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Items: 1 to 50 of 168

1.

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases.

Crotty S.

Immunity. 2019 May 21;50(5):1132-1148. doi: 10.1016/j.immuni.2019.04.011. Review.

PMID:
31117010
2.

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance.

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S.

Cell. 2019 May 16;177(5):1153-1171.e28. doi: 10.1016/j.cell.2019.04.012. Epub 2019 May 9.

PMID:
31080066
3.

Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells.

Dan JM, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales SL, Anderson EL, LaRock CN, Vijayanand P, Seumois G, Layfield D, Cutress RI, Ottensmeier CH, Lindestam Arlehamn CS, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau3776. doi: 10.1126/scitranslmed.aau3776.

4.

Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf.

Li F, Zeng Z, Xing S, Gullicksrud JA, Shan Q, Choi J, Badovinac VP, Crotty S, Peng W, Xue HH.

Nat Commun. 2018 Dec 21;9(1):5452. doi: 10.1038/s41467-018-07853-z.

5.

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.

Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Lee JH, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, Burton DR.

Immunity. 2019 Jan 15;50(1):241-252.e6. doi: 10.1016/j.immuni.2018.11.011. Epub 2018 Dec 11.

6.

When designing vaccines, consider the starting material: the human B cell repertoire.

Havenar-Daughton C, Abbott RK, Schief WR, Crotty S.

Curr Opin Immunol. 2018 Aug;53:209-216. doi: 10.1016/j.coi.2018.08.002. Epub 2018 Sep 3. Review.

7.

Foundation species patch configuration mediates salt marsh biodiversity, stability and multifunctionality.

Crotty SM, Sharp SJ, Bersoza AC, Prince KD, Cronk K, Johnson EE, Angelini C.

Ecol Lett. 2018 Nov;21(11):1681-1692. doi: 10.1111/ele.13146. Epub 2018 Aug 23.

PMID:
30141246
8.

Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials.

Patricia D'Souza M, Allen MA, Baumblatt JAG, Boggiano C, Crotty S, Grady C, Havenar-Daughton C, Heit A, Hu DJ, Kunwar N, McElrath MJ; Lymph Node Webinar Contributors.

Vaccine. 2018 Sep 11;36(38):5671-5677. doi: 10.1016/j.vaccine.2018.07.071. Epub 2018 Aug 7.

PMID:
30097219
9.

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.

Cho S, Lee HM, Yu IS, Choi YS, Huang HY, Hashemifar SS, Lin LL, Chen MC, Afanasiev ND, Khan AA, Lin SW, Rudensky AY, Crotty S, Lu LF.

Nat Commun. 2018 Jul 16;9(1):2757. doi: 10.1038/s41467-018-05196-3.

10.

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.

Havenar-Daughton C, Sarkar A, Kulp DW, Toy L, Hu X, Deresa I, Kalyuzhniy O, Kaushik K, Upadhyay AA, Menis S, Landais E, Cao L, Diedrich JK, Kumar S, Schiffner T, Reiss SM, Seumois G, Yates JR, Paulson JC, Bosinger SE, Wilson IA, Schief WR, Crotty S.

Sci Transl Med. 2018 Jul 4;10(448). pii: eaat0381. doi: 10.1126/scitranslmed.aat0381.

11.

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters.

da Silva Antunes R, Babor M, Carpenter C, Khalil N, Cortese M, Mentzer AJ, Seumois G, Petro CD, Purcell LA, Vijayanand P, Crotty S, Pulendran B, Peters B, Sette A.

J Clin Invest. 2018 Aug 31;128(9):3853-3865. doi: 10.1172/JCI121309. Epub 2018 Aug 6.

12.

The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.

Wang D, Diao H, Getzler AJ, Rogal W, Frederick MA, Milner J, Yu B, Crotty S, Goldrath AW, Pipkin ME.

Immunity. 2018 Apr 17;48(4):659-674.e6. doi: 10.1016/j.immuni.2018.03.028.

13.

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data.

