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Items: 45

1.

Optimizing the Use of Electronic Data Sources in Clinical Trials: The Technology Landscape.

Kellar E, Bornstein S, Caban A, Crouthamel M, Celingant C, McIntire PA, Johnson C, Mehta P, Sikirica V, Wilson B.

Ther Innov Regul Sci. 2017 Sep;51(5):551-567. doi: 10.1177/2168479017718875. Epub 2017 Jul 11.

PMID:
30231687
2.

Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study.

Crouthamel M, Quattrocchi E, Watts S, Wang S, Berry P, Garcia-Gancedo L, Hamy V, Williams RE.

JMIR Mhealth Uhealth. 2018 Sep 13;6(9):e177. doi: 10.2196/mhealth.9656.

3.

The short-term and long-term effects of bariatric/metabolic surgery on subcutaneous adipose tissue inflammation in humans.

Hagman DK, Larson I, Kuzma JN, Cromer G, Makar K, Rubinow KB, Foster-Schubert KE, van Yserloo B, Billing PS, Landerholm RW, Crouthamel M, Flum DR, Cummings DE, Kratz M.

Metabolism. 2017 May;70:12-22. doi: 10.1016/j.metabol.2017.01.030. Epub 2017 Feb 2.

4.

Transport properties of valsartan, sacubitril and its active metabolite (LBQ657) as determinants of disposition.

Hanna I, Alexander N, Crouthamel MH, Davis J, Natrillo A, Tran P, Vapurcuyan A, Zhu B.

Xenobiotica. 2018 Mar;48(3):300-313. doi: 10.1080/00498254.2017.1295171. Epub 2017 Mar 10.

PMID:
28281384
5.

Optimizing the Use of Electronic Data Sources in Clinical Trials: The Landscape, Part 1.

Kellar E, Bornstein SM, Caban A, Célingant C, Crouthamel M, Johnson C, McIntire PA, Milstead KR, Patterson JK, Wilson B.

Ther Innov Regul Sci. 2016 Nov;50(6):682-696. doi: 10.1177/2168479016670689. Epub 2016 Oct 14.

PMID:
30231749
6.

Mobile health: the power of wearables, sensors, and apps to transform clinical trials.

Munos B, Baker PC, Bot BM, Crouthamel M, de Vries G, Ferguson I, Hixson JD, Malek LA, Mastrototaro JJ, Misra V, Ozcan A, Sacks L, Wang P.

Ann N Y Acad Sci. 2016 Jul;1375(1):3-18. doi: 10.1111/nyas.13117. Epub 2016 Jul 6.

PMID:
27384501
7.

Incidental gastric mesenchymal tumors identified during laparoscopic sleeve gastrectomy.

Crouthamel MR, Kaufman JA, Billing JP, Billing PS, Landerholm RW.

Surg Obes Relat Dis. 2015 Sep-Oct;11(5):1025-8. doi: 10.1016/j.soard.2015.06.004. Epub 2015 Jun 10.

PMID:
26645488
8.

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.

Mohammad HP, Smitheman KN, Kamat CD, Soong D, Federowicz KE, Van Aller GS, Schneck JL, Carson JD, Liu Y, Butticello M, Bonnette WG, Gorman SA, Degenhardt Y, Bai Y, McCabe MT, Pappalardi MB, Kasparec J, Tian X, McNulty KC, Rouse M, McDevitt P, Ho T, Crouthamel M, Hart TK, Concha NO, McHugh CF, Miller WH, Dhanak D, Tummino PJ, Carpenter CL, Johnson NW, Hann CL, Kruger RG.

Cancer Cell. 2015 Jul 13;28(1):57-69. doi: 10.1016/j.ccell.2015.06.002.

9.

Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells.

Chavkin NW, Chia JJ, Crouthamel MH, Giachelli CM.

Exp Cell Res. 2015 Apr 10;333(1):39-48. doi: 10.1016/j.yexcr.2015.02.002. Epub 2015 Feb 13.

10.

Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.

