Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 392



Viswanathan VK, Manoharan SRR, Crowther D.

Spine (Phila Pa 1976). 2020 Feb 1;45(3):E179. doi: 10.1097/BRS.0000000000003334. No abstract available.


Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting.

Fabre KM, Delsing L, Hicks R, Colclough N, Crowther DC, Ewart L.

Adv Drug Deliv Rev. 2019 Feb 1;140:129-135. doi: 10.1016/j.addr.2018.09.009. Epub 2018 Sep 22. Review.


Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease.

Younan ND, Chen KF, Rose RS, Crowther DC, Viles JH.

J Biol Chem. 2018 Aug 24;293(34):13090-13099. doi: 10.1074/jbc.RA118.003319. Epub 2018 Jun 10.


Central and peripheral circadian clocks and their role in Alzheimer's disease.

Chauhan R, Chen KF, Kent BA, Crowther DC.

Dis Model Mech. 2017 Oct 1;10(10):1187-1199. doi: 10.1242/dmm.030627. Review.


TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.

Thornton P, Sevalle J, Deery MJ, Fraser G, Zhou Y, Ståhl S, Franssen EH, Dodd RB, Qamar S, Gomez Perez-Nievas B, Nicol LS, Eketjäll S, Revell J, Jones C, Billinton A, St George-Hyslop PH, Chessell I, Crowther DC.

EMBO Mol Med. 2017 Oct;9(10):1366-1378. doi: 10.15252/emmm.201707673.


Type-2 diabetes-associated variants with cross-trait relevance: Post-GWAs strategies for biological function interpretation.

Frau F, Crowther D, Ruetten H, Allebrandt KV.

Mol Genet Metab. 2017 May;121(1):43-50. doi: 10.1016/j.ymgme.2017.03.004. Epub 2017 Mar 22.


Mechanistic interplay between ceramide and insulin resistance.

Reali F, Morine MJ, Kahramanoğulları O, Raichur S, Schneider HC, Crowther D, Priami C.

Sci Rep. 2017 Jan 23;7:41231. doi: 10.1038/srep41231.


CCT complex restricts neuropathogenic protein aggregation via autophagy.

Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC.

Nat Commun. 2016 Dec 8;7:13821. doi: 10.1038/ncomms13821.


Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model.

Khabirova E, Chen KF, O'Neill JS, Crowther DC.

Sci Rep. 2016 Sep 23;6:33759. doi: 10.1038/srep33759.


Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

Roussel BD, Lomas DA, Crowther DC.

Epileptic Disord. 2016 Sep 1;18(S2):103-110. Review.


Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity.

Ott S, Vishnivetskaya A, Malmendal A, Crowther DC.

Neurobiol Aging. 2016 May;41:39-52. doi: 10.1016/j.neurobiolaging.2016.01.009. Epub 2016 Feb 11.


Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems.

El-Khoury R, Kaulio E, Lassila KA, Crowther DC, Jacobs HT, Rustin P.

Free Radic Biol Med. 2016 Jul;96:57-66. doi: 10.1016/j.freeradbiomed.2016.04.006. Epub 2016 Apr 14.


IKAP: A heuristic framework for inference of kinase activities from Phosphoproteomics data.

Mischnik M, Sacco F, Cox J, Schneider HC, Schäfer M, Hendlich M, Crowther D, Mann M, Klabunde T.

Bioinformatics. 2016 Feb 1;32(3):424-31. doi: 10.1093/bioinformatics/btv699. Epub 2015 Dec 1.


Sample Size Calculations for Detecting Disease-Modifying Osteoarthritis Drug Effects on Knee Replacement Incidence in Clinical Trials: Data From the Osteoarthritis Initiative.

Ried JS, Flechsenhar K, Bartnik E, Crowther D, Dietrich A, Eckstein F.

Arthritis Rheumatol. 2015 Dec;67(12):3174-83. doi: 10.1002/art.39334.


Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer's Disease.

Lim JY, Ott S, Crowther DC.

Methods Mol Biol. 2016;1303:227-39. doi: 10.1007/978-1-4939-2627-5_13.


Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model.

Ott S, Dziadulewicz N, Crowther DC.

Dis Model Mech. 2015 Jul 1;8(7):657-67. doi: 10.1242/dmm.019042. Epub 2015 Apr 23.


The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ.

Lim JY, Reighard CP, Crowther DC.

Hum Mol Genet. 2015 Jul 15;24(14):3929-38. doi: 10.1093/hmg/ddv130. Epub 2015 May 7.


The use of fidaxomicin for treatment of relapsed Clostridium difficile infections in patients with cancer.

Esmaily-Fard A, Tverdek FP, Crowther DM, Ghantoji SS, Adachi JA, Chemaly RF.

Pharmacotherapy. 2014 Nov;34(11):1220-5. doi: 10.1002/phar.1479. Epub 2014 Aug 28.


Insights into amyloid disease from fly models.

Chen KF, Crowther DC.

