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Items: 1 to 50 of 115

1.

Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.

Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC.

Purinergic Signal. 2019 Sep;15(3):375-385. doi: 10.1007/s11302-019-09664-3. Epub 2019 Jun 26.

PMID:
31243614
2.

Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway.

Bisht K, Canesin G, Cheytan T, Li M, Nemeth Z, Csizmadia E, Woodruff TM, Stec DE, Bulmer AC, Otterbein LE, Wegiel B.

J Immunol. 2019 May 15;202(10):2982-2990. doi: 10.4049/jimmunol.1701443. Epub 2019 Apr 5.

PMID:
30952817
3.

Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis.

Wiltberger G, Wu Y, Lange U, Hau HM, Tapper E, Krenzien F, Atanasov G, Benzing C, Feldbrügge L, Csizmadia E, Broschewitz J, Bartels M, Seehofer D, Jonas S, Berg T, Hessel P, Ascherl R, Neumann UP, Pratschke J, Robson SC, Schmelzle M.

Aliment Pharmacol Ther. 2019 Mar;49(6):779-788. doi: 10.1111/apt.15089.

PMID:
30811647
4.

Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury.

Hedblom A, Hejazi SM, Canesin G, Choudhury R, Hanafy KA, Csizmadia E, Persson JL, Wegiel B.

Cell Death Dis. 2019 Jan 25;10(2):72. doi: 10.1038/s41419-019-1342-6.

5.

HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn's disease.

Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS.

J Autoimmun. 2018 Nov;94:122-133. doi: 10.1016/j.jaut.2018.07.022. Epub 2018 Aug 8.

PMID:
30098863
6.

Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide.

Zheng Y, Ji X, Yu B, Ji K, Gallo D, Csizmadia E, Zhu M, Choudhury MR, De La Cruz LKC, Chittavong V, Pan Z, Yuan Z, Otterbein LE, Wang B.

Nat Chem. 2018 Jul;10(7):787-794. doi: 10.1038/s41557-018-0055-2. Epub 2018 May 14.

7.

Carbon monoxide protects the kidney through the central circadian clock and CD39.

Correa-Costa M, Gallo D, Csizmadia E, Gomperts E, Lieberum JL, Hauser CJ, Ji X, Wang B, Câmara NOS, Robson SC, Otterbein LE.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2302-E2310. doi: 10.1073/pnas.1716747115. Epub 2018 Feb 20.

8.

Serum Activity of Macrophage-Derived Adenosine Deaminase 2 Is Associated With Liver Fibrosis in Nonalcoholic Fatty Liver Disease.

Jiang ZG, Sandhu B, Feldbrügge L, Yee EU, Csizmadia E, Mitsuhashi S, Huang J, Afdhal NH, Robson SC, Lai M.

Clin Gastroenterol Hepatol. 2018 Jul;16(7):1170-1172. doi: 10.1016/j.cgh.2017.11.028. Epub 2017 Nov 21. No abstract available.

9.

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis.

Feldbrügge L, Jiang ZG, Csizmadia E, Mitsuhashi S, Tran S, Yee EU, Rothweiler S, Vaid KA, Sévigny J, Schmelzle M, Popov YV, Robson SC.

Purinergic Signal. 2018 Mar;14(1):37-46. doi: 10.1007/s11302-017-9590-3. Epub 2017 Nov 13.

10.

Corrigendum: Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.

Kang YJ, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, Yan CT.

Nat Commun. 2017 Aug 14;8:15795. doi: 10.1038/ncomms15795.

11.

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury.

Savio LEB, de Andrade Mello P, Figliuolo VR, de Avelar Almeida TF, Santana PT, Oliveira SDS, Silva CLM, Feldbrügge L, Csizmadia E, Minshall RD, Longhi MS, Wu Y, Robson SC, Coutinho-Silva R.

J Hepatol. 2017 Oct;67(4):716-726. doi: 10.1016/j.jhep.2017.05.021. Epub 2017 May 26.

12.

Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice.

De Giorgi M, Enjyoji K, Jiang G, Csizmadia E, Mitsuhashi S, Gumina RJ, Smolenski RT, Robson SC.

J Lipid Res. 2017 Jul;58(7):1292-1305. doi: 10.1194/jlr.M072132. Epub 2017 May 9.