Upadhyay AA, Kauffman RC, Wolabaugh AN, Cho A, Patel NB, Reiss SM, Havenar-Daughton C, Dawoud RA, Tharp GK, Sanz I, Pulendran B, Crotty S, Lee FE, Wrammert J, Bosinger SE.

Genome Med. 2018 Mar 20;10(1):20. doi: 10.1186/s13073-018-0528-3.

14.

Characterization of murine antibody responses to vaccinia virus envelope protein A14 reveals an immunodominant antigen lacking of effective neutralization targets.

Meng X, Kaever T, Yan B, Traktman P, Zajonc DM, Peters B, Crotty S, Xiang Y.

Virology. 2018 May;518:284-292. doi: 10.1016/j.virol.2018.03.005. Epub 2018 Mar 17.

15.

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.

Gaddis DE, Padgett LE, Wu R, McSkimming C, Romines V, Taylor AM, McNamara CA, Kronenberg M, Crotty S, Thomas MJ, Sorci-Thomas MG, Hedrick CC.

Nat Commun. 2018 Mar 15;9(1):1095. doi: 10.1038/s41467-018-03493-5.

16.

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, Kasturi S, Pulendran B, Wilson IA, Montefiori DC, Sanders RW, Ward AB, Moore JP.

PLoS Pathog. 2018 Feb 23;14(2):e1006913. doi: 10.1371/journal.ppat.1006913. eCollection 2018 Feb.

17.

Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses.

da Silva Antunes R, Paul S, Sidney J, Weiskopf D, Dan JM, Phillips E, Mallal S, Crotty S, Sette A, Lindestam Arlehamn CS.

PLoS One. 2018 Feb 20;13(2):e0193382. doi: 10.1371/journal.pone.0193382. eCollection 2018.

18.

A natural history model of New England salt marsh die-off.

Pettengill TM, Crotty SM, Angelini C, Bertness MD.

Oecologia. 2018 Mar;186(3):621-632. doi: 10.1007/s00442-018-4078-6. Epub 2018 Jan 22. Review.

PMID:
29357031
19.

Erratum: Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.

Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW.

Nature. 2018 Feb 15;554(7692):392. doi: 10.1038/nature25445. Epub 2018 Jan 10.

PMID:
29320476
20.

Raging evolution of a B cell response to a viral infection.

Crotty S.

Nat Rev Immunol. 2018 Feb;18(2):79. doi: 10.1038/nri.2017.219. Epub 2018 Jan 2. No abstract available.

PMID:
29292394
21.

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens.

Abbott RK, Lee JH, Menis S, Skog P, Rossi M, Ota T, Kulp DW, Bhullar D, Kalyuzhniy O, Havenar-Daughton C, Schief WR, Nemazee D, Crotty S.

Immunity. 2018 Jan 16;48(1):133-146.e6. doi: 10.1016/j.immuni.2017.11.023. Epub 2017 Dec 26.

22.

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.

Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW.

Nature. 2017 Dec 14;552(7684):253-257. doi: 10.1038/nature24993. Epub 2017 Dec 6. Erratum in: Nature. 2018 Jan 10;:.

23.

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.

Kulp DW, Steichen JM, Pauthner M, Hu X, Schiffner T, Liguori A, Cottrell CA, Havenar-Daughton C, Ozorowski G, Georgeson E, Kalyuzhniy O, Willis JR, Kubitz M, Adachi Y, Reiss SM, Shin M, de Val N, Ward AB, Crotty S, Burton DR, Schief WR.

Nat Commun. 2017 Nov 21;8(1):1655. doi: 10.1038/s41467-017-01549-6.

24.

Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.

Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM.

J Biol Chem. 2018 Jan 5;293(1):390-401. doi: 10.1074/jbc.M117.814541. Epub 2017 Nov 9.

25.

Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells.

Reiss S, Baxter AE, Cirelli KM, Dan JM, Morou A, Daigneault A, Brassard N, Silvestri G, Routy JP, Havenar-Daughton C, Crotty S, Kaufmann DE.

PLoS One. 2017 Oct 24;12(10):e0186998. doi: 10.1371/journal.pone.0186998. eCollection 2017.

