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Emerging collaborative research platforms for the next generation of physical activity, sleep and exercise medicine guidelines: the Prospective Physical Activity, Sitting, and Sleep consortium (ProPASS).

Stamatakis E, Koster A, Hamer M, Rangul V, Lee IM, Bauman AE, Atkin AJ, Aadahl M, Matthews CE, Mork PJ, Askie L, Cistulli P, Granat M, Palm P, Crowley PJ, Stevens M, Gupta N, Pulakka A, Stenholm S, Arvidsson D, Mishra G, Wennberg P, Chastin S, Ekelund U, Holtermann A.

Br J Sports Med. 2019 May 10. pii: bjsports-2019-100786. doi: 10.1136/bjsports-2019-100786. [Epub ahead of print] No abstract available.


Membrane proteomic analysis reveals overlapping and independent functions of Streptococcus mutans Ffh, YidC1, and YidC2.

Mishra S, Crowley PJ, Wright KR, Palmer SR, Walker AR, Datta S, Brady LJ.

Mol Oral Microbiol. 2019 Aug;34(4):131-152. doi: 10.1111/omi.12261. Epub 2019 Jun 7.


Quasiperiodic Quantum Ising Transitions in 1D.

Crowley PJD, Chandran A, Laumann CR.

Phys Rev Lett. 2018 Apr 27;120(17):175702. doi: 10.1103/PhysRevLett.120.175702.


Specific binding of a naturally occurring amyloidogenic fragment of Streptococcus mutans adhesin P1 to intact P1 on the cell surface characterized by solid state NMR spectroscopy.

Tang W, Bhatt A, Smith AN, Crowley PJ, Brady LJ, Long JR.

J Biomol NMR. 2016 Feb;64(2):153-64. doi: 10.1007/s10858-016-0017-1. Epub 2016 Feb 2.


Modern Approaches to Quality Assurance of Drug Formulations.

Jampilek J, Crowley PJ, Olsen M, Tam K.

Biomed Res Int. 2015;2015:126478. doi: 10.1155/2015/126478. Epub 2015 May 20. No abstract available.


Binding forces of Streptococcus mutans P1 adhesin.

Sullan RM, Li JK, Crowley PJ, Brady LJ, Dufrêne YF.

ACS Nano. 2015 Feb 24;9(2):1448-60. doi: 10.1021/nn5058886. Epub 2015 Feb 11.


Identification of a supramolecular functional architecture of Streptococcus mutans adhesin P1 on the bacterial cell surface.

Heim KP, Sullan RM, Crowley PJ, El-Kirat-Chatel S, Beaussart A, Tang W, Besingi R, Dufrene YF, Brady LJ.

J Biol Chem. 2015 Apr 3;290(14):9002-19. doi: 10.1074/jbc.M114.626663. Epub 2015 Feb 9.


An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1.

Heim KP, Crowley PJ, Long JR, Kailasan S, McKenna R, Brady LJ.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15746-51. doi: 10.1073/pnas.1413018111. Epub 2014 Oct 20.


Immunogenicity and in vitro and in vivo protective effects of antibodies targeting a recombinant form of the Streptococcus mutans P1 surface protein.

Batista MT, Souza RD, Ferreira EL, Robinette R, Crowley PJ, Rodrigues JF, Brady LJ, Ferreira LC, Ferreira RC.

Infect Immun. 2014 Dec;82(12):4978-88. doi: 10.1128/IAI.02074-14. Epub 2014 Sep 15.


YlxM is a newly identified accessory protein that influences the function of signal recognition particle pathway components in Streptococcus mutans.

Williams ML, Crowley PJ, Hasona A, Brady LJ.

J Bacteriol. 2014 Jun;196(11):2043-52. doi: 10.1128/JB.01465-13. Epub 2014 Mar 21.


Alterations in immunodominance of Streptococcus mutans AgI/II: lessons learned from immunomodulatory antibodies.

Robinette RA, Heim KP, Oli MW, Crowley PJ, McArthur WP, Brady LJ.

Vaccine. 2014 Jan 9;32(3):375-82. doi: 10.1016/j.vaccine.2013.11.023. Epub 2013 Nov 16.


An intramolecular interaction involving the N terminus of a streptococcal adhesin affects its conformation and adhesive function.

Heim KP, Crowley PJ, Brady LJ.

J Biol Chem. 2013 May 10;288(19):13762-74. doi: 10.1074/jbc.M113.459974. Epub 2013 Mar 28.


Dramatic impact of using protective equipment on the level of hurling-related head injuries: an ultimately successful 27-year programme.

Crowley PJ, Crowley MJ.

Br J Sports Med. 2014 Jan;48(2):147-50. doi: 10.1136/bjsports-2012-092014. Epub 2013 Feb 16.


Functional amyloid formation by Streptococcus mutans.

Oli MW, Otoo HN, Crowley PJ, Heim KP, Nascimento MM, Ramsook CB, Lipke PN, Brady LJ.