Essays Biochem. 2014;56:69-83. doi: 10.1042/bse0560069.


The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

Khabirova E, Moloney A, Marciniak SJ, Williams J, Lomas DA, Oliver SG, Favrin G, Sattelle DB, Crowther DC.

PLoS One. 2014 Jul 31;9(7):e102985. doi: 10.1371/journal.pone.0102985. eCollection 2014.


Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.

Wacker J, Rönicke R, Westermann M, Wulff M, Reymann KG, Dobson CM, Horn U, Crowther DC, Luheshi LM, Fändrich M.

Acta Neuropathol Commun. 2014 Apr 11;2:43. doi: 10.1186/2051-5960-2-43.


The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster.

Hermansson E, Schultz S, Crowther D, Linse S, Winblad B, Westermark G, Johansson J, Presto J.

Dis Model Mech. 2014 Jun;7(6):659-65. doi: 10.1242/dmm.014787. Epub 2014 Mar 28.


Retro-inversal of intracellular selected β-amyloid-interacting peptides: implications for a novel Alzheimer's disease treatment.

Acerra N, Kad NM, Griffith DA, Ott S, Crowther DC, Mason JM.

Biochemistry. 2014 Apr 8;53(13):2101-11. doi: 10.1021/bi5001257. Epub 2014 Mar 21.


The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease.

Chen KF, Possidente B, Lomas DA, Crowther DC.

Dis Model Mech. 2014 Apr;7(4):445-58. doi: 10.1242/dmm.014134. Epub 2014 Feb 26.


20 years of GPnotebook: from a medical student project to a national resource.

McMorran J, Crowther D, McMorran S.

Br J Gen Pract. 2014 Feb;64(619):92-3. doi: 10.3399/bjgp14X677202. No abstract available.


Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly.

Favrin G, Bean DM, Bilsland E, Boyer H, Fischer BE, Russell S, Crowther DC, Baylis HA, Oliver SG, Giannakou ME.

Sci Rep. 2013 Dec 16;3:3512. doi: 10.1038/srep03512.


The lack of predictors for rapid progression in prostate cancer patients receiving sipuleucel-T.

Ng L, Heck W, Lavsa S, Crowther D, Atkinson B, Xiao L, Araujo J.

Cancers (Basel). 2013 May 6;5(2):511-8. doi: 10.3390/cancers5020511.


Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma (DLBCL).

Mudaliar MA, Haggart RD, Miele G, Sellar G, Tan KA, Goodlad JR, Milne E, Vail DM, Kurzman I, Crowther D, Argyle DJ.

PLoS One. 2013 Sep 4;8(9):e72591. doi: 10.1371/journal.pone.0072591. eCollection 2013.


Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity.

Kruppa AJ, Ott S, Chandraratna DS, Irving JA, Page RM, Speretta E, Seto T, Camargo LM, Marciniak SJ, Lomas DA, Crowther DC.

Biochim Biophys Acta. 2013 Dec;1832(12):2115-26. doi: 10.1016/j.bbadis.2013.07.019. Epub 2013 Aug 2.


Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

Roussel BD, Newton TM, Malzer E, Simecek N, Haq I, Thomas SE, Burr ML, Lehner PJ, Crowther DC, Marciniak SJ, Lomas DA.

Hum Mol Genet. 2013 Nov 15;22(22):4616-26. doi: 10.1093/hmg/ddt310. Epub 2013 Jun 28.


A clinician's guide to systematic reviews.

Crowther DM.

Nutr Clin Pract. 2013 Aug;28(4):459-62. doi: 10.1177/0884533613490742. Epub 2013 Jun 6.


Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies.

Wohlfart P, Linz W, Hübschle T, Linz D, Huber J, Hess S, Crowther D, Werner U, Ruetten H.

J Transl Med. 2013 Mar 28;11:84. doi: 10.1186/1479-5876-11-84.


Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development.

Malzer E, Szajewska-Skuta M, Dalton LE, Thomas SE, Hu N, Skaer H, Lomas DA, Crowther DC, Marciniak SJ.

J Cell Sci. 2013 Mar 15;126(Pt 6):1406-15. doi: 10.1242/jcs.117614. Epub 2013 Feb 15.


p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.

Thomas SE, Malzer E, Ordóñez A, Dalton LE, van 't Wout EF, Liniker E, Crowther DC, Lomas DA, Marciniak SJ.

J Biol Chem. 2013 Mar 15;288(11):7606-17. doi: 10.1074/jbc.M112.424655. Epub 2013 Jan 22.


Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology.

Lee CM, Mudaliar MA, Haggart DR, Wolf CR, Miele G, Vass JK, Higham DJ, Crowther D.

PLoS One. 2012;7(12):e48238. doi: 10.1371/journal.pone.0048238. Epub 2012 Dec 14.


Endoplasmic reticulum dysfunction in neurological disease.

Roussel BD, Kruppa AJ, Miranda E, Crowther DC, Lomas DA, Marciniak SJ.

