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Items: 1 to 50 of 69

1.

Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.

Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Del Fresno C, Dominguez-Andrés J, Aparicio N, Zur R, Shpiro N, Brown GD, Ardavín C, Netea MG, Alemany S, Sanz-Ezquerro JJ, Cuenda A.

EMBO Mol Med. 2018 May;10(5). pii: e8485. doi: 10.15252/emmm.201708485.

2.

p38γ and p38δ Are Involved in T Lymphocyte Development.

Risco A, Martin-Serrano MA, Barber DF, Cuenda A.

Front Immunol. 2018 Jan 29;9:65. doi: 10.3389/fimmu.2018.00065. eCollection 2018.

3.

Editorial: Mitogen Activated Protein Kinases.

Cuenda A, Lizcano JM, Lozano J.

Front Cell Dev Biol. 2017 Sep 14;5:80. doi: 10.3389/fcell.2017.00080. eCollection 2017. No abstract available.

4.

p38γ and p38δ: From Spectators to Key Physiological Players.

Cuenda A, Sanz-Ezquerro JJ.

Trends Biochem Sci. 2017 Jun;42(6):431-442. doi: 10.1016/j.tibs.2017.02.008. Epub 2017 May 1. Review.

PMID:
28473179
5.

p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis.

Rajamäki K, Mäyränpää MI, Risco A, Tuimala J, Nurmi K, Cuenda A, Eklund KK, Öörni K, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1937-46. doi: 10.1161/ATVBAHA.115.307312. Epub 2016 Jul 14.

PMID:
27417584
6.

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.

Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ, Hastie CJ, Lamont DJ, Torrente L, Chowdhry S, Benjamin IJ, Keyse SM, Cuenda A, Dinkova-Kostova AT.

Mol Cell Biol. 2016 Aug 26;36(18):2403-17. doi: 10.1128/MCB.00292-16. Print 2016 Sep 15.

7.

Hyperosmotic Stress Induces Tau Proteolysis by Caspase-3 Activation in SH-SY5Y Cells.

Olivera-Santa Catalina M, Caballero-Bermejo M, Argent R, Alonso JC, Cuenda A, Lorenzo MJ, Centeno F.

J Cell Biochem. 2016 Dec;117(12):2781-2790. doi: 10.1002/jcb.25579. Epub 2016 Aug 24.

PMID:
27152883
8.

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy.

Escós A, Risco A, Alsina-Beauchamp D, Cuenda A.

Front Cell Dev Biol. 2016 Apr 14;4:31. doi: 10.3389/fcell.2016.00031. eCollection 2016. Review.

9.

Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold.

Noseda R, Guerrero-Valero M, Alberizzi V, Previtali SC, Sherman DL, Palmisano M, Huganir RL, Nave KA, Cuenda A, Feltri ML, Brophy PJ, Bolino A.

PLoS Biol. 2016 Apr 12;14(4):e1002440. doi: 10.1371/journal.pbio.1002440. eCollection 2016 Apr.

10.

p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.

González-Terán B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernández-Cosido L, Mora A, Crainiciuc G, Sáiz ML, Bernardo E, Leiva-Vega L, Rodríguez E, Bondía V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G.

EMBO J. 2016 Mar 1;35(5):536-52. doi: 10.15252/embj.201591857. Epub 2016 Feb 3.

11.

Implication of Akt, ERK1/2 and alternative p38MAPK signalling pathways in human colon cancer cell apoptosis induced by green tea EGCG.

Cerezo-Guisado MI, Zur R, Lorenzo MJ, Risco A, Martín-Serrano MA, Alvarez-Barrientos A, Cuenda A, Centeno F.

Food Chem Toxicol. 2015 Oct;84:125-32. doi: 10.1016/j.fct.2015.08.017. Epub 2015 Aug 21.

PMID:
26303273
12.

Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.

Zur R, Garcia-Ibanez L, Nunez-Buiza A, Aparicio N, Liappas G, Escós A, Risco A, Page A, Saiz-Ladera C, Alsina-Beauchamp D, Montans J, Paramio JM, Cuenda A.

Oncotarget. 2015 May 30;6(15):12920-35.

13.

p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences: role in migration and invasion.

Arechederra M, Priego N, Vázquez-Carballo A, Sequera C, Gutiérrez-Uzquiza Á, Cerezo-Guisado MI, Ortiz-Rivero S, Roncero C, Cuenda A, Guerrero C, Porras A.

