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Metabolomic networks connect host-microbiome processes to human Clostridioides difficile infections.

Robinson JI, Weir WH, Crowley JR, Hink T, Reske KA, Kwon JH, Burnham CD, Dubberke ER, Mucha PJ, Henderson JP.

J Clin Invest. 2019 Aug 12;130:3792-3806. doi: 10.1172/JCI126905. eCollection 2019 Aug 12.


Findings from Quality Improvement Initiatives to Assess and Improve PET/CT FDG Injection Infiltration Rates in Multiple Centers.

Wong TZ, Benefield T, Masters SC, Kiser JW, Crowley JR, Osborne D, Mawlawi O, Barnwell J, Gupta P, Mintz A, Ryan KA kryan@luce, Perrin SR, Lattanze RK, Townsend DW.

J Nucl Med Technol. 2019 Jun 10. pii: jnmt.119.228098. doi: 10.2967/jnmt.119.228098. [Epub ahead of print]


Impact of an 18F-FDG PET/CT Radiotracer Injection Infiltration on Patient Management-A Case Report.

Kiser JW, Crowley JR, Wyatt DA, Lattanze RK.

Front Med (Lausanne). 2018 May 15;5:143. doi: 10.3389/fmed.2018.00143. eCollection 2018.


Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.

Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B.

Nat Commun. 2017 Jun 7;8:15750. doi: 10.1038/ncomms15750.


SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.

Mayer AL, Higgins CB, Heitmeier MR, Kraft TE, Qian X, Crowley JR, Hyrc KL, Beatty WL, Yarasheski KE, Hruz PW, DeBosch BJ.

Sci Rep. 2016 Dec 6;6:38586. doi: 10.1038/srep38586.


Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine.

Shields-Cutler RR, Crowley JR, Miller CD, Stapleton AE, Cui W, Henderson JP.

J Biol Chem. 2016 Dec 9;291(50):25901-25910. Epub 2016 Oct 25.


Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide.

Ippolito JE, Brandenburg MW, Ge X, Crowley JR, Kirmess KM, Som A, D'Avignon DA, Arbeit JM, Achilefu S, Yarasheski KE, Milbrandt J.

PLoS One. 2016 Jul 20;11(7):e0159675. doi: 10.1371/journal.pone.0159675. eCollection 2016.


Urinary Metabolomics Identifies a Molecular Correlate of Interstitial Cystitis/Bladder Pain Syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort.

Parker KS, Crowley JR, Stephens-Shields AJ, van Bokhoven A, Lucia MS, Lai HH, Andriole GL, Hooton TM, Mullins C, Henderson JP.

EBioMedicine. 2016 May;7:167-74. doi: 10.1016/j.ebiom.2016.03.040. Epub 2016 Mar 31.


Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.

DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH.

Sci Signal. 2016 Feb 23;9(416):ra21. doi: 10.1126/scisignal.aac5472.


Deconvoluting heme biosynthesis to target blood-stage malaria parasites.

Sigala PA, Crowley JR, Henderson JP, Goldberg DE.

Elife. 2015 Jul 14;4. doi: 10.7554/eLife.09143.


Human Urinary Composition Controls Antibacterial Activity of Siderocalin.

Shields-Cutler RR, Crowley JR, Hung CS, Stapleton AE, Aldrich CC, Marschall J, Henderson JP.

J Biol Chem. 2015 Jun 26;290(26):15949-60. doi: 10.1074/jbc.M115.645812. Epub 2015 Apr 10.


Metal selectivity by the virulence-associated yersiniabactin metallophore system.

Koh EI, Hung CS, Parker KS, Crowley JR, Giblin DE, Henderson JP.

Metallomics. 2015 Jun;7(6):1011-22. doi: 10.1039/c4mt00341a.


Malaria parasites produce volatile mosquito attractants.

Kelly M, Su CY, Schaber C, Crowley JR, Hsu FF, Carlson JR, Odom AR.

MBio. 2015 Mar 24;6(2). pii: e00235-15. doi: 10.1128/mBio.00235-15.


The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.

Ke H, Sigala PA, Miura K, Morrisey JM, Mather MW, Crowley JR, Henderson JP, Goldberg DE, Long CA, Vaidya AB.

J Biol Chem. 2014 Dec 12;289(50):34827-37. doi: 10.1074/jbc.M114.615831. Epub 2014 Oct 28.


