Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 99

1.

Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23.

Yan J, Allen S, Vijayan D, Li XY, Harjunpää H, Takeda K, Liu J, Cua DJ, Smyth MJ, Teng MWL.

Cancer Immunol Res. 2018 Jun 19. doi: 10.1158/2326-6066.CIR-18-0011. [Epub ahead of print]

PMID:
29921599
2.

Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy.

Mahne AE, Mauze S, Joyce-Shaikh B, Xia J, Bowman EP, Beebe AM, Cua DJ, Jain R.

Cancer Res. 2017 Mar 1;77(5):1108-1118. doi: 10.1158/0008-5472.CAN-16-0797. Epub 2016 Oct 20.

3.

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.

Guo Y, MacIsaac KD, Chen Y, Miller RJ, Jain R, Joyce-Shaikh B, Ferguson H, Wang IM, Cristescu R, Mudgett J, Engstrom L, Piers KJ, Baltus GA, Barr K, Zhang H, Mehmet H, Hegde LG, Hu X, Carter LL, Aicher TD, Glick G, Zaller D, Hawwari A, Correll CC, Jones DC, Cua DJ.

Cell Rep. 2016 Dec 20;17(12):3206-3218. doi: 10.1016/j.celrep.2016.11.073.

4.

IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema.

Fujii U, Miyahara N, Taniguchi A, Waseda K, Morichika D, Kurimoto E, Koga H, Kataoka M, Gelfand EW, Cua DJ, Yoshimura A, Tanimoto M, Kanehiro A.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):697-707.

PMID:
27351934
5.

A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease.

Zhou V, Agle K, Chen X, Beres A, Komorowski R, Belle L, Taylor C, Zhu F, Haribhai D, Williams CB, Verbsky J, Blumenschein W, Sadekova S, Bowman E, Ballantyne C, Weaver C, Serody DA, Vincent B, Serody J, Cua DJ, Drobyski WR.

J Clin Invest. 2016 Sep 1;126(9):3541-55. doi: 10.1172/JCI80874. Epub 2016 Aug 8.

6.

IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.

Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.

Cancer Sci. 2016 Sep;107(9):1206-14. doi: 10.1111/cas.13005. Epub 2016 Sep 1.

7.

Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies.

Wortham BW, Eppert BL, Flury JL, Garcia SM, Donica WR, Osterburg A, Joyce-Shaikh B, Cua DJ, Borchers MT.

J Immunol. 2016 Apr 15;196(8):3227-31. doi: 10.4049/jimmunol.1500978. Epub 2016 Feb 29.

8.

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.

Jain R, Chen Y, Kanno Y, Joyce-Shaikh B, Vahedi G, Hirahara K, Blumenschein WM, Sukumar S, Haines CJ, Sadekova S, McClanahan TK, McGeachy MJ, O'Shea JJ, Cua DJ.

Immunity. 2016 Jan 19;44(1):131-142. doi: 10.1016/j.immuni.2015.11.009. Epub 2015 Dec 29.

9.

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.

Lee JS, Tato CM, Joyce-Shaikh B, Gulen MF, Cayatte C, Chen Y, Blumenschein WM, Judo M, Ayanoglu G, McClanahan TK, Li X, Cua DJ.

Immunity. 2015 Oct 20;43(4):727-38. doi: 10.1016/j.immuni.2015.09.003. Epub 2015 Sep 29. Erratum in: Immunity. 2015 Nov 17;43(5):1022. Gulan, Fatih [corrected to Gulen, Muhammet F].

10.

Melatonin Lulling Th17 Cells to Sleep.

Lee JS, Cua DJ.

Cell. 2015 Sep 10;162(6):1212-4. doi: 10.1016/j.cell.2015.08.054.

11.

IL-26 AMPs up the T(H)17 arsenal.

Lee JS, Cua DJ.

Nat Immunol. 2015 Sep;16(9):897-8. doi: 10.1038/ni.3256. No abstract available.

