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Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites.

Stewart CJR, Crum CP, McCluggage WG, Park KJ, Rutgers JK, Oliva E, Malpica A, Parkash V, Matias-Guiu X, Ronnett BM.

Int J Gynecol Pathol. 2019 Jan;38 Suppl 1:S75-S92. doi: 10.1097/PGP.0000000000000553.


High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations.

Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA.

Int J Gynecol Pathol. 2019 Jan;38 Suppl 1:S40-S63. doi: 10.1097/PGP.0000000000000491.


The fallopian tube, "precursor escape" and narrowing the knowledge gap to the origins of high-grade serous carcinoma.

Soong TR, Howitt BE, Horowitz N, Nucci MR, Crum CP.

Gynecol Oncol. 2019 Feb;152(2):426-433. doi: 10.1016/j.ygyno.2018.11.033. Epub 2018 Nov 30. Review.


Back to the Future? The Fallopian Tube, Precursor Escape and a Dualistic Model of High-Grade Serous Carcinogenesis.

Soong TR, Kolin DL, Teschan NJ, Crum CP.

Cancers (Basel). 2018 Nov 28;10(12). pii: E468. doi: 10.3390/cancers10120468.


Frontiers in the Pathology and Pathogenesis of Ovarian Cancer: Cancer Precursors and "Precursor Escape".

Soong TR, Dinulescu DM, Xian W, Crum CP.

Hematol Oncol Clin North Am. 2018 Dec;32(6):915-928. doi: 10.1016/j.hoc.2018.07.013. Review.


HPV 6-associated HSIL/Squamous Carcinoma in the Anogenital Tract.

Liu MZ, Hung YP, Huang EC, Howitt BE, Nucci MR, Crum CP.

Int J Gynecol Pathol. 2018 Oct 11. doi: 10.1097/PGP.0000000000000556. [Epub ahead of print]


An Efficient Method for Cloning Gastrointestinal Stem Cells From Patients via Endoscopic Biopsies.

Duleba M, Qi Y, Mahalingam R, Liew AA, Neupane R, Flynn K, Rinaldi F, Vincent M, Crum CP, Ho KY, Hou JK, Hyams JS, Sylvester FA, McKeon F, Xian W.

Gastroenterology. 2019 Jan;156(1):20-23. doi: 10.1053/j.gastro.2018.08.062. Epub 2018 Oct 6. No abstract available.


Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.

Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ Jr, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D'Andrea AD.

Cancer Discov. 2018 Nov;8(11):1404-1421. doi: 10.1158/2159-8290.CD-18-0474. Epub 2018 Sep 13.


Targeted Genomic Profiling of Female Adnexal Tumors of Probable Wolffian Origin (FATWO).

Mirkovic J, Dong F, Sholl LM, Garcia E, Lindeman N, MacConaill L, Crum CP, Nucci MR, McCluggage WG, Howitt BE.

Int J Gynecol Pathol. 2018 Aug 21. doi: 10.1097/PGP.0000000000000545. [Epub ahead of print]


Surgical prevention strategies in ovarian cancer.

Mallen A, Soong TR, Townsend MK, Wenham RM, Crum CP, Tworoger SS.

Gynecol Oncol. 2018 Oct;151(1):166-175. doi: 10.1016/j.ygyno.2018.08.005. Epub 2018 Aug 4. Review.


Evidence for lineage continuity between early serous proliferations (ESPs) in the Fallopian tube and disseminated high-grade serous carcinomas.

Soong TR, Howitt BE, Miron A, Horowitz NS, Campbell F, Feltmate CM, Muto MG, Berkowitz RS, Nucci MR, Xian W, Crum CP.

J Pathol. 2018 Nov;246(3):344-351. doi: 10.1002/path.5145. Epub 2018 Sep 27.


Evidence of a Monoclonal Origin for Bilateral Serous Tubal Intraepithelial Neoplasia.

Meserve EE, Strickland KC, Miron A, Soong TR, Campbell F, Howitt BE, Crum CP.

Int J Gynecol Pathol. 2018 Jun 12. doi: 10.1097/PGP.0000000000000534. [Epub ahead of print]


Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia.

Watkins JC, Yang E, Crum CP, Herfs M, Gheit T, Tommasino M, Nucci MR.

Int J Gynecol Pathol. 2019 Mar;38(2):175-182. doi: 10.1097/PGP.0000000000000509.


Assessment of a Chemotherapy Response Score (CRS) System for Tubo-Ovarian High-Grade Serous Carcinoma (HGSC).

