lausanne). 2019 Feb 11;6:14. doi: 10.3389/fmed.2019.00014. eCollection 2019. Review.

16.

Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells.

Zhang J, He J, Johnson JL, Rahman F, Gavathiotis E, Cuervo AM, Catz SD.

Front Endocrinol (Lausanne). 2019 Feb 1;10:21. doi: 10.3389/fendo.2019.00021. eCollection 2019.

17.

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease.

di Domenico A, Carola G, Calatayud C, Pons-Espinal M, Muñoz JP, Richaud-Patin Y, Fernandez-Carasa I, Gut M, Faella A, Parameswaran J, Soriano J, Ferrer I, Tolosa E, Zorzano A, Cuervo AM, Raya A, Consiglio A.

Stem Cell Reports. 2019 Feb 12;12(2):213-229. doi: 10.1016/j.stemcr.2018.12.011. Epub 2019 Jan 10.

18.

Analysis of Chaperone-Mediated Autophagy.

Juste YR, Cuervo AM.

Methods Mol Biol. 2019;1880:703-727. doi: 10.1007/978-1-4939-8873-0_47.

PMID:
30610733
19.

The ULK1-FBXW5-SEC23B nexus controls autophagy.

Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyö D, Cuervo AM, Rossi M, Pagano M.

Elife. 2018 Dec 31;7. pii: e42253. doi: 10.7554/eLife.42253.

20.

Calprotectin strongly and independently predicts relapse in rheumatoid arthritis and polyarticular psoriatic arthritis patients treated with tumor necrosis factor inhibitors: a 1-year prospective cohort study.

Inciarte-Mundo J, Ramirez J, Hernández MV, Ruiz-Esquide V, Cuervo A, Cabrera-Villalba SR, Pascal M, Yagüe J, Cañete JD, Sanmarti R.

Arthritis Res Ther. 2018 Dec 13;20(1):275. doi: 10.1186/s13075-018-1764-z.

21.

Spanish Registry of Recent-onset Psoriatic Arthritis (REAPSER study): Aims and methodology.

Queiro R, Laiz A, Seoane-Mato D, Galindez Agirregoikoa E, Montilla C, Park HS, Bethencourt Baute JJ, Bustabad S, Pinto Tasende JA, Tejón P, Joven Ibáñez B, Ramírez J, Cuervo A, Cañete JD, Trenor Larraz P, Ordás C, Alonso S, García-Fernández E, Toniolo E, Moreno Ramos MJ, Beteta MD, Lojo Oliveira L, Navío Marco T, Cebrián L, Barbazán C, Maceiras F, Rodriguez-Moreno J, Steiner M, Muñoz-Fernández S, Nóvoa Medina FJ, León M, Rubio E, Medina Luezas J, Sánchez-González MD, Arévalo M, Gratacós J, Senabre JM, Rosas JC, Santos Soler G, Nieto-González JC, González C, López Robles A, Álvarez Castro C, Ruiz Montesino MD, Torrente-Segarra V, Fernández-Carballido C, Martínez-Vidal MP, Jovani V, Urruticoechea-Arana A, Cabello Fernández Y, Toledo MD, Almodóvar R, Belmonte-Serrano MÁ, Notario Ferreira I, Raya Álvarez E; Grupo de Trabajo del Proyecto REAPSER.

Reumatol Clin. 2019 Sep - Oct;15(5):252-257. doi: 10.1016/j.reuma.2018.09.008. Epub 2018 Dec 3. English, Spanish.

22.

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap.

Lee YA, Noon LA, Akat KM, Ybanez MD, Lee TF, Berres ML, Fujiwara N, Goossens N, Chou HI, Parvin-Nejad FP, Khambu B, Kramer EGM, Gordon R, Pfleger C, Germain D, John GR, Campbell KN, Yue Z, Yin XM, Cuervo AM, Czaja MJ, Fiel MI, Hoshida Y, Friedman SL.

Nat Commun. 2018 Nov 23;9(1):4962. doi: 10.1038/s41467-018-07338-z.

23.

Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.

