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Items: 25


Identification and Characterization of Efflux Transporters that Modulate the Subtoxic Disposition of Diclofenac and its Metabolites.

Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE.

Drug Metab Dispos. 2019 Aug 9. pii: dmd.119.086603. doi: 10.1124/dmd.119.086603. [Epub ahead of print]


Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice.

Lickteig AJ, Zhang Y, Klaassen CD, Csanaky IL.

Toxicol Sci. 2019 Jun 21. pii: kfz143. doi: 10.1093/toxsci/kfz143. [Epub ahead of print]


Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice.

Csanaky IL, Lickteig AJ, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Mar 15;343:48-61. doi: 10.1016/j.taap.2018.02.005. Epub 2018 Feb 13.


Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Appl Pharmacol. 2018 Jan 1;338:112-123. doi: 10.1016/j.taap.2017.11.014. Epub 2017 Nov 22.


Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARα-Dependent Manner.

Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD.

Toxicol Sci. 2017 Dec 1;160(2):351-360. doi: 10.1093/toxsci/kfx191.


Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver.

Lickteig AJ, Csanaky IL, Pratt-Hyatt M, Klaassen CD.

Toxicol Sci. 2016 Jun;151(2):403-18. doi: 10.1093/toxsci/kfw054. Epub 2016 Mar 16.


Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice.

Renaud HJ, Klaassen CD, Csanaky IL.

Drug Metab Dispos. 2016 Mar;44(3):366-9. doi: 10.1124/dmd.115.064766. Epub 2016 Jan 7.


Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice.

Selwyn FP, Csanaky IL, Zhang Y, Klaassen CD.

Drug Metab Dispos. 2015 Oct;43(10):1544-56. doi: 10.1124/dmd.115.065276. Epub 2015 Jul 21.


Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac.

Scialis RJ, Csanaky IL, Goedken MJ, Manautou JE.

Drug Metab Dispos. 2015 Jul;43(7):944-50. doi: 10.1124/dmd.114.061705. Epub 2015 Apr 20.


H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice.

Raveendran VV, Kassel KM, Smith DD, Luyendyk JP, Williams KJ, Cherian R, Reed GA, Flynn CA, Csanaky IL, Lickteig AL, Pratt-Hyatt MJ, Klaassen CD, Dileepan KN.

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G219-28. doi: 10.1152/ajpgi.00027.2014. Epub 2014 May 22.


Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis.

Kazgan N, Metukuri MR, Purushotham A, Lu J, Rao A, Lee S, Pratt-Hyatt M, Lickteig A, Csanaky IL, Zhao Y, Dawson PA, Li X.

Gastroenterology. 2014 Apr;146(4):1006-16. doi: 10.1053/j.gastro.2013.12.029. Epub 2013 Dec 31.


Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism.

Zhang Y, Csanaky IL, Selwyn FP, Lehman-McKeeman LD, Klaassen CD.

Biochem Pharmacol. 2013 Aug 1;86(3):437-45. doi: 10.1016/j.bcp.2013.05.020. Epub 2013 Jun 6.


Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.

Li F, Lu J, Cheng J, Wang L, Matsubara T, Csanaky IL, Klaassen CD, Gonzalez FJ, Ma X.

Nat Med. 2013 Apr;19(4):418-20. doi: 10.1038/nm.3104. Epub 2013 Mar 10.


Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity.

Kong B, Csanaky IL, Aleksunes LM, Patni M, Chen Q, Ma X, Jaeschke H, Weir S, Broward M, Klaassen CD, Guo GL.

Toxicol Appl Pharmacol. 2012 Jun 1;261(2):189-95. doi: 10.1016/j.taap.2012.04.001. Epub 2012 Apr 11.


Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.

Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD.

Toxicol Sci. 2012 Jun;127(2):451-62. doi: 10.1093/toxsci/kfs123. Epub 2012 Mar 29.


Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice.

Fu ZD, Csanaky IL, Klaassen CD.

Drug Metab Dispos. 2012 Jun;40(6):1216-25. doi: 10.1124/dmd.111.044461. Epub 2012 Mar 23.


Gender-divergent profile of bile acid homeostasis during aging of mice.

Fu ZD, Csanaky IL, Klaassen CD.

PLoS One. 2012;7(3):e32551. doi: 10.1371/journal.pone.0032551. Epub 2012 Mar 5.


Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability.

Zhang Y, Csanaky IL, Lehman-McKeeman LD, Klaassen CD.

Toxicol Sci. 2011 Dec;124(2):251-60. doi: 10.1093/toxsci/kfr236. Epub 2011 Sep 13.


Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS.

Huang J, Bathena SP, Csanaky IL, Alnouti Y.

J Pharm Biomed Anal. 2011 Jul 15;55(5):1111-9. doi: 10.1016/j.jpba.2011.03.035. Epub 2011 Apr 6.


Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.

Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD.

Hepatology. 2011 Jan;53(1):272-81. doi: 10.1002/hep.23984. Epub 2010 Oct 14.


Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.

Csanaky IL, Aleksunes LM, Tanaka Y, Klaassen CD.

Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G419-33. doi: 10.1152/ajpgi.90728.2008. Epub 2009 Jun 4.


Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.

Reisman SA, Csanaky IL, Aleksunes LM, Klaassen CD.

Toxicol Sci. 2009 May;109(1):31-40. doi: 10.1093/toxsci/kfp047. Epub 2009 Feb 26.


Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity.

Reisman SA, Csanaky IL, Yeager RL, Klaassen CD.

Toxicol Sci. 2009 May;109(1):24-30. doi: 10.1093/toxsci/kfp045. Epub 2009 Feb 26.


Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS.

Alnouti Y, Csanaky IL, Klaassen CD.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 1;873(2):209-17. doi: 10.1016/j.jchromb.2008.08.018. Epub 2008 Sep 3.


Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.

Lu H, Choudhuri S, Ogura K, Csanaky IL, Lei X, Cheng X, Song PZ, Klaassen CD.

Toxicol Sci. 2008 May;103(1):35-45. doi: 10.1093/toxsci/kfn038. Epub 2008 Feb 21.

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