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Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.

Sayers SR, Beavil RL, Fine NHF, Huang GC, Choudhary P, Pacholarz KJ, Barran PE, Butterworth S, Mills CE, Cruickshank JK, Silvestre MP, Poppitt SD, McGill AT, Lavery GG, Hodson DJ, Caton PW.

Diabetologia. 2019 Nov 15. doi: 10.1007/s00125-019-05029-y. [Epub ahead of print]


Optimizing observer performance of clinic blood pressure measurement: a position statement from the Lancet Commission on Hypertension Group.

Padwal R, Campbell NRC, Schutte AE, Olsen MH, Delles C, Etyang A, Cruickshank JK, Stergiou G, Rakotz MK, Wozniak G, Jaffe MG, Benjamin I, Parati G, Sharman JE.

J Hypertens. 2019 Sep;37(9):1737-1745. doi: 10.1097/HJH.0000000000002112.


Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study.

Etyang AO, Kapesa S, Odipo E, Bauni E, Kyobutungi C, Abdalla M, Muntner P, Musani SK, Macharia A, Williams TN, Cruickshank JK, Smeeth L, Scott JAG.

J Am Heart Assoc. 2019 Mar 19;8(6):e011771. doi: 10.1161/JAHA.118.011771.


Hydrochlorothiazide and the risk of skin cancer. A scientific statement of the British and Irish Hypertension Society.

Faconti L, Ferro A, Webb AJ, Cruickshank JK, Chowienczyk PJ; British and Irish Hypertension Society.

J Hum Hypertens. 2019 Apr;33(4):257-258. doi: 10.1038/s41371-019-0190-2. Epub 2019 Mar 6. No abstract available.


Fruit and vegetable consumption and mental health across adolescence: evidence from a diverse urban British cohort study.

Huang P, O'Keeffe M, Elia C, Karamanos A, Goff LM, Maynard M, Cruickshank JK, Harding S.

Int J Behav Nutr Phys Act. 2019 Feb 8;16(1):19. doi: 10.1186/s12966-019-0780-y.


Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomized controlled VaSera trial.

Faconti L, Mills CE, Govoni V, Gu H, Morant S, Jiang B, Cruickshank JK, Webb AJ.

Br J Clin Pharmacol. 2019 Jan;85(1):169-180. doi: 10.1111/bcp.13783. Epub 2018 Nov 13.


Global cities and cultural diversity: challenges and opportunities for young people's nutrition.

Harding S, Elia C, Huang P, Atherton C, Covey K, O'Donnell G, Cole E, Almughamisi M, Read UM, Dregan A, George T, Wolfe I, Cruickshank JK, Maynard M, Goff LM, O'Keeffe M.

Proc Nutr Soc. 2018 Nov;77(4):456-469. doi: 10.1017/S0029665118000472. Epub 2018 Sep 27.


Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.

Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT, Ford I, Cruickshank JK, Caulfield MJ, Padmanabhan S, Mackenzie IS, Salsbury J, Brown MJ; British Hypertension Society programme of Prevention And Treatment of Hypertension With Algorithm based Therapy (PATHWAY) Study Group.

Lancet Diabetes Endocrinol. 2018 Jun;6(6):464-475. doi: 10.1016/S2213-8587(18)30071-8. Epub 2018 Apr 11. Erratum in: Lancet Diabetes Endocrinol. 2018 Aug;6(8):e16.


Longitudinal changes in vascular function parameters in pregnant women with chronic hypertension and association with adverse outcome: a cohort study.

Webster LM, Myers JE, Nelson-Piercy C, Mills C, Watt-Coote I, Khalil A, Seed PT, Cruickshank JK, Chappell LC.

Ultrasound Obstet Gynecol. 2019 May;53(5):638-648. doi: 10.1002/uog.19021. Epub 2019 Mar 14.


The influence of racism on cigarette smoking: Longitudinal study of young people in a British multiethnic cohort.