Bayó-Puxan N, Terrasso AP, Creyssels S, Simão D, Begon-Pescia C, Lavigne M, Salinas S, Bernex F, Bosch A, Kalatzis V, Levade T, Cuervo AM, Lory P, Consiglio A, Brito C, Kremer EJ.

Sci Rep. 2018 Nov 9;8(1):16644. doi: 10.1038/s41598-018-34523-3.

24.

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.

Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS.

Acta Neuropathol. 2019 Jan;137(1):71-88. doi: 10.1007/s00401-018-1925-9. Epub 2018 Oct 31.

PMID:
30382371
25.

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans.

Walters RO, Arias E, Diaz A, Burgos ES, Guan F, Tiano S, Mao K, Green CL, Qiu Y, Shah H, Wang D, Hudgins AD, Tabrizian T, Tosti V, Shechter D, Fontana L, Kurland IJ, Barzilai N, Cuervo AM, Promislow DEL, Huffman DM.

Cell Rep. 2018 Oct 16;25(3):663-676.e6. doi: 10.1016/j.celrep.2018.09.065.

26.

An extinct hummingbird species that never was: a cautionary tale about sampling issues in molecular phylogenetics.

PÉrez-emÁn JL, Ferreira JP, GutiÉrrez-Pinto N, Cuervo AM, CÉspedes LN, Witt CC, Cadena CD.

Zootaxa. 2018 Jul 2;4442(3):491-497. doi: 10.11646/zootaxa.4442.3.11.

PMID:
30313979
27.

Aging as a Biological Target for Prevention and Therapy.

Barzilai N, Cuervo AM, Austad S.

JAMA. 2018 Oct 2;320(13):1321-1322. doi: 10.1001/jama.2018.9562. No abstract available.

PMID:
30242337
28.

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD.

Schultz ML, Krus KL, Kaushik S, Dang D, Chopra R, Qi L, Shakkottai VG, Cuervo AM, Lieberman AP.

Nat Commun. 2018 Sep 10;9(1):3671. doi: 10.1038/s41467-018-06115-2.

29.

Selective autophagy as a potential therapeutic target for neurodegenerative disorders.

Scrivo A, Bourdenx M, Pampliega O, Cuervo AM.

Lancet Neurol. 2018 Sep;17(9):802-815. doi: 10.1016/S1474-4422(18)30238-2. Review.

30.

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A.

Pajares M, Rojo AI, Arias E, Díaz-Carretero A, Cuervo AM, Cuadrado A.

Autophagy. 2018;14(8):1310-1322. doi: 10.1080/15548627.2018.1474992. Epub 2018 Jul 26.

31.

Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging.

Bejarano E, Murray JW, Wang X, Pampliega O, Yin D, Patel B, Yuste A, Wolkoff AW, Cuervo AM.

Aging Cell. 2018 Aug;17(4):e12777. doi: 10.1111/acel.12777. Epub 2018 May 29.

32.

The coming of age of chaperone-mediated autophagy.

Kaushik S, Cuervo AM.

Nat Rev Mol Cell Biol. 2018 Jun;19(6):365-381. doi: 10.1038/s41580-018-0001-6. Review.

33.

On geographic barriers and Pleistocene glaciations: Tracing the diversification of the Russet-crowned Warbler (Myiothlypis coronata) along the Andes.

Prieto-Torres DA, Cuervo AM, Bonaccorso E.

PLoS One. 2018 Mar 9;13(3):e0191598. doi: 10.1371/journal.pone.0191598. eCollection 2018.

34.

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D.

Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19.

35.

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100.

Amengual J, Guo L, Strong A, Madrigal-Matute J, Wang H, Kaushik S, Brodsky JL, Rader DJ, Cuervo AM, Fisher EA.

Circ Res. 2018 Feb 16;122(4):568-582. doi: 10.1161/CIRCRESAHA.117.311240. Epub 2018 Jan 4.

36.

Chaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone.

Tekirdag K, Cuervo AM.

J Biol Chem. 2018 Apr 13;293(15):5414-5424. doi: 10.1074/jbc.R117.818237. Epub 2017 Dec 15. Review.

37.