Ditzel HM, Strickland KC, Meserve EE, Stover E, Konstantinopoulos PA, Matulonis UA, Muto MG, Liu JF, Feltmate C, Horowitz N, Berkowitz RS, Gupta M, Hecht JL, Lin DI, Jochumsen KM, Welch WR, Hirsch MS, Quade BJ, Lee KR, Crum CP, Mutter GL, Nucci MR, Howitt BE.

Int J Gynecol Pathol. 2018 May 10. doi: 10.1097/PGP.0000000000000513. [Epub ahead of print]


SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma.

Kolin DL, Dong F, Baltay M, Lindeman N, MacConaill L, Nucci MR, Crum CP, Howitt BE.

Mod Pathol. 2018 Sep;31(9):1442-1456. doi: 10.1038/s41379-018-0049-z. Epub 2018 Apr 26.


A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

Herfs M, Roncarati P, Koopmansch B, Peulen O, Bruyere D, Lebeau A, Hendrick E, Hubert P, Poncin A, Penny W, Piazzon N, Monnien F, Guenat D, Mougin C, Prétet JL, Vuitton L, Segers K, Lambert F, Bours V, de Leval L, Valmary-Degano S, Quick CM, Crum CP, Delvenne P.

Br J Cancer. 2018 May;118(10):1302-1312. doi: 10.1038/s41416-018-0049-2. Epub 2018 Apr 27.


Origin of clear cell carcinoma: nature or nurture?

Kolin DL, Dinulescu DM, Crum CP.

J Pathol. 2018 Feb;244(2):131-134. doi: 10.1002/path.5009. Epub 2018 Jan 2.


Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer.

Elias KM, Fendler W, Stawiski K, Fiascone SJ, Vitonis AF, Berkowitz RS, Frendl G, Konstantinopoulos P, Crum CP, Kedzierska M, Cramer DW, Chowdhury D.

Elife. 2017 Oct 31;6. pii: e28932. doi: 10.7554/eLife.28932.


Targeted Genomic Profiling Reveals Recurrent KRAS Mutations in Mesonephric-like Adenocarcinomas of the Female Genital Tract.

Mirkovic J, McFarland M, Garcia E, Sholl LM, Lindeman N, MacConaill L, Dong F, Hirsch M, Nucci MR, Quick CM, Crum CP, McCluggage WG, Howitt BE.

Am J Surg Pathol. 2018 Feb;42(2):227-233. doi: 10.1097/PAS.0000000000000958.


Identification of ALK Rearrangements in Malignant Peritoneal Mesothelioma.

Hung YP, Dong F, Watkins JC, Nardi V, Bueno R, Dal Cin P, Godleski JJ, Crum CP, Chirieac LR.

JAMA Oncol. 2018 Feb 1;4(2):235-238. doi: 10.1001/jamaoncol.2017.2918.


Comprehensive Human Papillomavirus Genotyping in Cervical Squamous Cell Carcinomas and Its Relevance to Cervical Cancer Prevention in Malawian Women.

Howitt BE, Herfs M, Tomoka T, Kamiza S, Gheit T, Tommasino M, Delvenne P, Crum CP, Milner D.

J Glob Oncol. 2016 Aug 10;3(3):227-234. doi: 10.1200/JGO.2015.001909. eCollection 2017 Jun.


Epidermodysplasia Verruciformis-like HPV Infection of the Vulva in Immunosuppressed Women.

Pohthipornthawat N, Feldman S, Granter SR, Laga AC, Crum CP, Herfs M.

Int J Gynecol Pathol. 2018 May;37(3):233-238. doi: 10.1097/PGP.0000000000000417.


Frequency of "incidental" serous tubal intraepithelial carcinoma (STIC) in women without a history of or genetic risk factor for high-grade serous carcinoma: A six-year study.

Meserve EEK, Mirkovic J, Conner JR, Yang E, Muto MG, Horowitz N, Strickland KC, Howitt BE, Crum CP.

Gynecol Oncol. 2017 Jul;146(1):69-73. doi: 10.1016/j.ygyno.2017.04.015. Epub 2017 May 4.


Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis.

Herfs M, Soong TR, Delvenne P, Crum CP.

Viruses. 2017 Apr 20;9(4). pii: E85. doi: 10.3390/v9040085. Review.


Iron addiction: a novel therapeutic target in ovarian cancer.

Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV.

Oncogene. 2017 Jul 20;36(29):4089-4099. doi: 10.1038/onc.2017.11. Epub 2017 Mar 20.


Serous tubal intraepithelial neoplasia: the concept and its application.

Meserve EEK, Brouwer J, Crum CP.

Mod Pathol. 2017 May;30(5):710-721. doi: 10.1038/modpathol.2016.238. Epub 2017 Jan 20. Review.


