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Items: 1 to 50 of 65

1.

High-affinity interactions and signal transduction between Aβ oligomers and TREM2.

Lessard CB, Malnik SL, Zhou Y, Ladd TB, Cruz PE, Ran Y, Mahan TE, Chakrabaty P, Holtzman DM, Ulrich JD, Colonna M, Golde TE.

EMBO Mol Med. 2018 Nov;10(11). pii: e9027. doi: 10.15252/emmm.201809027.

2.

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.

Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, Moore BD, Liu X, Ceballos-Diaz C, Rosario AM, Medway C, Janus C, Li HD, Dickson DW, Giasson BI, Price ND, Younkin SG, Ertekin-Taner N, Golde TE.

J Exp Med. 2018 Sep 3;215(9):2247-2264. doi: 10.1084/jem.20180484.

PMID:
30158114
3.

Short Aβ peptides attenuate Aβ42 toxicity in vivo.

Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, Rincon-Limas D, Fernandez-Funez P, Golde TE.

J Exp Med. 2018 Jan 2;215(1):283-301. doi: 10.1084/jem.20170600. Epub 2017 Dec 5.

4.

Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage.

Leclerc JL, Santiago-Moreno J, Dang A, Lampert AS, Cruz PE, Rosario AM, Golde TE, Doré S.

J Cereb Blood Flow Metab. 2018 Jun;38(6):1032-1046. doi: 10.1177/0271678X16679170. Epub 2016 Nov 19.

PMID:
27864463
5.

Therapeutic angiogenesis induced by human umbilical cord tissue-derived mesenchymal stromal cells in a murine model of hindlimb ischemia.

Pereira AR, Mendes TF, Ministro A, Teixeira M, Filipe M, Santos JM, Bárcia RN, Goyri-O'Neill J, Pinto F, Cruz PE, Cruz HJ, Santos SC.

Stem Cell Res Ther. 2016 Sep 29;7(1):145.

6.

Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro.

Cipriano M, Freyer N, Knöspel F, Oliveira NG, Barcia R, Cruz PE, Cruz H, Castro M, Santos JM, Zeilinger K, Miranda JP.

Arch Toxicol. 2017 Apr;91(4):1815-1832. doi: 10.1007/s00204-016-1838-0. Epub 2016 Sep 2.

PMID:
27590069
7.

Microglia-specific targeting by novel capsid-modified AAV6 vectors.

Rosario AM, Cruz PE, Ceballos-Diaz C, Strickland MR, Siemienski Z, Pardo M, Schob KL, Li A, Aslanidi GV, Srivastava A, Golde TE, Chakrabarty P.

Mol Ther Methods Clin Dev. 2016 Apr 13;3:16026. doi: 10.1038/mtm.2016.26. eCollection 2016.

8.

Re-Opening the Critical Window for Estrogen Therapy.

Bean LA, Kumar A, Rani A, Guidi M, Rosario AM, Cruz PE, Golde TE, Foster TC.

J Neurosci. 2015 Dec 9;35(49):16077-93. doi: 10.1523/JNEUROSCI.1890-15.2015.

9.

IFN-γ promotes τ phosphorylation without affecting mature tangles.

Li A, Ceballos-Diaz C, DiNunno N, Levites Y, Cruz PE, Lewis J, Golde TE, Chakrabarty P.

FASEB J. 2015 Oct;29(10):4384-98. doi: 10.1096/fj.15-275834. Epub 2015 Jul 8.

10.

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.

Ceballos-Diaz C, Rosario AM, Park HJ, Chakrabarty P, Sacino A, Cruz PE, Siemienski Z, Lara N, Moran C, Ravelo N, Golde TE, McFarland NR.

Mol Neurodegener. 2015 Jul 8;10:25. doi: 10.1186/s13024-015-0026-7.

11.

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Bárcia RN, Santos JM, Filipe M, Teixeira M, Martins JP, Almeida J, Água-Doce A, Almeida SC, Varela A, Pohl S, Dittmar KE, Calado S, Simões SI, Gaspar MM, Cruz ME, Lindenmaier W, Graça L, Cruz H, Cruz PE.