Microbiology. 2012 Dec;158(Pt 12):2903-16. doi: 10.1099/mic.0.060855-0. Epub 2012 Oct 18.


Do helmets worn for hurling fail to protect the ear? Identification of an emerging injury pattern.

Martin-Smith JD, Chan JC, Power KT, Crowley PJ, Clover AJ.

Br J Sports Med. 2012 Dec;46(16):1134-6. doi: 10.1136/bjsports-2012-091280. Epub 2012 Sep 12.


YidC1 and YidC2 are functionally distinct proteins involved in protein secretion, biofilm formation and cariogenicity of Streptococcus mutans.

Palmer SR, Crowley PJ, Oli MW, Ruelf MA, Michalek SM, Brady LJ.

Microbiology. 2012 Jul;158(Pt 7):1702-12. doi: 10.1099/mic.0.059139-0. Epub 2012 Apr 13.


Re: Tanriverdi et al.: Emergent stenting after uncomplicated ureteroscopy: evaluation of 23 patients (Urology 2011;77:305-308).

Proano JM, Crowley PJ.

Urology. 2011 Jul;78(1):234; author reply 234-5. doi: 10.1016/j.urology.2011.02.056. No abstract available.


Crystal structure of the C-terminal region of Streptococcus mutans antigen I/II and characterization of salivary agglutinin adherence domains.

Larson MR, Rajashankar KR, Crowley PJ, Kelly C, Mitchell TJ, Brady LJ, Deivanayagam C.

J Biol Chem. 2011 Jun 17;286(24):21657-66. doi: 10.1074/jbc.M111.231100. Epub 2011 Apr 19.


Induction of neutralizing antibodies in mice immunized with an amino-terminal polypeptide of Streptococcus mutans P1 protein produced by a recombinant Bacillus subtilis strain.

Tavares MB, Silva BM, Cavalcante RC, Souza RD, Luiz WB, Paccez JD, Crowley PJ, Brady LJ, Ferreira LC, Ferreira RC.

FEMS Immunol Med Microbiol. 2010 Jul 1;59(2):131-42. doi: 10.1111/j.1574-695X.2010.00669.x. Epub 2010 Mar 10.


Elongated fibrillar structure of a streptococcal adhesin assembled by the high-affinity association of alpha- and PPII-helices.

Larson MR, Rajashankar KR, Patel MH, Robinette RA, Crowley PJ, Michalek S, Brady LJ, Deivanayagam C.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5983-8. doi: 10.1073/pnas.0912293107. Epub 2010 Mar 15.


Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 1: pyrido[2,3-b]pyrazines.

Crowley PJ, Lamberth C, Müller U, Wendeborn S, Nebel K, Williams J, Sageot OA, Carter N, Mathie T, Kempf HJ, Godwin J, Schneiter P, Dobler MR.

Pest Manag Sci. 2010 Feb;66(2):178-85. doi: 10.1002/ps.1852.


Independent gene duplications of the YidC/Oxa/Alb3 family enabled a specialized cotranslational function.

Funes S, Hasona A, Bauerschmitt H, Grubbauer C, Kauff F, Collins R, Crowley PJ, Palmer SR, Brady LJ, Herrmann JM.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6656-61. doi: 10.1073/pnas.0809951106. Epub 2009 Apr 6.


The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.

Crowley PJ, Berry EA, Cromartie T, Daldal F, Godfrey CR, Lee DW, Phillips JE, Taylor A, Viner R.

Bioorg Med Chem. 2008 Dec 15;16(24):10345-55. doi: 10.1016/j.bmc.2008.10.030. Epub 2008 Oct 17.


Requirements for surface expression and function of adhesin P1 from Streptococcus mutans.

Crowley PJ, Seifert TB, Isoda R, van Tilburg M, Oli MW, Robinette RA, McArthur WP, Bleiweis AS, Brady LJ.

Infect Immun. 2008 Jun;76(6):2456-68. doi: 10.1128/IAI.01315-07. Epub 2008 Mar 24.


Low dose lipid formulations: effects on gastric emptying and biliary secretion.

Kossena GA, Charman WN, Wilson CG, O'Mahony B, Lindsay B, Hempenstall JM, Davison CL, Crowley PJ, Porter CJ.

Pharm Res. 2007 Nov;24(11):2084-96. Epub 2007 Jul 27.


Neuroethics and national security.

Canli T, Brandon S, Casebeer W, Crowley PJ, Du Rousseau D, Greely HT, Pascual-Leone A.

Am J Bioeth. 2007 May;7(5):3-13. Review. No abstract available.


Response to open peer commentaries on "Neuroethics and national security".

Canli T, Brandon S, Casebeer W, Crowley PJ, Durousseau D, Greely HT, Pascual-Leones A.

Am J Bioeth. 2007 May;7(5):W1-3. No abstract available.


Membrane composition changes and physiological adaptation by Streptococcus mutans signal recognition particle pathway mutants.

Hasona A, Zuobi-Hasona K, Crowley PJ, Abranches J, Ruelf MA, Bleiweis AS, Brady LJ.

