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Items: 1 to 50 of 146


Association of Nicotine with Osteochondrogenesis and Osteoarthritis Development: The State of the Art of Preclinical Research.

Cai X, Gao L, Cucchiarini M, Madry H.

J Clin Med. 2019 Oct 16;8(10). pii: E1699. doi: 10.3390/jcm8101699. Review.


Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment.

Daniels O, Frisch J, Venkatesan JK, Rey-Rico A, Schmitt G, Cucchiarini M.

J Clin Med. 2019 Oct 7;8(10). pii: E1637. doi: 10.3390/jcm8101637.


Topographic modeling of early human osteoarthritis in sheep.

Oláh T, Reinhard J, Gao L, Haberkamp S, Goebel LKH, Cucchiarini M, Madry H.

Sci Transl Med. 2019 Sep 4;11(508). pii: eaax6775. doi: 10.1126/scitranslmed.aax6775.


Remodeling of Human Osteochondral Defects via rAAV-Mediated Co-Overexpression of TGF-β and IGF-I from Implanted Human Bone Marrow-Derived Mesenchymal Stromal Cells.

Morscheid S, Venkatesan JK, Rey-Rico A, Schmitt G, Cucchiarini M.

J Clin Med. 2019 Aug 28;8(9). pii: E1326. doi: 10.3390/jcm8091326.


Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine.

Venkatesan JK, Rey-Rico A, Cucchiarini M.

Tissue Eng Regen Med. 2019 Feb 21;16(4):345-355. doi: 10.1007/s13770-019-00179-x. eCollection 2019 Aug. Review.


Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells.

Morscheid S, Rey-Rico A, Schmitt G, Madry H, Cucchiarini M, Venkatesan JK.

Int J Mol Sci. 2019 May 27;20(10). pii: E2591. doi: 10.3390/ijms20102591.


Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery.

Rey-Rico A, Cucchiarini M.

Polymers (Basel). 2019 Mar 19;11(3). pii: E514. doi: 10.3390/polym11030514. Review.


An overview of thermal necrosis: present and future.

Mediouni M, Kucklick T, Poncet S, Madiouni R, Abouaomar A, Madry H, Cucchiarini M, Chopko B, Vaughan N, Arora M, Gökkuş K, Lozoya Lara M, Paiva Cedeño L, Volosnikov A, Hesmati M, Ho K.

Curr Med Res Opin. 2019 May 10:1-8. doi: 10.1080/03007995.2019.1603671. [Epub ahead of print]


[Future Aspects of Clinical Osteoarthritis Therapies in the Continuum of Translational Research].

Schrenker S, Gao L, Cucchiarini M, Madry H.

Z Orthop Unfall. 2019 Feb 6. doi: 10.1055/a-0806-8225. [Epub ahead of print] German.


Biomaterials and Gene Therapy: A Smart Combination for MSC Musculoskeletal Engineering.

Mesure B, Menu P, Venkatesan JK, Cucchiarini M, Velot É.

Curr Stem Cell Res Ther. 2019;14(4):337-343. doi: 10.2174/1574888X14666181205121658.


Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair.

Cucchiarini M, Madry H.

Nat Rev Rheumatol. 2019 Jan;15(1):18-29. doi: 10.1038/s41584-018-0125-2. Review.


Injectable Systems for Intra-Articular Delivery of Mesenchymal Stromal Cells for Cartilage Treatment: A Systematic Review of Preclinical and Clinical Evidence.

Roffi A, Nakamura N, Sanchez M, Cucchiarini M, Filardo G.

Int J Mol Sci. 2018 Oct 25;19(11). pii: E3322. doi: 10.3390/ijms19113322.


Cells, soluble factors and matrix harmonically play the concert of allograft integration.

de Girolamo L, Ragni E, Cucchiarini M, van Bergen CJA, Hunziker EB, Chubinskaya S.

Knee Surg Sports Traumatol Arthrosc. 2019 Jun;27(6):1717-1725. doi: 10.1007/s00167-018-5182-1. Epub 2018 Oct 5. Review.


Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part II: treatment options.

Abat F, Alfredson H, Cucchiarini M, Madry H, Marmotti A, Mouton C, Oliveira JM, Pereira H, Peretti GM, Spang C, Stephen J, van Bergen CJA, de Girolamo L.

J Exp Orthop. 2018 Sep 24;5(1):38. doi: 10.1186/s40634-018-0145-5. Review.


Asymptomatic focal calcium pyrophosphate crystal deposition within partially failed repair tissue after matrix-assisted autologous chondrocyte implantation.

Gao L, Oláh T, Cucchiarini M, Madry H.

Knee Surg Sports Traumatol Arthrosc. 2019 Jun;27(6):1939-1942. doi: 10.1007/s00167-018-5136-7. Epub 2018 Sep 10.


Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment.

Venkatesan JK, Gardner O, Rey-Rico A, Eglin D, Alini M, Stoddart MJ, Cucchiarini M, Madry H.