26.

Multiple stressors and the potential for synergistic loss of New England salt marshes.

Crotty SM, Angelini C, Bertness MD.

PLoS One. 2017 Aug 31;12(8):e0183058. doi: 10.1371/journal.pone.0183058. eCollection 2017.

27.

Absence of the neurogenesis-dependent nuclear receptor TLX induces inflammation in the hippocampus.

Kozareva DA, Hueston CM, Ó'Léime CS, Crotty S, Dockery P, Cryan JF, Nolan YM.

J Neuroimmunol. 2019 Jun 15;331:87-96. doi: 10.1016/j.jneuroim.2017.08.008. Epub 2017 Aug 20.

PMID:
28844503
28.

Germinal center enhancement by extended antigen availability.

Cirelli KM, Crotty S.

Curr Opin Immunol. 2017 Aug;47:64-69. doi: 10.1016/j.coi.2017.06.008. Epub 2017 Jul 21. Review.

29.

A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers.

Wing JB, Kitagawa Y, Locci M, Hume H, Tay C, Morita T, Kidani Y, Matsuda K, Inoue T, Kurosaki T, Crotty S, Coban C, Ohkura N, Sakaguchi S.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6400-E6409. doi: 10.1073/pnas.1705551114. Epub 2017 Jul 11.

30.

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR.

Immunity. 2017 Jun 20;46(6):1073-1088.e6. doi: 10.1016/j.immuni.2017.05.007.

31.

Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.

Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW.

Nat Immunol. 2017 May 18;18(6):705. doi: 10.1038/ni0617-705b. No abstract available.

PMID:
28518161
32.

Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells.

Schulten V, Tripple V, Seumois G, Qian Y, Scheuermann RH, Fu Z, Locci M, Rosales S, Vijayanand P, Sette A, Alam R, Crotty S, Peters B.

J Allergy Clin Immunol. 2018 Feb;141(2):775-777.e6. doi: 10.1016/j.jaci.2017.04.032. Epub 2017 May 12. No abstract available.

33.

Development of an animal model of progressive vaccinia in nu/nu mice and the use of bioluminescence imaging for assessment of the efficacy of monoclonal antibodies against vaccinial B5 and L1 proteins.

Zaitseva M, Thomas A, Meseda CA, Cheung CYK, Diaz CG, Xiang Y, Crotty S, Golding H.

Antiviral Res. 2017 Aug;144:8-20. doi: 10.1016/j.antiviral.2017.05.002. Epub 2017 May 8.

PMID:
28495463
34.
35.

Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.

Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW.

Nat Immunol. 2017 May;18(5):573-582. doi: 10.1038/ni.3706. Epub 2017 Mar 13. Erratum in: Nat Immunol. 2017 May 18;18(6):705.

36.

T cells control the generation of nanomolar-affinity anti-glycan antibodies.

Polonskaya Z, Deng S, Sarkar A, Kain L, Comellas-Aragones M, McKay CS, Kaczanowska K, Holt M, McBride R, Palomo V, Self KM, Taylor S, Irimia A, Mehta SR, Dan JM, Brigger M, Crotty S, Schoenberger SP, Paulson JC, Wilson IA, Savage PB, Finn MG, Teyton L.

J Clin Invest. 2017 Apr 3;127(4):1491-1504. doi: 10.1172/JCI91192. Epub 2017 Mar 13.

37.

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem.

Havenar-Daughton C, Lee JH, Crotty S.

Immunol Rev. 2017 Jan;275(1):49-61. doi: 10.1111/imr.12512. Review.

PMID:
28133798
38.

Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses.

da Silva Antunes R, Paul S, Sidney J, Weiskopf D, Dan JM, Phillips E, Mallal S, Crotty S, Sette A, Lindestam Arlehamn CS.

PLoS One. 2017 Jan 12;12(1):e0169086. doi: 10.1371/journal.pone.0169086. eCollection 2017. Erratum in: PLoS One. 2018 Feb 20;13(2):e0193382.

39.

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques.

Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira ELV, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B.

