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Items: 1 to 50 of 86


Delphi consensus recommendations for a treatment algorithm in pulmonary sarcoidosis.

Rahaghi FF, Baughman RP, Saketkoo LA, Sweiss NJ, Barney JB, Birring SS, Costabel U, Crouser ED, Drent M, Gerke AK, Grutters JC, Hamzeh NY, Huizar I, Ennis James W 4th, Kalra S, Kullberg S, Li H, Lower EE, Maier LA, Mirsaeidi M, Müller-Quernheim J, Carmona Porquera EM, Samavati L, Valeyre D, Scholand MB.

Eur Respir Rev. 2020 Mar 20;29(155). pii: 190146. doi: 10.1183/16000617.0146-2019. Print 2020 Mar 31. Review.


Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.

Hotchkiss RS, Colston E, Yende S, Crouser ED, Martin GS, Albertson T, Bartz RR, Brakenridge SC, Delano MJ, Park PK, Donnino MW, Tidswell M, Mayr FB, Angus DC, Coopersmith CM, Moldawer LL, Catlett IM, Girgis IG, Ye J, Grasela DM.

Intensive Care Med. 2019 Oct;45(10):1360-1371. doi: 10.1007/s00134-019-05704-z. Epub 2019 Oct 1.


Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.

Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC.

JAMA Netw Open. 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686.


Monocyte Distribution Width: A Novel Indicator of Sepsis-2 and Sepsis-3 in High-Risk Emergency Department Patients.

Crouser ED, Parrillo JE, Seymour CW, Angus DC, Bicking K, Esguerra VG, Peck-Palmer OM, Magari RT, Julian MW, Kleven JM, Raj PJ, Procopio G, Careaga D, Tejidor L.

Crit Care Med. 2019 Aug;47(8):1018-1025. doi: 10.1097/CCM.0000000000003799.


What Is the Skinny on Obesity During Sepsis?

Crouser ED, Caldwell CC, Hotchkiss RS.

Crit Care Med. 2019 May;47(5):735-736. doi: 10.1097/CCM.0000000000003707. No abstract available.


Lessons Learned from the ABCs of Granuloma Formation.

Crouser ED.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):277-278. doi: 10.1165/rcmb.2019-0076ED. No abstract available.


Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).

Hotchkiss RS, Colston E, Yende S, Angus DC, Moldawer LL, Crouser ED, Martin GS, Coopersmith CM, Brakenridge S, Mayr FB, Park PK, Ye J, Catlett IM, Girgis IG, Grasela DM.

Crit Care Med. 2019 May;47(5):632-642. doi: 10.1097/CCM.0000000000003685.


IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model.

Locke LW, Crouser ED, White P, Julian MW, Caceres EG, Papp AC, Le VT, Sadee W, Schlesinger LS.

Am J Respir Cell Mol Biol. 2019 Jan;60(1):84-95. doi: 10.1165/rcmb.2018-0053OC.


Blue Light Illuminates a Novel Sepsis Treatment.

Pannu S, Crouser ED.

Crit Care Med. 2018 Aug;46(8):1381-1382. doi: 10.1097/CCM.0000000000003241. No abstract available.


Role of imbalance between Th17 and regulatory T-cells in sarcoidosis.

Crouser ED.

Curr Opin Pulm Med. 2018 Sep;24(5):521-526. doi: 10.1097/MCP.0000000000000498. Review.


Sepsis-Induced Renal Failure: Ischemia or Toxemia?

Crouser ED.

Crit Care Med. 2018 Apr;46(4):658-660. doi: 10.1097/CCM.0000000000002970. No abstract available.


Survival After MI in a Community Cohort Study: Contribution of Comorbidities in NSTEMI.

Foraker RE, Guha A, Chang H, O'Brien EC, Bower JK, Crouser ED, Rosamond WD, Raman SV.

Glob Heart. 2018 Mar;13(1):13-18. doi: 10.1016/j.gheart.2018.01.002. Epub 2018 Mar 5.


Potential immunotherapies for sarcoidosis.

Le V, Crouser ED.

Expert Opin Biol Ther. 2018 Apr;18(4):399-407. doi: 10.1080/14712598.2018.1427727. Epub 2018 Jan 17. Review.


Application of "Omics" and Systems Biology to Sarcoidosis Research.

Crouser ED, Fingerlin TE, Yang IV, Maier LA, Nana-Sinkam P, Collman RG, Kaminski N.

Ann Am Thorac Soc. 2017 Dec;14(Supplement_6):S445-S451. doi: 10.1513/AnnalsATS.201707-567OT. Review.


Executive Summary of the NHLBI Workshop Report: Leveraging Current Scientific Advancements to Understand Sarcoidosis Variability and Improve Outcomes.

Maier LA, Crouser ED, Martin WJ 2nd, Eu J.

Ann Am Thorac Soc. 2017 Dec;14(Supplement_6):S415-S420. doi: 10.1513/AnnalsATS.201707-563OT. Review.


Endothelial Damage During Septic Shock: Significance and Implications for Future Therapies.

