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Items: 39


A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.

Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, Baenziger JE, Ulens C.

Nat Chem Biol. 2019 Oct 7. doi: 10.1038/s41589-019-0369-4. [Epub ahead of print]


Structure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ion-bound configuration.

Tilegenova C, Cortes DM, Jahovic N, Hardy E, Hariharan P, Guan L, Cuello LG.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16829-16834. doi: 10.1073/pnas.1901888116. Epub 2019 Aug 6.


Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel.

Li J, Ostmeyer J, Cuello LG, Perozo E, Roux B.

J Gen Physiol. 2018 Oct 1;150(10):1408-1420. doi: 10.1085/jgp.201812082. Epub 2018 Aug 2.


Inverted allosteric coupling between activation and inactivation gates in K+ channels.

Labro AJ, Cortes DM, Tilegenova C, Cuello LG.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5426-5431. doi: 10.1073/pnas.1800559115. Epub 2018 May 7.


Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria.

Fiori MC, Krishnan S, Kjellgren A, Cuello LG, Altenberg GA.

Molecules. 2017 Nov 25;22(12). pii: E2063. doi: 10.3390/molecules22122063.


The gating cycle of a K+ channel at atomic resolution.

Cuello LG, Cortes DM, Perozo E.

Elife. 2017 Nov 22;6. pii: e28032. doi: 10.7554/eLife.28032.


CW-EPR Spectroscopy and Site-Directed Spin Labeling to Study the Structural Dynamics of Ion Channels.

Tilegenova C, Elberson BW, Marien Cortes D, Cuello LG.

Methods Mol Biol. 2018;1684:279-288. doi: 10.1007/978-1-4939-7362-0_21.


A Cell-Based Assay to Assess Hemichannel Function.

Krishnan S, Fiori MC, Cuello LG, Altenberg GA.

Yale J Biol Med. 2017 Mar 29;90(1):87-95. eCollection 2017 Mar. Review.


Activation of the mechanosensitive ion channel MscL by mechanical stimulation of supported Droplet-Hydrogel bilayers.

Rosholm KR, Baker MA, Ridone P, Nakayama Y, Rohde PR, Cuello LG, Lee LK, Martinac B.

Sci Rep. 2017 Mar 27;7:45180. doi: 10.1038/srep45180.


A cost-effective protocol for the over-expression and purification of fully-functional and more stable Erwinia chrysanthemi ligand-gated ion channel.

Elberson BW, Whisenant TE, Cortes DM, Cuello LG.

Protein Expr Purif. 2017 May;133:177-186. doi: 10.1016/j.pep.2017.03.006. Epub 2017 Mar 7.


Hysteresis of KcsA potassium channel's activation- deactivation gating is caused by structural changes at the channel's selectivity filter.

Tilegenova C, Cortes DM, Cuello LG.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3234-3239. doi: 10.1073/pnas.1618101114. Epub 2017 Mar 6.


Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function.

Hilgers RH, Kundumani-Sridharan V, Subramani J, Chen LC, Cuello LG, Rusch NJ, Das KC.

Sci Transl Med. 2017 Feb 8;9(376). pii: eaaf6094. doi: 10.1126/scitranslmed.aaf6094.


An Escherichia coli-Based Assay to Assess the Function of Recombinant Human Hemichannels.

Krishnan S, Fiori MC, Whisenant TE, Cortes DM, Altenberg GA, Cuello LG.

SLAS Discov. 2017 Feb;22(2):135-143. doi: 10.1177/1087057116675321. Epub 2016 Oct 28.


An improved method for the cost-effective expression and purification of large quantities of KcsA.

Tilegenova C, Vemulapally S, Cortes DM, Cuello LG.

Protein Expr Purif. 2016 Nov;127:53-60. doi: 10.1016/j.pep.2016.07.002. Epub 2016 Jul 5.


Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display.

Zhao R, Dai H, Mendelman N, Cuello LG, Chill JH, Goldstein SA.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E7013-21. doi: 10.1073/pnas.1514728112. Epub 2015 Dec 1.


Voltage-dependent BK and Hv1 channels expressed in non-excitable tissues: New therapeutics opportunities as targets in human diseases.

Morera FJ, Saravia J, Pontigo JP, Vargas-Chacoff L, Contreras GF, Pupo A, Lorenzo Y, Castillo K, Tilegenova C, Cuello LG, Gonzalez C.

Pharmacol Res. 2015 Nov;101:56-64. doi: 10.1016/j.phrs.2015.08.011. Epub 2015 Aug 21. Review.


Functional hemichannels formed by human connexin 26 expressed in bacteria.

Fiori MC, Krishnan S, Cortes DM, Retamal MA, Reuss L, Altenberg GA, Cuello LG.