Int J Mol Sci. 2018 Sep 5;19(9). pii: E2635. doi: 10.3390/ijms19092635.


Effects of TGF-β Overexpression via rAAV Gene Transfer on the Early Repair Processes in an Osteochondral Defect Model in Minipigs.

Cucchiarini M, Asen AK, Goebel L, Venkatesan JK, Schmitt G, Zurakowski D, Menger MD, Laschke MW, Madry H.

Am J Sports Med. 2018 Jul;46(8):1987-1996. doi: 10.1177/0363546518773709. Epub 2018 May 24.


Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room.

Cengiz IF, Pereira H, de Girolamo L, Cucchiarini M, Espregueira-Mendes J, Reis RL, Oliveira JM.

J Exp Orthop. 2018 May 22;5(1):14. doi: 10.1186/s40634-018-0133-9. Review.


Effective Remodelling of Human Osteoarthritic Cartilage by sox9 Gene Transfer and Overexpression upon Delivery of rAAV Vectors in Polymeric Micelles.

Rey-Rico A, Venkatesan JK, Schmitt G, Speicher-Mentges S, Madry H, Cucchiarini M.

Mol Pharm. 2018 Jul 2;15(7):2816-2826. doi: 10.1021/acs.molpharmaceut.8b00331. Epub 2018 May 24.


Subchondral drilling for articular cartilage repair: a systematic review of translational research.

Gao L, Goebel LKH, Orth P, Cucchiarini M, Madry H.

Dis Model Mech. 2018 Jun 19;11(6). pii: dmm034280. doi: 10.1242/dmm.034280. Review.


Controlled release of gene therapy constructs from solid scaffolds for therapeutic applications in orthopedics.

Venkatesan JK, Falentin-Daudré C, Leroux A, Migonney V, Cucchiarini M.

Discov Med. 2018 Apr;25(138):195-203. Review.


Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(ɛ-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus-Mediated SOX9 Gene Transfer.

Venkatesan JK, Moutos FT, Rey-Rico A, Estes BT, Frisch J, Schmitt G, Madry H, Guilak F, Cucchiarini M.

Hum Gene Ther. 2018 Nov;29(11):1277-1286. doi: 10.1089/hum.2017.165. Epub 2018 Jun 11.


Sustained spatiotemporal release of TGF-β1 confers enhanced very early chondrogenic differentiation during osteochondral repair in specific topographic patterns.

Asen AK, Goebel L, Rey-Rico A, Sohier J, Zurakowski D, Cucchiarini M, Madry H.

FASEB J. 2018 Oct;32(10):5298-5311. doi: 10.1096/fj.201800105R. Epub 2018 Apr 24.


PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine-An Overview.

Rey-Rico A, Cucchiarini M.

Int J Mol Sci. 2018 Mar 8;19(3). pii: E775. doi: 10.3390/ijms19030775. Review.


Autologous Matrix-Induced Chondrogenesis: A Systematic Review of the Clinical Evidence.

Gao L, Orth P, Cucchiarini M, Madry H.

Am J Sports Med. 2019 Jan;47(1):222-231. doi: 10.1177/0363546517740575. Epub 2017 Nov 21.


rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model.

Rey-Rico A, Venkatesan JK, Schmitt G, Concheiro A, Madry H, Alvarez-Lorenzo C, Cucchiarini M.

Int J Nanomedicine. 2017 Sep 19;12:6985-6996. doi: 10.2147/IJN.S144579. eCollection 2017.


A review of translational medicine. The future paradigm: how can we connect the orthopedic dots better?

Mediouni M, R Schlatterer D, Madry H, Cucchiarini M, Rai B.

Curr Med Res Opin. 2018 Jul;34(7):1217-1229. doi: 10.1080/03007995.2017.1385450. Epub 2017 Nov 1. Review.


Effects of solid acellular type-I/III collagen biomaterials on in vitro and in vivo chondrogenesis of mesenchymal stem cells.

Gao L, Orth P, Cucchiarini M, Madry H.

Expert Rev Med Devices. 2017 Sep;14(9):717-732. doi: 10.1080/17434440.2017.1368386.


Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors.

Venkatesan JK, Frisch J, Rey-Rico A, Schmitt G, Madry H, Cucchiarini M.

J Exp Orthop. 2017 Dec;4(1):22. doi: 10.1186/s40634-017-0097-1. Epub 2017 Jun 21.


Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects.

Madry H, Gao L, Eichler H, Orth P, Cucchiarini M.

Stem Cells Int. 2017;2017:1609685. doi: 10.1155/2017/1609685. Epub 2017 May 14. Review.


Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach.

Abat F, Alfredson H, Cucchiarini M, Madry H, Marmotti A, Mouton C, Oliveira JM, Pereira H, Peretti GM, Romero-Rodriguez D, Spang C, Stephen J, van Bergen CJA, de Girolamo L.