J Biol Chem. 2015 Feb 13;290(7):4383-97. doi: 10.1074/jbc.M114.582239. Epub 2014 Dec 29.

14.

Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer.

Del Reino P, Alsina-Beauchamp D, Escós A, Cerezo-Guisado MI, Risco A, Aparicio N, Zur R, Fernandez-Estévez M, Collantes E, Montans J, Cuenda A.

Cancer Res. 2014 Nov 1;74(21):6150-60. doi: 10.1158/0008-5472.CAN-14-0870. Epub 2014 Sep 12.

15.

Alternative p38 MAPKs are essential for collagen-induced arthritis.

Criado G, Risco A, Alsina-Beauchamp D, Pérez-Lorenzo MJ, Escós A, Cuenda A.

Arthritis Rheumatol. 2014 May;66(5):1208-17. doi: 10.1002/art.38327.

16.

Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells.

Aguilera-Montilla N, Chamorro S, Nieto C, Sánchez-Cabo F, Dopazo A, Fernández-Salguero PM, Rodríguez-Fernández JL, Pello OM, Andrés V, Cuenda A, Alonso B, Domínguez-Soto A, Sánchez-Ramón S, Corbí AL.

Blood. 2013 Apr 11;121(15):e108-17. doi: 10.1182/blood-2012-07-445106. Epub 2013 Feb 21.

17.

Functional significance of SRJ domain mutations in CITED2.

Chen CM, Bentham J, Cosgrove C, Braganca J, Cuenda A, Bamforth SD, Schneider JE, Watkins H, Keavney B, Davies B, Bhattacharya S.

PLoS One. 2012;7(10):e46256. doi: 10.1371/journal.pone.0046256. Epub 2012 Oct 17.

18.

p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation.

Risco A, del Fresno C, Mambol A, Alsina-Beauchamp D, MacKenzie KF, Yang HT, Barber DF, Morcelle C, Arthur JS, Ley SC, Ardavin C, Cuenda A.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11200-5. doi: 10.1073/pnas.1207290109. Epub 2012 Jun 25.

19.

New Insights into the p38γ and p38δ MAPK Pathways.

Risco A, Cuenda A.

J Signal Transduct. 2012;2012:520289. doi: 10.1155/2012/520289. Epub 2011 Nov 30.

20.

Evidence of p38γ and p38δ involvement in cell transformation processes.

Cerezo-Guisado MI, del Reino P, Remy G, Kuma Y, Arthur JS, Gallego-Ortega D, Cuenda A.

Carcinogenesis. 2011 Jul;32(7):1093-9. doi: 10.1093/carcin/bgr079. Epub 2011 May 10.

PMID:
21558321
21.

Alternative ERK5 regulation by phosphorylation during the cell cycle.

Iñesta-Vaquera FA, Campbell DG, Tournier C, Gómez N, Lizcano JM, Cuenda A.

Cell Signal. 2010 Dec;22(12):1829-37. doi: 10.1016/j.cellsig.2010.07.010. Epub 2010 Jul 25.

PMID:
20667468
22.

ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis.

Iñesta-Vaquera FA, Campbell DG, Arthur JS, Cuenda A.

Biochem Biophys Res Commun. 2010 Aug 13;399(1):84-90. doi: 10.1016/j.bbrc.2010.07.046. Epub 2010 Jul 17.

PMID:
20643107
23.

p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock.

Sabio G, Cerezo-Guisado MI, Del Reino P, Iñesta-Vaquera FA, Rousseau S, Arthur JS, Campbell DG, Centeno F, Cuenda A.

J Cell Sci. 2010 Aug 1;123(Pt 15):2596-604. doi: 10.1242/jcs.066514. Epub 2010 Jul 6.

24.

p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9.

Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, Iftner T, Cuenda A, Chen G.

J Biol Chem. 2010 May 14;285(20):15149-58. doi: 10.1074/jbc.M110.105429. Epub 2010 Mar 15.

25.

p38-{gamma}-dependent gene silencing restricts entry into the myogenic differentiation program.

Gillespie MA, Le Grand F, Scimè A, Kuang S, von Maltzahn J, Seale V, Cuenda A, Ranish JA, Rudnicki MA.

J Cell Biol. 2009 Dec 28;187(7):991-1005. doi: 10.1083/jcb.200907037. Epub 2009 Dec 21.

26.

Differential activation of p38MAPK isoforms by MKK6 and MKK3.

