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Items: 1 to 50 of 80

1.

CuII (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease.

Southon AA, Szostak K, Acevedo KM, Dent KA, Volitakis I, Belaidi AA, Barnham KJ, Crouch PJ, Ayton S, Donnelly PS, Bush AI.

Br J Pharmacol. 2019 Oct 26. doi: 10.1111/bph.14881. [Epub ahead of print]

PMID:
31655003
2.

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups.

Paterson BM, Cullinane C, Crouch PJ, White AR, Barnham KJ, Roselt PD, Noonan W, Binns D, Hicks RJ, Donnelly PS.

Inorg Chem. 2019 Apr 1;58(7):4540-4552. doi: 10.1021/acs.inorgchem.9b00117. Epub 2019 Mar 14.

PMID:
30869878
3.

Potential Diagnostic Imaging of Alzheimer's Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques.

McInnes LE, Noor A, Kysenius K, Cullinane C, Roselt P, McLean CA, Chiu FCK, Powell AK, Crouch PJ, White JM, Donnelly PS.

Inorg Chem. 2019 Mar 4;58(5):3382-3395. doi: 10.1021/acs.inorgchem.8b03466. Epub 2019 Feb 20.

PMID:
30785268
4.

Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1.

Kysenius K, Hilton JB, Paul B, Hare DJ, Crouch PJ.

Metallomics. 2019 Jan 23;11(1):141-150. doi: 10.1039/c8mt00242h.

PMID:
30255176
5.

A versatile quantitative microdroplet elemental imaging method optimised for integration in biochemical workflows for low-volume samples.

Kysenius K, Paul B, Hilton JB, Liddell JR, Hare DJ, Crouch PJ.

Anal Bioanal Chem. 2019 Jan;411(3):603-616. doi: 10.1007/s00216-018-1362-6. Epub 2018 Sep 15.

PMID:
30218126
6.

The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1G37R mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1.

Hilton JB, Kysenius K, White AR, Crouch PJ.

Exp Neurol. 2018 Sep;307:118-128. doi: 10.1016/j.expneurol.2018.06.006. Epub 2018 Jun 12.

7.

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke.

Tuo QZ, Lei P, Jackman KA, Li XL, Xiong H, Li XL, Liuyang ZY, Roisman L, Zhang ST, Ayton S, Wang Q, Crouch PJ, Ganio K, Wang XC, Pei L, Adlard PA, Lu YM, Cappai R, Wang JZ, Liu R, Bush AI.

Mol Psychiatry. 2017 Nov;22(11):1520-1530. doi: 10.1038/mp.2017.171. Epub 2017 Sep 8.

PMID:
28886009
8.

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, Liddell JR, White AR.

Hum Mol Genet. 2017 May 1;26(9):1732-1746. doi: 10.1093/hmg/ddx093.

PMID:
28334913
9.

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord.

Hilton JB, Mercer SW, Lim NK, Faux NG, Buncic G, Beckman JS, Roberts BR, Donnelly PS, White AR, Crouch PJ.

Sci Rep. 2017 Feb 13;7:42292. doi: 10.1038/srep42292.

10.

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS).

Hare DJ, Kysenius K, Paul B, Knauer B, Hutchinson RW, O'Connor C, Fryer F, Hennessey TP, Bush AI, Crouch PJ, Doble PA.

J Vis Exp. 2017 Jan 22;(119). doi: 10.3791/55042.

11.

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

Mot AI, Liddell JR, White AR, Crouch PJ.

Int J Biochem Cell Biol. 2016 Oct;79:128-138. doi: 10.1016/j.biocel.2016.08.029. Epub 2016 Aug 30.

12.

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.

Perera ND, Sheean RK, Crouch PJ, White AR, Horne MK, Turner BJ.

Hum Mol Genet. 2016 Sep 15;25(18):4080-4093. doi: 10.1093/hmg/ddw247. Epub 2016 Jul 27.

PMID:
27466204
13.

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.

Hilton JB, White AR, Crouch PJ.

Metallomics. 2016 Sep 1;8(9):1002-11. doi: 10.1039/c6mt00099a. Epub 2016 Jun 30.

PMID:
27357743
14.

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex.

Hare DJ, Raven EP, Roberts BR, Bogeski M, Portbury SD, McLean CA, Masters CL, Connor JR, Bush AI, Crouch PJ, Doble PA.