13.

Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.

Feldbrügge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Müller CE, Sévigny J, Robson SC, Jiang ZG.

J Crohns Colitis. 2017 Sep 1;11(9):1113-1123. doi: 10.1093/ecco-jcc/jjx058.

14.

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.

Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC.

JCI Insight. 2017 May 4;2(9). pii: 92791. doi: 10.1172/jci.insight.92791. eCollection 2017 May 4.

15.

Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.

Seth P, Csizmadia E, Hedblom A, Vuerich M, Xie H, Li M, Longhi MS, Wegiel B.

Cancer Res. 2017 Jul 1;77(13):3632-3643. doi: 10.1158/0008-5472.CAN-16-2938. Epub 2017 Apr 26.

16.

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity.

Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, Timmons JJ, Morgan TM, Wang Y, Levantini E, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, Avigan DE, Ye H, Karp JM, Signoretti S, Balk SP, Cantley LC.

Cancer Discov. 2017 Jul;7(7):750-765. doi: 10.1158/2159-8290.CD-16-0778. Epub 2017 Mar 8.

17.

Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.

Kang YJ, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, Yan CT.

Nat Commun. 2017 Jan 17;8:14013. doi: 10.1038/ncomms14013. Erratum in: Nat Commun. 2017 Aug 14;8:15795.

18.

A20 Haploinsufficiency Aggravates Transplant Arteriosclerosis in Mouse Vascular Allografts: Implications for Clinical Transplantation.

Moll HP, Lee A, Peterson CR, Revuelta Cervantes J, Wojcik BM, Parulkar A, Mele A, LoGerfo PJ, Siracuse JJ, Csizmadia E, da Silva CG, Ferran C.

Transplantation. 2016 Nov;100(11):e106-e116.

19.

Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer.

Miao R, Wu Y, Zhang H, Zhou H, Sun X, Csizmadia E, He L, Zhao Y, Jiang C, Miksad RA, Ghaziani T, Robson SC, Zhao H.

Sci Rep. 2016 Sep 13;6:33121. doi: 10.1038/srep33121.

20.

Luminal Extracellular Vesicles (EVs) in Inflammatory Bowel Disease (IBD) Exhibit Proinflammatory Effects on Epithelial Cells and Macrophages.

Mitsuhashi S, Feldbrügge L, Csizmadia E, Mitsuhashi M, Robson SC, Moss AC.

Inflamm Bowel Dis. 2016 Jul;22(7):1587-95. doi: 10.1097/MIB.0000000000000840.

21.

CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease.

Liberal R, Grant CR, Ma Y, Csizmadia E, Jiang ZG, Heneghan MA, Yee EU, Mieli-Vergani G, Vergani D, Robson SC, Longhi MS.

J Autoimmun. 2016 Aug;72:102-12. doi: 10.1016/j.jaut.2016.05.005. Epub 2016 May 20.

22.

Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth.

Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa DB, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B.

Oncotarget. 2016 Apr 26;7(17):23919-32. doi: 10.18632/oncotarget.8081.

23.

Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes.

Thornley TB, Agarwal KA, Kyriazis P, Ma L, Chipashvili V, Aker JE, Korniotis S, Csizmadia E, Strom TB, Koulmanda M.

PLoS One. 2016 Mar 4;11(3):e0150792. doi: 10.1371/journal.pone.0150792. eCollection 2016.

24.

Decreased peroxisome proliferator-activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris.

Dozsa A, Mihaly J, Dezso B, Csizmadia E, Keresztessy T, Marko L, Rühl R, Remenyik E, Nagy L.

Clin Exp Dermatol. 2016 Jul;41(5):547-51. doi: 10.1111/ced.12794. Epub 2016 Jan 23.

PMID:
26800853
25.

N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome.

Volpi S, Santori E, Abernethy K, Mizui M, Dahlberg CI, Recher M, Capuder K, Csizmadia E, Ryan D, Mathew D, Tsokos GC, Snapper S, Westerberg LS, Thrasher AJ, Candotti F, Notarangelo LD.

Blood. 2016 Jan 14;127(2):216-20. doi: 10.1182/blood-2015-05-643817. Epub 2015 Oct 14.

