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Items: 1 to 50 of 177

1.

Engineered immunogen binding to alum adjuvant enhances humoral immunity.

Moyer TJ, Kato Y, Abraham W, Chang JYH, Kulp DW, Watson N, Turner HL, Menis S, Abbott RK, Bhiman JN, Melo MB, Simon HA, Herrera-De la Mata S, Liang S, Seumois G, Agarwal Y, Li N, Burton DR, Ward AB, Schief WR, Crotty S, Irvine DJ.

Nat Med. 2020 Feb 17. doi: 10.1038/s41591-020-0753-3. [Epub ahead of print]

PMID:
32066977
2.

Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations.

Havenar-Daughton C, Newton IG, Zare SY, Reiss SM, Schwan B, Suh MJ, Hasteh F, Levi G, Crotty S.

J Immunol Methods. 2020 Jan 17:112746. doi: 10.1016/j.jim.2020.112746. [Epub ahead of print]

PMID:
31958451
3.

Reinvigorating NIH Grant Peer Review.

Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, Krummel M, Pepper M, Rothlin CV, Wherry EJ; Once-a-Year Pledge Supporters.

Immunity. 2020 Jan 14;52(1):1-3. doi: 10.1016/j.immuni.2019.12.016. No abstract available.

PMID:
31940266
4.

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance.

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S.

Cell. 2020 Jan 9;180(1):206. doi: 10.1016/j.cell.2019.12.027. No abstract available.

5.

Optimizing coastal restoration with the stress gradient hypothesis.

Fischman HS, Crotty SM, Angelini C.

Proc Biol Sci. 2019 Dec 18;286(1917):20191978. doi: 10.1098/rspb.2019.1978. Epub 2019 Dec 18.

PMID:
31847771
6.

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization.

Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, Bosinger SE, Schief WR, Irvine DJ, Silvestri G, Crotty S.

Cell Rep. 2019 Nov 12;29(7):1756-1766.e8. doi: 10.1016/j.celrep.2019.10.008.

7.

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.

Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR.

Science. 2019 Dec 6;366(6470). pii: eaax4380. doi: 10.1126/science.aax4380. Epub 2019 Oct 31.

PMID:
31672916
8.

GHOST: Recovering Historical Signal from Heterotachously Evolved Sequence Alignments.

Crotty SM, Minh BQ, Bean NG, Holland BR, Tuke J, Jermiin LS, Haeseler AV.

Syst Biol. 2020 Mar 1;69(2):249-264. doi: 10.1093/sysbio/syz051.

PMID:
31364711
9.

Editorial overview: Vaccine immunology: what is seen and not seen.

Crotty S.

Curr Opin Immunol. 2019 Aug;59:iii-v. doi: 10.1016/j.coi.2019.05.010. Epub 2019 Jun 21. No abstract available.

PMID:
31235312
10.

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases.

Crotty S.

Immunity. 2019 May 21;50(5):1132-1148. doi: 10.1016/j.immuni.2019.04.011. Review.

PMID:
31117010
11.

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance.

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S.

Cell. 2019 May 16;177(5):1153-1171.e28. doi: 10.1016/j.cell.2019.04.012. Epub 2019 May 9. Erratum in: Cell. 2020 Jan 9;180(1):206.

PMID:
31080066
12.

Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells.

Dan JM, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales SL, Anderson EL, LaRock CN, Vijayanand P, Seumois G, Layfield D, Cutress RI, Ottensmeier CH, Lindestam Arlehamn CS, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau3776. doi: 10.1126/scitranslmed.aau3776.

13.

Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf.

Li F, Zeng Z, Xing S, Gullicksrud JA, Shan Q, Choi J, Badovinac VP, Crotty S, Peng W, Xue HH.

Nat Commun. 2018 Dec 21;9(1):5452. doi: 10.1038/s41467-018-07853-z.

14.

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.

Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Lee JH, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, Burton DR.

Immunity. 2019 Jan 15;50(1):241-252.e6. doi: 10.1016/j.immuni.2018.11.011. Epub 2018 Dec 11.

