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T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor-Expressing T Cells.

Lapteva N, Gilbert M, Diaconu I, Rollins LA, Al-Sabbagh M, Naik S, Krance RA, Tripic T, Hiregange M, Raghavan D, Dakhova O, Rouce RH, Liu H, Omer B, Savoldo B, Dotti G, Cruz CR, Sharpe K, Gates M, Orozco A, Durett A, Pacheco E, Gee AP, Ramos CA, Heslop HE, Brenner MK, Rooney CM.

Clin Cancer Res. 2019 Sep 26. doi: 10.1158/1078-0432.CCR-18-3199. [Epub ahead of print]


Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization.

Powell AB, Yadavilli S, Saunders D, Van Pelt S, Chorvinsky E, Burga RA, Albihani S, Hanley PJ, Xu Z, Pei Y, Yvon ES, Hwang EI, Bollard CM, Nazarian J, Cruz CRY.

J Transl Med. 2019 Sep 23;17(1):321. doi: 10.1186/s12967-019-2055-4.


Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multi-Tumor Associated Antigen Specific Cytotoxic T Lymphocytes: A Phase I Study.

Hont AB, Cruz CR, Ulrey R, O'Brien B, Stanojevic M, Datar A, Albihani S, Saunders D, Hanajiri R, Panchapakesan K, Darko S, Banerjee P, Fortiz MF, Hoq F, Lang H, Wang Y, Hanley PJ, Dome JS, Bollard CM, Meany HJ.

J Clin Oncol. 2019 Sep 10;37(26):2349-2359. doi: 10.1200/JCO.19.00177. Epub 2019 Jul 29.


Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients.

Abraham AA, John TD, Keller MD, Cruz CRN, Salem B, Roesch L, Liu H, Hoq F, Grilley BJ, Gee AP, Dave H, Jacobsohn DA, Krance RA, Shpall EJ, Martinez CA, Hanley PJ, Bollard CM.

Blood Adv. 2019 Jul 23;3(14):2057-2068. doi: 10.1182/bloodadvances.2019000201. Erratum in: Blood Adv. 2019 Aug 27;3(16):2453.


Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer.

Patel S, Burga RA, Powell AB, Chorvinsky EA, Hoq N, McCormack SE, Van Pelt SN, Hanley PJ, Cruz CRY.

Front Oncol. 2019 Apr 10;9:196. doi: 10.3389/fonc.2019.00196. eCollection 2019. Review.


Engineering the TGFβ Receptor to Enhance the Therapeutic Potential of Natural Killer Cells as an Immunotherapy for Neuroblastoma.

Burga RA, Yvon E, Chorvinsky E, Fernandes R, Cruz CRY, Bollard CM.

Clin Cancer Res. 2019 Jul 15;25(14):4400-4412. doi: 10.1158/1078-0432.CCR-18-3183. Epub 2019 Apr 22.


Differential Expression of Wilms' Tumor Protein in Diffuse Intrinsic Pontine Glioma.

Lee S, Kambhampati M, Yadavilli S, Gordish-Dressman H, Santi M, Cruz CR, Packer RJ, Almira-Suarez MI, Hwang EI, Nazarian J.

J Neuropathol Exp Neurol. 2019 May 1;78(5):380-388. doi: 10.1093/jnen/nlz021.


Mycobacteria-Specific T Cells May Be Expanded From Healthy Donors and Are Near Absent in Primary Immunodeficiency Disorders.

Patel S, Lang H, Sani G, Freeman AF, Leiding J, Hanley PJ, Cruz CR, Grant M, Wang Y, Oshrine B, Palmer C, Holland SM, Bollard CM, Keller MD.

Front Immunol. 2019 Mar 29;10:621. doi: 10.3389/fimmu.2019.00621. eCollection 2019.


HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals.

Sung JA, Patel S, Clohosey ML, Roesch L, Tripic T, Kuruc JD, Archin N, Hanley PJ, Cruz CR, Goonetilleke N, Eron JJ, Rooney CM, Gay CL, Bollard CM, Margolis DM.

