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Toward understanding genomic instability, mitochondrial dysfunction and aging.

Fakouri NB, Hou Y, Demarest TG, Christiansen LS, Okur MN, Mohanty JG, Croteau DL, Bohr VA.

FEBS J. 2018 Sep 20. doi: 10.1111/febs.14663. [Epub ahead of print] Review.


Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis.

Luptak I, Croteau D, Valentine C, Qin F, Siwik D, Remick D, Colucci WS, Hobai I.

Shock. 2018 Aug 10. doi: 10.1097/SHK.0000000000001245. [Epub ahead of print]


Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention.

Baptiste BA, Katchur SR, Fivenson EM, Croteau DL, Rumsey WL, Bohr VA.

Free Radic Biol Med. 2018 Aug 20;124:149-162. doi: 10.1016/j.freeradbiomed.2018.05.094. Epub 2018 Jun 5.


HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau.

Anderson AM, Croteau D, Ellis RJ, Rosario D, Potter M, Guillemin GJ, Brew BJ, Woods SP, Letendre SL.

J Neuroimmunol. 2018 Jun 15;319:13-18. doi: 10.1016/j.jneuroim.2018.03.007. Epub 2018 Mar 18.


Acute acalculous cholecystitis: A new safety risk for patients with MS treated with alemtuzumab.

Croteau D, Flowers C, Kulick CG, Brinker A, Kortepeter CM.

Neurology. 2018 May 1;90(18):e1548-e1552. doi: 10.1212/WNL.0000000000005422. Epub 2018 Mar 30.


Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation.

Panagia M, Chen HH, Croteau D, Iris Chen YC, Ran C, Luptak I, Josephson L, Colucci WS, Sosnovik DE.

Circ Cardiovasc Imaging. 2018 Mar;11(3):e007007. doi: 10.1161/CIRCIMAGING.117.007007. Review.


NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5.


Decreased ATP production and myocardial contractile reserve in metabolic heart disease.

Luptak I, Sverdlov AL, Panagia M, Qin F, Pimentel DR, Croteau D, Siwik DA, Ingwall JS, Bachschmid MM, Balschi JA, Colucci WS.

J Mol Cell Cardiol. 2018 Mar;116:106-114. doi: 10.1016/j.yjmcc.2018.01.017. Epub 2018 Feb 1.


Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

Lu H, Shamanna RA, de Freitas JK, Okur M, Khadka P, Kulikowicz T, Holland PP, Tian J, Croteau DL, Davis AJ, Bohr VA.

Nat Commun. 2017 Dec 11;8(1):2039. doi: 10.1038/s41467-017-02146-3.


Recent Advances in Understanding Werner Syndrome.

Shamanna RA, Croteau DL, Lee JH, Bohr VA.

F1000Res. 2017 Sep 28;6:1779. doi: 10.12688/f1000research.12110.1. eCollection 2017. Review.


NAD+ in Aging: Molecular Mechanisms and Translational Implications.

Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA.

Trends Mol Med. 2017 Oct;23(10):899-916. doi: 10.1016/j.molmed.2017.08.001. Epub 2017 Sep 9. Review.


DNA polymerase beta participates in mitochondrial DNA repair.

Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM 3rd, Sobol RW, Yasui A, Bohr VA.

Mol Cell Biol. 2017 May 30. pii: MCB.00237-17. doi: 10.1128/MCB.00237-17. [Epub ahead of print]


RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.

Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau DL, Bohr VA.

Nucleic Acids Res. 2017 Feb 17;45(3):1566. doi: 10.1093/nar/gkw1216.


NAD+ in DNA repair and mitochondrial maintenance.

Croteau DL, Fang EF, Nilsen H, Bohr VA.

Cell Cycle. 2017 Mar 19;16(6):491-492. doi: 10.1080/15384101.2017.1285631. Epub 2017 Feb 1. No abstract available.


Short-term caloric restriction in db/db mice improves myocardial function and increases high molecular weight (HMW) adiponectin.

Xu XJ, Babo E, Qin F, Croteau D, Colucci WS.

IJC Metab Endocr. 2016 Dec;13:28-34. Epub 2016 Oct 20.


Human RECQL1 participates in telomere maintenance.

Popuri V, Hsu J, Khadka P, Horvath K, Liu Y, Croteau DL, Bohr VA.

Nucleic Acids Res. 2017 Mar 17;45(5):2935. doi: 10.1093/nar/gkw1217. No abstract available.


WRN regulates pathway choice between classical and alternative non-homologous end joining.

Shamanna RA, Lu H, de Freitas JK, Tian J, Croteau DL, Bohr VA.

Nat Commun. 2016 Dec 6;7:13785. doi: 10.1038/ncomms13785.


Cockayne syndrome: Clinical features, model systems and pathways.

Karikkineth AC, Scheibye-Knudsen M, Fivenson E, Croteau DL, Bohr VA.

Ageing Res Rev. 2017 Jan;33:3-17. doi: 10.1016/j.arr.2016.08.002. Epub 2016 Aug 6. Review.


NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA.

Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004.


DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.

