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Items: 1 to 50 of 62

1.

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.

Intlekofer AM, Shih AH, Wang B, Nazir A, Rustenburg AS, Albanese SK, Patel M, Famulare C, Correa FM, Takemoto N, Durani V, Liu H, Taylor J, Farnoud N, Papaemmanuil E, Cross JR, Tallman MS, Arcila ME, Roshal M, Petsko GA, Wu B, Choe S, Konteatis ZD, Biller SA, Chodera JD, Thompson CB, Levine RL, Stein EM.

Nature. 2018 Jul;559(7712):125-129. doi: 10.1038/s41586-018-0251-7. Epub 2018 Jun 27.

PMID:
29950729
2.

Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia.

Santomasso BD, Park JH, Salloum D, Riviere I, Flynn J, Mead E, Halton E, Wang X, Senechal B, Purdon T, Cross JR, Liu H, Vachha B, Chen X, DeAngelis LM, Li D, Bernal Y, Gonen M, Wendel HG, Sadelain M, Brentjens RJ.

Cancer Discov. 2018 Aug;8(8):958-971. doi: 10.1158/2159-8290.CD-17-1319. Epub 2018 Jun 7.

PMID:
29880584
3.

Pre-surgical trial of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer: a New York Cancer Consortium trial.

Kalinsky K, Sparano JA, Zhong X, Andreopoulou E, Taback B, Wiechmann L, Feldman SM, Ananthakrishnan P, Ahmad A, Cremers S, Sireci AN, Cross JR, Marks DK, Mundi P, Connolly E, Crew KD, Maurer MA, Hibshoosh H, Lee S, Hershman DL.

Clin Transl Oncol. 2018 May 7. doi: 10.1007/s12094-018-1888-2. [Epub ahead of print]

PMID:
29736694
4.

Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT.

Haak BW, Littmann ER, Chaubard JL, Pickard AJ, Fontana E, Adhi F, Gyaltshen Y, Ling L, Morjaria SM, Peled JU, van den Brink MR, Geyer AI, Cross JR, Pamer EG, Taur Y.

Blood. 2018 Jun 28;131(26):2978-2986. doi: 10.1182/blood-2018-01-828996. Epub 2018 Apr 19.

PMID:
29674425
5.

Corrigendum: Commensal bacteria make GPCR ligands that mimic human signalling molecules.

Cohen LJ, Esterhazy D, Kim SH, Lemetre C, Aguilar RR, Gordon EA, Pickard AJ, Cross JR, Emiliano AB, Han SM, Chu J, Vila-Farres X, Kaplitt J, Rogoz A, Calle PY, Hunter C, Bitok JK, Brady SF.

Nature. 2018 Apr 4;556(7699):135. doi: 10.1038/nature25997.

PMID:
29620727
6.

Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

Staffas A, Burgos da Silva M, Slingerland AE, Lazrak A, Bare CJ, Holman CD, Docampo MD, Shono Y, Durham B, Pickard AJ, Cross JR, Stein-Thoeringer C, Velardi E, Tsai JJ, Jahn L, Jay H, Lieberman S, Smith OM, Pamer EG, Peled JU, Cohen DE, Jenq RR, van den Brink MRM.

Cell Host Microbe. 2018 Apr 11;23(4):447-457.e4. doi: 10.1016/j.chom.2018.03.002. Epub 2018 Mar 22.

PMID:
29576480
7.

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation.

Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, Dai L, Shimada M, Cross JR, Zhao Y, Roeder RG, Allis CD.

Mol Cell. 2018 Feb 1;69(3):533. doi: 10.1016/j.molcel.2018.01.013. No abstract available.

8.

Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor.

Vitiello GA, Medina BD, Zeng S, Bowler TG, Zhang JQ, Loo JK, Param NJ, Liu M, Moral AJ, Zhao JN, Rossi F, Antonescu CR, Balachandran VP, Cross JR, DeMatteo RP.

Clin Cancer Res. 2018 Feb 15;24(4):972-984. doi: 10.1158/1078-0432.CCR-17-2697. Epub 2017 Dec 15.

PMID:
29246941
9.

In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors.

Salamanca-Cardona L, Shah H, Poot AJ, Correa FM, Di Gialleonardo V, Lui H, Miloushev VZ, Granlund KL, Tee SS, Cross JR, Thompson CB, Keshari KR.

Cell Metab. 2017 Dec 5;26(6):830-841.e3. doi: 10.1016/j.cmet.2017.10.001. Epub 2017 Oct 19.

PMID:
29056515
10.

Commensal bacteria make GPCR ligands that mimic human signalling molecules.

