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Items: 1 to 50 of 852

1.

Fighting fire with fire: development of intranasal nalmefene to treat synthetic opioid overdose.

Krieter P, Gyaw S, Crystal R, Skolnick P.

J Pharmacol Exp Ther. 2019 Apr 2. pii: jpet.118.256115. doi: 10.1124/jpet.118.256115. [Epub ahead of print]

2.

Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects.

Johansson J, Hirvonen J, Lovró Z, Ekblad L, Kaasinen V, Rajasilta O, Helin S, Tuisku J, Sirén S, Pennanen M, Agrawal A, Crystal R, Vainio PJ, Alho H, Scheinin M.

Neuropsychopharmacology. 2019 Aug;44(9):1667-1673. doi: 10.1038/s41386-019-0368-x. Epub 2019 Mar 13.

PMID:
30867551
3.

Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts.

Pasquier J, Spurgeon M, Bradic M, Thomas B, Robay A, Chidiac O, Dib MJ, Turjoman R, Liberska A, Staudt M, Fakhro KA, Menzies R, Jayyousi A, Zirie M, Suwaidi JA, Malik RA, Talal T, Rafii A, Mezey J, Rodriguez-Flores J, Crystal RG, Abi Khalil C.

Epigenomics. 2019 Feb;11(3):281-296. doi: 10.2217/epi-2018-0144. Epub 2018 Nov 1.

4.

Intrapleural Gene Therapy for Alpha-1 Antitrypsin Deficiency-Related Lung Disease.

Stiles KM, Sondhi D, Kaminsky SM, De BP, Rosenberg JB, Crystal RG.

Chronic Obstr Pulm Dis. 2018 Aug 17;5(4):244-257. doi: 10.15326/jcopdf.5.4.2017.0160.

5.

Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes.

Zuo WL, Yang J, Strulovici-Barel Y, Salit J, Rostami M, Mezey JG, O'Beirne SL, Kaner RJ, Crystal RG.

Eur Respir J. 2019 May 18;53(5). pii: 1702553. doi: 10.1183/13993003.02553-2017. Print 2019 May.

PMID:
30705127
6.

Enhanced Intranasal Absorption of Naltrexone by Dodecyl Maltopyranoside: Implications for the Treatment of Opioid Overdose.

Krieter P, Gyaw S, Chiang CN, Crystal R, Skolnick P.

J Clin Pharmacol. 2019 Jul;59(7):947-957. doi: 10.1002/jcph.1384. Epub 2019 Jan 30.

7.

Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease).

Sindelar M, Dyke JP, Deeb RS, Sondhi D, Kaminsky SM, Kosofsky BE, Ballon DJ, Crystal RG, Gross SS.

Sci Rep. 2018 Oct 15;8(1):15229. doi: 10.1038/s41598-018-33449-0.

8.

Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia.

Pagovich OE, Vo ML, Zhao ZZ, Petropoulos IN, Yuan M, Lertsuwanroj B, Ciralsky J, Lai E, Kiss S, D'Amico DJ, Mezey JG, Malik RA, Crystal RG.

Ann Neurol. 2018 Dec;84(6):893-904. doi: 10.1002/ana.25355.

PMID:
30294800
9.

Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population.

O'Beirne SL, Salit J, Rodriguez-Flores JL, Staudt MR, Abi Khalil C, Fakhro KA, Robay A, Ramstetter MD, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Bener A, Mahmoud M, Chiuchiolo MJ, Al-Shakaki A, Chidiac O, Stadler D, Mezey JG, Crystal RG.

PLoS One. 2018 Sep 13;13(9):e0199837. doi: 10.1371/journal.pone.0199837. eCollection 2018.

10.

THE JEREMIAH METZGER LECTURE NOVEL THERAPEUTIC STRATEGIES OF ALLERGIC AND IMMUNOLOGIC DISORDERS.

Crystal RG, Pagovich OE.

Trans Am Clin Climatol Assoc. 2018;129:250-265. Review.

11.

Disease characteristics and progression in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease: an observational cohort study.