Stem Cells Int. 2015;2015:583984. doi: 10.1155/2015/583984. Epub 2015 May 12.

12.

A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo.

Levites Y, O'Nuallain B, Puligedda RD, Ondrejcak T, Adekar SP, Chen C, Cruz PE, Rosario AM, Macy S, Mably AJ, Walsh DM, Vidal R, Solomon A, Brown D, Rowan MJ, Golde TE, Dessain SK.

J Neurosci. 2015 Apr 22;35(16):6265-76. doi: 10.1523/JNEUROSCI.5109-14.2015.

13.

IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

Chakrabarty P, Li A, Ceballos-Diaz C, Eddy JA, Funk CC, Moore B, DiNunno N, Rosario AM, Cruz PE, Verbeeck C, Sacino A, Nix S, Janus C, Price ND, Das P, Golde TE.

Neuron. 2015 Feb 4;85(3):519-33. doi: 10.1016/j.neuron.2014.11.020. Epub 2015 Jan 22.

14.

Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.

Jung JI, Premraj S, Cruz PE, Ladd TB, Kwak Y, Koo EH, Felsenstein KM, Golde TE, Ran Y.

PLoS One. 2014 Oct 28;9(10):e111553. doi: 10.1371/journal.pone.0111553. eCollection 2014.

15.

Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.

Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y.

Mol Ther. 2015 Jan;23(1):53-62. doi: 10.1038/mt.2014.180. Epub 2014 Sep 17.

16.

Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.

Jung JI, Ran Y, Cruz PE, Rosario AM, Ladd TB, Kukar TL, Koo EH, Felsenstein KM, Golde TE.

Biochemistry. 2014 Apr 1;53(12):1947-57. doi: 10.1021/bi401521t. Epub 2014 Mar 20.

17.

Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.

Martins JP, Santos JM, de Almeida JM, Filipe MA, de Almeida MV, Almeida SC, Água-Doce A, Varela A, Gilljam M, Stellan B, Pohl S, Dittmar K, Lindenmaier W, Alici E, Graça L, Cruz PE, Cruz HJ, Bárcia RN.

Stem Cell Res Ther. 2014 Jan 17;5(1):9. doi: 10.1186/scrt398.

18.

γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.

Ran Y, Cruz PE, Ladd TB, Fauq AH, Jung JI, Matthews J, Felsenstein KM, Golde TE.

J Biol Chem. 2014 Feb 7;289(6):3276-87. doi: 10.1074/jbc.M113.512921. Epub 2013 Dec 18.

19.

Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.

Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI.

Brain Res. 2013 Aug 2;1524:62-73. doi: 10.1016/j.brainres.2013.06.006. Epub 2013 Jun 15.

20.

Conformational templating of α-synuclein aggregates in neuronal-glial cultures.

Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE.

Mol Neurodegener. 2013 May 28;8:17. doi: 10.1186/1750-1326-8-17.

21.

Downstream processing of lentiviral vectors: releasing bottlenecks.

Bandeira V, Peixoto C, Rodrigues AF, Cruz PE, Alves PM, Coroadinha AS, Carrondo MJ.

Hum Gene Ther Methods. 2012 Aug;23(4):255-63. doi: 10.1089/hgtb.2012.059. Epub 2012 Aug 30.

PMID:
22934827
22.

Antioxidant and antimicrobial activities of aporphinoids and other alkaloids from the bark of Annona salzmannii A. DC. (Annonaceae).

Costa EV, da Cruz PE, de Lourenço CC, de Souza Moraes VR, de Lima Nogueira PC, Salvador MJ.

Nat Prod Res. 2013;27(11):1002-6. doi: 10.1080/14786419.2012.688044. Epub 2012 May 15.

PMID:
22582985
23.

Manufacturing of retroviruses.

Cruz PE, Rodrigues T, Carmo M, Wirth D, Amaral AI, Alves PM, Coroadinha AS.

Methods Mol Biol. 2011;737:157-82. doi: 10.1007/978-1-61779-095-9_7.

PMID:
21590397
24.