Neuroimage. 2016 Aug 15;137:124-131. doi: 10.1016/j.neuroimage.2016.05.057. Epub 2016 May 24.

PMID:
27233149
15.

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

Wright DJ, Gray LJ, Finkelstein DI, Crouch PJ, Pow D, Pang TY, Li S, Smith ZM, Francis PS, Renoir T, Hannan AJ.

Hum Mol Genet. 2016 Jul 15;25(14):2923-2933. Epub 2016 May 14.

PMID:
27179791
16.

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD.

Williams JR, Trias E, Beilby PR, Lopez NI, Labut EM, Bradford CS, Roberts BR, McAllum EJ, Crouch PJ, Rhoads TW, Pereira C, Son M, Elliott JL, Franco MC, Estévez AG, Barbeito L, Beckman JS.

Neurobiol Dis. 2016 May;89:1-9. doi: 10.1016/j.nbd.2016.01.020. Epub 2016 Jan 27.

17.

Intracellular distribution of fluorescent copper and zinc bis(thiosemicarbazonato) complexes measured with fluorescence lifetime spectroscopy.

Hickey JL, James JL, Henderson CA, Price KA, Mot AI, Buncic G, Crouch PJ, White JM, White AR, Smith TA, Donnelly PS.

Inorg Chem. 2015 Oct 5;54(19):9556-67. doi: 10.1021/acs.inorgchem.5b01599. Epub 2015 Sep 23.

PMID:
26397162
18.

Toward hypoxia-selective rhenium and technetium tricarbonyl complexes.

North AJ, Hayne DJ, Schieber C, Price K, White AR, Crouch PJ, Rigopoulos A, O'Keefe GJ, Tochon-Danguy H, Scott AM, White JM, Ackermann U, Donnelly PS.

Inorg Chem. 2015 Oct 5;54(19):9594-610. doi: 10.1021/acs.inorgchem.5b01691. Epub 2015 Sep 16.

19.

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

Lewis V, Johanssen VA, Crouch PJ, Klug GM, Hooper NM, Collins SJ.

Cell Mol Life Sci. 2016 Feb;73(3):667-83. doi: 10.1007/s00018-015-2022-z. Epub 2015 Aug 23.

PMID:
26298290
20.

Editorial: Metals and neurodegeneration: restoring the balance.

White AR, Kanninen KM, Crouch PJ.

Front Aging Neurosci. 2015 Jul 2;7:127. doi: 10.3389/fnagi.2015.00127. eCollection 2015. No abstract available.

21.

Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis.

Crouch PJ.

Neurology. 2015 May 19;84(20):2038. doi: 10.1212/WNL.0000000000001600. Epub 2015 Apr 22. No abstract available.

PMID:
25904689
22.

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

McAllum EJ, Roberts BR, Hickey JL, Dang TN, Grubman A, Donnelly PS, Liddell JR, White AR, Crouch PJ.

Neurobiol Dis. 2015 Sep;81:20-4. doi: 10.1016/j.nbd.2015.02.023. Epub 2015 Mar 10.

23.

Metal-deficient SOD1 in amyotrophic lateral sclerosis.

Hilton JB, White AR, Crouch PJ.

J Mol Med (Berl). 2015 May;93(5):481-7. doi: 10.1007/s00109-015-1273-3. Epub 2015 Mar 11. Review.

24.

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

Moujalled D, James JL, Yang S, Zhang K, Duncan C, Moujalled DM, Parker SJ, Caragounis A, Lidgerwood G, Turner BJ, Atkin JD, Grubman A, Liddell JR, Proepper C, Boeckers TM, Kanninen KM, Blair I, Crouch PJ, White AR.

Hum Mol Genet. 2015 Mar 15;24(6):1655-69. doi: 10.1093/hmg/ddu578. Epub 2014 Nov 19.

PMID:
25410660
25.

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder.

Grubman A, James SA, James J, Duncan C, Volitakis I, Hickey JL, Crouch PJ, Donnelly PS, Kanninen KM, Liddell JR, Cotman SL, de Jonge, White AR.

Chem Sci. 2014 Jun;5(6):2503-2516.

26.

