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Items: 1 to 50 of 68

1.

Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease.

Taylor HN, Warner EE, Armbrust MJ, Crowley VM, Olsen KJ, Jackson RN.

RNA Biol. 2019 Jun 28:1-10. doi: 10.1080/15476286.2019.1634965. [Epub ahead of print]

PMID:
31232162
2.

The Proteome-Wide Potential for Reversible Covalency at Cysteine.

Senkane K, Vinogradova EV, Suciu RM, Crowley VM, Zaro BW, Bradshaw JM, Brameld KA, Cravatt BF.

Angew Chem Int Ed Engl. 2019 Aug 12;58(33):11385-11389. doi: 10.1002/anie.201905829. Epub 2019 Jul 5.

PMID:
31222866
3.

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16.

Zhang X, Crowley VM, Wucherpfennig TG, Dix MM, Cravatt BF.

Nat Chem Biol. 2019 Jul;15(7):737-746. doi: 10.1038/s41589-019-0279-5. Epub 2019 Jun 17.

PMID:
31209349
4.

The influence of dietary supplementation with cranberry tablets on the urinary risk factors for nephrolithiasis.

Redmond EJ, Murphy CF, Leonard J, Faulds K, Abdelfadil S, Crowley VE, Lynch TH, Manecksha RP.

World J Urol. 2019 Mar;37(3):561-566. doi: 10.1007/s00345-018-2344-1. Epub 2018 Jul 23.

PMID:
30039387
5.

Endothelial Activation: The Ang/Tie Axis in Sepsis.

Leligdowicz A, Richard-Greenblatt M, Wright J, Crowley VM, Kain KC.

Front Immunol. 2018 Apr 24;9:838. doi: 10.3389/fimmu.2018.00838. eCollection 2018. Review.

6.

Undetectable high-density lipoprotein cholesterol in acute malaria.

Rakovac Tisdall A, Crowley VEF, Crook MA.

J Clin Lipidol. 2018 May - Jun;12(3):822-825. doi: 10.1016/j.jacl.2018.02.019. Epub 2018 Mar 9.

PMID:
29609858
7.

Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.

Que NLS, Crowley VM, Duerfeldt AS, Zhao J, Kent CN, Blagg BSJ, Gewirth DT.

J Med Chem. 2018 Apr 12;61(7):2793-2805. doi: 10.1021/acs.jmedchem.7b01608. Epub 2018 Mar 20.

8.

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.

Huard DJE, Crowley VM, Du Y, Cordova RA, Sun Z, Tomlin MO, Dickey CA, Koren J 3rd, Blair L, Fu H, Blagg BSJ, Lieberman RL.

ACS Chem Biol. 2018 Apr 20;13(4):933-941. doi: 10.1021/acschembio.7b01083. Epub 2018 Feb 20.

9.

Adjunctive therapy for severe malaria: a review and critical appraisal.

Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Kain KC, Bassat Q.

Malar J. 2018 Jan 24;17(1):47. doi: 10.1186/s12936-018-2195-7. Review.

10.

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.

Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J 3rd, Dickey CA.

Sci Rep. 2017 Dec 20;7(1):17951. doi: 10.1038/s41598-017-18344-4.

11.

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria.

Crowley VM, Ayi K, Lu Z, Liby KT, Sporn M, Kain KC.

Malar J. 2017 Nov 14;16(1):463. doi: 10.1186/s12936-017-2109-0.

12.

Resorcinol-Based Grp94-Selective Inhibitors.

Khandelwal A, Crowley VM, Blagg BSJ.

ACS Med Chem Lett. 2017 Sep 1;8(10):1013-1018. doi: 10.1021/acsmedchemlett.7b00193. eCollection 2017 Oct 12.

13.

Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer.

Crowley VM, Huard DJE, Lieberman RL, Blagg BSJ.

Chemistry. 2017 Nov 7;23(62):15775-15782. doi: 10.1002/chem.201703398. Epub 2017 Sep 27.

14.

Verification of Abbott 25-OH-vitamin D assay on the architect system.

Hutchinson K, Healy M, Crowley V, Louw M, Rochev Y.

Pract Lab Med. 2017 Jan 17;7:27-35. doi: 10.1016/j.plabm.2017.01.001. eCollection 2017 Apr.

15.

Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria.

Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Bila R, Mucavele H, Mayor A, Bassat Q, Kain KC.

Malar J. 2017 May 23;16(1):215. doi: 10.1186/s12936-017-1858-0.

16.

The benefits of utilising geo-mapping for visualising the vitamin D status of Dublin city and the surrounding urban districts.

Laird E, Shannon T, Crowley VEF, Healy M.

Ir J Med Sci. 2017 Nov;186(4):807-813. doi: 10.1007/s11845-016-1517-4. Epub 2016 Oct 21.

PMID:
27770264
17.

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC.

Sci Transl Med. 2016 Sep 28;8(358):358ra128. doi: 10.1126/scitranslmed.aaf6812.

18.

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.

Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS.

J Med Chem. 2016 Apr 14;59(7):3471-88. doi: 10.1021/acs.jmedchem.6b00085. Epub 2016 Apr 4.