J Exp Orthop. 2017 Dec;4(1):18. doi: 10.1186/s40634-017-0092-6. Epub 2017 May 30. Review.


Supramolecular polypseudorotaxane gels for controlled delivery of rAAV vectors in human mesenchymal stem cells for regenerative medicine.

Rey-Rico A, Babicz H, Madry H, Concheiro A, Alvarez-Lorenzo C, Cucchiarini M.

Int J Pharm. 2017 Oct 15;531(2):492-503. doi: 10.1016/j.ijpharm.2017.05.050. Epub 2017 May 25.


Genome editing for human osteoarthritis - a perspective.

Almarza D, Cucchiarini M, Loughlin J.

Osteoarthritis Cartilage. 2017 Aug;25(8):1195-1198. doi: 10.1016/j.joca.2017.05.003. Epub 2017 May 18. No abstract available.


Smart and Controllable rAAV Gene Delivery Carriers in Progenitor Cells for Human Musculoskeletal Regenerative Medicine with a Focus on the Articular Cartilage.

Rey-Rico A, Cucchiarini M.

Curr Gene Ther. 2017;17(2):127-138. doi: 10.2174/1566523217666170510162459. Review.


Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes.

Frisch J, Orth P, Rey-Rico A, Venkatesan JK, Schmitt G, Madry H, Kohn D, Cucchiarini M.

J Cell Mol Med. 2017 Nov;21(11):2748-2758. doi: 10.1111/jcmm.13190. Epub 2017 May 3.


New cell engineering approaches for cartilage regenerative medicine.

Cucchiarini M.

Biomed Mater Eng. 2017;28(s1):S201-S207. doi: 10.3233/BME-171642. Review.


Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair.

Gao L, Orth P, Müller-Brandt K, Goebel LK, Cucchiarini M, Madry H.

Sci Rep. 2017 Mar 27;7:45189. doi: 10.1038/srep45189.


Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates.

Tao K, Rey-Rico A, Frisch J, Venkatesan JK, Schmitt G, Madry H, Lin J, Cucchiarini M.

J Exp Orthop. 2017 Dec;4(1):4. doi: 10.1186/s40634-017-0077-5. Epub 2017 Feb 7.


Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno-Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor-β Gene Delivery.

Frisch J, Orth P, Venkatesan JK, Rey-Rico A, Schmitt G, Kohn D, Madry H, Cucchiarini M.

Stem Cells Transl Med. 2017 Jan;6(1):249-260. doi: 10.5966/sctm.2016-0149. Epub 2016 Aug 29.


Hydrogels for precision meniscus tissue engineering: a comprehensive review.

Rey-Rico A, Cucchiarini M, Madry H.

Connect Tissue Res. 2017 May - Jul;58(3-4):317-328. doi: 10.1080/03008207.2016.1276576. Epub 2017 Jan 4. Review.


Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems - a study in adult sheep.

Goebel L, Orth P, Cucchiarini M, Pape D, Madry H.

Osteoarthritis Cartilage. 2017 Apr;25(4):581-588. doi: 10.1016/j.joca.2016.10.014. Epub 2016 Oct 24.


Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair.

Rey-Rico A, Madry H, Cucchiarini M.

Biomed Res Int. 2016;2016:1215263. doi: 10.1155/2016/1215263. Epub 2016 Aug 23.


Basic science of osteoarthritis.

Cucchiarini M, de Girolamo L, Filardo G, Oliveira JM, Orth P, Pape D, Reboul P.

J Exp Orthop. 2016 Dec;3(1):22. doi: 10.1186/s40634-016-0060-6. Epub 2016 Sep 13.


A novel algorithm for a precise analysis of subchondral bone alterations.

Gao L, Orth P, Goebel LK, Cucchiarini M, Madry H.

Sci Rep. 2016 Sep 6;6:32982. doi: 10.1038/srep32982.


Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates.

Frisch J, Venkatesan JK, Rey-Rico A, Zawada AM, Schmitt G, Madry H, Cucchiarini M.

J Exp Orthop. 2016 Dec;3(1):16. doi: 10.1186/s40634-016-0052-6. Epub 2016 Jul 29.


PEO-PPO-PEO Carriers for rAAV-Mediated Transduction of Human Articular Chondrocytes in Vitro and in a Human Osteochondral Defect Model.

Rey-Rico A, Frisch J, Venkatesan JK, Schmitt G, Rial-Hermida I, Taboada P, Concheiro A, Madry H, Alvarez-Lorenzo C, Cucchiarini M.

ACS Appl Mater Interfaces. 2016 Aug 17;8(32):20600-13. doi: 10.1021/acsami.6b06509. Epub 2016 Aug 3.


Gene- and Stem Cell-Based Approaches to Regulate Hypertrophic Differentiation in Articular Cartilage Disorders.

Frisch J, Cucchiarini M.

Stem Cells Dev. 2016 Oct;25(20):1495-1512. Epub 2016 Jul 15.


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