26.

Heme oxygenase-1 in macrophages controls prostate cancer progression.

Nemeth Z, Li M, Csizmadia E, Döme B, Johansson M, Persson JL, Seth P, Otterbein L, Wegiel B.

Oncotarget. 2015 Oct 20;6(32):33675-88. doi: 10.18632/oncotarget.5284.

27.

Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration.

Studer P, da Silva CG, Revuelta Cervantes JM, Mele A, Csizmadia E, Siracuse JJ, Damrauer SM, Peterson CR, Candinas D, Stroka DM, Ma A, Bhasin M, Ferran C.

Cell Death Differ. 2015 Dec;22(12):2068-77. doi: 10.1038/cdd.2015.52. Epub 2015 May 15.

28.

A20 regulates atherogenic interferon (IFN)-γ signaling in vascular cells by modulating basal IFNβ levels.

Moll HP, Lee A, Minussi DC, da Silva CG, Csizmadia E, Bhasin M, Ferran C.

J Biol Chem. 2014 Nov 7;289(45):30912-24. doi: 10.1074/jbc.M114.591966. Epub 2014 Sep 12.

29.

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers.

Bon J, Kahloon R, Zhang Y, Xue J, Fuhrman CR, Tan J, Burger M, Kass DJ, Csizmadia E, Otterbein L, Chandra D, Bhargava A, Pilewski JM, Roodman GD, Sciurba FC, Duncan SR.

PLoS One. 2014 Sep 12;9(9):e105066. doi: 10.1371/journal.pone.0105066. eCollection 2014.

30.

Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma.

Jiang ZG, Wu Y, Csizmadia E, Feldbrügge L, Enjyoji K, Tigges J, Toxavidis V, Stephan H, Müller CE, McKnight CJ, Moss A, Robson SC.

Purinergic Signal. 2014 Dec;10(4):611-8. doi: 10.1007/s11302-014-9423-6. Epub 2014 Aug 28. Erratum in: Purinergic Signal. 2014 Dec;10(4):855. Müller, Christina E [corrected to Müller, Christa E].

31.

A20 deficiency causes spontaneous neuroinflammation in mice.

Guedes RP, Csizmadia E, Moll HP, Ma A, Ferran C, da Silva CG.

J Neuroinflammation. 2014 Jul 16;11:122. doi: 10.1186/1742-2094-11-122.

32.

Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.

Thornley TB, Fang Z, Balasubramanian S, Larocca RA, Gong W, Gupta S, Csizmadia E, Degauque N, Kim BS, Koulmanda M, Kuchroo VK, Strom TB.

J Clin Invest. 2014 Aug;124(8):3443-54. doi: 10.1172/JCI73527. Epub 2014 Jul 1.

33.

Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells.

Wegiel B, Hedblom A, Li M, Gallo D, Csizmadia E, Harris C, Nemeth Z, Zuckerbraun BS, Soares M, Persson JL, Otterbein LE.

Cell Death Dis. 2014 Mar 20;5:e1139. doi: 10.1038/cddis.2014.97.

34.

Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration.

Li M, Gallo D, Csizmadia E, Otterbein LE, Wegiel B.

Thromb Haemost. 2014 May 5;111(5):951-9. doi: 10.1160/TH13-09-0748. Epub 2014 Jan 30.

PMID:
24477332
35.

Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth.

Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE.

Cancer Res. 2013 Dec 1;73(23):7009-21. doi: 10.1158/0008-5472.CAN-13-1075. Epub 2013 Oct 11.

36.

Molecular biomarkers of vascular dysfunction in obstructive sleep apnea.

Kaczmarek E, Bakker JP, Clarke DN, Csizmadia E, Kocher O, Veves A, Tecilazich F, O'Donnell CP, Ferran C, Malhotra A.

PLoS One. 2013 Jul 29;8(7):e70559. doi: 10.1371/journal.pone.0070559. Print 2013.

37.

Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients.

Xue J, Kass DJ, Bon J, Vuga L, Tan J, Csizmadia E, Otterbein L, Soejima M, Levesque MC, Gibson KF, Kaminski N, Pilewski JM, Donahoe M, Sciurba FC, Duncan SR.