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

Roberts BR, Lim NK, McAllum EJ, Donnelly PS, Hare DJ, Doble PA, Turner BJ, Price KA, Lim SC, Paterson BM, Hickey JL, Rhoads TW, Williams JR, Kanninen KM, Hung LW, Liddell JR, Grubman A, Monty JF, Llanos RM, Kramer DR, Mercer JF, Bush AI, Masters CL, Duce JA, Li QX, Beckman JS, Barnham KJ, White AR, Crouch PJ.

J Neurosci. 2014 Jun 4;34(23):8021-31. doi: 10.1523/JNEUROSCI.4196-13.2014.

27.

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Grubman A, Pollari E, Duncan C, Caragounis A, Blom T, Volitakis I, Wong A, Cooper J, Crouch PJ, Koistinaho J, Jalanko A, White AR, Kanninen KM.

Metallomics. 2014 Apr;6(4):932-43.

PMID:
24804307
28.

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

Lim NK, Hung LW, Pang TY, Mclean CA, Liddell JR, Hilton JB, Li QX, White AR, Hannan AJ, Crouch PJ.

Hum Mol Genet. 2014 Aug 1;23(15):4051-63. doi: 10.1093/hmg/ddu119. Epub 2014 Mar 14.

PMID:
24634145
29.

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

Bica L, Liddell JR, Donnelly PS, Duncan C, Caragounis A, Volitakis I, Paterson BM, Cappai R, Grubman A, Camakaris J, Crouch PJ, White AR.

PLoS One. 2014 Feb 28;9(2):e90070. doi: 10.1371/journal.pone.0090070. eCollection 2014.

30.

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder.

Grubman A, Lidgerwood GE, Duncan C, Bica L, Tan JL, Parker SJ, Caragounis A, Meyerowitz J, Volitakis I, Moujalled D, Liddell JR, Hickey JL, Horne M, Longmuir S, Koistinaho J, Donnelly PS, Crouch PJ, Tammen I, White AR, Kanninen KM.

Acta Neuropathol Commun. 2014 Feb 28;2:25. doi: 10.1186/2051-5960-2-25.

31.

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Dang TN, Lim NK, Grubman A, Li QX, Volitakis I, White AR, Crouch PJ.

Front Aging Neurosci. 2014 Feb 11;6:15. doi: 10.3389/fnagi.2014.00015. eCollection 2014.

32.

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.

Walker AK, Soo KY, Sundaramoorthy V, Parakh S, Ma Y, Farg MA, Wallace RH, Crouch PJ, Turner BJ, Horne MK, Atkin JD.

PLoS One. 2013 Nov 29;8(11):e81170. doi: 10.1371/journal.pone.0081170. eCollection 2013.

33.

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

McAllum EJ, Lim NK, Hickey JL, Paterson BM, Donnelly PS, Li QX, Liddell JR, Barnham KJ, White AR, Crouch PJ.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec;14(7-8):586-90. doi: 10.3109/21678421.2013.824000. Epub 2013 Aug 19.

PMID:
23952668
34.

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.

Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR.

PLoS One. 2013 Jun 26;8(6):e67433. doi: 10.1371/journal.pone.0067433. Print 2013.

35.

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.

Dang TN, Dobson-Stone C, Glaros EN, Kim WS, Hallupp M, Bartley L, Piguet O, Hodges JR, Halliday GM, Double KL, Schofield PR, Crouch PJ, Kwok JB.

Dis Model Mech. 2013 Sep;6(5):1198-204. doi: 10.1242/dmm.011460. Epub 2013 Jun 20.

36.

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis.

Kanninen KM, Grubman A, Caragounis A, Duncan C, Parker SJ, Lidgerwood GE, Volitakis I, Ganio G, Crouch PJ, White AR.

Biol Open. 2013 May 20;2(6):635-46. doi: 10.1242/bio.20134804. Print 2013 Jun 15.

37.

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

Duncan C, Bica L, Crouch PJ, Caragounis A, Lidgerwood GE, Parker SJ, Meyerowitz J, Volitakis I, Liddell JR, Raghupathi R, Paterson BM, Duffield MD, Cappai R, Donnelly PS, Grubman A, Camakaris J, Keating DJ, White AR.

Metallomics. 2013 Jun;5(6):700-14. doi: 10.1039/c3mt20231c.

PMID:
23661118
38.

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.

Tan JL, Li QX, Ciccotosto GD, Crouch PJ, Culvenor JG, White AR, Evin G.