Kratz M, Coats BR, Hisert KB, Hagman D, Mutskov V, Peris E, Schoenfelt KQ, Kuzma JN, Larson I, Billing PS, Landerholm RW, Crouthamel M, Gozal D, Hwang S, Singh PK, Becker L.

Cell Metab. 2014 Oct 7;20(4):614-25. doi: 10.1016/j.cmet.2014.08.010. Epub 2014 Sep 18.

11.

Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.

Dumble M, Crouthamel MC, Zhang SY, Schaber M, Levy D, Robell K, Liu Q, Figueroa DJ, Minthorn EA, Seefeld MA, Rouse MB, Rabindran SK, Heerding DA, Kumar R.

PLoS One. 2014 Jun 30;9(6):e100880. doi: 10.1371/journal.pone.0100880. eCollection 2014.

12.

Outpatient laparoscopic sleeve gastrectomy in a free-standing ambulatory surgery center: first 250 cases.

Billing PS, Crouthamel MR, Oling S, Landerholm RW.

Surg Obes Relat Dis. 2014 Jan-Feb;10(1):101-5. doi: 10.1016/j.soard.2013.07.005. Epub 2013 Jul 17.

PMID:
24094869
13.

Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.

Crouthamel MH, Lau WL, Leaf EM, Chavkin NW, Wallingford MC, Peterson DF, Li X, Liu Y, Chin MT, Levi M, Giachelli CM.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2625-32. doi: 10.1161/ATVBAHA.113.302249. Epub 2013 Aug 22.

14.

Fibroblast growth factor 23 is not associated with and does not induce arterial calcification.

Scialla JJ, Lau WL, Reilly MP, Isakova T, Yang HY, Crouthamel MH, Chavkin NW, Rahman M, Wahl P, Amaral AP, Hamano T, Master SR, Nessel L, Chai B, Xie D, Kallem RR, Chen J, Lash JP, Kusek JW, Budoff MJ, Giachelli CM, Wolf M; Chronic Renal Insufficiency Cohort Study Investigators.

Kidney Int. 2013 Jun;83(6):1159-68. doi: 10.1038/ki.2013.3. Epub 2013 Feb 6.

15.

Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development.

Liu L, Sánchez-Bonilla M, Crouthamel M, Giachelli C, Keel S.

Exp Hematol. 2013 May;41(5):432-43.e7. doi: 10.1016/j.exphem.2013.01.004. Epub 2013 Jan 30.

16.

Arterial calcification in chronic kidney disease: key roles for calcium and phosphate.

Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM.

Circ Res. 2011 Sep 2;109(6):697-711. doi: 10.1161/CIRCRESAHA.110.234914. Review.

17.

Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers.

Crouthamel MH, Kelly EJ, Ho RJ.

Transgenic Res. 2012 Feb;21(1):113-30. doi: 10.1007/s11248-011-9512-z. Epub 2011 May 3.

18.

An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution.

Crouthamel M, Abankwa D, Zhang L, DiLizio C, Manning DR, Hancock JF, Wedegaertner PB.

Mol Pharmacol. 2010 Oct;78(4):767-77. doi: 10.1124/mol.110.066340. Epub 2010 Jul 27.

19.

A novel MDR1 GT1292-3TG (Cys431Leu) genetic variation and its effect on P-glycoprotein biologic functions.

Crouthamel MH, Wu D, Yang Z, Ho RJ.

AAPS J. 2010 Dec;12(4):548-55. doi: 10.1208/s12248-010-9216-y. Epub 2010 Jul 10.

20.

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.

Rajapakse HA, Nantermet PG, Selnick HG, Barrow JC, McGaughey GB, Munshi S, Lindsley SR, Young MB, Ngo PL, Holloway MK, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1885-9. doi: 10.1016/j.bmcl.2010.01.137. Epub 2010 Feb 4.

PMID:
20176482
21.

Thoracoscopic repair of congenital diaphragmatic hernia in infancy.

Lao OB, Crouthamel MR, Goldin AB, Sawin RS, Waldhausen JH, Kim SS.

J Laparoendosc Adv Surg Tech A. 2010 Apr;20(3):271-6. doi: 10.1089/lap.2009.0150.

