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Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure.

Cubbon RM, Lowry JE, Drozd M, Hall M, Gierula J, Paton MF, Byrom R, Kearney LC, Barth JH, Kearney MT, Witte KK.

Eur J Nutr. 2018 Aug 18. doi: 10.1007/s00394-018-1806-y. [Epub ahead of print]


Effects of Ivabradine on Hemodynamic and Functional Parameters in Left Ventricular Systolic Dysfunction: a Systematic Review and Meta-analysis.

Patel PA, Ali N, Roy A, Pinder S, Cubbon RM, Kearney MT, Witte KK.

J Gen Intern Med. 2018 Sep;33(9):1561-1570. doi: 10.1007/s11606-018-4578-4. Epub 2018 Jul 18.


Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice.

Sengupta A, Patel PA, Yuldasheva NY, Mughal RS, Galloway S, Viswambharan H, Walker AMN, Aziz A, Smith J, Ali N, Mercer BN, Imrie H, Sukumar P, Wheatcroft SB, Kearney MT, Cubbon RM.

Endocrinology. 2018 Aug 1;159(8):2917-2925. doi: 10.1210/en.2018-00215.


Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin.

Pedicini L, Miteva KT, Hawley V, Gaunt HJ, Appleby HL, Cubbon RM, Marszalek K, Kearney MT, Beech DJ, McKeown L.

Sci Rep. 2018 May 15;8(1):7569. doi: 10.1038/s41598-018-25853-3.


Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure.

Witte KK, Patel PA, Walker AMN, Schechter CB, Drozd M, Sengupta A, Byrom R, Kearney LC, Sapsford RJ, Kearney MT, Cubbon RM.

Heart. 2018 Jun;104(12):993-998. doi: 10.1136/heartjnl-2017-312539. Epub 2018 Jan 31.


Rate-Response Programming Tailored to the Force-Frequency Relationship Improves Exercise Tolerance in Chronic Heart Failure.

Gierula J, Paton MF, Lowry JE, Jamil HA, Byrom R, Drozd M, Garnham JO, Cubbon RM, Cairns DA, Kearney MT, Witte KK.

JACC Heart Fail. 2018 Feb;6(2):105-113. doi: 10.1016/j.jchf.2017.09.018. Epub 2017 Dec 6.


Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance.

Aziz A, Haywood NJ, Cordell PA, Smith J, Yuldasheva NY, Sengupta A, Ali N, Mercer BN, Mughal RS, Riches K, Cubbon RM, Porter KE, Kearney MT, Wheatcroft SB.

Endocrinology. 2018 Feb 1;159(2):696-709. doi: 10.1210/en.2017-00572.


Cardiac resynchronization therapy outcomes in patients with chronic heart failure: cardiac resynchronization therapy with pacemaker versus cardiac resynchronization therapy with defibrillator.

Drozd M, Gierula J, Lowry JE, Paton MF, Joy E, Jamil HA, Cubbon RM, Kearney MT, Cairns DA, Witte KK.

J Cardiovasc Med (Hagerstown). 2017 Dec;18(12):962-967. doi: 10.2459/JCM.0000000000000584.


Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes.

Witte KK, Drozd M, Walker AMN, Patel PA, Kearney JC, Chapman S, Sapsford RJ, Gierula J, Paton MF, Lowry J, Kearney MT, Cubbon RM.

Diabetes Care. 2018 Jan;41(1):136-142. doi: 10.2337/dc17-1406. Epub 2017 Oct 5.


Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ.

Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3.


Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Watt NT, Gage MC, Patel PA, Viswambharan H, Sukumar P, Galloway S, Yuldasheva NY, Imrie H, Walker AMN, Griffin KJ, Makava N, Skromna A, Bridge K, Beech DJ, Schurmans S, Wheatcroft SB, Kearney MT, Cubbon RM.

Diabetes. 2017 Nov;66(11):2808-2821. doi: 10.2337/db17-0062. Epub 2017 Aug 22.


Association analyses based on false discovery rate implicate new loci for coronary artery disease.

Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I, Lai FY, Hopewell JC, Giannakopoulou O, Jiang T, Hamby SE, Di Angelantonio E, Assimes TL, Bottinger EP, Chambers JC, Clarke R, Palmer CNA, Cubbon RM, Ellinor P, Ermel R, Evangelou E, Franks PW, Grace C, Gu D, Hingorani AD, Howson JMM, Ingelsson E, Kastrati A, Kessler T, Kyriakou T, Lehtimäki T, Lu X, Lu Y, März W, McPherson R, Metspalu A, Pujades-Rodriguez M, Ruusalepp A, Schadt EE, Schmidt AF, Sweeting MJ, Zalloua PA, AlGhalayini K, Keavney BD, Kooner JS, Loos RJF, Patel RS, Rutter MK, Tomaszewski M, Tzoulaki I, Zeggini E, Erdmann J, Dedoussis G, Björkegren JLM; EPIC-CVD Consortium; CARDIoGRAMplusC4D; UK Biobank CardioMetabolic Consortium CHD working group, Schunkert H, Farrall M, Danesh J, Samani NJ, Watkins H, Deloukas P.