Read UM, Karamanos A, João Silva M, Molaodi OR, Enayat ZE, Cassidy A, Cruickshank JK, Harding S.

PLoS One. 2018 Jan 24;13(1):e0190496. doi: 10.1371/journal.pone.0190496. eCollection 2018.


Implication of Free Fatty Acids in Thrombin Generation and Fibrinolysis in Vascular Inflammation in Zucker Rats and Evolution with Aging.

Lagrange J, Didelot M, Mohamadi A, Walton LA, Bloemen S, de Laat B, Louis H, Thornton SN, Derby B, Sherratt MJ, Fève B, Challande P, Akhtar R, Cruickshank JK, Lacolley P, Regnault V.

Front Physiol. 2017 Nov 22;8:949. doi: 10.3389/fphys.2017.00949. eCollection 2017.


Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.

MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P, Mackenzie IS, Padmanabhan S, McCann GP, Salsbury J, McInnes G, Brown MJ; British Hypertension Society Programme of Prevention And Treatment of Hypertension With Algorithm‐based Therapy (PATHWAY).

J Am Heart Assoc. 2017 Nov 18;6(11). pii: e006986. doi: 10.1161/JAHA.117.006986.


Blood Pressure and Arterial Stiffness in Kenyan Adolescents With the Sickle Cell Trait.

Etyang AO, Wandabwa CK, Kapesa S, Muthumbi E, Odipo E, Wamukoya M, Ngomi N, Haregu T, Kyobutungi C, Williams TN, Makale J, Macharia A, Cruickshank JK, Smeeth L, Scott JAG.

Am J Epidemiol. 2018 Feb 1;187(2):199-205. doi: 10.1093/aje/kwx232.


Reducing Arterial Stiffness Independently of Blood Pressure: The VaSera Trial.

Mills CE, Govoni V, Faconti L, Casagrande ML, Morant SV, Webb AJ, Cruickshank JK.

J Am Coll Cardiol. 2017 Sep 26;70(13):1683-1684. doi: 10.1016/j.jacc.2017.07.765. No abstract available.


Labetalol Versus Nifedipine as Antihypertensive Treatment for Chronic Hypertension in Pregnancy: A Randomized Controlled Trial.

Webster LM, Myers JE, Nelson-Piercy C, Harding K, Cruickshank JK, Watt-Coote I, Khalil A, Wiesender C, Seed PT, Chappell LC.

Hypertension. 2017 Nov;70(5):915-922. doi: 10.1161/HYPERTENSIONAHA.117.09972. Epub 2017 Sep 11.


Longitudinal study of the influence of lung function on vascular health from adolescence to early adulthood in a British multiethnic cohort.

Lu Y, Sooky L, Silva MJ, Molaodi OR, Karamanos A, Cruickshank JK, Harding S.

J Hypertens. 2017 Nov;35(11):2185-2191. doi: 10.1097/HJH.0000000000001455.


Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia.

Etyang AO, Khayeka-Wandabwa C, Kapesa S, Muthumbi E, Odipo E, Wamukoya M, Ngomi N, Haregu T, Kyobutungi C, Tendwa M, Makale J, Macharia A, Cruickshank JK, Smeeth L, Scott JA, Williams TN.

J Am Heart Assoc. 2017 Apr 5;6(4). pii: e005613. doi: 10.1161/JAHA.117.005613.


Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization.

Sharman JE, Avolio AP, Baulmann J, Benetos A, Blacher J, Blizzard CL, Boutouyrie P, Chen CH, Chowienczyk P, Cockcroft JR, Cruickshank JK, Ferreira I, Ghiadoni L, Hughes A, Jankowski P, Laurent S, McDonnell BJ, McEniery C, Millasseau SC, Papaioannou TG, Parati G, Park JB, Protogerou AD, Roman MJ, Schillaci G, Segers P, Stergiou GS, Tomiyama H, Townsend RR, Van Bortel LM, Wang J, Wassertheurer S, Weber T, Wilkinson IB, Vlachopoulos C.