PMID:
26287587
12.

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.

Teng MW, Bowman EP, McElwee JJ, Smyth MJ, Casanova JL, Cooper AM, Cua DJ.

Nat Med. 2015 Jul;21(7):719-29. doi: 10.1038/nm.3895. Epub 2015 Jun 29. Review.

PMID:
26121196
13.

Spondyloarthropathy: interleukin 23 and disease modification.

Sherlock JP, Taylor PC, Buckley CD, Cua DJ.

Lancet. 2015 May 23;385(9982):2017-8. doi: 10.1016/S0140-6736(15)60970-9. No abstract available.

PMID:
26009213
14.

A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals.

Wei YL, Han A, Glanville J, Fang F, Zuniga LA, Lee JS, Cua DJ, Chien YH.

Front Immunol. 2015 Mar 23;6:118. doi: 10.3389/fimmu.2015.00118. eCollection 2015.

15.

IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology.

Aychek T, Mildner A, Yona S, Kim KW, Lampl N, Reich-Zeliger S, Boon L, Yogev N, Waisman A, Cua DJ, Jung S.

Nat Commun. 2015 Mar 12;6:6525. doi: 10.1038/ncomms7525.

16.

IL-23 p19 knockout mice exhibit minimal defects in responses to primary and secondary infection with Francisella tularensis LVS.

Kurtz SL, Chou AY, Kubelkova K, Cua DJ, Elkins KL.

PLoS One. 2014 Oct 8;9(10):e109898. doi: 10.1371/journal.pone.0109898. eCollection 2014.

17.

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing.

Gaffen SL, Jain R, Garg AV, Cua DJ.

Nat Rev Immunol. 2014 Sep;14(9):585-600. doi: 10.1038/nri3707. Review.

18.

IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.

Li H, Hsu HC, Wu Q, Yang P, Li J, Luo B, Oukka M, Steele CH 3rd, Cua DJ, Grizzle WE, Mountz JD.

Nat Commun. 2014 Jul 8;5:4259. doi: 10.1038/ncomms5259.

19.

The emerging landscape of RORγt biology.

Lee JS, Cua DJ.

Immunity. 2014 Apr 17;40(4):451-2. doi: 10.1016/j.immuni.2014.04.005.

20.

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.

Chan IH, Jain R, Tessmer MS, Gorman D, Mangadu R, Sathe M, Vives F, Moon C, Penaflor E, Turner S, Ayanoglu G, Chang C, Basham B, Mumm JB, Pierce RH, Yearley JH, McClanahan TK, Phillips JH, Cua DJ, Bowman EP, Kastelein RA, LaFace D.

Mucosal Immunol. 2014 Jul;7(4):842-56. doi: 10.1038/mi.2013.101. Epub 2013 Nov 27.

PMID:
24280935
21.

The critical role of interleukin-23 in spondyloarthropathy.

Sherlock JP, Buckley CD, Cua DJ.

Mol Immunol. 2014 Jan;57(1):38-43. doi: 10.1016/j.molimm.2013.06.010. Epub 2013 Aug 1. Review.

PMID:
23910729
22.

Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23.

Haines CJ, Chen Y, Blumenschein WM, Jain R, Chang C, Joyce-Shaikh B, Porth K, Boniface K, Mattson J, Basham B, Anderton SM, McClanahan TK, Sadekova S, Cua DJ, McGeachy MJ.

Cell Rep. 2013 May 30;3(5):1378-88. doi: 10.1016/j.celrep.2013.03.035. Epub 2013 Apr 25.

23.

Interleukin-23: a promising therapeutic target in seronegative spondyloarthropathy.

Sherlock JP, Cua DJ.

Curr Opin Pharmacol. 2013 Jun;13(3):445-8. doi: 10.1016/j.coph.2013.03.002. Epub 2013 Mar 26. Review.

PMID:
23540587
24.

Th17 cell development: from the cradle to the grave.