Cohen LJ, Esterhazy D, Kim SH, Lemetre C, Aguilar RR, Gordon EA, Pickard AJ, Cross JR, Emiliano AB, Han SM, Chu J, Vila-Farres X, Kaplitt J, Rogoz A, Calle PY, Hunter C, Bitok JK, Brady SF.

Nature. 2017 Sep 7;549(7670):48-53. doi: 10.1038/nature23874. Epub 2017 Aug 30. Erratum in: Nature. 2018 Apr 4;556(7699):135.

11.

MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα.

Bae S, Lee MJ, Mun SH, Giannopoulou EG, Yong-Gonzalez V, Cross JR, Murata K, Giguère V, van der Meulen M, Park-Min KH.

J Clin Invest. 2017 Jun 30;127(7):2555-2568. doi: 10.1172/JCI89935. Epub 2017 May 22.

12.

Corrigendum: Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.

Chen Q, Boire A, Jin X, Valiente M, Emrah Er E, Lopez-Soto A, Jacob LS, Patwa R, Shah H, Xu K, Cross JR, Massagué J.

Nature. 2017 Apr 6;544(7648):124. doi: 10.1038/nature21730. Epub 2017 Mar 29. No abstract available.

PMID:
28355178
13.

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH.

Intlekofer AM, Wang B, Liu H, Shah H, Carmona-Fontaine C, Rustenburg AS, Salah S, Gunner MR, Chodera JD, Cross JR, Thompson CB.

Nat Chem Biol. 2017 May;13(5):494-500. doi: 10.1038/nchembio.2307. Epub 2017 Mar 6.

14.

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.

Guryanova OA, Shank K, Spitzer B, Luciani L, Koche RP, Garrett-Bakelman FE, Ganzel C, Durham BH, Mohanty A, Hoermann G, Rivera SA, Chramiec AG, Pronier E, Bastian L, Keller MD, Tovbin D, Loizou E, Weinstein AR, Gonzalez AR, Lieu YK, Rowe JM, Pastore F, McKenney AS, Krivtsov AV, Sperr WR, Cross JR, Mason CE, Tallman MS, Arcila ME, Abdel-Wahab O, Armstrong SA, Kubicek S, Staber PB, Gönen M, Paietta EM, Melnick AM, Nimer SD, Mukherjee S, Levine RL.

Nat Med. 2016 Dec;22(12):1488-1495. doi: 10.1038/nm.4210. Epub 2016 Nov 14.

15.

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.

Chen Q, Boire A, Jin X, Valiente M, Er EE, Lopez-Soto A, Jacob L, Patwa R, Shah H, Xu K, Cross JR, Massagué J.

Nature. 2016 May 26;533(7604):493-498. doi: 10.1038/nature18268. Epub 2016 May 18. Erratum in: Nature. 2017 Apr 6;544(7648):124.

16.

Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial.

Xu R, Shimizu F, Hovinga K, Beal K, Karimi S, Droms L, Peck KK, Gutin P, Iorgulescu JB, Kaley T, DeAngelis L, Pentsova E, Nolan C, Grommes C, Chan T, Bobrow D, Hormigo A, Cross JR, Wu N, Takebe N, Panageas K, Ivy P, Supko JG, Tabar V, Omuro A.

Clin Cancer Res. 2016 Oct 1;22(19):4786-4796. Epub 2016 May 6.

17.

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

Monticelli LA, Buck MD, Flamar AL, Saenz SA, Tait Wojno ED, Yudanin NA, Osborne LC, Hepworth MR, Tran SV, Rodewald HR, Shah H, Cross JR, Diamond JM, Cantu E, Christie JD, Pearce EL, Artis D.

Nat Immunol. 2016 Jun;17(6):656-65. doi: 10.1038/ni.3421. Epub 2016 Apr 4.

18.

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.

de la Fuente MI, Young RJ, Rubel J, Rosenblum M, Tisnado J, Briggs S, Arevalo-Perez J, Cross JR, Campos C, Straley K, Zhu D, Dong C, Thomas A, Omuro AA, Nolan CP, Pentsova E, Kaley TJ, Oh JH, Noeske R, Maher E, Choi C, Gutin PH, Holodny AI, Yen K, DeAngelis LM, Mellinghoff IK, Thakur SB.

Neuro Oncol. 2016 Feb;18(2):283-90. doi: 10.1093/neuonc/nov307. Epub 2015 Dec 20.

19.

Hypoxia Induces Production of L-2-Hydroxyglutarate.

Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Thompson CB.