15.

When designing vaccines, consider the starting material: the human B cell repertoire.

Havenar-Daughton C, Abbott RK, Schief WR, Crotty S.

Curr Opin Immunol. 2018 Aug;53:209-216. doi: 10.1016/j.coi.2018.08.002. Epub 2018 Sep 3. Review.

16.

Foundation species patch configuration mediates salt marsh biodiversity, stability and multifunctionality.

Crotty SM, Sharp SJ, Bersoza AC, Prince KD, Cronk K, Johnson EE, Angelini C.

Ecol Lett. 2018 Nov;21(11):1681-1692. doi: 10.1111/ele.13146. Epub 2018 Aug 23.

PMID:
30141246
17.

Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials.

Patricia D'Souza M, Allen MA, Baumblatt JAG, Boggiano C, Crotty S, Grady C, Havenar-Daughton C, Heit A, Hu DJ, Kunwar N, McElrath MJ; Lymph Node Webinar Contributors.

Vaccine. 2018 Sep 11;36(38):5671-5677. doi: 10.1016/j.vaccine.2018.07.071. Epub 2018 Aug 7.

PMID:
30097219
18.

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.

Cho S, Lee HM, Yu IS, Choi YS, Huang HY, Hashemifar SS, Lin LL, Chen MC, Afanasiev ND, Khan AA, Lin SW, Rudensky AY, Crotty S, Lu LF.

Nat Commun. 2018 Jul 16;9(1):2757. doi: 10.1038/s41467-018-05196-3.

19.

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.

Havenar-Daughton C, Sarkar A, Kulp DW, Toy L, Hu X, Deresa I, Kalyuzhniy O, Kaushik K, Upadhyay AA, Menis S, Landais E, Cao L, Diedrich JK, Kumar S, Schiffner T, Reiss SM, Seumois G, Yates JR, Paulson JC, Bosinger SE, Wilson IA, Schief WR, Crotty S.

Sci Transl Med. 2018 Jul 4;10(448). pii: eaat0381. doi: 10.1126/scitranslmed.aat0381.

20.

Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters.

da Silva Antunes R, Babor M, Carpenter C, Khalil N, Cortese M, Mentzer AJ, Seumois G, Petro CD, Purcell LA, Vijayanand P, Crotty S, Pulendran B, Peters B, Sette A.

J Clin Invest. 2018 Aug 31;128(9):3853-3865. doi: 10.1172/JCI121309. Epub 2018 Aug 6.

21.

The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.

Wang D, Diao H, Getzler AJ, Rogal W, Frederick MA, Milner J, Yu B, Crotty S, Goldrath AW, Pipkin ME.

Immunity. 2018 Apr 17;48(4):659-674.e6. doi: 10.1016/j.immuni.2018.03.028.

22.

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data.

Upadhyay AA, Kauffman RC, Wolabaugh AN, Cho A, Patel NB, Reiss SM, Havenar-Daughton C, Dawoud RA, Tharp GK, Sanz I, Pulendran B, Crotty S, Lee FE, Wrammert J, Bosinger SE.

Genome Med. 2018 Mar 20;10(1):20. doi: 10.1186/s13073-018-0528-3.

23.

Characterization of murine antibody responses to vaccinia virus envelope protein A14 reveals an immunodominant antigen lacking of effective neutralization targets.

Meng X, Kaever T, Yan B, Traktman P, Zajonc DM, Peters B, Crotty S, Xiang Y.

Virology. 2018 May;518:284-292. doi: 10.1016/j.virol.2018.03.005. Epub 2018 Mar 17.

24.

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.

Gaddis DE, Padgett LE, Wu R, McSkimming C, Romines V, Taylor AM, McNamara CA, Kronenberg M, Crotty S, Thomas MJ, Sorci-Thomas MG, Hedrick CC.

Nat Commun. 2018 Mar 15;9(1):1095. doi: 10.1038/s41467-018-03493-5.

25.

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, Kasturi S, Pulendran B, Wilson IA, Montefiori DC, Sanders RW, Ward AB, Moore JP.