Mol Ther. 2018 Oct 3;26(10):2496-2506. doi: 10.1016/j.ymthe.2018.08.015. Epub 2018 Sep 21.


A New Method for Reactivating and Expanding T Cells Specific for Rhizopus oryzae.

Castillo P, Wright KE, Kontoyiannis DP, Walsh T, Patel S, Chorvinsky E, Bose S, Hazrat Y, Omer B, Albert N, Leen AM, Rooney CM, Bollard CM, Cruz CRY.

Mol Ther Methods Clin Dev. 2018 Mar 14;9:305-312. doi: 10.1016/j.omtm.2018.03.003. eCollection 2018 Jun 15.


HIV-Specific T Cells Generated from Naive T Cells Suppress HIV In Vitro and Recognize Wide Epitope Breadths.

Patel S, Chorvinsky E, Albihani S, Cruz CR, Jones RB, Shpall EJ, Margolis DM, Ambinder RF, Bollard CM.

Mol Ther. 2018 Jun 6;26(6):1435-1446. doi: 10.1016/j.ymthe.2018.04.009. Epub 2018 Apr 12.


Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.

Huang SH, Ren Y, Thomas AS, Chan D, Mueller S, Ward AR, Patel S, Bollard CM, Cruz CR, Karandish S, Truong R, Macedo AB, Bosque A, Kovacs C, Benko E, Piechocka-Trocha A, Wong H, Jeng E, Nixon DF, Ho YC, Siliciano RF, Walker BD, Jones RB.

J Clin Invest. 2018 Feb 1;128(2):876-889. doi: 10.1172/JCI97555. Epub 2018 Jan 22.


Human papilloma virus-specific T cells can be generated from naïve T cells for use as an immunotherapeutic strategy for immunocompromised patients.

McCormack SE, Cruz CRY, Wright KE, Powell AB, Lang H, Trimble C, Keller MD, Fuchs E, Bollard CM.

Cytotherapy. 2018 Mar;20(3):385-393. doi: 10.1016/j.jcyt.2017.11.010. Epub 2018 Jan 10.


Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma.

Bollard CM, Tripic T, Cruz CR, Dotti G, Gottschalk S, Torrano V, Dakhova O, Carrum G, Ramos CA, Liu H, Wu MF, Marcogliese AN, Barese C, Zu Y, Lee DY, O'Connor O, Gee AP, Brenner MK, Heslop HE, Rooney CM.

J Clin Oncol. 2018 Apr 10;36(11):1128-1139. doi: 10.1200/JCO.2017.74.3179. Epub 2018 Jan 9.


Toward a Rapid Production of Multivirus-Specific T Cells Targeting BKV, Adenovirus, CMV, and EBV from Umbilical Cord Blood.

Dave H, Luo M, Blaney JW, Patel S, Barese C, Cruz CR, Shpall EJ, Bollard CM, Hanley PJ.

Mol Ther Methods Clin Dev. 2017 Mar 8;5:13-21. doi: 10.1016/j.omtm.2017.02.001. eCollection 2017 Jun 16.


HIV Receives a "One Two Knockout Punch".

Cruz CR, Bollard CM.

Mol Ther. 2017 Mar 1;25(3):566-567. doi: 10.1016/j.ymthe.2017.02.001. Epub 2017 Feb 8. No abstract available.


Cord blood natural killer cells expressing a dominant negative TGF-β receptor: Implications for adoptive immunotherapy for glioblastoma.

Yvon ES, Burga R, Powell A, Cruz CR, Fernandes R, Barese C, Nguyen T, Abdel-Baki MS, Bollard CM.

Cytotherapy. 2017 Mar;19(3):408-418. doi: 10.1016/j.jcyt.2016.12.005. Epub 2017 Jan 19.


Prussian blue nanoparticle-based photothermal therapy combined with checkpoint inhibition for photothermal immunotherapy of neuroblastoma.

