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Items: 45


ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection.

Thi EP, Dhillon AP, Ardzinski A, Bidirici-Ertekin L, Cobarrubias KD, Cuconati A, Kondratowicz AS, Kwak K, Li AHL, Miller A, Pasetka C, Pei L, Phelps JR, Snead NM, Wang X, Ye X, Sofia MJ, Lee ACH.

ACS Infect Dis. 2019 May 10;5(5):725-737. doi: 10.1021/acsinfecdis.8b00191. Epub 2018 Nov 19.


Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation.

Mani N, Cole AG, Phelps JR, Ardzinski A, Cobarrubias KD, Cuconati A, Dorsey BD, Evangelista E, Fan K, Guo F, Guo H, Guo JT, Harasym TO, Kadhim S, Kultgen SG, Lee ACH, Li AHL, Long Q, Majeski SA, Mao R, McClintock KD, Reid SP, Rijnbrand R, Snead NM, Micolochick Steuer HM, Stever K, Tang S, Wang X, Zhao Q, Sofia MJ.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00082-18. doi: 10.1128/AAC.00082-18. Print 2018 Jun.


HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways.

Guo F, Zhao Q, Sheraz M, Cheng J, Qi Y, Su Q, Cuconati A, Wei L, Du Y, Li W, Chang J, Guo JT.

PLoS Pathog. 2017 Sep 25;13(9):e1006658. doi: 10.1371/journal.ppat.1006658. eCollection 2017 Sep.


Microtiter-Format Assays for HBV Antigen Quantitation in Nonclinical Applications.

Goddard CD, Bildrici-Ertekin L, Wang X, Cuconati A.

Methods Mol Biol. 2017;1540:203-209.


Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents.

Lu H, Rogowskyj J, Yu W, Venkatesh A, Khan N, Nakagawa S, Goossens N, Koh AP, Higashi T, Gunasekaran G, Schwarz ME, Hiotis SP, Xu X, Kinney W, Hoshida Y, Block T, Cuconati A, Du Y.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5819-5824. doi: 10.1016/j.bmcl.2016.10.015. Epub 2016 Oct 10.


A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein.

Guo F, Wu S, Julander J, Ma J, Zhang X, Kulp J, Cuconati A, Block TM, Du Y, Guo JT, Chang J.

J Virol. 2016 Nov 14;90(23):10774-10788. doi: 10.1128/JVI.01253-16. Print 2016 Dec 1.


Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators.

Cai D, Wang X, Yan R, Mao R, Liu Y, Ji C, Cuconati A, Guo H.

Antiviral Res. 2016 Aug;132:26-37. doi: 10.1016/j.antiviral.2016.05.005. Epub 2016 May 13.


Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes.

Yan R, Zhang Y, Cai D, Liu Y, Cuconati A, Guo H.

PLoS One. 2015 Jun 12;10(6):e0129889. doi: 10.1371/journal.pone.0129889. eCollection 2015.


Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.

Zhao X, Guo F, Comunale MA, Mehta A, Sehgal M, Jain P, Cuconati A, Lin H, Block TM, Chang J, Guo JT.

Antimicrob Agents Chemother. 2015 Jan;59(1):206-16. doi: 10.1128/AAC.03999-14. Epub 2014 Oct 27.


An interferon-beta promoter reporter assay for high throughput identification of compounds against multiple RNA viruses.

Guo F, Zhao X, Gill T, Zhou Y, Campagna M, Wang L, Liu F, Zhang P, DiPaolo L, Du Y, Xu X, Jiang D, Wei L, Cuconati A, Block TM, Guo JT, Chang J.

Antiviral Res. 2014 Jul;107:56-65. doi: 10.1016/j.antiviral.2014.04.010. Epub 2014 Apr 30.


Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.

Zhao X, Guo F, Liu F, Cuconati A, Chang J, Block TM, Guo JT.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6756-61. doi: 10.1073/pnas.1320856111. Epub 2014 Apr 21.


Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein.

Mao R, Nie H, Cai D, Zhang J, Liu H, Yan R, Cuconati A, Block TM, Guo JT, Guo H.

PLoS Pathog. 2013;9(7):e1003494. doi: 10.1371/journal.ppat.1003494. Epub 2013 Jul 11.


Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus.

Du Y, Ye H, Guo F, Wang L, Gill T, Khan N, Cuconati A, Guo JT, Block TM, Chang J, Xu X.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4258-62. doi: 10.1016/j.bmcl.2013.04.052. Epub 2013 May 9.


Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.

Chang J, Warren TK, Zhao X, Gill T, Guo F, Wang L, Comunale MA, Du Y, Alonzi DS, Yu W, Ye H, Liu F, Guo JT, Mehta A, Cuconati A, Butters TD, Bavari S, Xu X, Block TM.

Antiviral Res. 2013 Jun;98(3):432-40. doi: 10.1016/j.antiviral.2013.03.023. Epub 2013 Apr 8.


Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids.

Campagna MR, Liu F, Mao R, Mills C, Cai D, Guo F, Zhao X, Ye H, Cuconati A, Guo H, Chang J, Xu X, Block TM, Guo JT.

J Virol. 2013 Jun;87(12):6931-42. doi: 10.1128/JVI.00582-13. Epub 2013 Apr 10.


N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.

Du Y, Ye H, Gill T, Wang L, Guo F, Cuconati A, Guo JT, Block TM, Chang J, Xu X.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2172-6. doi: 10.1016/j.bmcl.2013.01.108. Epub 2013 Feb 1.


Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system.