Cellular fusion for gene delivery to SCA1 affected Purkinje neurons.

Chen KA, Cruz PE, Lanuto DJ, Flotte TR, Borchelt DR, Srivastava A, Zhang J, Steindler DA, Zheng T.

Mol Cell Neurosci. 2011 May;47(1):61-70. doi: 10.1016/j.mcn.2011.03.003. Epub 2011 Mar 17.

25.

Adenovirus vector production and purification.

Silva AC, Peixoto C, Lucas T, Küppers C, Cruz PE, Alves PM, Kochanek S.

Curr Gene Ther. 2010 Dec;10(6):437-55. Review.

PMID:
21054247
26.

Production of retroviral vectors: review.

Coroadinha AS, Gama-Norton L, Amaral AI, Hauser H, Alves PM, Cruz PE.

Curr Gene Ther. 2010 Dec;10(6):456-73. Review.

PMID:
21054246
27.

N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance.

Martino AT, Mueller C, Braag S, Cruz PE, Campbell-Thompson M, Jin S, Flotte TR.

Am J Respir Cell Mol Biol. 2011 Jun;44(6):824-30. doi: 10.1165/rcmb.2009-0285OC. Epub 2010 Aug 6.

28.

Thermosensitivity of the reverse transcription process as an inactivation mechanism of lentiviral vectors.

Carmo M, Dias JD, Panet A, Coroadinha AS, Carrondo MJ, Alves PM, Cruz PE.

Hum Gene Ther. 2009 Oct;20(10):1168-76. doi: 10.1089/hum.2009.068.

PMID:
19537947
29.

Stabilization of gammaretroviral and lentiviral vectors: from production to gene transfer.

Carmo M, Alves A, Rodrigues AF, Coroadinha AS, Carrondo MJ, Alves PM, Cruz PE.

J Gene Med. 2009 Aug;11(8):670-8. doi: 10.1002/jgm.1353.

PMID:
19507176
30.

Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism.

Mu W, Long DA, Ouyang X, Agarwal A, Cruz PE, Roncal CA, Nakagawa T, Yu X, Hauswirth WW, Johnson RJ.

Am J Physiol Renal Physiol. 2009 Jan;296(1):F145-52. doi: 10.1152/ajprenal.90430.2008. Epub 2008 Oct 29.

31.

Removal of envelope protein-free retroviral vectors by anion-exchange chromatography to improve product quality.

Rodrigues T, Alves A, Lopes A, Carrondo MJ, Alves PM, Cruz PE.

J Sep Sci. 2008 Oct;31(20):3509-18. doi: 10.1002/jssc.200800195.

PMID:
18830959
32.

Purification of recombinant rotavirus VP7 glycoprotein for the study of in vitro rotavirus-like particles assembly.

Mellado MC, Peixoto C, Cruz PE, Carrondo MJ, Alves PM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 15;874(1-2):89-94. doi: 10.1016/j.jchromb.2008.09.002. Epub 2008 Sep 7.

PMID:
18805074
33.

From retroviral vector production to gene transfer: spontaneous inactivation is caused by loss of reverse transcription capacity.

Carmo M, Panet A, Carrondo MJ, Alves PM, Cruz PE.

J Gene Med. 2008 Apr;10(4):383-91. doi: 10.1002/jgm.1163.

PMID:
18240154
34.

The promise of gene therapy for the treatment of alpha-1 antitrypsin deficiency.

Cruz PE, Mueller C, Flotte TR.

Pharmacogenomics. 2007 Sep;8(9):1191-8. Review.

PMID:
17924834
35.

In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA.

Cruz PE, Mueller C, Cossette TL, Golant A, Tang Q, Beattie SG, Brantly M, Campbell-Thompson M, Blomenkamp KS, Teckman JH, Flotte TR.

Lab Invest. 2007 Sep;87(9):893-902. Epub 2007 Jun 25.

36.

Scaleable purification process for gene therapy retroviral vectors.

Rodrigues T, Carvalho A, Carmo M, Carrondo MJ, Alves PM, Cruz PE.