Misiak M, Vergara Greeno R, Baptiste BA, Sykora P, Liu D, Cordonnier S, Fang EF, Croteau DL, Mattson MP, Bohr VA.

Aging Cell. 2017 Feb;16(1):162-172. doi: 10.1111/acel.12541. Epub 2016 Sep 30.


Utilizing a Two-stage Design to Investigate the Safety and Potential Efficacy of Monthly Naltrexone Plus Once-daily Bupropion as a Treatment for Methamphetamine Use Disorder.

Mooney LJ, Hillhouse MP, Thomas C, Ang A, Sharma G, Terry G, Chang L, Walker R, Trivedi M, Croteau D, Sparenborg S, Ling W.

J Addict Med. 2016 Jul-Aug;10(4):236-43. doi: 10.1097/ADM.0000000000000218.


RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.

Lu H, Shamanna RA, Keijzers G, Anand R, Rasmussen LJ, Cejka P, Croteau DL, Bohr VA.

Cell Rep. 2016 Jun 28;16(1):161-173. doi: 10.1016/j.celrep.2016.05.079. Epub 2016 Jun 16.


Genome instability in Alzheimer disease.

Hou Y, Song H, Croteau DL, Akbari M, Bohr VA.

Mech Ageing Dev. 2017 Jan;161(Pt A):83-94. doi: 10.1016/j.mad.2016.04.005. Epub 2016 Apr 20. Review.


Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.

Shamanna RA, Lu H, Croteau DL, Arora A, Agarwal D, Ball G, Aleskandarany MA, Ellis IO, Pommier Y, Madhusudan S, Bohr VA.

Oncotarget. 2016 Mar 22;7(12):13269-84. doi: 10.18632/oncotarget.7906.


Nuclear DNA damage signalling to mitochondria in ageing.

Fang EF, Scheibye-Knudsen M, Chua KF, Mattson MP, Croteau DL, Bohr VA.

Nat Rev Mol Cell Biol. 2016 May;17(5):308-21. doi: 10.1038/nrm.2016.14. Epub 2016 Mar 9. Review.


Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge.

Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS.

J Am Heart Assoc. 2015 Dec 31;5(1). pii: e002277. doi: 10.1161/JAHA.115.002277.


RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins.

Khadka P, Croteau DL, Bohr VA.

DNA Repair (Amst). 2016 Jan;37:53-66. doi: 10.1016/j.dnarep.2015.11.005. Epub 2015 Dec 2.


RECQL4 helicase has oncogenic potential in sporadic breast cancers.

Arora A, Agarwal D, Abdel-Fatah TM, Lu H, Croteau DL, Moseley P, Aleskandarany MA, Green AR, Ball G, Rakha EA, Chan SY, Ellis IO, Wang LL, Zhao Y, Balajee AS, Bohr VA, Madhusudan S.

J Pathol. 2016 Mar;238(4):495-501. doi: 10.1002/path.4681. Epub 2016 Feb 2.


Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.

Arora A, Abdel-Fatah TM, Agarwal D, Doherty R, Croteau DL, Moseley PM, Hameed K, Green A, Aleskandarany MA, Rakha EA, Patterson K, Ball G, Chan SY, Ellis IO, Bohr VA, Bryant HE, Madhusudan S.

Carcinogenesis. 2016 Jan;37(1):63-71. doi: 10.1093/carcin/bgv163. Epub 2015 Nov 19.


Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients.

Ma Q, Vaida F, Wong J, Sanders CA, Kao YT, Croteau D, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, Morgello S, Simpson DM, Heaton RK, Grant I, Letendre SL; CHARTER Group.

J Neurovirol. 2016 Apr;22(2):170-8. doi: 10.1007/s13365-015-0382-7. Epub 2015 Sep 25.


Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.

Khadka P, Hsu JK, Veith S, Tadokoro T, Shamanna RA, Mangerich A, Croteau DL, Bohr VA.

Mol Cell Biol. 2015 Dec;35(23):3974-89. doi: 10.1128/MCB.00427-15. Epub 2015 Sep 21.


DNA Damage, DNA Repair, Aging, and Neurodegeneration.

Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA.

Cold Spring Harb Perspect Med. 2015 Sep 18;5(10). pii: a025130. doi: 10.1101/cshperspect.a025130. Review.


The role of DNA base excision repair in brain homeostasis and disease.

Akbari M, Morevati M, Croteau D, Bohr VA.

DNA Repair (Amst). 2015 Aug;32:172-9. doi: 10.1016/j.dnarep.2015.04.029. Epub 2015 May 1. Review.


Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.

Ghosh S, Canugovi C, Yoon JS, Wilson DM 3rd, Croteau DL, Mattson MP, Bohr VA.

Neurobiol Aging. 2015 Jul;36(7):2319-2330. doi: 10.1016/j.neurobiolaging.2015.04.004. Epub 2015 Apr 17.


DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.

Sykora P, Misiak M, Wang Y, Ghosh S, Leandro GS, Liu D, Tian J, Baptiste BA, Cong WN, Brenerman BM, Fang E, Becker KG, Hamilton RJ, Chigurupati S, Zhang Y, Egan JM, Croteau DL, Wilson DM 3rd, Mattson MP, Bohr VA.