Cano-Mejia J, Burga RA, Sweeney EE, Fisher JP, Bollard CM, Sandler AD, Cruz CRY, Fernandes R.

Nanomedicine. 2017 Feb;13(2):771-781. doi: 10.1016/j.nano.2016.10.015. Epub 2016 Nov 5.


Human parainfluenza virus-3 can be targeted by rapidly ex vivo expanded T lymphocytes.

McLaughlin LP, Lang H, Williams E, Wright KE, Powell A, Cruz CR, Colberg-Poley AM, Barese C, Hanley PJ, Bollard CM, Keller MD.

Cytotherapy. 2016 Dec;18(12):1515-1524. doi: 10.1016/j.jcyt.2016.08.010. Epub 2016 Sep 28.


Gene-modified, cell-based therapies-an overview.

Powell AB, Williams K, Cruz CRY.

Cytotherapy. 2016 Nov;18(11):1351-1359. doi: 10.1016/j.jcyt.2016.09.001. Review. No abstract available.



Cruz CRY, Andreeff M, Barrett J.

Cytotherapy. 2016 Nov;18(11):1349-1350. doi: 10.1016/j.jcyt.2016.09.004. Epub 2016 Sep 26. No abstract available.


Gene Modification of Human Natural Killer Cells Using a Retroviral Vector.

Kellner JN, Cruz CR, Bollard CM, Yvon ES.

Methods Mol Biol. 2016;1441:203-13. doi: 10.1007/978-1-4939-3684-7_17.


PAP Treatment Discontinuation: a Sign of OSA Improve after Bariatric Surgery?

da Cruz CR, Santos PR, Rodriguez AM.

Obes Surg. 2016 Jul;26(7):1584-5. doi: 10.1007/s11695-016-2170-8. No abstract available.


Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes.

Naik S, Nicholas SK, Martinez CA, Leen AM, Hanley PJ, Gottschalk SM, Rooney CM, Hanson IC, Krance RA, Shpall EJ, Cruz CR, Amrolia P, Lucchini G, Bunin N, Heimall J, Klein OR, Gennery AR, Slatter MA, Vickers MA, Orange JS, Heslop HE, Bollard CM, Keller MD.

J Allergy Clin Immunol. 2016 May;137(5):1498-1505.e1. doi: 10.1016/j.jaci.2015.12.1311. Epub 2016 Feb 24.


Comparison of the patient and partner satisfaction with 700CX and Titan penile prostheses.

Otero JR, Cruz CR, Gómez BG, Geli JS, Polo JM, Castañé ER, Antolín AR.

Asian J Androl. 2017 May-Jun;19(3):321-325. doi: 10.4103/1008-682X.172822.


Functionally Active HIV-Specific T Cells that Target Gag and Nef Can Be Expanded from Virus-Naïve Donors and Target a Range of Viral Epitopes: Implications for a Cure Strategy after Allogeneic Hematopoietic Stem Cell Transplantation.

Patel S, Lam S, Cruz CR, Wright K, Cochran C, Ambinder RF, Bollard CM.

Biol Blood Marrow Transplant. 2016 Mar;22(3):536-41. doi: 10.1016/j.bbmt.2015.12.007. Epub 2015 Dec 22.


Adoptive Immunotherapy For Leukemia With Ex vivo Expanded T Cells.

Cruz CR, Bollard CM.

Curr Drug Targets. 2017;18(3):271-280. doi: 10.2174/1389450117666160209143529. Review.


Adoptive T-cell therapies for refractory/relapsed leukemia and lymphoma: current strategies and recent advances.

McLaughlin L, Cruz CR, Bollard CM.

Ther Adv Hematol. 2015 Dec;6(6):295-307. doi: 10.1177/2040620715594736. Review.


Adoptive transfer of Aspergillus-specific T cells as a novel anti-fungal therapy for hematopoietic stem cell transplant recipients: Progress and challenges.

Papadopoulou A, Kaloyannidis P, Yannaki E, Cruz CR.