Escherichia coli biofilms have an organized and complex extracellular matrix structure.

Hung C, Zhou Y, Pinkner JS, Dodson KW, Crowley JR, Heuser J, Chapman MR, Hadjifrangiskou M, Henderson JP, Hultgren SJ.

MBio. 2013 Sep 10;4(5):e00645-13. doi: 10.1128/mBio.00645-13.


Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum.

Sigala PA, Crowley JR, Hsieh S, Henderson JP, Goldberg DE.

J Biol Chem. 2012 Nov 2;287(45):37793-807. doi: 10.1074/jbc.M112.414078. Epub 2012 Sep 19.


The siderophore yersiniabactin binds copper to protect pathogens during infection.

Chaturvedi KS, Hung CS, Crowley JR, Stapleton AE, Henderson JP.

Nat Chem Biol. 2012 Aug;8(8):731-6. doi: 10.1038/nchembio.1020. Epub 2012 Jul 8.


Postprandial leucine and insulin responses and toxicological effects of a novel whey protein hydrolysate-based supplement in rats.

Toedebusch RG, Childs TE, Hamilton SR, Crowley JR, Booth FW, Roberts MD.

J Int Soc Sports Nutr. 2012 Jun 6;9(1):24. doi: 10.1186/1550-2783-9-24.


Substrate metabolism during basal and hyperinsulinemic conditions in adolescents and young-adults with Barth syndrome.

Cade WT, Spencer CT, Reeds DN, Waggoner AD, O'Connor R, Maisenbacher M, Crowley JR, Byrne BJ, Peterson LR.

J Inherit Metab Dis. 2013 Jan;36(1):91-101. doi: 10.1007/s10545-012-9486-x. Epub 2012 May 12.


Treatment and prevention of urinary tract infection with orally active FimH inhibitors.

Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ.

Sci Transl Med. 2011 Nov 16;3(109):109ra115. doi: 10.1126/scitranslmed.3003021.


Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation.

Crawford PA, Crowley JR, Sambandam N, Muegge BD, Costello EK, Hamady M, Knight R, Gordon JI.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11276-81. doi: 10.1073/pnas.0902366106. Epub 2009 Jun 22.


The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts.

Shui YB, Holekamp NM, Kramer BC, Crowley JR, Wilkins MA, Chu F, Malone PE, Mangers SJ, Hou JH, Siegfried CJ, Beebe DC.

Arch Ophthalmol. 2009 Apr;127(4):475-82. doi: 10.1001/archophthalmol.2008.621.


Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli.

Henderson JP, Crowley JR, Pinkner JS, Walker JN, Tsukayama P, Stamm WE, Hooton TM, Hultgren SJ.

PLoS Pathog. 2009 Feb;5(2):e1000305. doi: 10.1371/journal.ppat.1000305. Epub 2009 Feb 20.


Tetrahydrofurandiols (THF-diols), leukotoxindiols (LTX-diols), and endocrine disruption in rats.

Markaverich BM, Alejandro M, Thompson T, Mani S, Reyna A, Portillo W, Sharp J, Turk J, Crowley JR.

Environ Health Perspect. 2007 May;115(5):702-8. Epub 2007 Jan 29.


Leukotoxin diols from ground corncob bedding disrupt estrous cyclicity in rats and stimulate MCF-7 breast cancer cell proliferation.

Markaverich BM, Crowley JR, Alejandro MA, Shoulars K, Casajuna N, Mani S, Reyna A, Sharp J.

Environ Health Perspect. 2005 Dec;113(12):1698-704.


An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers.

Ippolito JE, Xu J, Jain S, Moulder K, Mennerick S, Crowley JR, Townsend RR, Gordon JI.

Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9901-6. Epub 2005 Jul 5.


Nuclear type II [3H]estradiol binding sites: a histone H3-H4 complex.

Shoulars K, Rodrigues MA, Crowley JR, Turk J, Thompson T, Markaverich BM.

J Steroid Biochem Mol Biol. 2005 Jun;96(1):19-30.


Neuronal expression of myeloperoxidase is increased in Alzheimer's disease.

Green PS, Mendez AJ, Jacob JS, Crowley JR, Growdon W, Hyman BT, Heinecke JW.

J Neurochem. 2004 Aug;90(3):724-33.