PLoS Pathog. 2018 Feb 23;14(2):e1006913. doi: 10.1371/journal.ppat.1006913. eCollection 2018 Feb.

26.

Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses.

da Silva Antunes R, Paul S, Sidney J, Weiskopf D, Dan JM, Phillips E, Mallal S, Crotty S, Sette A, Lindestam Arlehamn CS.

PLoS One. 2018 Feb 20;13(2):e0193382. doi: 10.1371/journal.pone.0193382. eCollection 2018.

27.

A natural history model of New England salt marsh die-off.

Pettengill TM, Crotty SM, Angelini C, Bertness MD.

Oecologia. 2018 Mar;186(3):621-632. doi: 10.1007/s00442-018-4078-6. Epub 2018 Jan 22. Review.

PMID:
29357031
28.

Erratum: Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.

Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW.

Nature. 2018 Feb 15;554(7692):392. doi: 10.1038/nature25445. Epub 2018 Jan 10.

PMID:
29320476
29.

Raging evolution of a B cell response to a viral infection.

Crotty S.

Nat Rev Immunol. 2018 Feb;18(2):79. doi: 10.1038/nri.2017.219. Epub 2018 Jan 2. No abstract available.

PMID:
29292394
30.

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens.

Abbott RK, Lee JH, Menis S, Skog P, Rossi M, Ota T, Kulp DW, Bhullar D, Kalyuzhniy O, Havenar-Daughton C, Schief WR, Nemazee D, Crotty S.

Immunity. 2018 Jan 16;48(1):133-146.e6. doi: 10.1016/j.immuni.2017.11.023. Epub 2017 Dec 26.

31.

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours.

Milner JJ, Toma C, Yu B, Zhang K, Omilusik K, Phan AT, Wang D, Getzler AJ, Nguyen T, Crotty S, Wang W, Pipkin ME, Goldrath AW.

Nature. 2017 Dec 14;552(7684):253-257. doi: 10.1038/nature24993. Epub 2017 Dec 6. Erratum in: Nature. 2018 Jan 10;:.

32.

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.

Kulp DW, Steichen JM, Pauthner M, Hu X, Schiffner T, Liguori A, Cottrell CA, Havenar-Daughton C, Ozorowski G, Georgeson E, Kalyuzhniy O, Willis JR, Kubitz M, Adachi Y, Reiss SM, Shin M, de Val N, Ward AB, Crotty S, Burton DR, Schief WR.

Nat Commun. 2017 Nov 21;8(1):1655. doi: 10.1038/s41467-017-01549-6.

33.

Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.

Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM.

J Biol Chem. 2018 Jan 5;293(1):390-401. doi: 10.1074/jbc.M117.814541. Epub 2017 Nov 9.

34.

Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells.

Reiss S, Baxter AE, Cirelli KM, Dan JM, Morou A, Daigneault A, Brassard N, Silvestri G, Routy JP, Havenar-Daughton C, Crotty S, Kaufmann DE.

PLoS One. 2017 Oct 24;12(10):e0186998. doi: 10.1371/journal.pone.0186998. eCollection 2017.

35.

Multiple stressors and the potential for synergistic loss of New England salt marshes.

Crotty SM, Angelini C, Bertness MD.

PLoS One. 2017 Aug 31;12(8):e0183058. doi: 10.1371/journal.pone.0183058. eCollection 2017.

36.

Absence of the neurogenesis-dependent nuclear receptor TLX induces inflammation in the hippocampus.

Kozareva DA, Hueston CM, Ó'Léime CS, Crotty S, Dockery P, Cryan JF, Nolan YM.

J Neuroimmunol. 2019 Jun 15;331:87-96. doi: 10.1016/j.jneuroim.2017.08.008. Epub 2017 Aug 20.

PMID:
28844503
37.

Germinal center enhancement by extended antigen availability.

Cirelli KM, Crotty S.

Curr Opin Immunol. 2017 Aug;47:64-69. doi: 10.1016/j.coi.2017.06.008. Epub 2017 Jul 21. Review.