Nickel M, Simonati A, Jacoby D, Lezius S, Kilian D, Van de Graaf B, Pagovich OE, Kosofsky B, Yohay K, Downs M, Slasor P, Ajayi T, Crystal RG, Kohlschütter A, Sondhi D, Schulz A.

Lancet Child Adolesc Health. 2018 Aug;2(8):582-590. doi: 10.1016/S2352-4642(18)30179-2. Epub 2018 Jul 2. Erratum in: Lancet Child Adolesc Health. 2018 Sep;2(9):e24.

PMID:
30119717
12.

Gene therapy for C1 esterase inhibitor deficiency in a Murine Model of Hereditary angioedema.

Qiu T, Chiuchiolo MJ, Whaley AS, Russo AR, Sondhi D, Kaminsky SM, Crystal RG, Pagovich OE.

Allergy. 2019 Jun;74(6):1081-1089. doi: 10.1111/all.13582. Epub 2019 Mar 19.

PMID:
30059156
13.

Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome.

O'Beirne SL, Shenoy SA, Salit J, Strulovici-Barel Y, Kaner RJ, Visvanathan S, Fine JS, Mezey JG, Crystal RG.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1413-1422. doi: 10.1164/rccm.201712-2526OC.

PMID:
29897792
14.

Ontogeny and Biology of Human Small Airway Epithelial Club Cells.

Zuo WL, Shenoy SA, Li S, O'Beirne SL, Strulovici-Barel Y, Leopold PL, Wang G, Staudt MR, Walters MS, Mason C, Kaner RJ, Mezey JG, Crystal RG.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1375-1388. doi: 10.1164/rccm.201710-2107OC.

PMID:
29874100
15.

Point-of-care whole-exome sequencing of idiopathic male infertility.

Fakhro KA, Elbardisi H, Arafa M, Robay A, Rodriguez-Flores JL, Al-Shakaki A, Syed N, Mezey JG, Abi Khalil C, Malek JA, Al-Ansari A, Al Said S, Crystal RG.

Genet Med. 2018 Nov;20(11):1365-1373. doi: 10.1038/gim.2018.10. Epub 2018 Apr 12.

PMID:
29790874
16.

Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes.

Staudt MR, Salit J, Kaner RJ, Hollmann C, Crystal RG.

Respir Res. 2018 May 14;19(1):78. doi: 10.1186/s12931-018-0778-z.

17.

p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells.

Patel V, Singh VP, Pinnamaneni JP, Sanagasetti D, Olive J, Mathison M, Cooney A, Flores ER, Crystal RG, Yang J, Rosengart TK.

J Thorac Cardiovasc Surg. 2018 Aug;156(2):556-565.e1. doi: 10.1016/j.jtcvs.2018.03.162. Epub 2018 Apr 13.

PMID:
29716728
18.

A systematic review on the genetics of male infertility in the era of next-generation sequencing.

Robay A, Abbasi S, Akil A, El-Bardisi H, Arafa M, Crystal RG, Fakhro KA.

Arab J Urol. 2018 Feb 14;16(1):53-64. doi: 10.1016/j.aju.2017.12.003. eCollection 2018 Mar.

19.

In Vivo Potency Assay for Adeno-Associated Virus-Based Gene Therapy Vectors Using AAVrh.10 as an Example.

De BP, Chen A, Salami CO, Van de Graaf B, Rosenberg JB, Pagovich OE, Sondhi D, Crystal RG, Kaminsky SM.

Hum Gene Ther Methods. 2018 Jun;29(3):146-155. doi: 10.1089/hgtb.2017.246. Epub 2018 Jun 8.

PMID:
29706115
20.

Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2.

Markmann S, J Christie-Reid J, Rosenberg JB, De BP, Kaminsky SM, Crystal RG, Sondhi D.

Exp Neurol. 2018 Aug;306:22-33. doi: 10.1016/j.expneurol.2018.04.001. Epub 2018 Apr 12.

PMID:
29655638
21.

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration.