Nat Genet. 2017 Sep;49(9):1385-1391. doi: 10.1038/ng.3913. Epub 2017 Jul 17.


Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain.

Haywood NJ, Cordell PA, Tang KY, Makova N, Yuldasheva NY, Imrie H, Viswambharan H, Bruns AF, Cubbon RM, Kearney MT, Wheatcroft SB.

Diabetes. 2017 Feb;66(2):287-299. doi: 10.2337/db16-0997. Epub 2016 Nov 10.


Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.

Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood N, Walker AM, Skromna A, Makova N, Galloway S, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft SB, Cubbon RM, Kearney MT.

Circ Res. 2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.309678. Epub 2016 Dec 5.


Reply: The Paradox of Heart Failure and Atrial Fibrillation.

Gierula J, Paton MF, Byrom R, Cubbon RM, Kearney MT, Witte KK.

J Am Coll Cardiol. 2016 Sep 13;68(11):1253. doi: 10.1016/j.jacc.2016.06.038. No abstract available.


Pericytes in diabetes-associated vascular disease.

Warmke N, Griffin KJ, Cubbon RM.

J Diabetes Complications. 2016 Nov - Dec;30(8):1643-1650. doi: 10.1016/j.jdiacomp.2016.08.005. Epub 2016 Aug 12. Review.


Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction.

Walker AM, Patel PA, Rajwani A, Groves D, Denby C, Kearney L, Sapsford RJ, Witte KK, Kearney MT, Cubbon RM.

Diab Vasc Dis Res. 2016 Sep;13(5):331-40. doi: 10.1177/1479164116653342. Epub 2016 Jun 22.


Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure.

Jamil HA, Gierula J, Paton MF, Byrom R, Lowry JE, Cubbon RM, Cairns DA, Kearney MT, Witte KK.

J Am Coll Cardiol. 2016 Apr 26;67(16):1885-96. doi: 10.1016/j.jacc.2016.02.042.


Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study.

Witte KK, Byrom R, Gierula J, Paton MF, Jamil HA, Lowry JE, Gillott RG, Barnes SA, Chumun H, Kearney LC, Greenwood JP, Plein S, Law GR, Pavitt S, Barth JH, Cubbon RM, Kearney MT.

J Am Coll Cardiol. 2016 Jun 7;67(22):2593-603. doi: 10.1016/j.jacc.2016.03.508. Epub 2016 Apr 4.


Cardio-oncology: Concepts and practice.

Cubbon RM, Lyon AR.

Indian Heart J. 2016 Apr;68 Suppl 1:S77-85. doi: 10.1016/j.ihj.2016.01.022. Epub 2016 Feb 11. Review.


Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification.

Cubbon RM, Witte KK, Kearney LC, Gierula J, Byrom R, Paton M, Sengupta A, Patel PA, Mn Walker A, Cairns DA, Rajwani A, Hall AS, Sapsford RJ, Kearney MT.

Heart. 2016 May 15;102(10):735-40. doi: 10.1136/heartjnl-2015-308939. Epub 2016 Feb 8.


Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance.

Cubbon RM, Kearney MT, Wheatcroft SB.

Trends Endocrinol Metab. 2016 Feb;27(2):96-104. doi: 10.1016/j.tem.2015.11.009. Epub 2015 Dec 20. Review.


Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure.

Cubbon RM, Ruff N, Groves D, Eleuteri A, Denby C, Kearney L, Ali N, Walker AM, Jamil H, Gierula J, Gale CP, Batin PD, Nolan J, Shah AM, Fox KA, Sapsford RJ, Witte KK, Kearney MT.

Heart. 2016 Feb;102(3):223-9. doi: 10.1136/heartjnl-2015-308428. Epub 2015 Dec 16.


An evaluation of 20 year survival in patients with diabetes mellitus and acute myocardial infarction.

Patel PA, Cubbon RM, Sapsford RJ, Gillott RG, Grant PJ, Witte KK, Kearney MT, Hall AS.

Int J Cardiol. 2016 Jan 15;203:141-4. doi: 10.1016/j.ijcard.2015.10.094. Epub 2015 Oct 22.


Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

Lin S, Malkani S, Lombardo M, Yang L, Mills SG, Chapman K, Thompson JE, Zhang WX, Wang R, Cubbon RM, O'Neill EA, Hale JJ.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5402-8. doi: 10.1016/j.bmcl.2015.09.016. Epub 2015 Sep 8.