J Immunol. 2013 Sep 1;191(5):2089-95. doi: 10.4049/jimmunol.1203476. Epub 2013 Jul 19.

38.

Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma.

Yoshida S, Kornek M, Ikenaga N, Schmelzle M, Masuzaki R, Csizmadia E, Wu Y, Robson SC, Schuppan D.

Hepatology. 2013 Nov;58(5):1667-80. doi: 10.1002/hep.26526. Epub 2013 Sep 19.

PMID:
23729316
39.

Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation.

Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto DW, Otterbein LE, Popov Y.

Am J Pathol. 2013 Jul;183(1):182-94. doi: 10.1016/j.ajpath.2013.03.018. Epub 2013 May 14.

40.

CD39 modulates hematopoietic stem cell recruitment and promotes liver regeneration in mice and humans after partial hepatectomy.

Schmelzle M, Duhme C, Junger W, Salhanick SD, Chen Y, Wu Y, Toxavidis V, Csizmadia E, Han L, Bian S, Fürst G, Nowak M, Karp SJ, Knoefel WT, Esch JSA, Robson SC.

Ann Surg. 2013 Apr;257(4):693-701. doi: 10.1097/SLA.0b013e31826c3ec2.

41.

Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury.

Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC.

Am J Respir Cell Mol Biol. 2013 May;48(5):601-9. doi: 10.1165/rcmb.2012-0180OC.

42.

Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses.

Kahloon RA, Xue J, Bhargava A, Csizmadia E, Otterbein L, Kass DJ, Bon J, Soejima M, Levesque MC, Lindell KO, Gibson KF, Kaminski N, Banga G, Oddis CV, Pilewski JM, Sciurba FC, Donahoe M, Zhang Y, Duncan SR.

Am J Respir Crit Care Med. 2013 Apr 1;187(7):768-75. doi: 10.1164/rccm.201203-0506OC.

43.

A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals.

da Silva CG, Studer P, Skroch M, Mahiou J, Minussi DC, Peterson CR, Wilson SW, Patel VI, Ma A, Csizmadia E, Ferran C.

Hepatology. 2013 May;57(5):2014-25. doi: 10.1002/hep.26197. Epub 2013 Apr 5.

44.

Scar formation and lack of regeneration in adult and neonatal liver after stromal injury.

Masuzaki R, Zhao SR, Csizmadia E, Yannas I, Karp SJ.

Wound Repair Regen. 2013 Jan-Feb;21(1):122-30. doi: 10.1111/j.1524-475X.2012.00868.x. Epub 2012 Dec 10.

PMID:
23228176
45.

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.

El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, Csizmadia E, Mariani O, Zhu C, Campagne A, Toner M, Bhatia SN, Irimia D, Vincent-Salomon A, Karnoub AE.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17460-5. doi: 10.1073/pnas.1206653109. Epub 2012 Oct 2.

46.

CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease.

Doherty GA, Bai A, Hanidziar D, Longhi MS, Lawlor GO, Putheti P, Csizmadia E, Nowak M, Cheifetz AS, Moss AC, Robson SC.

Eur J Immunol. 2012 Nov;42(11):3062-72. doi: 10.1002/eji.201242623.

47.

Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice.

Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC.

Hepatology. 2013 Jan;57(1):205-16. doi: 10.1002/hep.25989.

48.

Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury.

Bhasin M, Huang Z, Pradhan-Nabzdyk L, Malek JY, LoGerfo PJ, Contreras M, Guthrie P, Csizmadia E, Andersen N, Kocher O, Ferran C, LoGerfo FW.

PLoS One. 2012;7(6):e39123. doi: 10.1371/journal.pone.0039123. Epub 2012 Jun 15.

49.

Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs.

Banz Y, Hess OM, Meier P, Korchagina EY, Gordeeva EA, Robson SC, Gajanayake T, Csizmadia E, Mettler D, Haeberli A, Bovin NV, Rieben R.

Cardiology. 2012;121(1):59-70. doi: 10.1159/000336485. Epub 2012 Mar 2.

PMID:
22398380
50.

B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.

Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD.

Blood. 2012 Mar 22;119(12):2819-28. doi: 10.1182/blood-2011-09-379412. Epub 2012 Feb 1.

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