Zhang H, Yang J, Walters MS, Staudt MR, Strulovici-Barel Y, Salit J, Mezey JG, Leopold PL, Crystal RG.

Oncotarget. 2018 Feb 16;9(18):14324-14337. doi: 10.18632/oncotarget.24511. eCollection 2018 Mar 6.

22.

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease.

Rosenberg JB, Kaplitt MG, De BP, Chen A, Flagiello T, Salami C, Pey E, Zhao L, Ricart Arbona RJ, Monette S, Dyke JP, Ballon DJ, Kaminsky SM, Sondhi D, Petsko GA, Paul SM, Crystal RG.

Hum Gene Ther Clin Dev. 2018 Mar;29(1):24-47. doi: 10.1089/humc.2017.231. Epub 2018 Mar 13.

23.

At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.

Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley PMA, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine R 3rd, Rafii S, Rennard SI, Segal LN, Shaykhiev R, Stevenson C, Tal-Singer R, Vestbo J, Woodruff PG, Curtis JL, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1540-1551. doi: 10.1164/rccm.201710-2028PP. No abstract available. Erratum in: Am J Respir Crit Care Med. 2018 Dec 1;198(11):1463.

24.

Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population.

Yousri NA, Fakhro KA, Robay A, Rodriguez-Flores JL, Mohney RP, Zeriri H, Odeh T, Kader SA, Aldous EK, Thareja G, Kumar M, Al-Shakaki A, Chidiac OM, Mohamoud YA, Mezey JG, Malek JA, Crystal RG, Suhre K.

Nat Commun. 2018 Jan 23;9(1):333. doi: 10.1038/s41467-017-01972-9.

25.

Biology of the Adrenal Gland Cortex Obviates Effective Use of Adeno-Associated Virus Vectors to Treat Hereditary Adrenal Disorders.

Markmann S, De BP, Reid J, Jose CL, Rosenberg JB, Leopold PL, Kaminsky SM, Sondhi D, Pagovich O, Crystal RG.

Hum Gene Ther. 2018 Apr;29(4):403-412. doi: 10.1089/hum.2017.203. Epub 2018 Mar 20.

PMID:
29316814
26.

Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: an uncontrolled phase 1/2 clinical trial.

Tardieu M, Zérah M, Gougeon ML, Ausseil J, de Bournonville S, Husson B, Zafeiriou D, Parenti G, Bourget P, Poirier B, Furlan V, Artaud C, Baugnon T, Roujeau T, Crystal RG, Meyer C, Deiva K, Heard JM.

Lancet Neurol. 2017 Sep;16(9):712-720. doi: 10.1016/S1474-4422(17)30169-2. Epub 2017 Jul 14.

PMID:
28713035
27.

Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium.

Wang G, Zhou H, Strulovici-Barel Y, Al-Hijji M, Ou X, Salit J, Walters MS, Staudt MR, Kaner RJ, Crystal RG.

Autophagy. 2017 Jul 3;13(7):1205-1220. doi: 10.1080/15548627.2017.1301327. Epub 2017 May 26.

28.

Refining Current Scientific Priorities and Identifying New Scientific Gaps in HIV-Related Heart, Lung, Blood, and Sleep Research.

Twigg HL 3rd, Crystal R, Currier J, Ridker P, Berliner N, Kiem HP, Rutherford G, Zou S, Glynn S, Wong R, Peprah E, Engelgau M, Creazzo T, Colombini-Hatch S, Caler E.

AIDS Res Hum Retroviruses. 2017 Sep;33(9):889-897. doi: 10.1089/AID.2017.0026. Epub 2017 Jun 26.

29.

An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci.

Ju JH, Shenoy SA, Crystal RG, Mezey JG.

PLoS Comput Biol. 2017 May 15;13(5):e1005537. doi: 10.1371/journal.pcbi.1005537. eCollection 2017 May.

30.

HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype.

Chung NPY, Ou X, Khan KMF, Salit J, Kaner RJ, Crystal RG.

Cell Rep. 2017 May 9;19(6):1091-1100. doi: 10.1016/j.celrep.2017.04.026.