Proteomic signatures reveal a dualistic and clinically relevant classification of anal canal carcinoma.

Herfs M, Longuespée R, Quick CM, Roncarati P, Suarez-Carmona M, Hubert P, Lebeau A, Bruyere D, Mazzucchelli G, Smargiasso N, Baiwir D, Lai K, Dunn A, Obregon F, Yang EJ, Pauw E, Crum CP, Delvenne P.

J Pathol. 2017 Mar;241(4):522-533. doi: 10.1002/path.4858. Epub 2017 Jan 27.


Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA.

Watkins JC, Howitt BE, Horowitz NS, Ritterhouse LL, Dong F, MacConaill LE, Garcia E, Lindeman NI, Lee LJ, Berkowitz RS, Nucci MR, Crum CP.

Mod Pathol. 2017 Mar;30(3):448-458. doi: 10.1038/modpathol.2016.187. Epub 2016 Nov 11.


Universal Screening for Mismatch-Repair Deficiency in Endometrial Cancers to Identify Patients With Lynch Syndrome and Lynch-like Syndrome.

Watkins JC, Yang EJ, Muto MG, Feltmate CM, Berkowitz RS, Horowitz NS, Syngal S, Yurgelun MB, Chittenden A, Hornick JL, Crum CP, Sholl LM, Howitt BE.

Int J Gynecol Pathol. 2017 Mar;36(2):115-127. doi: 10.1097/PGP.0000000000000312.


p16ink4 and cytokeratin 7 immunostaining in predicting HSIL outcome for low-grade squamous intraepithelial lesions: a case series, literature review and commentary.

Huang EC, Tomic MM, Hanamornroongruang S, Meserve EE, Herfs M, Crum CP.

Mod Pathol. 2016 Dec;29(12):1501-1510. doi: 10.1038/modpathol.2016.141. Epub 2016 Aug 12. Review.


Vestibular Mast Cell Density in Vulvodynia: A Case-Controlled Study.

Papoutsis D, Haefner HK, Crum CP, Opipari AW Jr, Reed BD.

J Low Genit Tract Dis. 2016 Jul;20(3):275-9. doi: 10.1097/LGT.0000000000000221.


Rationale for Developing a Specimen Bank to Study the Pathogenesis of High-Grade Serous Carcinoma: A Review of the Evidence.

Sherman ME, Drapkin RI, Horowitz NS, Crum CP, Friedman S, Kwon JS, Levine DA, Shih IeM, Shoupe D, Swisher EM, Walker J, Trabert B, Greene MH, Samimi G, Temkin SM, Minasian LM.

Cancer Prev Res (Phila). 2016 Sep;9(9):713-20. doi: 10.1158/1940-6207.CAPR-15-0384. Epub 2016 May 24. Review.


Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas.

Ritterhouse LL, Nowak JA, Strickland KC, Garcia EP, Jia Y, Lindeman NI, Macconaill LE, Konstantinopoulos PA, Matulonis UA, Liu J, Berkowitz RS, Nucci MR, Crum CP, Sholl LM, Howitt BE.

Mod Pathol. 2016 Aug;29(8):893-903. doi: 10.1038/modpathol.2016.82. Epub 2016 May 6.


Genetic Basis for PD-L1 Expression in Squamous Cell Carcinomas of the Cervix and Vulva.

Howitt BE, Sun HH, Roemer MG, Kelley A, Chapuy B, Aviki E, Pak C, Connelly C, Gjini E, Shi Y, Lee L, Viswanathan A, Horowitz N, Neuberg D, Crum CP, Lindeman NL, Kuo F, Ligon AH, Freeman GJ, Hodi FS, Shipp MA, Rodig SJ.

JAMA Oncol. 2016 Apr;2(4):518-22. doi: 10.1001/jamaoncol.2015.6326.


Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion.

Yamamoto Y, Wang X, Bertrand D, Kern F, Zhang T, Duleba M, Srivastava S, Khor CC, Hu Y, Wilson LH, Blaszyk H, Rolshud D, Teh M, Liu J, Howitt BE, Vincent M, Crum CP, Nagarajan N, Ho KY, McKeon F, Xian W.

Nat Commun. 2016 Jan 19;7:10380. doi: 10.1038/ncomms10380.


Preventing Ovarian Cancer.

Crum CP.

J Clin Oncol. 2016 Jan 10;34(2):198-9. doi: 10.1200/JCO.2015.62.9519. Epub 2015 Nov 16. No abstract available.


In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells.