Eur Heart J. 2017 Oct 1;38(37):2805-2812. doi: 10.1093/eurheartj/ehw632. Review. No abstract available.


Longitudinal study of cardiometabolic risk from early adolescence to early adulthood in an ethnically diverse cohort.

Harding S, Silva MJ, Molaodi OR, Enayat ZE, Cassidy A, Karamanos A, Read UM, Cruickshank JK.

BMJ Open. 2016 Dec 14;6(12):e013221. doi: 10.1136/bmjopen-2016-013221.


Clinical and Epidemiological Implications of 24-Hour Ambulatory Blood Pressure Monitoring for the Diagnosis of Hypertension in Kenyan Adults: A Population-Based Study.

Etyang AO, Warne B, Kapesa S, Munge K, Bauni E, Cruickshank JK, Smeeth L, Scott JA.

J Am Heart Assoc. 2016 Dec 15;5(12). pii: e004797.


Arterial stiffness in hypertensive and type 2 diabetes patients in Ghana: comparison of the cardio-ankle vascular index and central aortic techniques.

Yeboah K, Antwi DA, Gyan B, Govoni V, Mills CE, Cruickshank JK, Amoah AG.

BMC Endocr Disord. 2016 Sep 29;16(1):53.


Birth weight was longitudinally associated with cardiometabolic risk markers in mid-adulthood.

Mzayek F, Cruickshank JK, Amoah D, Srinivasan S, Chen W, Berenson GS.

Ann Epidemiol. 2016 Sep;26(9):643-7. doi: 10.1016/j.annepidem.2016.07.013. Epub 2016 Aug 10.


2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents.

Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, Invitti C, Litwin M, Mancia G, Pall D, Rascher W, Redon J, Schaefer F, Seeman T, Sinha M, Stabouli S, Webb NJ, Wühl E, Zanchetti A.

J Hypertens. 2016 Oct;34(10):1887-920. doi: 10.1097/HJH.0000000000001039.


The Malaria-High Blood Pressure Hypothesis.

Etyang AO, Smeeth L, Cruickshank JK, Scott JA.

Circ Res. 2016 Jun 24;119(1):36-40. doi: 10.1161/CIRCRESAHA.116.308763. Epub 2016 May 5. Review.


Ethnic Differences in and Childhood Influences on Early Adult Pulse Wave Velocity: The Determinants of Adolescent, Now Young Adult, Social Wellbeing, and Health Longitudinal Study.

Cruickshank JK, Silva MJ, Molaodi OR, Enayat ZE, Cassidy A, Karamanos A, Read UM, Faconti L, Dall P, Stansfield B, Harding S.

Hypertension. 2016 Jun;67(6):1133-41. doi: 10.1161/HYPERTENSIONAHA.115.07079. Epub 2016 May 2.


A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies.

Akhtar R, Cruickshank JK, Zhao X, Derby B, Weber T.

Artery Res. 2016 Mar;13:1-5.


Maternal BMI Associations with Maternal and Cord Blood Vitamin D Levels in a North American Subset of Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Participants.

Josefson JL, Reisetter A, Scholtens DM, Price HE, Metzger BE, Langman CB; HAPO Study Cooperative Research Group.

PLoS One. 2016 Mar 4;11(3):e0150221. doi: 10.1371/journal.pone.0150221. eCollection 2016. Erratum in: PLoS One. 2016;11(4):e0153339.


Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial.

Brown MJ, Williams B, Morant SV, Webb DJ, Caulfield MJ, Cruickshank JK, Ford I, McInnes G, Sever P, Salsbury J, Mackenzie IS, Padmanabhan S, MacDonald TM; British Hypertension Society's Prevention and Treatment of Hypertension with Algorithm-based Therapy (PATHWAY) Studies Group.

Lancet Diabetes Endocrinol. 2016 Feb;4(2):136-47. doi: 10.1016/S2213-8587(15)00377-0. Epub 2015 Oct 18.


Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial.

Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I, Cruickshank JK, Caulfield MJ, Salsbury J, Mackenzie I, Padmanabhan S, Brown MJ; British Hypertension Society's PATHWAY Studies Group.

Lancet. 2015 Nov 21;386(10008):2059-2068. doi: 10.1016/S0140-6736(15)00257-3. Epub 2015 Sep 20.


Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension.

Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Salsbury J, Morant S, Ford I, Brown MJ.

BMJ Open. 2015 Aug 7;5(8):e008951. doi: 10.1136/bmjopen-2015-008951.


Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension.

Brown MJ, Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Salsbury J, Morant S, Ford I.

BMJ Open. 2015 Aug 7;5(8):e008086. doi: 10.1136/bmjopen-2015-008086.


Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial.

MacDonald TM, Williams B, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Mackenzie IS, Salsbury J, Morant S, Ford I, Brown MJ.

BMJ Open. 2015 Aug 7;5(8):e007645. doi: 10.1136/bmjopen-2015-007645.


Future Treatment of Hypertension: Shifting the Focus from Blood Pressure Lowering to Arterial Stiffness Modulation?

Fok H, Cruickshank JK.

Curr Hypertens Rep. 2015 Aug;17(8):67. doi: 10.1007/s11906-015-0569-6. Review.


Birth weight and maternal socioeconomic circumstances were inversely related to systolic blood pressure among Afro-Caribbean young adults.

Ferguson TS, Younger-Coleman NO, Tulloch-Reid MK, Knight-Madden JM, Bennett NR, Samms-Vaughan M, Ashley D, McCaw-Binns A, Molaodi OR, Cruickshank JK, Harding S, Wilks RJ.

J Clin Epidemiol. 2015 Sep;68(9):1002-9. doi: 10.1016/j.jclinepi.2015.01.026. Epub 2015 Feb 12.


Childhood obesity affects adult metabolic syndrome and diabetes.

Liang Y, Hou D, Zhao X, Wang L, Hu Y, Liu J, Cheng H, Yang P, Shan X, Yan Y, Cruickshank JK, Mi J.

Endocrine. 2015 Sep;50(1):87-92. doi: 10.1007/s12020-015-0560-7. Epub 2015 Mar 10.


Molecular phenotyping of a UK population: defining the human serum metabolome.

Dunn WB, Lin W, Broadhurst D, Begley P, Brown M, Zelena E, Vaughan AA, Halsall A, Harding N, Knowles JD, Francis-McIntyre S, Tseng A, Ellis DI, O'Hagan S, Aarons G, Benjamin B, Chew-Graham S, Moseley C, Potter P, Winder CL, Potts C, Thornton P, McWhirter C, Zubair M, Pan M, Burns A, Cruickshank JK, Jayson GC, Purandare N, Wu FC, Finn JD, Haselden JN, Nicholls AW, Wilson ID, Goodacre R, Kell DB.

Metabolomics. 2015;11:9-26. Epub 2014 Jul 25.


Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

Anderson SG, Dunn WB, Banerjee M, Brown M, Broadhurst DI, Goodacre R, Cooper GJ, Kell DB, Cruickshank JK.

PLoS One. 2014 Sep 3;9(9):e103217. doi: 10.1371/journal.pone.0103217. eCollection 2014.


Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors.

Herbert A, Cruickshank JK, Laurent S, Boutouyrie P; Reference Values for Arterial Measurements Collaboration.

Eur Heart J. 2014 Nov 21;35(44):3122-33. doi: 10.1093/eurheartj/ehu293. Epub 2014 Aug 11.


Localized micro- and nano-scale remodelling in the diabetic aorta.

Akhtar R, Cruickshank JK, Zhao X, Walton LA, Gardiner NJ, Barrett SD, Graham HK, Derby B, Sherratt MJ.