Sudden cardiac death in patients with diabetes mellitus and chronic heart failure.

Walker AM, Cubbon RM.

Diab Vasc Dis Res. 2015 Jul;12(4):228-33. doi: 10.1177/1479164115573225. Epub 2015 Apr 10. Review.


Piezo1 integration of vascular architecture with physiological force.

Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ.

Nature. 2014 Nov 13;515(7526):279-282. doi: 10.1038/nature13701. Epub 2014 Aug 10.


Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype.

Yuldasheva NY, Rashid ST, Haywood NJ, Cordell P, Mughal R, Viswambharan H, Imrie H, Sukumar P, Cubbon RM, Aziz A, Gage M, Mbonye KA, Smith J, Galloway S, Skromna A, Scott DJ, Kearney MT, Wheatcroft SB.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2051-8. doi: 10.1161/ATVBAHA.114.304121. Epub 2014 Jul 10.


Patients with long-term permanent pacemakers have a high prevalence of left ventricular dysfunction.

Gierula J, Cubbon RM, Jamil HA, Byrom RJ, Waldron ZL, Pavitt S, Kearney MT, Witte KK.

J Cardiovasc Med (Hagerstown). 2015 Nov;16(11):743-50. doi: 10.2459/JCM.0000000000000117.


Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.

Cubbon RM, Yuldasheva NY, Viswambharan H, Mercer BN, Baliga V, Stephen SL, Askham J, Sukumar P, Skromna A, Mughal RS, Walker AM, Bruns A, Bailey MA, Galloway S, Imrie H, Gage MC, Rakobowchuk M, Li J, Porter KE, Ponnambalam S, Wheatcroft SB, Beech DJ, Kearney MT.

Stem Cells. 2014 Oct;32(10):2714-23. doi: 10.1002/stem.1766.


Prospective development and validation of a model to predict heart failure hospitalisation.

Cubbon RM, Woolston A, Adams B, Gale CP, Gilthorpe MS, Baxter PD, Kearney LC, Mercer B, Rajwani A, Batin PD, Kahn M, Sapsford RJ, Witte KK, Kearney MT.

Heart. 2014 Jun;100(12):923-9. doi: 10.1136/heartjnl-2013-305294. Epub 2014 Mar 19.


Calcium, phosphate and calcium phosphate product are markers of outcome in patients with chronic heart failure.

Cubbon RM, Thomas CH, Drozd M, Gierula J, Jamil HA, Byrom R, Barth JH, Kearney MT, Witte KK.

J Nephrol. 2015 Apr;28(2):209-15. doi: 10.1007/s40620-014-0075-y. Epub 2014 Mar 11.


Pacing-associated left ventricular dysfunction? Think reprogramming first!

Gierula J, Jamil HA, Byrom R, Joy ER, Cubbon RM, Kearney MT, Witte KK.

Heart. 2014 May;100(10):765-9. doi: 10.1136/heartjnl-2013-304905. Epub 2014 Jan 15.


Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.

Gage MC, Yuldasheva NY, Viswambharan H, Sukumar P, Cubbon RM, Galloway S, Imrie H, Skromna A, Smith J, Jackson CL, Kearney MT, Wheatcroft SB.

Atherosclerosis. 2013 Sep;230(1):131-9. doi: 10.1016/j.atherosclerosis.2013.06.017. Epub 2013 Jun 29.


Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction.

Gierula J, Cubbon RM, Jamil HA, Byrom R, Baxter PD, Pavitt S, Gilthorpe MS, Hewison J, Kearney MT, Witte KK.

Europace. 2013 Nov;15(11):1609-14. doi: 10.1093/europace/eut148. Epub 2013 Jun 4.


Importance of insulin resistance to vascular repair and regeneration.

Cubbon RM, Mercer BN, Sengupta A, Kearney MT.

Free Radic Biol Med. 2013 Jul;60:246-63. doi: 10.1016/j.freeradbiomed.2013.02.028. Epub 2013 Mar 4. Review.


Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.

Sukumar P, Viswambharan H, Imrie H, Cubbon RM, Yuldasheva N, Gage M, Galloway S, Skromna A, Kandavelu P, Santos CX, Gatenby VK, Smith J, Beech DJ, Wheatcroft SB, Channon KM, Shah AM, Kearney MT.

Diabetes. 2013 Jun;62(6):2130-4. doi: 10.2337/db12-1294. Epub 2013 Jan 24.


Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology.

Cubbon RM, Adams B, Rajwani A, Mercer BN, Patel PA, Gherardi G, Gale CP, Batin PD, Ajjan R, Kearney L, Wheatcroft SB, Sapsford RJ, Witte KK, Kearney MT.