38.

A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers.

Wing JB, Kitagawa Y, Locci M, Hume H, Tay C, Morita T, Kidani Y, Matsuda K, Inoue T, Kurosaki T, Crotty S, Coban C, Ohkura N, Sakaguchi S.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6400-E6409. doi: 10.1073/pnas.1705551114. Epub 2017 Jul 11.

39.

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR.

Immunity. 2017 Jun 20;46(6):1073-1088.e6. doi: 10.1016/j.immuni.2017.05.007.

40.

Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.

Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW.

Nat Immunol. 2017 May 18;18(6):705. doi: 10.1038/ni0617-705b. No abstract available.

PMID:
28518161
41.

Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells.

Schulten V, Tripple V, Seumois G, Qian Y, Scheuermann RH, Fu Z, Locci M, Rosales S, Vijayanand P, Sette A, Alam R, Crotty S, Peters B.

J Allergy Clin Immunol. 2018 Feb;141(2):775-777.e6. doi: 10.1016/j.jaci.2017.04.032. Epub 2017 May 12. No abstract available.

42.

Development of an animal model of progressive vaccinia in nu/nu mice and the use of bioluminescence imaging for assessment of the efficacy of monoclonal antibodies against vaccinial B5 and L1 proteins.

Zaitseva M, Thomas A, Meseda CA, Cheung CYK, Diaz CG, Xiang Y, Crotty S, Golding H.

Antiviral Res. 2017 Aug;144:8-20. doi: 10.1016/j.antiviral.2017.05.002. Epub 2017 May 8.

PMID:
28495463
43.
44.

Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.

Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW.

Nat Immunol. 2017 May;18(5):573-582. doi: 10.1038/ni.3706. Epub 2017 Mar 13. Erratum in: Nat Immunol. 2017 May 18;18(6):705.

45.

T cells control the generation of nanomolar-affinity anti-glycan antibodies.

Polonskaya Z, Deng S, Sarkar A, Kain L, Comellas-Aragones M, McKay CS, Kaczanowska K, Holt M, McBride R, Palomo V, Self KM, Taylor S, Irimia A, Mehta SR, Dan JM, Brigger M, Crotty S, Schoenberger SP, Paulson JC, Wilson IA, Savage PB, Finn MG, Teyton L.

J Clin Invest. 2017 Apr 3;127(4):1491-1504. doi: 10.1172/JCI91192. Epub 2017 Mar 13.

46.

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem.

Havenar-Daughton C, Lee JH, Crotty S.

Immunol Rev. 2017 Jan;275(1):49-61. doi: 10.1111/imr.12512. Review.

PMID:
28133798
47.

Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses.

da Silva Antunes R, Paul S, Sidney J, Weiskopf D, Dan JM, Phillips E, Mallal S, Crotty S, Sette A, Lindestam Arlehamn CS.

PLoS One. 2017 Jan 12;12(1):e0169086. doi: 10.1371/journal.pone.0169086. eCollection 2017. Erratum in: PLoS One. 2018 Feb 20;13(2):e0193382.

48.

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques.

Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira ELV, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B.

J Virol. 2017 Jan 31;91(4). pii: e01844-16. doi: 10.1128/JVI.01844-16. Print 2017 Feb 15.

49.

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.

Havenar-Daughton C, Carnathan DG, Torrents de la Peña A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, Mohammed AUR, Huang J, Gumber S, Garcia A, Kasturi SP, Pulendran B, Moore JP, Ahmed R, Seumois G, Burton DR, Sanders RW, Silvestri G, Crotty S.

Cell Rep. 2016 Nov 22;17(9):2195-2209. doi: 10.1016/j.celrep.2016.10.085.

50.

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.

Tam HH, Melo MB, Kang M, Pelet JM, Ruda VM, Foley MH, Hu JK, Kumari S, Crampton J, Baldeon AD, Sanders RW, Moore JP, Crotty S, Langer R, Anderson DG, Chakraborty AK, Irvine DJ.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6639-E6648. Epub 2016 Oct 4.

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