Biosci Rep. 2015 Mar 18;35(2). pii: e00177. doi: 10.1042/BSR20140089.


Functional analysis and regulation of purified connexin hemichannels.

Fiori MC, Reuss L, Cuello LG, Altenberg GA.

Front Physiol. 2014 Feb 25;5:71. doi: 10.3389/fphys.2014.00071. eCollection 2014. Review.


Biochemical and structural analysis of the hyperpolarization-activated K(+) channel MVP.

Randich AM, Cuello LG, Wanderling SS, Perozo E.

Biochemistry. 2014 Mar 18;53(10):1627-36. doi: 10.1021/bi4014243. Epub 2014 Mar 7.


Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography.

Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18716-21. doi: 10.1073/pnas.1313156110. Epub 2013 Oct 28.


Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations.

Pan AC, Cuello LG, Perozo E, Roux B.

J Gen Physiol. 2011 Dec;138(6):571-80. doi: 10.1085/jgp.201110670.


Mechanism of activation gating in the full-length KcsA K+ channel.

Uysal S, Cuello LG, Cortes DM, Koide S, Kossiakoff AA, Perozo E.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11896-9. doi: 10.1073/pnas.1105112108. Epub 2011 Jul 5.


Structural dynamics of the magnesium-bound conformation of CorA in a lipid bilayer.

Dalmas O, Cuello LG, Jogini V, Cortes DM, Roux B, Perozo E.

Structure. 2010 Jul 14;18(7):868-78. doi: 10.1016/j.str.2010.04.009.


Structural basis for the coupling between activation and inactivation gates in K(+) channels.

Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E.

Nature. 2010 Jul 8;466(7303):272-5. doi: 10.1038/nature09136.


Structural mechanism of C-type inactivation in K(+) channels.

Cuello LG, Jogini V, Cortes DM, Perozo E.

Nature. 2010 Jul 8;466(7303):203-8. doi: 10.1038/nature09153.


Design and characterization of a constitutively open KcsA.

Cuello LG, Jogini V, Cortes DM, Sompornpisut A, Purdy MD, Wiener MC, Perozo E.

FEBS Lett. 2010 Mar 19;584(6):1133-8. doi: 10.1016/j.febslet.2010.02.015. Epub 2010 Feb 12.


A molecular mechanism for proton-dependent gating in KcsA.

Cuello LG, Cortes DM, Jogini V, Sompornpisut A, Perozo E.

FEBS Lett. 2010 Mar 19;584(6):1126-32. doi: 10.1016/j.febslet.2010.02.003. Epub 2010 Feb 6.


A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.

Takacs Z, Toups M, Kollewe A, Johnson E, Cuello LG, Driessens G, Biancalana M, Koide A, Ponte CG, Perozo E, Gajewski TF, Suarez-Kurtz G, Koide S, Goldstein SA.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22211-6. doi: 10.1073/pnas.0910123106. Epub 2009 Dec 10.


Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer.

Chakrapani S, Cuello LG, Cortes DM, Perozo E.

Structure. 2008 Mar;16(3):398-409. doi: 10.1016/j.str.2007.12.015.


Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction.

Blunck R, Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F.

J Gen Physiol. 2006 Nov;128(5):569-81. Epub 2006 Oct 16.


Molecular determinants of gating at the potassium-channel selectivity filter.

Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, Roux B, Perozo E.

Nat Struct Mol Biol. 2006 Apr;13(4):311-8. Epub 2006 Mar 12.


Voltage-dependent gating at the KcsA selectivity filter.

Cordero-Morales JF, Cuello LG, Perozo E.

Nat Struct Mol Biol. 2006 Apr;13(4):319-22. Epub 2006 Mar 12.


Electrostatic interaction of a K+ channel RCK domain with charged membrane surfaces.

Ptak CP, Cuello LG, Perozo E.

Biochemistry. 2005 Jan 11;44(1):62-71.


Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer.

Cuello LG, Cortes DM, Perozo E.

Science. 2004 Oct 15;306(5695):491-5.


EPR approaches to ion channel structure and function.

Perozo E, Cuello LG, Cortes DM, Liu YS, Sompornpisut P.

Novartis Found Symp. 2002;245:146-58; discussion 158-64, 165-8. Review.


Structural rearrangements underlying K+-channel activation gating.

Perozo E, Cortes DM, Cuello LG.

Science. 1999 Jul 2;285(5424):73-8.


Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy.

Perozo E, Cortes DM, Cuello LG.

Nat Struct Biol. 1998 Jun;5(6):459-69.


pH-dependent gating in the Streptomyces lividans K+ channel.

Cuello LG, Romero JG, Cortes DM, Perozo E.

Biochemistry. 1998 Mar 10;37(10):3229-36.


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