J Gene Med. 2007 Apr;9(4):233-43.

PMID:
17428003
37.

Purification of retroviral vectors for clinical application: biological implications and technological challenges.

Rodrigues T, Carrondo MJ, Alves PM, Cruz PE.

J Biotechnol. 2007 Jan 10;127(3):520-41. Epub 2006 Jul 31. Review.

PMID:
16950534
38.

Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.

Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, Watkins LR.

Pain. 2006 Dec 15;126(1-3):294-308. Epub 2006 Sep 1.

PMID:
16949747
39.

Screening anion-exchange chromatographic matrices for isolation of onco-retroviral vectors.

Rodrigues T, Carvalho A, Roldão A, Carrondo MJ, Alves PM, Cruz PE.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):59-68. Epub 2006 May 11.

PMID:
16697280
40.

Relationship between retroviral vector membrane and vector stability.

Carmo M, Faria TQ, Falk H, Coroadinha AS, Teixeira M, Merten OW, Gény-Fiamma C, Alves PM, Danos O, Panet A, Carrondo MJ, Cruz PE.

J Gen Virol. 2006 May;87(Pt 5):1349-56.

PMID:
16603538
41.

Screening of novel excipients for improving the stability of retroviral and adenoviral vectors.

Cruz PE, Silva AC, Roldão A, Carmo M, Carrondo MJ, Alves PM.

Biotechnol Prog. 2006 Mar-Apr;22(2):568-76.

PMID:
16599578
42.

Retrovirus producer cell line metabolism: implications on viral productivity.

Coroadinha AS, Alves PM, Santos SS, Cruz PE, Merten OW, Carrondo MJ.

Appl Microbiol Biotechnol. 2006 Oct;72(6):1125-35. Epub 2006 Apr 6.

PMID:
16598449
43.

Effect of medium sugar source on the production of retroviral vectors for gene therapy.

Coroadinha AS, Ribeiro J, Roldão A, Cruz PE, Alves PM, Merten OW, Carrondo MJ.

Biotechnol Bioeng. 2006 May 5;94(1):24-36.

PMID:
16514678
44.

Purification of adenoviral vectors using expanded bed chromatography.

Peixoto C, Ferreira TB, Carrondo MJ, Cruz PE, Alves PM.

J Virol Methods. 2006 Mar;132(1-2):121-6. Epub 2005 Nov 2.

PMID:
16266756
45.

IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.

Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, Cruz PE, Roncal CA, Glushakova OY, Chiodo VA, Atkinson MA, Hauswirth WW, Flotte TR, Rodriguez-Iturbe B, Johnson RJ.

J Am Soc Nephrol. 2005 Dec;16(12):3651-60. Epub 2005 Oct 26.

46.

Triple layered rotavirus VLP production: kinetics of vector replication, mRNA stability and recombinant protein production.

Vieira HL, Estêvão C, Roldão A, Peixoto CC, Sousa MF, Cruz PE, Carrondo MJ, Alves PM.

J Biotechnol. 2005 Oct 17;120(1):72-82. Epub 2005 Jul 14.

PMID:
16023241
47.

Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.

Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Cruz PE, Hauswirth WW, Madsen KM, Croker BP, Berns KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7251-6. Epub 2005 May 6.

48.

Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.

Milligan ED, Sloane EM, Langer SJ, Cruz PE, Chacur M, Spataro L, Wieseler-Frank J, Hammack SE, Maier SF, Flotte TR, Forsayeth JR, Leinwand LA, Chavez R, Watkins LR.

Mol Pain. 2005 Feb 25;1:9.

49.

Quantitation of MLV-based retroviral vectors using real-time RT-PCR.

Carmo M, Peixoto C, Coroadinha AS, Alves PM, Cruz PE, Carrondo MJ.

J Virol Methods. 2004 Aug;119(2):115-9.

PMID:
15158592
50.

Integrated process optimization: lessons from retrovirus and virus-like particle production.

Cruz PE, Maranga L, Carrondo MJ.

J Biotechnol. 2002 Nov 13;99(3):199-214.

PMID:
12385709

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