31.

Smoking-Dependent Distal-to-Proximal Repatterning of the Adult Human Small Airway Epithelium.

Yang J, Zuo WL, Fukui T, Chao I, Gomi K, Lee B, Staudt MR, Kaner RJ, Strulovici-Barel Y, Salit J, Crystal RG, Shaykhiev R.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):340-352. doi: 10.1164/rccm.201608-1672OC.

32.

Waterpipe smoking induces epigenetic changes in the small airway epithelium.

Walters MS, Salit J, Ju JH, Staudt MR, Kaner RJ, Rogalski AM, Sodeinde TB, Rahim R, Strulovici-Barel Y, Mezey JG, Almulla AM, Sattar H, Mahmoud M, Crystal RG.

PLoS One. 2017 Mar 8;12(3):e0171112. doi: 10.1371/journal.pone.0171112. eCollection 2017.

33.

Radioiodinated Capsids Facilitate In Vivo Non-Invasive Tracking of Adeno-Associated Gene Transfer Vectors.

Kothari P, De BP, He B, Chen A, Chiuchiolo MJ, Kim D, Nikolopoulou A, Amor-Coarasa A, Dyke JP, Voss HU, Kaminsky SM, Foley CP, Vallabhajosula S, Hu B, DiMagno SG, Sondhi D, Crystal RG, Babich JW, Ballon D.

Sci Rep. 2017 Jan 6;7:39594. doi: 10.1038/srep39594.

34.

Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling.

Gomi K, Tang Y, Arbelaez V, Crystal RG, Walters MS.

Stem Cell Rev. 2017 Apr;13(2):309-317. doi: 10.1007/s12015-016-9707-z.

35.

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.

Liu W, Zhao L, Blackman B, Parmar M, Wong MY, Woo T, Yu F, Chiuchiolo MJ, Sondhi D, Kaminsky SM, Crystal RG, Paul SM.

J Neurosci. 2016 Dec 7;36(49):12425-12435. Erratum in: J Neurosci. 2017 Mar 29;37(13):3734.

36.

Genetic Modification of the Lung Directed Toward Treatment of Human Disease.

Sondhi D, Stiles KM, De BP, Crystal RG.

Hum Gene Ther. 2017 Jan;28(1):3-84. doi: 10.1089/hum.2016.152. Review.

PMID:
27927014
37.

Compelling evidence for the efficacy of α1-antitrypsin augmentation treatment for α1-antitrypsin deficiency.

Crystal RG.

Lancet Respir Med. 2017 Jan;5(1):7-8. doi: 10.1016/S2213-2600(16)30434-9. Epub 2016 Dec 2. No abstract available.

PMID:
27916479
38.

Two hits in one: whole genome sequencing unveils LIG4 syndrome and urofacial syndrome in a case report of a child with complex phenotype.

Fadda A, Butt F, Tomei S, Deola S, Lo B, Robay A, Al-Shakaki A, Al-Hajri N, Crystal R, Kambouris M, Wang E, Marincola FM, Fakhro KA, Cugno C.

BMC Med Genet. 2016 Nov 17;17(1):84.

39.

Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques.

Evans SM, Foltin RW, Hicks MJ, Rosenberg JB, De BP, Janda KD, Kaminsky SM, Crystal RG.

Pharmacol Biochem Behav. 2016 Nov - Dec;150-151:76-86. doi: 10.1016/j.pbb.2016.09.008. Epub 2016 Sep 30.

40.

In situ reprogramming to transdifferentiate fibroblasts into cardiomyocytes using adenoviral vectors: Implications for clinical myocardial regeneration.

Mathison M, Singh VP, Chiuchiolo MJ, Sanagasetti D, Mao Y, Patel VB, Yang J, Kaminsky SM, Crystal RG, Rosengart TK.

J Thorac Cardiovasc Surg. 2017 Feb;153(2):329-339.e3. doi: 10.1016/j.jtcvs.2016.09.041. Epub 2016 Sep 23.

41.

Anti-Epidermal Growth Factor Receptor Gene Therapy for Glioblastoma.