Nucleic Acids Res. 2015 Jan;43(2):943-59. doi: 10.1093/nar/gku1356. Epub 2014 Dec 30.


Protecting the mitochondrial powerhouse.

Scheibye-Knudsen M, Fang EF, Croteau DL, Wilson DM 3rd, Bohr VA.

Trends Cell Biol. 2015 Mar;25(3):158-70. doi: 10.1016/j.tcb.2014.11.002. Epub 2014 Dec 11. Review.


Loss of NEIL1 causes defects in olfactory function in mice.

Canugovi C, Misiak M, Scheibye-Knudsen M, Croteau DL, Mattson MP, Bohr VA.

Neurobiol Aging. 2015 Feb;36(2):1007-12. doi: 10.1016/j.neurobiolaging.2014.09.026. Epub 2014 Oct 14.


A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.

Scheibye-Knudsen M, Mitchell SJ, Fang EF, Iyama T, Ward T, Wang J, Dunn CA, Singh N, Veith S, Hasan-Olive MM, Mangerich A, Wilson MA, Mattson MP, Bergersen LH, Cogger VC, Warren A, Le Couteur DG, Moaddel R, Wilson DM 3rd, Croteau DL, de Cabo R, Bohr VA.

Cell Metab. 2014 Nov 4;20(5):840-855. doi: 10.1016/j.cmet.2014.10.005. Epub 2014 Nov 4.


The role of RecQ helicases in non-homologous end-joining.

Keijzers G, Maynard S, Shamanna RA, Rasmussen LJ, Croteau DL, Bohr VA.

Crit Rev Biochem Mol Biol. 2014 Nov-Dec;49(6):463-72. doi: 10.3109/10409238.2014.942450. Epub 2014 Jul 22. Review.


Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders.

Scheibye-Knudsen M, Fang EF, Croteau DL, Bohr VA.

Autophagy. 2014 Aug;10(8):1468-9. doi: 10.4161/auto.29321. Epub 2014 Jun 12.


RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex.

Shamanna RA, Singh DK, Lu H, Mirey G, Keijzers G, Salles B, Croteau DL, Bohr VA.

Carcinogenesis. 2014 Nov;35(11):2415-24. doi: 10.1093/carcin/bgu137. Epub 2014 Jun 18.


Functional gallbladder disorder: an increasingly common diagnosis.

Croteau DI.

Am Fam Physician. 2014 May 15;89(10):779-84. No abstract available.


Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.

Lu H, Fang EF, Sykora P, Kulikowicz T, Zhang Y, Becker KG, Croteau DL, Bohr VA.

Cell Death Dis. 2014 May 15;5:e1226. doi: 10.1038/cddis.2014.168.


Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA.

Cell. 2014 May 8;157(4):882-896. doi: 10.1016/j.cell.2014.03.026.


Human RECQL1 participates in telomere maintenance.

Popuri V, Hsu J, Khadka P, Horvath K, Liu Y, Croteau DL, Bohr VA.

Nucleic Acids Res. 2014 May;42(9):5671-88. doi: 10.1093/nar/gku200. Epub 2014 Mar 12. Erratum in: Nucleic Acids Res. 2017 Mar 17;45(5):2935.


Human RecQ helicases in DNA repair, recombination, and replication.

Croteau DL, Popuri V, Opresko PL, Bohr VA.

Annu Rev Biochem. 2014;83:519-52. doi: 10.1146/annurev-biochem-060713-035428. Epub 2014 Mar 3. Review.


Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease.

Canugovi C, Shamanna RA, Croteau DL, Bohr VA.

Neurobiol Aging. 2014 Jun;35(6):1293-300. doi: 10.1016/j.neurobiolaging.2014.01.004. Epub 2014 Jan 8.


Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells.

Maynard S, Keijzers G, Gram M, Desler C, Bendix L, Budtz-Jørgensen E, Molbo D, Croteau DL, Osler M, Stevnsner T, Rasmussen LJ, Dela F, Avlund K, Bohr VA.

Aging (Albany NY). 2013 Nov;5(11):850-64.


Transarterial embolization of symptomatic focal nodular hyperplasia.

Birn J, Williams TR, Croteau D, Schwartz S, Sturza S, Getzen T.

J Vasc Interv Radiol. 2013 Nov;24(11):1647-55. doi: 10.1016/j.jvir.2013.07.012. Epub 2013 Aug 31.


Increases in brain white matter abnormalities and subcortical gray matter are linked to CD4 recovery in HIV infection.

Fennema-Notestine C, Ellis RJ, Archibald SL, Jernigan TL, Letendre SL, Notestine RJ, Taylor MJ, Theilmann RJ, Julaton MD, Croteau DJ, Wolfson T, Heaton RK, Gamst AC, Franklin DR Jr, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I; CHARTER Group.

J Neurovirol. 2013 Aug;19(4):393-401. doi: 10.1007/s13365-013-0185-7. Epub 2013 Jul 10.

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