Crit Rev Oncol Hematol. 2016 Feb;98:62-72. doi: 10.1016/j.critrevonc.2015.10.005. Epub 2015 Oct 20. Review.


A closer look at chimeric antigen receptor specificity.

Cruz CR.

Cytotherapy. 2014 Oct;16(10):1323-4. doi: 10.1016/j.jcyt.2014.08.002. Epub 2014 Sep 16. No abstract available.


CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo.

Hanley PJ, Melenhorst JJ, Nikiforow S, Scheinberg P, Blaney JW, Demmler-Harrison G, Cruz CR, Lam S, Krance RA, Leung KS, Martinez CA, Liu H, Douek DC, Heslop HE, Rooney CM, Shpall EJ, Barrett AJ, Rodgers JR, Bollard CM.

Sci Transl Med. 2015 Apr 29;7(285):285ra63. doi: 10.1126/scitranslmed.aaa2546. Erratum in: Sci Transl Med. 2016 Jan 13;8(321):321er1.


Acute gastroenteritis and enteric viruses in hospitalised children in southern Brazil: aetiology, seasonality and clinical outcomes.

Raboni SM, Damasio GA, Ferreira CE, Pereira LA, Nogueira MB, Vidal LR, Cruz CR, Almeida SM.

Mem Inst Oswaldo Cruz. 2014 Jul;109(4):428-35.


Low rate of infusional toxicity after expanded cord blood transplantation.

Bear AS, Hanley PJ, Bosque DM, Cruz CR, Kaur I, Liu H, Kebriaei P, Hosing C, Rezvani K, Oran B, De Lima MJ, Bollard CM, Shpall EJ.

Cytotherapy. 2014 Aug;16(8):1153-7. doi: 10.1016/j.jcyt.2013.12.011. Epub 2014 Feb 28.


Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study.

Cruz CR, Micklethwaite KP, Savoldo B, Ramos CA, Lam S, Ku S, Diouf O, Liu E, Barrett AJ, Ito S, Shpall EJ, Krance RA, Kamble RT, Carrum G, Hosing CM, Gee AP, Mei Z, Grilley BJ, Heslop HE, Rooney CM, Brenner MK, Bollard CM, Dotti G.

Blood. 2013 Oct 24;122(17):2965-73. doi: 10.1182/blood-2013-06-506741. Epub 2013 Sep 12. Erratum in: Blood. 2014 May 22;123(21):3364.


Robust T cell responses to aspergillosis in chronic granulomatous disease: implications for immunotherapy.

Cruz CR, Lam S, Hanley PJ, Bear AS, Langston C, Cohen AJ, Liu H, Martinez CA, Krance RA, Heslop HE, Rooney CM, Hanson IC, Bollard CM.

Clin Exp Immunol. 2013 Oct;174(1):89-96. doi: 10.1111/cei.12156.


Molecular characterization of rotavirus genotypes in immunosuppressed and non-immunosuppressed pediatric patients.

Pereira LA, Ferreira CE, Turchetto GD, Nogueira MB, Vidal LR, Cruz CR, Debur MC, Almeida SM, Raboni SM.

J Pediatr (Rio J). 2013 May-Jun;89(3):278-85. doi: 10.1016/j.jped.2012.11.002. Epub 2013 Apr 26.


Memória fonológica em crianças bilíngues bimodais e crianças com implante coclear.

de Quadros RM, Cruz CR, Pizzio AL.

Rev Virtual Estud Ling. 2012;10(19):185-212. Portuguese.


Childhood acute bacterial meningitis: risk factors for acute neurological complications and neurological sequelae.

Antoniuk SA, Hamdar F, Ducci RD, Kira AT, Cat MN, Cruz CR.

J Pediatr (Rio J). 2011 Nov-Dec;87(6):535-40. doi: 10.2223/JPED.2138.


T cells as vehicles for cancer vaccination.

Bear AS, Cruz CR, Foster AE.

J Biomed Biotechnol. 2011;2011:417403. doi: 10.1155/2011/417403. Epub 2011 Oct 27. Review.