Remy G, Risco AM, Iñesta-Vaquera FA, González-Terán B, Sabio G, Davis RJ, Cuenda A.

Cell Signal. 2010 Apr;22(4):660-7. doi: 10.1016/j.cellsig.2009.11.020. Epub 2009 Dec 11.

PMID:
20004242
27.

p38delta and PKD1: kinase switches for insulin secretion.

Cuenda A, Nebreda AR.

Cell. 2009 Jan 23;136(2):209-10. doi: 10.1016/j.cell.2009.01.005.

28.

Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation.

Iñesta-Vaquera FA, Centeno F, del Reino P, Sabio G, Peggie M, Cuenda A.

FEBS J. 2009 Jan;276(2):387-400. doi: 10.1111/j.1742-4658.2008.06783.x. Epub 2008 Nov 28.

29.

p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.

Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G.

J Biol Chem. 2007 Oct 26;282(43):31398-408. Epub 2007 Aug 27.

30.

p38 MAP-kinases pathway regulation, function and role in human diseases.

Cuenda A, Rousseau S.

Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24. Review.

31.

CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway.

Rousseau S, Dolado I, Beardmore V, Shpiro N, Marquez R, Nebreda AR, Arthur JS, Case LM, Tessier-Lavigne M, Gaestel M, Cuenda A, Cohen P.

Cell Signal. 2006 Nov;18(11):1897-905. Epub 2006 Mar 6.

PMID:
16574378
32.
33.

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.

Eyers CE, McNeill H, Knebel A, Morrice N, Arthur SJ, Cuenda A, Cohen P.

Biochem J. 2005 Jul 1;389(Pt 1):127-35.

34.

BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

Kuma Y, Sabio G, Bain J, Shpiro N, Márquez R, Cuenda A.

J Biol Chem. 2005 May 20;280(20):19472-9. Epub 2005 Mar 8.

35.

p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.

Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, Murray-Tait V, Centeno F, Goedert M, Morrice NA, Cuenda A.

EMBO J. 2005 Mar 23;24(6):1134-45. Epub 2005 Feb 24.

36.

Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.

Feijoo C, Campbell DG, Jakes R, Goedert M, Cuenda A.

J Cell Sci. 2005 Jan 15;118(Pt 2):397-408. Epub 2005 Jan 4.

37.

A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.

McNeill H, Knebel A, Arthur JS, Cuenda A, Cohen P.

Biochem J. 2004 Dec 1;384(Pt 2):391-400.

38.

Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.

Sabio G, Reuver S, Feijoo C, Hasegawa M, Thomas GM, Centeno F, Kuhlendahl S, Leal-Ortiz S, Goedert M, Garner C, Cuenda A.

Biochem J. 2004 May 15;380(Pt 1):19-30.

39.
40.

Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.

Mora A, Sabio G, Risco AM, Cuenda A, Alonso JC, Soler G, Centeno F.

Cell Signal. 2002 Jun;14(6):557-62.

PMID:
11897496
41.

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells.

Mora A, Sabio G, González-Polo RA, Cuenda A, Alessi DR, Alonso JC, Fuentes JM, Soler G, Centeno F.

J Neurochem. 2001 Jul;78(1):199-206.

42.

Use of kinase inhibitors to dissect signaling pathways.

Cuenda A, Alessi DR.

Methods Mol Biol. 2000;99:161-75. Review. No abstract available.

PMID:
10909084
43.

Methods to assay stress-activated protein kinases.

Cuenda A.

Methods Mol Biol. 2000;99:127-43. Review. No abstract available.

PMID:
10909082
44.

Mitogen-activated protein kinase kinase 4 (MKK4).

Cuenda A.

Int J Biochem Cell Biol. 2000 Jun;32(6):581-7. Review.

PMID:
10785355
45.
46.

Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.

Hasegawa M, Cuenda A, Spillantini MG, Thomas GM, Buée-Scherrer V, Cohen P, Goedert M.

J Biol Chem. 1999 Apr 30;274(18):12626-31.

47.
49.

Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6).

Cuenda A, Goedert M, Craxton M, Jakes R, Cohen P.

Biochem Soc Trans. 1997 Nov;25(4):S569. No abstract available.

PMID:
9449997
50.

Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli.

Hazzalin CA, Cuenda A, Cano E, Cohen P, Mahadevan LC.

Oncogene. 1997 Nov 6;15(19):2321-31.

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