Crouser ED, Matthay MA.

Chest. 2017 Jul;152(1):1-3. doi: 10.1016/j.chest.2017.02.016. No abstract available.


Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker.

Crouser ED, Parrillo JE, Seymour C, Angus DC, Bicking K, Tejidor L, Magari R, Careaga D, Williams J, Closser DR, Samoszuk M, Herren L, Robart E, Chaves F.

Chest. 2017 Sep;152(3):518-526. doi: 10.1016/j.chest.2017.05.039. Epub 2017 Jun 15.


A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.

Crouser ED, White P, Caceres EG, Julian MW, Papp AC, Locke LW, Sadee W, Schlesinger LS.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):487-498. doi: 10.1165/rcmb.2016-0321OC.


Steroids and β-Agonists in Acute Respiratory Distress Syndrome: Timing Is Everything.

Englert JA, Crouser ED.

Crit Care Med. 2017 May;45(5):914-915. doi: 10.1097/CCM.0000000000002385. No abstract available.


Exosomal MicroRNA for Detection of Cardiac Sarcoidosis.

Crouser ED, Hamzeh NY, Maier LA, Julian MW, Gillespie M, Rahman M, Baxter D, Wu X, Nana-Sinkam SP, Wang K.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):931-934. doi: 10.1164/rccm.201611-2183LE. No abstract available.


Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.

Crouser ED, Hotchkiss RS.

Crit Care Med. 2017 Jan;45(1):145-147. No abstract available.


Cardiac Electrical and Structural Changes During Bacterial Infection: An Instructive Model to Study Cardiac Dysfunction in Sepsis.

Makara MA, Hoang KV, Ganesan LP, Crouser ED, Gunn JS, Turner J, Schlesinger LS, Mohler PJ, Rajaram MV.

J Am Heart Assoc. 2016 Sep 12;5(9). pii: e003820. doi: 10.1161/JAHA.116.003820.


Severe Sarcoidosis Phenotypes: An Occupational Hazard?

Crouser ED, Amin EN.

Chest. 2016 Aug;150(2):263-5. doi: 10.1016/j.chest.2016.02.663. No abstract available.


In-silico modeling of granulomatous diseases.

Crouser ED.

Curr Opin Pulm Med. 2016 Sep;22(5):500-8. doi: 10.1097/MCP.0000000000000296. Review.


Sepsis-Induced Endoplasmic Reticulum Stress: A Matter of Life and Death?

Crouser ED.

Crit Care Med. 2016 Aug;44(8):1626-7. doi: 10.1097/CCM.0000000000001694. No abstract available.


Resolution of abnormal cardiac MRI T2 signal following immune suppression for cardiac sarcoidosis.

Crouser ED, Ruden E, Julian MW, Raman SV.

J Investig Med. 2016 Aug;64(6):1148-50. doi: 10.1136/jim-2016-000144. Epub 2016 Jun 27.


Sarcoidosis and T-Helper Cells. Th1, Th17, or Th17.1?

Georas SN, Chapman TJ, Crouser ED.

Am J Respir Crit Care Med. 2016 Jun 1;193(11):1198-200. doi: 10.1164/rccm.201512-2419ED. No abstract available.


Effect of disrupted mitochondria as a source of damage-associated molecular patterns on the production of tumor necrosis factor α by splenocytes from dogs.

Friedenberg SG, Strange HR, Guillaumin J, VanGundy ZC, Crouser ED, Papenfuss TL.

Am J Vet Res. 2016 Jun;77(6):604-12. doi: 10.2460/ajvr.77.6.604.


Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes.

Julian MW, Strange HR, Ballinger MN, Hotchkiss RS, Papenfuss TL, Crouser ED.

PLoS One. 2015 Jul 28;10(7):e0132921. doi: 10.1371/journal.pone.0132921. eCollection 2015.


Proceedings of the 2014 AASOG conference.

Crouser ED, Judson MA.

Sarcoidosis Vasc Diffuse Lung Dis. 2015 Jan 5;31(4):359-63. No abstract available.


Mathematical model of sarcoidosis.

Hao W, Crouser ED, Friedman A.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16065-70. doi: 10.1073/pnas.1417789111. Epub 2014 Oct 27.


Current best practice in the management of pulmonary and systemic sarcoidosis.

Amin EN, Closser DR, Crouser ED.

Ther Adv Respir Dis. 2014 Aug;8(4):111-132. Epub 2014 Jul 17.


Mitochondria in lung biology and pathology: more than just a powerhouse.

Schumacker PT, Gillespie MN, Nakahira K, Choi AM, Crouser ED, Piantadosi CA, Bhattacharya J.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L962-74. doi: 10.1152/ajplung.00073.2014. Epub 2014 Apr 18. Review.


Improved detection of cardiac sarcoidosis using magnetic resonance with myocardial T2 mapping.

Crouser ED, Ono C, Tran T, He X, Raman SV.