Yamamoto Y, Ning G, Howitt BE, Mehra K, Wu L, Wang X, Hong Y, Kern F, Wei TS, Zhang T, Nagarajan N, Basuli D, Torti S, Brewer M, Choolani M, McKeon F, Crum CP, Xian W.

J Pathol. 2016 Mar;238(4):519-530. doi: 10.1002/path.4649. Epub 2016 Jan 9.


Stathmin 1 and p16(INK4A) are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma.

Novak M, Lester J, Karst AM, Parkash V, Hirsch MS, Crum CP, Karlan BY, Drapkin R.

Gynecol Oncol. 2015 Oct;139(1):104-11. doi: 10.1016/j.ygyno.2015.07.100. Epub 2015 Jul 20.


Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.

Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB.

Nat Commun. 2015 Jun 17;6:7419. doi: 10.1038/ncomms8419.


Cloning and variation of ground state intestinal stem cells.

Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W.

Nature. 2015 Jun 11;522(7555):173-8. doi: 10.1038/nature14484. Epub 2015 Jun 3.


Cervical cancer: squamocolumnar junction ablation--tying up loose ends?

Herfs M, Crum CP.

Nat Rev Clin Oncol. 2015 Jul;12(7):378-80. doi: 10.1038/nrclinonc.2015.104. Epub 2015 Jun 2. No abstract available.


Microanatomy of the cervical and anorectal squamocolumnar junctions: a proposed model for anatomical differences in HPV-related cancer risk.

Yang EJ, Quick MC, Hanamornroongruang S, Lai K, Doyle LA, McKeon FD, Xian W, Crum CP, Herfs M.

Mod Pathol. 2015 Jul;28(7):994-1000. doi: 10.1038/modpathol.2015.54. Epub 2015 May 15.


Carcinogenic HPV infection in the cervical squamo-columnar junction.

Mirkovic J, Howitt BE, Roncarati P, Demoulin S, Suarez-Carmona M, Hubert P, McKeon FD, Xian W, Li A, Delvenne P, Crum CP, Herfs M.

J Pathol. 2015 Jul;236(3):265-71. doi: 10.1002/path.4533. Epub 2015 Apr 27.


Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center.

Davis MR, Howitt BE, Quade BJ, Crum CP, Horowitz NS, Goldstein DP, Berkowitz RS.

Gynecol Oncol. 2015 Jun;137(3):456-61. doi: 10.1016/j.ygyno.2015.03.006. Epub 2015 Mar 12.


Ovarian cancer survival by tumor dominance, a surrogate for site of origin.

Ivanova A, Loo A, Tworoger S, Crum CP, Fan I, McLaughlin JR, Rosen B, Risch H, Narod SA, Kotsopoulos J.

Cancer Causes Control. 2015 Apr;26(4):601-8. doi: 10.1007/s10552-015-0547-y. Epub 2015 Mar 13.


Salpingectomy as a potential ovarian cancer risk-reducing procedure.

Poole EM, Rice MS, Crum CP, Tworoger SS.

J Natl Cancer Inst. 2015 Jan 27;107(2). pii: dju490. doi: 10.1093/jnci/dju490. Print 2015 Feb. No abstract available.


Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women.

Chung TK, Van Hummelen P, Chan PK, Cheung TH, Yim SF, Yu MY, Ducar MD, Thorner AR, MacConaill LE, Doran G, Pedamallu CS, Ojesina AI, Wong RR, Wang VW, Freeman SS, Lau TS, Kwong J, Chan LK, Fromer M, May T, Worley MJ Jr, Esselen KM, Elias KM, Lawrence M, Getz G, Smith DI, Crum CP, Meyerson M, Berkowitz RS, Wong YF.

Int J Cancer. 2015 Aug 15;137(4):776-83. doi: 10.1002/ijc.29456. Epub 2015 Feb 13.


Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma.

Howitt BE, Hanamornroongruang S, Lin DI, Conner JE, Schulte S, Horowitz N, Crum CP, Meserve EE.

Am J Surg Pathol. 2015 Mar;39(3):287-93. doi: 10.1097/PAS.0000000000000369.


The utility of immunohistochemistry in the differential diagnosis of gynecologic disorders.

Kaspar HG, Crum CP.

Arch Pathol Lab Med. 2015 Jan;139(1):39-54. doi: 10.5858/arpa.2014-0057-RA. Review.


p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.

Zuo W, Zhang T, Wu DZ, Guan SP, Liew AA, Yamamoto Y, Wang X, Lim SJ, Vincent M, Lessard M, Crum CP, Xian W, McKeon F.

Nature. 2015 Jan 29;517(7536):616-20. doi: 10.1038/nature13903. Epub 2014 Nov 12.


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