Hicks MJ, Chiuchiolo MJ, Ballon D, Dyke JP, Aronowitz E, Funato K, Tabar V, Havlicek D, Fan F, Sondhi D, Kaminsky SM, Crystal RG.

PLoS One. 2016 Oct 6;11(10):e0162978. doi: 10.1371/journal.pone.0162978. eCollection 2016.

42.

EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium.

Zuo WL, Yang J, Gomi K, Chao I, Crystal RG, Shaykhiev R.

Stem Cells. 2017 Mar;35(3):824-837. doi: 10.1002/stem.2512. Epub 2016 Nov 17.

43.

Gene therapy for metachromatic leukodystrophy.

Rosenberg JB, Kaminsky SM, Aubourg P, Crystal RG, Sondhi D.

J Neurosci Res. 2016 Nov;94(11):1169-79. doi: 10.1002/jnr.23792. Review.

44.

Gene Therapy for Alpha-1 Antitrypsin Deficiency Lung Disease.

Chiuchiolo MJ, Crystal RG.

Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S352-69. doi: 10.1513/AnnalsATS.201506-344KV. Review.

45.

Correction: Type 2 Diabetes Risk Allele Loci in the Qatari Population.

O'Beirne SL, Salit J, Rodriguez-Flores JL, Staudt MR, Abi Khalil C, Fakhro KA, Robay A, Ramstetter MD, Al-Azwani IK, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Chiuchiolo MJ, Al-Shakaki A, Chidiac O, Gharbiah M, Bener A, Stadler D, Hackett NR, Mezey JG, Crystal RG.

PLoS One. 2016 Aug 23;11(8):e0161910. doi: 10.1371/journal.pone.0161910. eCollection 2016.

46.

Sarcoidosis in America. Analysis Based on Health Care Use.

Baughman RP, Field S, Costabel U, Crystal RG, Culver DA, Drent M, Judson MA, Wolff G.

Ann Am Thorac Soc. 2016 Aug;13(8):1244-52. doi: 10.1513/AnnalsATS.201511-760OC.

PMID:
27509154
47.

Persistence of circulating endothelial microparticles in COPD despite smoking cessation.

Strulovici-Barel Y, Staudt MR, Krause A, Gordon C, Tilley AE, Harvey BG, Kaner RJ, Hollmann C, Mezey JG, Bitter H, Pillai SG, Hilton H, Wolff G, Stevenson CS, Visvanathan S, Fine JS, Crystal RG.

Thorax. 2016 Dec;71(12):1137-1144. doi: 10.1136/thoraxjnl-2015-208274. Epub 2016 Jul 26.

48.

The Role of Interleukin-23 in the Early Development of Emphysema in HIV1(+) Smokers.

Barjaktarevic IZ, Crystal RG, Kaner RJ.

J Immunol Res. 2016;2016:3463104. doi: 10.1155/2016/3463104. Epub 2016 Jun 29.

49.

The Qatar genome: a population-specific tool for precision medicine in the Middle East.

Fakhro KA, Staudt MR, Ramstetter MD, Robay A, Malek JA, Badii R, Al-Marri AA, Abi Khalil C, Al-Shakaki A, Chidiac O, Stadler D, Zirie M, Jayyousi A, Salit J, Mezey JG, Crystal RG, Rodriguez-Flores JL.

Hum Genome Var. 2016 Jun 30;3:16016. doi: 10.1038/hgv.2016.16. eCollection 2016.

50.

Type 2 Diabetes Risk Allele Loci in the Qatari Population.

O'Beirne SL, Salit J, Rodriguez-Flores JL, Staudt MR, Abi Khalil C, Fakhro KA, Robay A, Ramstetter MD, Al-Azwani IK, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Chiuchiolo MJ, Al-Shakaki A, Chidiac O, Gharbiah M, Bener A, Stadler D, Hackett NR, Mezey JG, Crystal RG.

PLoS One. 2016 Jul 6;11(7):e0156834. doi: 10.1371/journal.pone.0156834. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0161910.

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