Am J Respir Crit Care Med. 2014 Jan 1;189(1):109-12. doi: 10.1164/rccm.201309-1668LE. No abstract available.


Nonischemic myocardial changes detected by cardiac magnetic resonance in critical care patients with sepsis.

Siddiqui Y, Crouser ED, Raman SV.

Am J Respir Crit Care Med. 2013 Oct 15;188(8):1037-9. doi: 10.1164/rccm.201304-0744LE. No abstract available.


At-risk but viable myocardium in a large animal model of non ST-segment elevation acute coronary syndrome: cardiovascular magnetic resonance with ex vivo validation.

Chang H, Tran T, Billman GE, Julian MW, Hamlin RL, Simonetti OP, Ambrosio G, Baker PB 3rd, Shao G, Crouser ED, Raman SV.

J Cardiovasc Magn Reson. 2013 Oct 9;15:94. doi: 10.1186/1532-429X-15-94.


Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells.

Julian MW, Shao G, Vangundy ZC, Papenfuss TL, Crouser ED.

PLoS One. 2013 Aug 12;8(8):e72354. doi: 10.1371/journal.pone.0072354. eCollection 2013.


Sustained reduction of central line-associated bloodstream infections in an intensive care unit using a top-down and bottom-up approach.

Sopirala MM, Smyer J, Fawley L, Mangino JE, Lustberg ME, Lu J, Chucta S, Crouser ED.

Am J Infect Control. 2013 Feb;41(2):183-4. doi: 10.1016/j.ajic.2012.07.013. No abstract available.


Autophagy, the first step towards recovery from critical illness.

Crouser ED.

Crit Care Med. 2013 Jan;41(1):358-9. doi: 10.1097/CCM.0b013e31826bf37c. No abstract available.


Nicotine treatment improves Toll-like receptor 2 and Toll-like receptor 9 responsiveness in active pulmonary sarcoidosis.

Julian MW, Shao G, Schlesinger LS, Huang Q, Cosmar DG, Bhatt NY, Culver DA, Baughman RP, Wood KL, Crouser ED.

Chest. 2013 Feb 1;143(2):461-470. doi: 10.1378/chest.12-0383.


Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA.

Julian MW, Shao G, Bao S, Knoell DL, Papenfuss TL, VanGundy ZC, Crouser ED.

J Immunol. 2012 Jul 1;189(1):433-43. doi: 10.4049/jimmunol.1101375. Epub 2012 Jun 6.


Quantitative computerized two-point correlation analysis of lung CT scans correlates with pulmonary function in pulmonary sarcoidosis.

Erdal BS, Crouser ED, Yildiz V, King MA, Patterson AT, Knopp MV, Clymer BD.

Chest. 2012 Dec;142(6):1589-1597. doi: 10.1378/chest.11-2027.


Unexpectedly high prevalence of sarcoidosis in a representative U.S. Metropolitan population.

Erdal BS, Clymer BD, Yildiz VO, Julian MW, Crouser ED.

Respir Med. 2012 Jun;106(6):893-9. doi: 10.1016/j.rmed.2012.02.007. Epub 2012 Mar 13.


Warming up to hypothermia for treatment of severe sepsis*.

Crouser ED.

Crit Care Med. 2012 Mar;40(3):1020-2. doi: 10.1097/CCM.0b013e31823b894f. No abstract available. Erratum in: Crit Care Med. 2012 May;40(5):1697.


Differential expression of microRNA and predicted targets in pulmonary sarcoidosis.

Crouser ED, Julian MW, Crawford M, Shao G, Yu L, Planck SR, Rosenbaum JT, Patrick Nana-Sinkam S.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):886-91. doi: 10.1016/j.bbrc.2011.12.068. Epub 2011 Dec 24.


Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis.

Julian MW, Bao S, Knoell DL, Fahy RJ, Shao G, Crouser ED.

Int J Exp Pathol. 2011 Oct;92(5):366-76. doi: 10.1111/j.1365-2613.2011.00783.x. Epub 2011 Aug 13.


An in silico modeling approach to understanding the dynamics of sarcoidosis.

Aguda BD, Marsh CB, Thacker M, Crouser ED.

PLoS One. 2011;6(5):e19544. doi: 10.1371/journal.pone.0019544. Epub 2011 May 27.


Mitochondrial dysfunction during sepsis: still more questions than answers.

Exline MC, Crouser ED.

Crit Care Med. 2011 May;39(5):1216-7. doi: 10.1097/CCM.0b013e31821487cb. No abstract available.


Mitochondrial mechanisms are at the 'heart' of novel ischemia-reperfusion therapies.

Crouser ED, Parinandi N.

Crit Care Med. 2011 Mar;39(3):593-5. doi: 10.1097/CCM.0b013e31820a515b. No abstract available.


Formyl peptide receptor ligands promote wound closure in lung epithelial cells.

Shao G, Julian MW, Bao S, McCullers MK, Lai JP, Knoell DL, Crouser ED.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):264-9. doi: 10.1165/rcmb.2010-0246RC. Epub 2010 Oct 1.

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