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Items: 17


Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure.

Cruz-Topete D, Oakley RH, Carroll NG, He B, Myers PH, Xu X, Watts MN, Trosclair K, Glasscock E, Dominic P, Cidlowski JA.

J Am Heart Assoc. 2019 Aug 6;8(15):e011012. doi: 10.1161/JAHA.118.011012. Epub 2019 Jul 17.


Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice.

Oakley RH, Cruz-Topete D, He B, Foley JF, Myers PH, Xu X, Gomez-Sanchez CE, Chambon P, Willis MS, Cidlowski JA.

Sci Signal. 2019 Apr 16;12(577). pii: eaau9685. doi: 10.1126/scisignal.aau9685.


Hypothalamic-Pituitary-Adrenal Axis Modulation of Glucocorticoids in the Cardiovascular System.

Burford NG, Webster NA, Cruz-Topete D.

Int J Mol Sci. 2017 Oct 16;18(10). pii: E2150. doi: 10.3390/ijms18102150. Review.


Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.

Cruz-Topete D, He B, Xu X, Cidlowski JA.

J Biol Chem. 2016 Sep 9;291(37):19374-86. doi: 10.1074/jbc.M116.725903. Epub 2016 Jul 22.


Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice.

Cruz-Topete D, Myers PH, Foley JF, Willis MS, Cidlowski JA.

Endocrinology. 2016 Jul;157(7):2759-71. doi: 10.1210/en.2015-1604. Epub 2016 May 24.


Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver.

He B, Cruz-Topete D, Oakley RH, Xiao X, Cidlowski JA.

Mol Cell Biol. 2015 Dec 28;36(5):714-30. doi: 10.1128/MCB.00908-15.


One hormone, two actions: anti- and pro-inflammatory effects of glucocorticoids.

Cruz-Topete D, Cidlowski JA.

Neuroimmunomodulation. 2015;22(1-2):20-32. doi: 10.1159/000362724. Epub 2014 Sep 12. Review.


Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease.

Oakley RH, Ren R, Cruz-Topete D, Bird GS, Myers PH, Boyle MC, Schneider MD, Willis MS, Cidlowski JA.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17035-40. doi: 10.1073/pnas.1302546110. Epub 2013 Sep 30.


Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosis.

Ren R, Oakley RH, Cruz-Topete D, Cidlowski JA.

Endocrinology. 2012 Nov;153(11):5346-60. doi: 10.1210/en.2012-1563. Epub 2012 Sep 18.


Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers.

Burgos-Ramos E, Sackmann-Sala L, Baquedano E, Cruz-Topete D, Barrios V, Argente J, Kopchick JJ.

Metabolism. 2012 Nov;61(11):1646-57. doi: 10.1016/j.metabol.2012.05.001. Epub 2012 Jun 1.


Identification of new biomarkers of low-dose GH replacement therapy in GH-deficient patients.

Cruz-Topete D, Jorgensen JO, Christensen B, Sackmann-Sala L, Krusenstjerna-Hafstrøm T, Jara A, Okada S, Kopchick JJ.

J Clin Endocrinol Metab. 2011 Jul;96(7):2089-97. doi: 10.1210/jc.2011-0197. Epub 2011 May 4.


Proteomic changes in the heart of diet-induced pre-diabetic mice.

Cruz-Topete D, List EO, Okada S, Kelder B, Kopchick JJ.

J Proteomics. 2011 May 1;74(5):716-27. doi: 10.1016/j.jprot.2011.02.018. Epub 2011 Feb 24.


Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.

List EO, Sackmann-Sala L, Berryman DE, Funk K, Kelder B, Gosney ES, Okada S, Ding J, Cruz-Topete D, Kopchick JJ.

Endocr Rev. 2011 Jun;32(3):356-86. doi: 10.1210/er.2010-0009. Epub 2010 Dec 1. Review.


Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers of disease activity.

Cruz-Topete D, Christensen B, Sackmann-Sala L, Okada S, Jorgensen JO, Kopchick JJ.

Eur J Endocrinol. 2011 Feb;164(2):157-67. doi: 10.1530/EJE-10-0754. Epub 2010 Nov 8.


Novel serum biomarkers for erythropoietin use in humans: a proteomic approach.

Christensen B, Sackmann-Sala L, Cruz-Topete D, Jørgensen JO, Jessen N, Lundby C, Kopchick JJ.

J Appl Physiol (1985). 2011 Jan;110(1):149-56. doi: 10.1152/japplphysiol.00665.2010. Epub 2010 Oct 21.


A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice.

Iwaki T, Cruz-Topete D, Castellino FJ.

J Thromb Haemost. 2008 Nov;6(11):1993-5. doi: 10.1111/j.1538-7836.2008.03142.x. No abstract available.


Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice.

Cruz-Topete D, Iwaki T, Ploplis VA, Castellino FJ.

J Pathol. 2006 Nov;210(3):325-33.


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