Lancet Neurol. 2013 Jan;12(1):105-18. doi: 10.1016/S1474-4422(12)70238-7. Review.


Functional genomics in Drosophila models of human disease.

Chen KF, Crowther DC.

Brief Funct Genomics. 2012 Sep;11(5):405-15. doi: 10.1093/bfgp/els038. Epub 2012 Aug 22. Review.


Improving Pediatric Adverse Drug Event Reporting through Clinical Pharmacy Services.

Crowther DM, Buck ML, McCarthy MW, Barton VW.

J Pediatr Pharmacol Ther. 2011 Oct;16(4):285-90. doi: 10.5863/1551-6776-16.4.285.


Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity.

Speretta E, Jahn TR, Tartaglia GG, Favrin G, Barros TP, Imarisio S, Lomas DA, Luheshi LM, Crowther DC, Dobson CM.

J Biol Chem. 2012 Jun 8;287(24):20748-54. doi: 10.1074/jbc.M112.350124. Epub 2012 Mar 29.


Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival.

Thackray AM, Muhammad F, Zhang C, Di Y, Jahn TR, Landgraf M, Crowther DC, Evers JF, Bujdoso R.

Biochem J. 2012 Jun 15;444(3):487-95. doi: 10.1042/BJ20112141.


Prion-induced toxicity in PrP transgenic Drosophila.

Thackray AM, Muhammad F, Zhang C, Denyer M, Spiropoulos J, Crowther DC, Bujdoso R.

Exp Mol Pathol. 2012 Apr;92(2):194-201. doi: 10.1016/j.yexmp.2012.01.005. Epub 2012 Jan 31.


Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity.

Chaudhuri R, McSharry C, Brady J, Donnelly I, Grierson C, McGuinness S, Jolly L, Weir CJ, Messow CM, Spears M, Miele G, Nocka K, Crowther D, Thompson J, Brannigan M, Lafferty J, Sproule M, Macnee W, Connell M, Murchison JT, Shepherd MC, Feuerstein G, Miller DK, Thomson NC.

J Allergy Clin Immunol. 2012 Mar;129(3):655-663.e8. doi: 10.1016/j.jaci.2011.12.996. Epub 2012 Feb 2. Erratum in: J Allergy Clin Immunol. 2013 Jun;131(6):1716.


Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.

Costa R, Speretta E, Crowther DC, Cardoso I.

J Biol Chem. 2011 Dec 2;286(48):41647-55. doi: 10.1074/jbc.M111.274548. Epub 2011 Oct 13.


Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster.

Kumita JR, Helmfors L, Williams J, Luheshi LM, Menzer L, Dumoulin M, Lomas DA, Crowther DC, Dobson CM, Brorsson AC.

FASEB J. 2012 Jan;26(1):192-202. doi: 10.1096/fj.11-185983. Epub 2011 Sep 29.


ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism.

Murakami T, Yang SP, Xie L, Kawano T, Fu D, Mukai A, Bohm C, Chen F, Robertson J, Suzuki H, Tartaglia GG, Vendruscolo M, Kaminski Schierle GS, Chan FT, Moloney A, Crowther D, Kaminski CF, Zhen M, St George-Hyslop P.

Hum Mol Genet. 2012 Jan 1;21(1):1-9. doi: 10.1093/hmg/ddr417. Epub 2011 Sep 23.


PChopper: high throughput peptide prediction for MRM/SRM transition design.

Afzal V, Huang JT, Atrih A, Crowther DJ.

BMC Bioinformatics. 2011 Aug 15;12:338. doi: 10.1186/1471-2105-12-338.


Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours.

Weidlich S, Walsh K, Crowther D, Burczynski ME, Feuerstein G, Carey FA, Steele RJ, Wolf CR, Miele G, Smith G.

Br J Cancer. 2011 Jul 12;105(2):246-54. doi: 10.1038/bjc.2011.197. Epub 2011 Jun 28.


The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster.

Kohlhoff KJ, Jahn TR, Lomas DA, Dobson CM, Crowther DC, Vendruscolo M.

Integr Biol (Camb). 2011 Jul;3(7):755-60. doi: 10.1039/c0ib00149j. Epub 2011 Jun 23.


Modeling serpin conformational diseases in Drosophila melanogaster.

Jahn TR, Malzer E, Roote J, Vishnivetskaya A, Imarisio S, Giannakou M, Panser K, Marciniak S, Crowther DC.

Methods Enzymol. 2011;499:227-58. doi: 10.1016/B978-0-12-386471-0.00012-2.


Unravelling the twists and turns of the serpinopathies.

Roussel BD, Irving JA, Ekeowa UI, Belorgey D, Haq I, Ordóñez A, Kruppa AJ, Duvoix A, Rashid ST, Crowther DC, Marciniak SJ, Lomas DA.

FEBS J. 2011 Oct;278(20):3859-67. doi: 10.1111/j.1742-4658.2011.08201.x. Epub 2011 Jun 20. Review.

Supplemental Content

Loading ...
Support Center