Lamontagne J, Mills C, Mao R, Goddard C, Cai D, Guo H, Cuconati A, Block T, Lu X.

Antiviral Res. 2013 Apr;98(1):19-26. doi: 10.1016/j.antiviral.2013.02.001. Epub 2013 Feb 13.


Chronic hepatitis B: what should be the goal for new therapies?

Block TM, Gish R, Guo H, Mehta A, Cuconati A, Thomas London W, Guo JT.

Antiviral Res. 2013 Apr;98(1):27-34. doi: 10.1016/j.antiviral.2013.01.006. Epub 2013 Feb 4.


Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells.

Cuconati A, Mills C, Goddard C, Zhang X, Yu W, Guo H, Xu X, Block TM.

PLoS One. 2013;8(1):e54595. doi: 10.1371/journal.pone.0054595. Epub 2013 Jan 23.


RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response.

Guo F, Mead J, Aliya N, Wang L, Cuconati A, Wei L, Li K, Block TM, Guo JT, Chang J.

PLoS One. 2012;7(10):e42583. doi: 10.1371/journal.pone.0042583. Epub 2012 Oct 3.


Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection.

Yu W, Gill T, Wang L, Du Y, Ye H, Qu X, Guo JT, Cuconati A, Zhao K, Block TM, Xu X, Chang J.

J Med Chem. 2012 Jul 12;55(13):6061-75. doi: 10.1021/jm300171v. Epub 2012 Jun 29.


Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation.

Cai D, Mills C, Yu W, Yan R, Aldrich CE, Saputelli JR, Mason WS, Xu X, Guo JT, Block TM, Cuconati A, Guo H.

Antimicrob Agents Chemother. 2012 Aug;56(8):4277-88. doi: 10.1128/AAC.00473-12. Epub 2012 May 29.


A Novel High-Throughput Screening Assay to Identify Inhibitors of HIV-1 gp120 Protein Interaction with DC-SIGN.

Tran TH, El Baz R, Cuconati A, Arthos J, Jain P, Khan ZK.

J Antivir Antiretrovir. 2011 Oct 17;3:49-54.


Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.

Yu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, Morrey JD, Motter NE, Zhao K, Block TM, Cuconati A, Xu X.

J Med Chem. 2011 Aug 25;54(16):5660-70. doi: 10.1021/jm200696v. Epub 2011 Aug 2.


Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses.

Guo H, Pan X, Mao R, Zhang X, Wang L, Lu X, Chang J, Guo JT, Passic S, Krebs FC, Wigdahl B, Warren TK, Retterer CJ, Bavari S, Xu X, Cuconati A, Block TM.

Antimicrob Agents Chemother. 2011 Feb;55(2):478-86. doi: 10.1128/AAC.00989-10. Epub 2010 Dec 6.


Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells.

Mao R, Zhang J, Jiang D, Cai D, Levy JM, Cuconati A, Block TM, Guo JT, Guo H.

J Virol. 2011 Jan;85(2):1048-57. doi: 10.1128/JVI.01998-10. Epub 2010 Nov 17.


Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells.

Guo H, Jiang D, Ma D, Chang J, Dougherty AM, Cuconati A, Block TM, Guo JT.

J Virol. 2009 Jan;83(2):847-58. doi: 10.1128/JVI.02008-08. Epub 2008 Oct 29.


A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.

Dougherty AM, Guo H, Westby G, Liu Y, Simsek E, Guo JT, Mehta A, Norton P, Gu B, Block T, Cuconati A.

Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37. Epub 2007 Sep 17.


Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway.

Guo H, Zhou T, Jiang D, Cuconati A, Xiao GH, Block TM, Guo JT.

J Virol. 2007 Sep;81(18):10072-80. Epub 2007 Jul 3.


Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen.

Gu B, Ouzunov S, Wang L, Mason P, Bourne N, Cuconati A, Block TM.

Antiviral Res. 2006 Jun;70(2):39-50.


DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells.

Cuconati A, Mukherjee C, Perez D, White E.

Genes Dev. 2003 Dec 1;17(23):2922-32. Epub 2003 Nov 21.


Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection.

Cuconati A, White E.

Genes Dev. 2002 Oct 1;16(19):2465-78. Review. No abstract available.


Bak and Bax function to limit adenovirus replication through apoptosis induction.

Cuconati A, Degenhardt K, Sundararajan R, Anschel A, White E.

J Virol. 2002 May;76(9):4547-58.


Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K.

Sundararajan R, Cuconati A, Nelson D, White E.

J Biol Chem. 2001 Nov 30;276(48):45120-7. Epub 2001 Sep 24.


Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA.

Verlinden Y, Cuconati A, Wimmer E, Rombaut B.

J Gen Virol. 2000 Nov;81(Pt 11):2751-4.


Brefeldin A inhibits cell-free, de novo synthesis of poliovirus.

Cuconati A, Molla A, Wimmer E.

J Virol. 1998 Aug;72(8):6456-64.


Genetic recombination of poliovirus in a cell-free system.

Duggal R, Cuconati A, Gromeier M, Wimmer E.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13786-91.


A protein linkage map of the P2 nonstructural proteins of poliovirus.

Cuconati A, Xiang W, Lahser F, Pfister T, Wimmer E.

J Virol. 1998 Feb;72(2):1297-307.


Molecular dissection of the multifunctional poliovirus RNA-binding protein 3AB.

Xiang W, Cuconati A, Paul AV, Cao X, Wimmer E.

RNA. 1995 Nov;1(9):892-904.

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