Inducible apoptosis as a safety switch for adoptive cell therapy.

Di Stasi A, Tey SK, Dotti G, Fujita Y, Kennedy-Nasser A, Martinez C, Straathof K, Liu E, Durett AG, Grilley B, Liu H, Cruz CR, Savoldo B, Gee AP, Schindler J, Krance RA, Heslop HE, Spencer DM, Rooney CM, Brenner MK.

N Engl J Med. 2011 Nov 3;365(18):1673-83. doi: 10.1056/NEJMoa1106152.


Histomorphometric and immunohistochemical analysis of infectious agents, T-cell subpopulations and inflammatory adhesion molecules in placentas from HIV-seropositive pregnant women.

Baurakiades E, Martins AP, Victor Moreschi N, Souza CD, Abujamra K, Saito AO, Mecatti MC, Santos MG, Pimentel CR, Silva LL, Cruz CR, de Noronha L.

Diagn Pathol. 2011 Oct 24;6:101. doi: 10.1186/1746-1596-6-101.


Cytotoxic T lymphocytes simultaneously targeting multiple tumor-associated antigens to treat EBV negative lymphoma.

Gerdemann U, Katari U, Christin AS, Cruz CR, Tripic T, Rousseau A, Gottschalk SM, Savoldo B, Vera JF, Heslop HE, Brenner MK, Bollard CM, Rooney CM, Leen AM.

Mol Ther. 2011 Dec;19(12):2258-68. doi: 10.1038/mt.2011.167. Epub 2011 Sep 13.


Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4.

Cruz CR, Gerdemann U, Leen AM, Shafer JA, Ku S, Tzou B, Horton TM, Sheehan A, Copeland A, Younes A, Rooney CM, Heslop HE, Bollard CM.

Clin Cancer Res. 2011 Nov 15;17(22):7058-66. doi: 10.1158/1078-0432.CCR-11-1873. Epub 2011 Sep 9. Erratum in: Clin Cancer Res. 2012 Feb 1;18(3):913. Dosage error in article text.


Seroprevalence of hepatitis A in children and adolescents.

Markus JR, Cruz CR, Maluf EM, Tahan TT, Hoffmann MM.

J Pediatr (Rio J). 2011 Sep-Oct;87(5):419-24. doi: 10.2223/JPED.2119. Epub 2011 Aug 12. English, Portuguese.


Expansion of T cells targeting multiple antigens of cytomegalovirus, Epstein-Barr virus and adenovirus to provide broad antiviral specificity after stem cell transplantation.

Hanley PJ, Shaffer DR, Cruz CR, Ku S, Tzou B, Liu H, Demmler-Harrison G, Heslop HE, Rooney CM, Gottschalk S, Bollard CM.

Cytotherapy. 2011 Sep;13(8):976-86. doi: 10.3109/14653249.2011.575356. Epub 2011 May 4.


Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil.

Raboni SM, Stella V, Cruz CR, França JB, Moreira S, Gonçalves L, Nogueira MB, Vidal LR, Almeida SM, Debur MC, Carraro H Jr, dos Santos CN.

J Clin Microbiol. 2011 Apr;49(4):1287-93. doi: 10.1128/JCM.02205-10. Epub 2011 Jan 19.


Adenovirus respiratory infection: significant increase in diagnosis using PCR comparing with antigen detection and culture methods.

Stroparo E, Cruz CR, Debur Mdo C, Vidal LR, Nogueira MB, Almeida SM, Pereira LA, Rotta I, Raboni SM.

Rev Inst Med Trop Sao Paulo. 2010 Nov-Dec;52(6):317-21.


An inflammatory reaction surrounding molluscum contagiosum as possible manifestation of immune reconstitution inflammatory syndrome in HIV infection.

de Carvalho VO, Cruz CR, Noronha L, Abagge KT, Lima HC.

Pediatr Dermatol. 2010 Nov-Dec;27(6):631-4. doi: 10.1111/j.1525-1470.2010.01322.x. Epub 2010 Nov 16.


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