J Bacteriol. 2007 Feb;189(4):1219-30. Epub 2006 Nov 3.


Influence of ethanol on aspirin release from hypromellose matrices.

Roberts M, Cespi M, Ford JL, Dyas AM, Downing J, Martini LG, Crowley PJ.

Int J Pharm. 2007 Mar 6;332(1-2):31-7. Epub 2006 Oct 6.


A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae.

Seifert KN, Adderson EE, Whiting AA, Bohnsack JF, Crowley PJ, Brady LJ.

Microbiology. 2006 Apr;152(Pt 4):1029-40.


Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2.

Hasona A, Crowley PJ, Levesque CM, Mair RW, Cvitkovitch DG, Bleiweis AS, Brady LJ.

Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17466-71. Epub 2005 Nov 17.


Highly-functionalised difluorinated cyclohexane polyols via the Diels-Alder reaction: regiochemical control via the phenylsulfonyl group.

Crowley PJ, Fawcett J, Griffith GA, Moralee AC, Percy JM, Salafia V.

Org Biomol Chem. 2005 Sep 21;3(18):3297-310. Epub 2005 Aug 11.


Solubilization of cellular membrane proteins from Streptococcus mutans for two-dimensional gel electrophoresis.

Zuobi-Hasona K, Crowley PJ, Hasona A, Bleiweis AS, Brady LJ.

Electrophoresis. 2005 Mar;26(6):1200-5.


An ffh mutant of Streptococcus mutans is viable and able to physiologically adapt to low pH in continuous culture.

Crowley PJ, Svensäter G, Snoep JL, Bleiweis AS, Brady LJ.

FEMS Microbiol Lett. 2004 May 15;234(2):315-24. Erratum in: FEMS Microbiol Lett. 2004 Jul 1;236(1):161.


Highly-functionalised difluorinated (hydroxymethyl)conduritol analogues via the Diels-Alder reactions of a difluorinated dienophile.

Arany A, Crowley PJ, Fawcett J, Hursthouse MB, Kariuki BM, Light ME, Moralee AC, Percy JM, Salafia V.

Org Biomol Chem. 2004 Feb 21;2(4):455-65. Epub 2004 Jan 21.


Basic and reductive sulfone-directed ring-opening reactions of difluorinated oxa[2.2.1]bicycloheptanes.

Crowley PJ, Fawcett J, Kariuki BM, Moralee AC, Percy JM, Salafia V.

Org Lett. 2002 Nov 14;4(23):4125-8.


Enhancing oral absorption in animals.

Crowley PJ, Martini LG.

Curr Opin Drug Discov Devel. 2001 Jan;4(1):73-80. Review.


Characterization of the sat operon in Streptococcus mutans: evidence for a role of Ffh in acid tolerance.

Kremer BH, van der Kraan M, Crowley PJ, Hamilton IR, Brady LJ, Bleiweis AS.

J Bacteriol. 2001 Apr;183(8):2543-52.


Tn917-lac mutagenesis of Streptococcus mutans to identify environmentally regulated genes.

Cvitkovitch DG, Gutierrez JA, Behari J, Youngman PJ, Wetz JE, Crowley PJ, Hillman JD, Brady LJ, Bleiweis AS.

FEMS Microbiol Lett. 2000 Jan 1;182(1):149-54.


Solubility parameter and oral absorption.

Martini LG, Avontuur P, George A, Willson RJ, Crowley PJ.

Eur J Pharm Biopharm. 1999 Nov;48(3):259-63.


Excipients as stabilizers.

Crowley PJ.

Pharm Sci Technolo Today. 1999 Jun;2(6):237-243.


Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress.

Gutierrez JA, Crowley PJ, Cvitkovitch DG, Brady LJ, Hamilton IR, Hillman JD, Bleiweis AS.

Microbiology. 1999 Feb;145 ( Pt 2):357-66.


Virulence of a spaP mutant of Streptococcus mutans in a gnotobiotic rat model.

Crowley PJ, Brady LJ, Michalek SM, Bleiweis AS.

Infect Immun. 1999 Mar;67(3):1201-6.


Deletion of the central proline-rich repeat domain results in altered antigenicity and lack of surface expression of the Streptococcus mutans P1 adhesin molecule.

Brady LJ, Cvitkovitch DG, Geric CM, Addison MN, Joyce JC, Crowley PJ, Bleiweis AS.

Infect Immun. 1998 Sep;66(9):4274-82.


Genetic and biochemical analysis of mutacin 1140, a lantibiotic from Streptococcus mutans.

Hillman JD, Novák J, Sagura E, Gutierrez JA, Brooks TA, Crowley PJ, Hess M, Azizi A, Leung K, Cvitkovitch D, Bleiweis AS.

Infect Immun. 1998 Jun;66(6):2743-9.


Genetic and physiologic analysis of a formyl-tetrahydrofolate synthetase mutant of Streptococcus mutans.

Crowley PJ, Gutierrez JA, Hillman JD, Bleiweis AS.

J Bacteriol. 1997 Mar;179(5):1563-72.

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