The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking.

Zhang J, Dudley-Rucker N, Crowley JR, Lopez-Perez E, Issandou M, Schaffer JE, Ory DS.

J Lipid Res. 2004 Feb;45(2):223-31. Epub 2003 Nov 16.


Insulin is protein-anabolic in chronic renal failure patients.

Lim VS, Yarasheski KE, Crowley JR, Fangman J, Flanigan M.

J Am Soc Nephrol. 2003 Sep;14(9):2297-304.


NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.

Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE, Ory DS.

J Biol Chem. 2003 Jul 11;278(28):25517-25. Epub 2003 Apr 28.


Identification of an endocrine disrupting agent from corn with mitogenic activity.

Markaverich BM, Alejandro MA, Markaverich D, Zitzow L, Casajuna N, Camarao N, Hill J, Bhirdo K, Faith R, Turk J, Crowley JR.

Biochem Biophys Res Commun. 2002 Mar 1;291(3):692-700.


Reactive chlorinating species produced during neutrophil activation target tissue plasmalogens: production of the chemoattractant, 2-chlorohexadecanal.

Thukkani AK, Hsu FF, Crowley JR, Wysolmerski RB, Albert CJ, Ford DA.

J Biol Chem. 2002 Feb 8;277(6):3842-9. Epub 2001 Nov 27.


Reactive chlorinating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens: identification of 2-chlorohexadecanal.

Albert CJ, Crowley JR, Hsu FF, Thukkani AK, Ford DA.

J Biol Chem. 2001 Jun 29;276(26):23733-41. Epub 2001 Apr 11.


Increased atherosclerosis in myeloperoxidase-deficient mice.

Brennan ML, Anderson MM, Shih DM, Qu XD, Wang X, Mehta AC, Lim LL, Shi W, Hazen SL, Jacob JS, Crowley JR, Heinecke JW, Lusis AJ.

J Clin Invest. 2001 Feb;107(4):419-30.


p-hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modifies phospholipid amino groups of low density lipoprotein in human atherosclerotic intima.

Heller JI, Crowley JR, Hazen SL, Salvay DM, Wagner P, Pennathur S, Heinecke JW.

J Biol Chem. 2000 Apr 7;275(14):9957-62.


Metabolism of genistein by rat and human cytochrome P450s.

Roberts-Kirchhoff ES, Crowley JR, Hollenberg PF, Kim H.

Chem Res Toxicol. 1999 Jul;12(7):610-6.


Clinical laboratory technician to clinical laboratory scientist articulation and distance learning.

Crowley JR, Laurich GA, Mobley RC, Arnette AH, Shaikh AH, Martin SM.

Clin Lab Sci. 1999 Jan-Feb;12(1):42-7.


Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues.

Heinecke JW, Hsu FF, Crowley JR, Hazen SL, Leeuwenburgh C, Mueller DM, Rasmussen JE, Turk J.

Methods Enzymol. 1999;300:124-44. No abstract available.


Modification of proteins and lipids by myeloperoxidase.

Hazen SL, Hsu FF, Gaut JP, Crowley JR, Heinecke JW.

Methods Enzymol. 1999;300:88-105. No abstract available.


Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1.

Roberts ES, Lin Hl, Crowley JR, Vuletich JL, Osawa Y, Hollenberg PF.

Chem Res Toxicol. 1998 Sep;11(9):1067-74.


Isotope dilution mass spectrometric quantification of 3-nitrotyrosine in proteins and tissues is facilitated by reduction to 3-aminotyrosine.

Crowley JR, Yarasheski K, Leeuwenburgh C, Turk J, Heinecke JW.

Anal Biochem. 1998 May 15;259(1):127-35.


Whole-body protein kinetics in children with kwashiorkor and infection: a comparison of egg white and milk as dietary sources of protein.

Manary MJ, Brewster DR, Broadhead RL, Graham SM, Hart CA, Crowley JR, Fjeld CR, Yarasheski KE.

Am J Clin Nutr. 1997 Sep;66(3):643-8.


Protein metabolism in children with edematous malnutrition and acute lower respiratory infection.

Manary MJ, Brewster DR, Broadhead RL, Crowley JR, Fjeld CR, Yarasheski KE.

Am J Clin Nutr. 1997 Apr;65(4):1005-10.


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