Molecular systematics and biogeography of lowland antpittas (Aves, Grallariidae): The role of vicariance and dispersal in the diversification of a widespread Neotropical lineage.

Carneiro L, Bravo GA, Aristizábal N, Cuervo AM, Aleixo A.

Mol Phylogenet Evol. 2018 Mar;120:375-389. doi: 10.1016/j.ympev.2017.11.019. Epub 2017 Dec 9.

38.

Humanin is an endogenous activator of chaperone-mediated autophagy.

Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kühn B, Cuervo AM, Muzumdar R.

J Cell Biol. 2018 Feb 5;217(2):635-647. doi: 10.1083/jcb.201606095. Epub 2017 Nov 29.

39.

Observation of Bacteriophage Ultrastructure by Cryo-electron Microscopy.

Cuervo A, Carrascosa JL.

Methods Mol Biol. 2018;1693:43-55. doi: 10.1007/978-1-4939-7395-8_5.

PMID:
29119431
40.

Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.

Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT.

Neurobiol Aging. 2018 Jan;61:1-12. doi: 10.1016/j.neurobiolaging.2017.09.007. Epub 2017 Sep 20.

41.

Interplay of pathogenic forms of human tau with different autophagic pathways.

Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Stiller B, Mandelkow EM, Mandelkow E, Cuervo AM.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12692. Epub 2017 Oct 12.

42.

Correction: A latitudinal phylogeographic diversity gradient in birds.

Smith BT, Seeholzer GF, Harvey MG, Cuervo AM, Brumfield RT.

PLoS Biol. 2017 Jul 14;15(7):e1002610. doi: 10.1371/journal.pbio.1002610. eCollection 2017 Jul.

43.

Molecular definitions of autophagy and related processes.

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G.

EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review.

44.

Positive association between population genetic differentiation and speciation rates in New World birds.

Harvey MG, Seeholzer GF, Smith BT, Rabosky DL, Cuervo AM, Brumfield RT.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6328-6333. doi: 10.1073/pnas.1617397114. Epub 2017 May 30.

45.

Clinical and sonographic biomarkers of structural damage progression in RA patients in clinical remission: A prospective study with 12 months follow-up.

Ramírez J, Narváez JA, Ruiz-Esquide V, Hernández-Gañán J, Cuervo A, Inciarte-Mundo J, Hernández MV, Sampayo-Cordero M, Pablos JL, Sanmartí R, Cañete JD.

Semin Arthritis Rheum. 2017 Dec;47(3):303-309. doi: 10.1016/j.semarthrit.2017.04.007. Epub 2017 May 1.

PMID:
28549731
46.

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.

Zhang J, Johnson JL, He J, Napolitano G, Ramadass M, Rocca C, Kiosses WB, Bucci C, Xin Q, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD.

J Biol Chem. 2017 Jun 23;292(25):10328-10346. doi: 10.1074/jbc.M116.764076. Epub 2017 May 2.

47.

Programmed mitophagy is essential for the glycolytic switch during cell differentiation.

Esteban-Martínez L, Sierra-Filardi E, McGreal RS, Salazar-Roa M, Mariño G, Seco E, Durand S, Enot D, Graña O, Malumbres M, Cvekl A, Cuervo AM, Kroemer G, Boya P.

EMBO J. 2017 Jun 14;36(12):1688-1706. doi: 10.15252/embj.201695916. Epub 2017 May 2.

48.

Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation.

Gomes LR, Menck CFM, Cuervo AM.

Autophagy. 2017 May 4;13(5):928-940. doi: 10.1080/15548627.2017.1293767. Epub 2017 Mar 2.

49.

A latitudinal phylogeographic diversity gradient in birds.

Smith BT, Seeholzer GF, Harvey MG, Cuervo AM, Brumfield RT.

PLoS Biol. 2017 Apr 13;15(4):e2001073. doi: 10.1371/journal.pbio.2001073. eCollection 2017 Apr. Erratum in: PLoS Biol. 2017 Jul 14;15(7):e1002610.

50.

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.

Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K.

Nat Med. 2017 Apr;23(4):429-438. doi: 10.1038/nm.4287. Epub 2017 Feb 20.

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