Diab Vasc Dis Res. 2013 Jul;10(4):330-6. doi: 10.1177/1479164112471064. Epub 2013 Jan 24.


Cell-specific insulin resistance: implications for atherosclerosis.

Rajwani A, Cubbon RM, Wheatcroft SB.

Diabetes Metab Res Rev. 2012 Nov;28(8):627-34. doi: 10.1002/dmrr.2336. Review.


Moderate and heavy metabolic stress interval training improve arterial stiffness and heart rate dynamics in humans.

Rakobowchuk M, Harris E, Taylor A, Cubbon RM, Birch KM.

Eur J Appl Physiol. 2013 Apr;113(4):839-49. doi: 10.1007/s00421-012-2486-6. Epub 2012 Sep 16.


Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

Imrie H, Viswambharan H, Sukumar P, Abbas A, Cubbon RM, Yuldasheva N, Gage M, Smith J, Galloway S, Skromna A, Rashid ST, Futers TS, Xuan S, Gatenby VK, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB, Kearney MT.

Diabetes. 2012 Sep;61(9):2359-68. doi: 10.2337/db11-1494. Epub 2012 Jun 25.


Diabetes mellitus and the heart.

Mercer BN, Morais S, Cubbon RM, Kearney MT.

Int J Clin Pract. 2012 Jul;66(7):640-7. doi: 10.1111/j.1742-1241.2012.02924.x. Review.


Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis.

Rajwani A, Ezzat V, Smith J, Yuldasheva NY, Duncan ER, Gage M, Cubbon RM, Kahn MB, Imrie H, Abbas A, Viswambharan H, Aziz A, Sukumar P, Vidal-Puig A, Sethi JK, Xuan S, Shah AM, Grant PJ, Porter KE, Kearney MT, Wheatcroft SB.

Diabetes. 2012 Apr;61(4):915-24. doi: 10.2337/db11-0963. Epub 2012 Feb 22.


Insulin- and growth factor-resistance impairs vascular regeneration in diabetes mellitus.

Cubbon RM, Ali N, Sengupta A, Kearney MT.

Curr Vasc Pharmacol. 2012 May;10(3):271-84. Review.


Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans.

Rakobowchuk M, Harris E, Taylor A, Baliga V, Cubbon RM, Rossiter HB, Birch KM.

Exp Physiol. 2012 Mar;97(3):375-85. doi: 10.1113/expphysiol.2011.062836. Epub 2011 Dec 16. Erratum in: Exp Physiol. 2013 Jan;98(1):349.


Association of diabetes with increased all-cause mortality following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction in the contemporary era.

Kahn MB, Cubbon RM, Mercer B, Wheatcroft AC, Gherardi G, Aziz A, Baliga V, Blaxill JM, McLenachan JM, Blackman DJ, Greenwood JP, Wheatcroft SB.

Diab Vasc Dis Res. 2012 Jan;9(1):3-9. doi: 10.1177/1479164111427752. Epub 2011 Nov 8.


The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.

Abbas A, Imrie H, Viswambharan H, Sukumar P, Rajwani A, Cubbon RM, Gage M, Smith J, Galloway S, Yuldeshava N, Kahn M, Xuan S, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB, Kearney MT.

Diabetes. 2011 Aug;60(8):2169-78. doi: 10.2337/db11-0197. Epub 2011 Jun 15.


Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras.

Cubbon RM, Gale CP, Kearney LC, Schechter CB, Brooksby WP, Nolan J, Fox KA, Rajwani A, Baig W, Groves D, Barlow P, Fisher AC, Batin PD, Kahn MB, Zaman AG, Shah AM, Byrne JA, Lindsay SJ, Sapsford RJ, Wheatcroft SB, Witte KK, Kearney MT.

Circ Heart Fail. 2011 Jul;4(4):396-403. doi: 10.1161/CIRCHEARTFAILURE.110.959882. Epub 2011 May 11.


Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.

Li J, Cubbon RM, Wilson LA, Amer MS, McKeown L, Hou B, Majeed Y, Tumova S, Seymour VA, Taylor H, Stacey M, O'Regan D, Foster R, Porter KE, Kearney MT, Beech DJ.

Circ Res. 2011 May 13;108(10):1190-8. doi: 10.1161/CIRCRESAHA.111.243352. Epub 2011 Mar 24.


Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration.

Kahn MB, Yuldasheva NY, Cubbon RM, Smith J, Rashid ST, Viswambharan H, Imrie H, Abbas A, Rajwani A, Aziz A, Baliga V, Sukumar P, Gage M, Kearney MT, Wheatcroft SB.

Diabetes. 2011 Apr;60(4):1295-303. doi: 10.2337/db10-1080. Epub 2011 Feb 11.

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