Acta Biomater. 2014 Nov;10(11):4843-4851. doi: 10.1016/j.actbio.2014.07.001. Epub 2014 Jul 9.


Haemostatic factors, lipoproteins and long-term mortality in a multi-ethnic population of Gujarati, African-Caribbean and European origin.

Anderson SG, Hutchings DC, Heald AH, Anderson CD, Sanders TA, Cruickshank JK.

Atherosclerosis. 2014 Sep;236(1):62-72. doi: 10.1016/j.atherosclerosis.2014.06.004. Epub 2014 Jun 18.


Impaired cardiovascular structure and function in adult survivors of severe acute malnutrition.

Tennant IA, Barnett AT, Thompson DS, Kips J, Boyne MS, Chung EE, Chung AP, Osmond C, Hanson MA, Gluckman PD, Segers P, Cruickshank JK, Forrester TE.

Hypertension. 2014 Sep;64(3):664-71. doi: 10.1161/HYPERTENSIONAHA.114.03230. Epub 2014 Jun 30.


Excess pressure integral predicts cardiovascular events independent of other risk factors in the conduit artery functional evaluation substudy of Anglo-Scandinavian Cardiac Outcomes Trial.

Davies JE, Lacy P, Tillin T, Collier D, Cruickshank JK, Francis DP, Malaweera A, Mayet J, Stanton A, Williams B, Parker KH, McG Thom SA, Hughes AD.

Hypertension. 2014 Jul;64(1):60-8. doi: 10.1161/HYPERTENSIONAHA.113.02838. Epub 2014 May 12.


Reference values for central blood pressure.

Weber T, Wassertheurer S, Hametner B, Herbert A, Boutouyrie P, Laurent S, Cruickshank JK.

J Am Coll Cardiol. 2014 Jun 3;63(21):2299. doi: 10.1016/j.jacc.2013.12.046. Epub 2014 Mar 5. No abstract available.


Circulating insulin-like growth factor-binding protein 3 levels, independent of insulin-like growth factor 1, associate with truncal fat and systolic blood pressure in South Asian and white European preschool children.

Patel L, Whatmore A, Davies J, Bansal N, Vyas A, Gemmell I, Oldroyd J, Cruickshank JK, Clayton P.

Horm Res Paediatr. 2014;81(2):109-17. doi: 10.1159/000355824. Epub 2013 Nov 20.


Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.

Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB.

J Am Coll Cardiol. 2014 Feb 25;63(7):636-646. doi: 10.1016/j.jacc.2013.09.063. Epub 2013 Nov 13. Review.


Differential effects of different vitamin D replacement strategies in patients with diabetes.

Alam U, Chan AW, Buazon A, Van Zeller C, Berry JL, Jugdey RS, Asghar O, Cruickshank JK, Petropoulos IN, Malik RA.

J Diabetes Complications. 2014 Jan-Feb;28(1):66-70. doi: 10.1016/j.jdiacomp.2013.09.003. Epub 2013 Oct 16.


The impact of malaria in pregnancy on changes in blood pressure in children during their first year of life.

Ayoola OO, Omotade OO, Gemmell I, Clayton PE, Cruickshank JK.

Hypertension. 2014 Jan;63(1):167-72. doi: 10.1161/HYPERTENSIONAHA.113.02238. Epub 2013 Oct 14.


Impact of diet on mortality from stroke: results from the U.S. multiethnic cohort study.

Sharma S, Cruickshank JK, Green DM, Vik S, Tome A, Kolonel LN.

J Am Coll Nutr. 2013;32(3):151-9. doi: 10.1080/07315724.2013.791798.


Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury.

Egom EE, Mamas MA, Chacko S, Stringer SE, Charlton-Menys V, El-Omar M, Chirico D, Clarke B, Neyses L, Cruickshank JK, Lei M, Fath-Ordoubadi F.

Front Physiol. 2013 Jun 13;4:130. doi: 10.3389/fphys.2013.00130. eCollection 2013.

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