Zúñiga LA, Jain R, Haines C, Cua DJ.

Immunol Rev. 2013 Mar;252(1):78-88. doi: 10.1111/imr.12036. Review.

PMID:
23405896
25.

Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.

Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S.

J Immunol. 2012 Oct 1;189(7):3641-52. Epub 2012 Aug 31.

26.

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.

Sherlock JP, Joyce-Shaikh B, Turner SP, Chao CC, Sathe M, Grein J, Gorman DM, Bowman EP, McClanahan TK, Yearley JH, Eberl G, Buckley CD, Kastelein RA, Pierce RH, Laface DM, Cua DJ.

Nat Med. 2012 Jul 1;18(7):1069-76. doi: 10.1038/nm.2817.

PMID:
22772566
27.

IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils.

Savarin C, Stohlman SA, Hinton DR, Ransohoff RM, Cua DJ, Bergmann CC.

J Neuroinflammation. 2012 May 29;9:104. doi: 10.1186/1742-2094-9-104.

28.

The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production.

Tato CM, Joyce-Shaikh B, Banerjee A, Chen Y, Sathe M, Ewald SE, Liu MR, Gorman D, McClanahan TK, Phillips JH, Heyworth PG, Cua DJ.

PLoS One. 2012;7(3):e31680. doi: 10.1371/journal.pone.0031680. Epub 2012 Mar 27.

29.

Orphan cytokine reveals IL-17 family secret.

Haines CJ, Cua DJ.

Immunity. 2011 Oct 28;35(4):498-500. doi: 10.1016/j.immuni.2011.10.008.

30.

Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.

Cheung R, Shen F, Phillips JH, McGeachy MJ, Cua DJ, Heyworth PG, Pierce RH.

J Clin Invest. 2011 Nov;121(11):4446-61. doi: 10.1172/JCI57682. Epub 2011 Oct 17.

31.

Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.

Xu M, Morishima N, Mizoguchi I, Chiba Y, Fujita K, Kuroda M, Iwakura Y, Cua DJ, Yasutomo K, Mizuguchi J, Yoshimoto T.

Eur J Immunol. 2011 Oct;41(10):2828-39. doi: 10.1002/eji.201141291. Epub 2011 Aug 31.

32.

Autoimmunity's collateral damage: Gut microbiota strikes 'back'.

Cua DJ, Sherlock JP.

Nat Med. 2011 Sep 7;17(9):1055-6. doi: 10.1038/nm0911-1055. No abstract available.

PMID:
21900923
33.

Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.

Chen Y, Haines CJ, Gutcher I, Hochweller K, Blumenschein WM, McClanahan T, Hämmerling G, Li MO, Cua DJ, McGeachy MJ.

Immunity. 2011 Mar 25;34(3):409-21. doi: 10.1016/j.immuni.2011.02.011.

34.

Fate mapping of IL-17-producing T cells in inflammatory responses.

Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, Cua DJ, Ahlfors H, Wilhelm C, Tolaini M, Menzel U, Garefalaki A, Potocnik AJ, Stockinger B.

Nat Immunol. 2011 Mar;12(3):255-63. doi: 10.1038/ni.1993. Epub 2011 Jan 30.

35.

A role for IL-27p28 as an antagonist of gp130-mediated signaling.

Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA.

Nat Immunol. 2010 Dec;11(12):1119-26. doi: 10.1038/ni.1957. Epub 2010 Nov 7.

36.

IL-17 regulates adipogenesis, glucose homeostasis, and obesity.

Zúñiga LA, Shen WJ, Joyce-Shaikh B, Pyatnova EA, Richards AG, Thom C, Andrade SM, Cua DJ, Kraemer FB, Butcher EC.

J Immunol. 2010 Dec 1;185(11):6947-59. doi: 10.4049/jimmunol.1001269. Epub 2010 Oct 29. Erratum in: J Immunol. 2011 Jan 15;186(2):1291.

37.

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.

Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, Grainger JR, Chen Q, Kanno Y, Watford WT, Sun HW, Eberl G, Shevach EM, Belkaid Y, Cua DJ, Chen W, O'Shea JJ.

Nature. 2010 Oct 21;467(7318):967-71. doi: 10.1038/nature09447.

38.

Interleukin-23 drives intestinal inflammation through direct activity on T cells.

Ahern PP, Schiering C, Buonocore S, McGeachy MJ, Cua DJ, Maloy KJ, Powrie F.

Immunity. 2010 Aug 27;33(2):279-88. doi: 10.1016/j.immuni.2010.08.010. Erratum in: Immunity. 2011 Mar 25;34(3):448.

39.

Innate IL-17-producing cells: the sentinels of the immune system.

Cua DJ, Tato CM.

Nat Rev Immunol. 2010 Jul;10(7):479-89. doi: 10.1038/nri2800. Epub 2010 Jun 18. Review. Erratum in: Nat Rev Immunol. 2010 Aug;10(8):611. Nat Rev Immunol. 2010 Jul;10(7):following 489.

PMID:
20559326
40.

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.

Joyce-Shaikh B, Bigler ME, Chao CC, Murphy EE, Blumenschein WM, Adamopoulos IE, Heyworth PG, Antonenko S, Bowman EP, McClanahan TK, Phillips JH, Cua DJ.

J Exp Med. 2010 Mar 15;207(3):579-89. doi: 10.1084/jem.20090516. Epub 2010 Mar 8.

41.

The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.

Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X.

Immunity. 2010 Jan 29;32(1):54-66. doi: 10.1016/j.immuni.2009.12.003. Epub 2010 Jan 7.

42.

Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals.

Martin B, Hirota K, Cua DJ, Stockinger B, Veldhoen M.

Immunity. 2009 Aug 21;31(2):321-30. doi: 10.1016/j.immuni.2009.06.020. Epub 2009 Aug 13.

43.

Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.

Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A.

Nat Med. 2009 Aug;15(8):946-50. doi: 10.1038/nm.1999. Epub 2009 Aug 2.

PMID:
19648929
44.

Role of IL-23 in mobilization of immunoregulatory nitric oxide- or superoxide-producing Gr-1+ cells from bone marrow.

Dietlin TA, Cua DJ, Burke KA, Lund BT, van der Veen RC.

Free Radic Biol Med. 2009 Aug 15;47(4):357-63. doi: 10.1016/j.freeradbiomed.2009.04.029. Epub 2009 May 3.

PMID:
19409487
45.

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.

Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA.

J Immunol. 2009 May 1;182(9):5748-56. doi: 10.4049/jimmunol.0801162.

46.

Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control.

Kapil P, Atkinson R, Ramakrishna C, Cua DJ, Bergmann CC, Stohlman SA.

J Virol. 2009 Jun;83(12):5978-86. doi: 10.1128/JVI.00315-09. Epub 2009 Apr 1.

47.

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.

Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R.

J Exp Med. 2009 Mar 16;206(3):535-48. doi: 10.1084/jem.20082293. Epub 2009 Mar 9.

48.

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.

McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, McClanahan TK, O'Shea JJ, Cua DJ.

Nat Immunol. 2009 Mar;10(3):314-24. doi: 10.1038/ni.1698. Epub 2009 Feb 1.

49.

Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis.

Yoshimura T, Sonoda KH, Ohguro N, Ohsugi Y, Ishibashi T, Cua DJ, Kobayashi T, Yoshida H, Yoshimura A.

Rheumatology (Oxford). 2009 Apr;48(4):347-54. doi: 10.1093/rheumatology/ken489. Epub 2009 Jan 22.

50.

Reconciling id, ego, and superego within interleukin-23.

Tato CM, Cua DJ.

Immunol Rev. 2008 Dec;226:103-11. doi: 10.1111/j.1600-065X.2008.00715.x. Review.

PMID:
19161419

Supplemental Content

Support Center