22.

Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors.

Kumar R, Crouthamel MC, Rominger DH, Gontarek RR, Tummino PJ, Levin RA, King AG.

Br J Cancer. 2009 Nov 17;101(10):1717-23. doi: 10.1038/sj.bjc.6605366. Epub 2009 Oct 20.

23.

MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents.

Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ.

Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. doi: 10.1007/s00280-008-0906-4. Epub 2009 Jan 4.

24.

Mechanism and management of AKT inhibitor-induced hyperglycemia.

Crouthamel MC, Kahana JA, Korenchuk S, Zhang SY, Sundaresan G, Eberwein DJ, Brown KK, Kumar R.

Clin Cancer Res. 2009 Jan 1;15(1):217-25. doi: 10.1158/1078-0432.CCR-08-1253.

25.

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.

Sankaranarayanan S, Holahan MA, Colussi D, Crouthamel MC, Devanarayan V, Ellis J, Espeseth A, Gates AT, Graham SL, Gregro AR, Hazuda D, Hochman JH, Holloway K, Jin L, Kahana J, Lai MT, Lineberger J, McGaughey G, Moore KP, Nantermet P, Pietrak B, Price EA, Rajapakse H, Stauffer S, Steinbeiser MA, Seabrook G, Selnick HG, Shi XP, Stanton MG, Swestock J, Tugusheva K, Tyler KX, Vacca JP, Wong J, Wu G, Xu M, Cook JJ, Simon AJ.

J Pharmacol Exp Ther. 2009 Jan;328(1):131-40. doi: 10.1124/jpet.108.143628. Epub 2008 Oct 14.

PMID:
18854490
26.

N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).

Crouthamel M, Thiyagarajan MM, Evanko DS, Wedegaertner PB.

Cell Signal. 2008 Oct;20(10):1900-10. doi: 10.1016/j.cellsig.2008.06.019. Epub 2008 Jul 2.

27.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.

PMID:
18156464
28.

Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity.

Kumar R, Knick VB, Rudolph SK, Johnson JH, Crosby RM, Crouthamel MC, Hopper TM, Miller CG, Harrington LE, Onori JA, Mullin RJ, Gilmer TM, Truesdale AT, Epperly AH, Boloor A, Stafford JA, Luttrell DK, Cheung M.

Mol Cancer Ther. 2007 Jul;6(7):2012-21.

29.

Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.

Stanton MG, Stauffer SR, Gregro AR, Steinbeiser M, Nantermet P, Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Ellis J, Lai MT, Espeseth AS, Shi XP, Jin L, Colussi D, Pietrak B, Huang Q, Xu M, Simon AJ, Graham SL, Vacca JP, Selnick H.

J Med Chem. 2007 Jul 26;50(15):3431-3. Epub 2007 Jun 21.

PMID:
17583334
30.

Assembly and trafficking of heterotrimeric G proteins.

Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB.

Biochemistry. 2007 Jul 3;46(26):7665-77. Epub 2007 Jun 9. Review.

31.

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.

Lindsley SR, Moore KP, Rajapakse HA, Selnick HG, Young MB, Zhu H, Munshi S, Kuo L, McGaughey GB, Colussi D, Crouthamel MC, Lai MT, Pietrak B, Price EA, Sankaranarayanan S, Simon AJ, Seabrook GR, Hazuda DJ, Pudvah NT, Hochman JH, Graham SL, Vacca JP, Nantermet PG.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4057-61. Epub 2007 Apr 27.

PMID:
17482814
32.

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).

Rajapakse HA, Nantermet PG, Selnick HG, Munshi S, McGaughey GB, Lindsley SR, Young MB, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP.

J Med Chem. 2006 Dec 14;49(25):7270-3.

PMID:
17149856
33.

Evaluating scoring functions for docking and designing beta-secretase inhibitors.

Katharine Holloway M, McGaughey GB, Coburn CA, Stachel SJ, Jones KG, Stanton EL, Gregro AR, Lai MT, Crouthamel MC, Pietrak BL, Munshi SK.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):823-7. Epub 2006 Oct 25.