19.

Stability and accuracy of total and free PSA values in samples stored at room temperature.

Forde JC, Blake O, Crowley VE, Lynch TH.

Ir J Med Sci. 2016 Nov;185(4):989-991. Epub 2015 Oct 6.

PMID:
26443748
20.

Deciphering the principles that govern mutually exclusive expression of Plasmodium falciparum clag3 genes.

Rovira-Graells N, Crowley VM, Bancells C, Mira-Martínez S, Ribas de Pouplana L, Cortés A.

Nucleic Acids Res. 2015 Sep 30;43(17):8243-57. doi: 10.1093/nar/gkv730. Epub 2015 Jul 21.

21.

Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?

Khandelwal A, Crowley VM, Blagg BSJ.

Med Res Rev. 2016 Jan;36(1):92-118. doi: 10.1002/med.21351. Epub 2015 May 25. Review.

22.

Postprandial adiponectin and gelatinase response to a high-fat versus an isoenergetic low-fat meal in lean, healthy men.

Kennedy A, Spiers JP, Crowley V, Williams E, Lithander FE.

Nutrition. 2015 Jun;31(6):863-70. doi: 10.1016/j.nut.2015.01.009. Epub 2015 Feb 26.

PMID:
25933495
23.

Development of radamide analogs as Grp94 inhibitors.

Muth A, Crowley V, Khandelwal A, Mishra S, Zhao J, Hall J, Blagg BS.

Bioorg Med Chem. 2014 Aug 1;22(15):4083-98. doi: 10.1016/j.bmc.2014.05.075. Epub 2014 Jun 12.

24.

Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.

Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA.

Hum Mol Genet. 2014 Dec 15;23(24):6470-80. doi: 10.1093/hmg/ddu367. Epub 2014 Jul 15.

25.

Habitual physical activity and cardiometabolic risk factors in adults with cerebral palsy.

Ryan JM, Crowley VE, Hensey O, Broderick JM, McGahey A, Gormley J.

Res Dev Disabil. 2014 Sep;35(9):1995-2002. doi: 10.1016/j.ridd.2014.03.051. Epub 2014 May 24.

26.

Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy.

Ryan JM, Crowley VE, Hensey O, McGahey A, Gormley J.

Arch Phys Med Rehabil. 2014 Aug;95(8):1540-6. doi: 10.1016/j.apmr.2014.03.029. Epub 2014 Apr 15.

27.

A transcriptional switch underlies commitment to sexual development in malaria parasites.

Kafsack BF, Rovira-Graells N, Clark TG, Bancells C, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA, Cortés A, Llinás M.

Nature. 2014 Mar 13;507(7491):248-52. doi: 10.1038/nature12920. Epub 2014 Feb 23.

28.

An Efficient Synthesis of 4(5)-Benzyl-L-Histidines Employing Catalytic Transfer Hydrogenolysis at Elevated Temperatures.

Smith DD, Gallagher AT, Crowley VM, Gergens WM, Abel PW, Hulce M.

Synthesis (Stuttg). 2014 Feb;46(4):515-521. doi: 10.1055/s-0033-1340462. Epub 2013 Dec 10.

29.

Postprandial effect of dietary fat quantity and quality on arterial stiffness and wave reflection: a randomised controlled trial.

Lithander FE, Herlihy LK, Walsh DM, Burke E, Crowley V, Mahmud A.

Nutr J. 2013 Jul 10;12:93. doi: 10.1186/1475-2891-12-93.

30.

Epigenetic switches in clag3 genes mediate blasticidin S resistance in malaria parasites.

Mira-Martínez S, Rovira-Graells N, Crowley VM, Altenhofen LM, Llinás M, Cortés A.

Cell Microbiol. 2013 Nov;15(11):1913-23. doi: 10.1111/cmi.12162. Epub 2013 Jul 19.

31.

Prevalence and predictors of diabetes and cardiometabolic risk among construction workers in Ireland: the Construction Workers Health Trust screening study.

Thabit H, Burns N, Shah S, Brema I, Crowley V, Finnegan F, Daly B, Nolan JJ.

Diab Vasc Dis Res. 2013 Jul;10(4):337-45. doi: 10.1177/1479164113479808. Epub 2013 Apr 26.

PMID:
23624762
32.

Pseudoexon activation in the HMBS gene as a cause of the nonerythroid form of acute intermittent porphyria.

Whatley SD, Mason NG, Rhodes JM, Stewart MF, Reed P, Crowley V, Darby CM, Badminton MN.

Clin Chem. 2013 Jul;59(7):1123-5. doi: 10.1373/clinchem.2012.199117. Epub 2013 Apr 22. No abstract available.

33.

A view on the role of epigenetics in the biology of malaria parasites.

Cortés A, Crowley VM, Vaquero A, Voss TS.

PLoS Pathog. 2012;8(12):e1002943. doi: 10.1371/journal.ppat.1002943. Epub 2012 Dec 13. Review. No abstract available.

34.

Standardization of assay methods reduces variability of total PSA measurements: an Irish study.

Forde JC, Marignol L, Blake O, McDermott T, Grainger R, Crowley VE, Lynch TH.