PLoS One. 2013 Apr 17;8(4):e61246. doi: 10.1371/journal.pone.0061246. Print 2013.

39.

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells.

Trounce IA, Crouch PJ, Carey KT, McKenzie M.

Biochim Biophys Acta. 2013 Jul;1827(7):817-25. doi: 10.1016/j.bbabio.2013.03.012. Epub 2013 Apr 6.

40.

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.

Kanninen KM, Grubman A, Meyerowitz J, Duncan C, Tan JL, Parker SJ, Crouch PJ, Paterson BM, Hickey JL, Donnelly PS, Volitakis I, Tammen I, Palmer DN, White AR.

PLoS One. 2013;8(3):e58644. doi: 10.1371/journal.pone.0058644. Epub 2013 Mar 14.

41.

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease.

Liddell JR, Obando D, Liu J, Ganio G, Volitakis I, Mok SS, Crouch PJ, White AR, Codd R.

Free Radic Biol Med. 2013 Jul;60:147-56. doi: 10.1016/j.freeradbiomed.2013.01.027. Epub 2013 Feb 4.

PMID:
23391576
42.

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.

Parker SJ, Meyerowitz J, James JL, Liddell JR, Nonaka T, Hasegawa M, Kanninen KM, Lim S, Paterson BM, Donnelly PS, Crouch PJ, White AR.

PLoS One. 2012;7(8):e42277. doi: 10.1371/journal.pone.0042277. Epub 2012 Aug 3.

43.

Therapeutic redistribution of metal ions to treat Alzheimer's disease.

Crouch PJ, Barnham KJ.

Acc Chem Res. 2012 Sep 18;45(9):1604-11. Epub 2012 Jun 29.

PMID:
22747493
44.

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.

Hung LW, Villemagne VL, Cheng L, Sherratt NA, Ayton S, White AR, Crouch PJ, Lim S, Leong SL, Wilkins S, George J, Roberts BR, Pham CL, Liu X, Chiu FC, Shackleford DM, Powell AK, Masters CL, Bush AI, O'Keefe G, Culvenor JG, Cappai R, Cherny RA, Donnelly PS, Hill AF, Finkelstein DI, Barnham KJ.

J Exp Med. 2012 Apr 9;209(4):837-54. doi: 10.1084/jem.20112285. Epub 2012 Apr 2.

45.

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates.

Parker SJ, Meyerowitz J, James JL, Liddell JR, Crouch PJ, Kanninen KM, White AR.

Neurochem Int. 2012 Mar;60(4):415-24. doi: 10.1016/j.neuint.2012.01.019. Epub 2012 Jan 27.

PMID:
22306778
46.

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

Donnelly PS, Liddell JR, Lim S, Paterson BM, Cater MA, Savva MS, Mot AI, James JL, Trounce IA, White AR, Crouch PJ.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):47-52. doi: 10.1073/pnas.1116227108. Epub 2011 Dec 15.

47.

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.

Soon CP, Donnelly PS, Turner BJ, Hung LW, Crouch PJ, Sherratt NA, Tan JL, Lim NK, Lam L, Bica L, Lim S, Hickey JL, Morizzi J, Powell A, Finkelstein DI, Culvenor JG, Masters CL, Duce J, White AR, Barnham KJ, Li QX.

J Biol Chem. 2011 Dec 23;286(51):44035-44. doi: 10.1074/jbc.M111.274407. Epub 2011 Oct 27.

48.

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5.

Du T, Caragounis A, Parker SJ, Meyerowitz J, La Fontaine S, Kanninen KM, Perreau VM, Crouch PJ, White AR.

Free Radic Biol Med. 2011 Dec 1;51(11):2060-72. doi: 10.1016/j.freeradbiomed.2011.09.006. Epub 2011 Sep 16.

PMID:
21971347
49.

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).

Price KA, Crouch PJ, Lim S, Paterson BM, Liddell JR, Donnelly PS, White AR.

Metallomics. 2011 Dec;3(12):1280-90. doi: 10.1039/c1mt00092f. Epub 2011 Sep 19.

PMID:
21927768
50.

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

Price KA, Crouch PJ, Volitakis I, Paterson BM, Lim S, Donnelly PS, White AR.

Inorg Chem. 2011 Oct 3;50(19):9594-605. doi: 10.1021/ic201334q. Epub 2011 Sep 1.

PMID:
21882803

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