PMID:
17107793
34.

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

Stachel SJ, Coburn CA, Sankaranarayanan S, Price EA, Wu G, Crouthamel M, Pietrak BL, Huang Q, Lineberger J, Espeseth AS, Jin L, Ellis J, Holloway MK, Munshi S, Allison T, Hazuda D, Simon AJ, Graham SL, Vacca JP.

J Med Chem. 2006 Oct 19;49(21):6147-50. Erratum in: J Med Chem. 2006 Nov 30;49(24):7252. Wu, Guoxin [added]; Crouthamel, Michelle [added].

PMID:
17034118
35.
36.

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.

Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.

J Neurochem. 2006 Jan;96(1):118-25. Epub 2005 Nov 21.

37.

Conformationally biased P3 amide replacements of beta-secretase inhibitors.

Stachel SJ, Coburn CA, Steele TG, Crouthamel MC, Pietrak BL, Lai MT, Holloway MK, Munshi SK, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2006 Feb;16(3):641-4. Epub 2005 Nov 2.

PMID:
16263281
38.

Biochemical and cell-based assays for characterization of BACE-1 inhibitors.

Pietrak BL, Crouthamel MC, Tugusheva K, Lineberger JE, Xu M, DiMuzio JM, Steele T, Espeseth AS, Stachel SJ, Coburn CA, Graham SL, Vacca JP, Shi XP, Simon AJ, Hazuda DJ, Lai MT.

Anal Biochem. 2005 Jul 1;342(1):144-51.

PMID:
15958191
39.

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, Crouthamel MC, Sankaranarayanan S, Simon A, Chen L, Lai MT, Pietrak B, DiMuzio J, Li Y, Xu M, Huang Q, Garsky V, Sardana MK, Hazuda DJ.

J Alzheimers Dis. 2005 Apr;7(2):139-48; discussion 173-80.

PMID:
15851852
40.

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

Espeseth AS, Xu M, Huang Q, Coburn CA, Jones KL, Ferrer M, Zuck PD, Strulovici B, Price EA, Wu G, Wolfe AL, Lineberger JE, Sardana M, Tugusheva K, Pietrak BL, Crouthamel MC, Lai MT, Dodson EC, Bazzo R, Shi XP, Simon AJ, Li Y, Hazuda DJ.

J Biol Chem. 2005 May 6;280(18):17792-7. Epub 2005 Feb 25.

41.

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

Stachel SJ, Coburn CA, Steele TG, Jones KG, Loutzenhiser EF, Gregro AR, Rajapakse HA, Lai MT, Crouthamel MC, Xu M, Tugusheva K, Lineberger JE, Pietrak BL, Espeseth AS, Shi XP, Chen-Dodson E, Holloway MK, Munshi S, Simon AJ, Kuo L, Vacca JP.

J Med Chem. 2004 Dec 16;47(26):6447-50.

PMID:
15588077
42.

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

Coburn CA, Stachel SJ, Li YM, Rush DM, Steele TG, Chen-Dodson E, Holloway MK, Xu M, Huang Q, Lai MT, DiMuzio J, Crouthamel MC, Shi XP, Sardana V, Chen Z, Munshi S, Kuo L, Makara GM, Annis DA, Tadikonda PK, Nash HM, Vacca JP, Wang T.

J Med Chem. 2004 Dec 2;47(25):6117-9.

PMID:
15566281
43.

Rational design and synthesis of selective BACE-1 inhibitors.

Brady SF, Singh S, Crouthamel MC, Holloway MK, Coburn CA, Garsky VM, Bogusky M, Pennington MW, Vacca JP, Hazuda D, Lai MT.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):601-4.

PMID:
14741251
44.

Temporal patterns in long-term survival after resuscitation from out-of-hospital cardiac arrest.

Rea TD, Crouthamel M, Eisenberg MS, Becker LJ, Lima AR.

Circulation. 2003 Sep 9;108(10):1196-201. Epub 2003 Aug 25.

PMID:
12939219
45.

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM.

J Biol Chem. 2003 Jun 20;278(25):22475-81. Epub 2003 Apr 8.

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