J Virol. 2017 Jan 31;91(4). pii: e01844-16. doi: 10.1128/JVI.01844-16. Print 2017 Feb 15.

40.

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.

Havenar-Daughton C, Carnathan DG, Torrents de la Peña A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, Mohammed AUR, Huang J, Gumber S, Garcia A, Kasturi SP, Pulendran B, Moore JP, Ahmed R, Seumois G, Burton DR, Sanders RW, Silvestri G, Crotty S.

Cell Rep. 2016 Nov 22;17(9):2195-2209. doi: 10.1016/j.celrep.2016.10.085.

41.

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.

Tam HH, Melo MB, Kang M, Pelet JM, Ruda VM, Foley MH, Hu JK, Kumari S, Crampton J, Baldeon AD, Sanders RW, Moore JP, Crotty S, Langer R, Anderson DG, Chakraborty AK, Irvine DJ.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6639-E6648. Epub 2016 Oct 4.

42.

Erratum: Activin A programs the differentiation of human TFH cells.

Locci M, Wu JE, Arumemi F, Mikulski Z, Dahlberg C, Miller AT, Crotty S.

Nat Immunol. 2016 Sep 20;17(10):1235. doi: 10.1038/ni1016-1235d. No abstract available.

PMID:
27648551
43.

Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells.

Bélanger S, Crotty S.

Nat Immunol. 2016 Sep 20;17(10):1135-6. doi: 10.1038/ni.3561. No abstract available.

PMID:
27648538
44.

Response to Comment on "A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood".

Dan JM, Havenar-Daughton C, Silvestri G, Sette A, Crotty S.

J Immunol. 2016 Oct 1;197(7):2558. doi: 10.4049/jimmunol.1601321. No abstract available.

45.

Erratum: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.

Pedros C, Zhang Y, Hu JK, Choi YS, Canonigo-Balancio AJ, Yates JR 3rd, Altman A, Crotty S, Kong KF.

Nat Immunol. 2016 Jul 19;17(8):1005. doi: 10.1038/ni0816-1005b. No abstract available.

PMID:
27434013
46.

Activin A programs the differentiation of human TFH cells.

Locci M, Wu JE, Arumemi F, Mikulski Z, Dahlberg C, Miller AT, Crotty S.

Nat Immunol. 2016 Aug;17(8):976-84. doi: 10.1038/ni.3494. Epub 2016 Jul 4. Erratum in: Nat Immunol. 2016 Sep 20;17(10):1235.

47.

Acquisition of the yeast Kluyveromyces marxianus from unpasteurised milk by a kefir grain enhances kefir quality.

Gethins L, Rea MC, Stanton C, Ross RP, Kilcawley K, O'Sullivan M, Crotty S, Morrissey JP.

FEMS Microbiol Lett. 2016 Aug;363(16). pii: fnw165. doi: 10.1093/femsle/fnw165. Epub 2016 Jul 1.

PMID:
27369085
48.

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.

Dan JM, Lindestam Arlehamn CS, Weiskopf D, da Silva Antunes R, Havenar-Daughton C, Reiss SM, Brigger M, Bothwell M, Sette A, Crotty S.

J Immunol. 2016 Aug 1;197(3):983-93. doi: 10.4049/jimmunol.1600318. Epub 2016 Jun 24.

49.

Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique.

Havenar-Daughton C, Reiss SM, Carnathan DG, Wu JE, Kendric K, Torrents de la Peña A, Kasturi SP, Dan JM, Bothwell M, Sanders RW, Pulendran B, Silvestri G, Crotty S.

J Immunol. 2016 Aug 1;197(3):994-1002. doi: 10.4049/jimmunol.1600320. Epub 2016 Jun 22.

50.

Polymer architectures via mass spectrometry and hyphenated techniques: A review.

Crotty S, Gerişlioğlu S, Endres KJ, Wesdemiotis C, Schubert US.

Anal Chim Acta. 2016 Aug 17;932:1-21. doi: 10.1016/j.aca.2016.05.024. Epub 2016 May 24. Review.

PMID:
27286765

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