BJU Int. 2012 Sep;110(5):644-50. doi: 10.1111/j.1464-410X.2011.10923.x. Epub 2012 Feb 16.

35.

Transcriptional variation in the malaria parasite Plasmodium falciparum.

Rovira-Graells N, Gupta AP, Planet E, Crowley VM, Mok S, Ribas de Pouplana L, Preiser PR, Bozdech Z, Cortés A.

Genome Res. 2012 May;22(5):925-38. doi: 10.1101/gr.129692.111. Epub 2012 Mar 13.

36.

Heterochromatin formation in bistable chromatin domains controls the epigenetic repression of clonally variant Plasmodium falciparum genes linked to erythrocyte invasion.

Crowley VM, Rovira-Graells N, Ribas de Pouplana L, Cortés A.

Mol Microbiol. 2011 Apr;80(2):391-406. doi: 10.1111/j.1365-2958.2011.07574.x. Epub 2011 Mar 1.

37.

Elevated tumour marker: an indication for imaging?

McMahon CJ, Crowley V, McCarroll N, Dunne R, Keogan MT.

Ann Clin Biochem. 2010 Jul;47(Pt 4):327-30. doi: 10.1258/acb.2010.009235. Epub 2010 May 28.

PMID:
20511377
38.

Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer.

Healy LA, Ryan AM, Carroll P, Ennis D, Crowley V, Boyle T, Kennedy MJ, Connolly E, Reynolds JV.

Clin Oncol (R Coll Radiol). 2010 May;22(4):281-8. doi: 10.1016/j.clon.2010.02.001. Epub 2010 Feb 26.

PMID:
20189371
39.

Introduction of an NT-proBNP assay to an acute admission unit--a 2-year audit.

Murtagh G, Canniffe C, Mahgoub M, Blake L, McCarroll N, Crowley V, Bennett K, Silke B.

Eur J Intern Med. 2009 Jan;20(1):58-62. doi: 10.1016/j.ejim.2008.04.021. Epub 2008 Jul 16.

PMID:
19237094
40.

Acute haemodynamic response to sleeping head-up at 6 inches in older inpatients.

Fan CW, Gasparro D, Crowley V, Cunningham CJ.

Clin Auton Res. 2009 Feb;19(1):51-7. doi: 10.1007/s10286-009-0516-1. Epub 2009 Feb 6.

PMID:
19198925
41.

The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population.

Hatunic M, Stapleton M, Hand E, DeLong C, Crowley VE, Nolan JJ.

Diabetes Res Clin Pract. 2009 Mar;83(3):316-9. doi: 10.1016/j.diabres.2008.12.004. Epub 2009 Jan 29.

PMID:
19185381
42.

Physiological effects of sleeping with the head of the bed elevated 18 in. in young healthy volunteers.

Fan CW, O'Sullivan E, Healy M, Gasparro D, Crowley V, Cunningham CJ.

Ir J Med Sci. 2008 Dec;177(4):371-7. doi: 10.1007/s11845-008-0233-0. Epub 2008 Oct 25.

PMID:
18953629
43.

Hereditary coproporphyria: report of an Irish kindred and identification of a novel gene mutation.

Gorman CS, Gill D, Darby C, Crowley V, Mahony MJ.

Ir Med J. 2008 Apr;101(4):125. No abstract available.

PMID:
18557518
44.

Overview of human obesity and central mechanisms regulating energy homeostasis.

Crowley VE.

Ann Clin Biochem. 2008 May;45(Pt 3):245-55. doi: 10.1258/acb.2007.007193. Review.

PMID:
18482911
45.

Psycho-educational groups for people with a dual diagnosis of psychosis and mild intellectual disability: a preliminary study.

Crowley V, Rose J, Smith J, Hobster K, Ansell E.

J Intellect Disabil. 2008 Mar;12(1):25-39. doi: 10.1177/1744629507086606.

PMID:
18337299
46.

Adverse metabolic profiles in a cohort of obese Irish children.

Finucane FM, Teong L, Pittock S, Fallon M, Hatunic M, Costigan C, Murphy N, Crowley VE, Nolan JJ.

Ann Clin Biochem. 2008 Mar;45(Pt 2):206-9. doi: 10.1258/acb.2007.007115.

PMID:
18325187
47.

A case of porphyria cutanea tarda resulting in digital amputation and improved by anastrazole.

Roche M, Daly P, Crowley V, Darby C, Barnes L.

Clin Exp Dermatol. 2007 May;32(3):327-8. No abstract available.

PMID:
17397360
49.

Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.

Barroso I, Luan J, Sandhu MS, Franks PW, Crowley V, Schafer AJ, O'Rahilly S, Wareham NJ.

Diabetologia. 2006 Mar;49(3):501-5. Epub 2006 Jan 25.

PMID:
16435105
50.

In vitro proteolysis of phosphoenolpyruvate carboxylase from developing castor oil seeds by an endogenous thiol endopeptidase.

Crowley V, Gennidakis S, Plaxton WC.

Plant Cell Physiol. 2005 Nov;46(11):1855-62. Epub 2005 Sep 27.

PMID:
16188875

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