Cell Metab. 2015 Aug 4;22(2):304-11. doi: 10.1016/j.cmet.2015.06.023. Epub 2015 Jul 23.

20.

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.

Su X, Yu Y, Zhong Y, Giannopoulou EG, Hu X, Liu H, Cross JR, Rätsch G, Rice CM, Ivashkiv LB.

Nat Immunol. 2015 Aug;16(8):838-849. doi: 10.1038/ni.3205. Epub 2015 Jun 29.

21.

Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease.

Jenq RR, Taur Y, Devlin SM, Ponce DM, Goldberg JD, Ahr KF, Littmann ER, Ling L, Gobourne AC, Miller LC, Docampo MD, Peled JU, Arpaia N, Cross JR, Peets TK, Lumish MA, Shono Y, Dudakov JA, Poeck H, Hanash AM, Barker JN, Perales MA, Giralt SA, Pamer EG, van den Brink MR.

Biol Blood Marrow Transplant. 2015 Aug;21(8):1373-83. doi: 10.1016/j.bbmt.2015.04.016. Epub 2015 May 11.

22.

Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation.

Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, Dai L, Shimada M, Cross JR, Zhao Y, Roeder RG, Allis CD.

Mol Cell. 2015 Apr 16;58(2):203-15. doi: 10.1016/j.molcel.2015.02.029. Epub 2015 Mar 26. Erratum in: Mol Cell. 2018 Feb 1;69(3):533.

23.

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo.

Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, Holland EC, Mellinghoff IK, Kung HF, Lewis JS, Thompson CB.

Sci Transl Med. 2015 Feb 11;7(274):274ra17. doi: 10.1126/scitranslmed.aaa1009.

24.

Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness.

Pedicord VA, Cross JR, Montalvo-Ortiz W, Miller ML, Allison JP.

J Immunol. 2015 Mar 1;194(5):2089-98. doi: 10.4049/jimmunol.1402390. Epub 2015 Jan 26.

25.

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells.

Carey BW, Finley LW, Cross JR, Allis CD, Thompson CB.

Nature. 2015 Feb 19;518(7539):413-6. doi: 10.1038/nature13981. Epub 2014 Dec 10.

26.

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.

Buffie CG, Bucci V, Stein RR, McKenney PT, Ling L, Gobourne A, No D, Liu H, Kinnebrew M, Viale A, Littmann E, van den Brink MR, Jenq RR, Taur Y, Sander C, Cross JR, Toussaint NC, Xavier JB, Pamer EG.

Nature. 2015 Jan 8;517(7533):205-8. doi: 10.1038/nature13828. Epub 2014 Oct 22.

27.

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.

Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB.

Mol Cell. 2014 Oct 23;56(2):205-218. doi: 10.1016/j.molcel.2014.08.018. Epub 2014 Sep 18.

28.

Serine catabolism regulates mitochondrial redox control during hypoxia.

Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, Thompson CB.

Cancer Discov. 2014 Dec;4(12):1406-17. doi: 10.1158/2159-8290.CD-14-0250. Epub 2014 Sep 3.

29.

Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia.

Piovan E, Yu J, Tosello V, Herranz D, Ambesi-Impiombato A, Da Silva AC, Sanchez-Martin M, Perez-Garcia A, Rigo I, Castillo M, Indraccolo S, Cross JR, de Stanchina E, Paietta E, Racevskis J, Rowe JM, Tallman MS, Basso G, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA.

Cancer Cell. 2013 Dec 9;24(6):766-76. doi: 10.1016/j.ccr.2013.10.022. Epub 2013 Nov 27.

30.

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY.

Nature. 2013 Dec 19;504(7480):451-5. doi: 10.1038/nature12726. Epub 2013 Nov 13.

31.

Induction of sarcomas by mutant IDH2.

Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB.

Genes Dev. 2013 Sep 15;27(18):1986-98. doi: 10.1101/gad.226753.113.

32.

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition.

Chen C, Liu Y, Lu C, Cross JR, Morris JP 4th, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW.

Genes Dev. 2013 Sep 15;27(18):1974-85. doi: 10.1101/gad.226613.113.

33.

Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight.

Song RB, Vite CH, Bradley CW, Cross JR.

J Vet Intern Med. 2013 Sep-Oct;27(5):1143-52. doi: 10.1111/jvim.12136. Epub 2013 Jul 19.

34.

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids.

Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8882-7. doi: 10.1073/pnas.1307237110. Epub 2013 May 13.

35.

The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.

Ward PS, Lu C, Cross JR, Abdel-Wahab O, Levine RL, Schwartz GK, Thompson CB.

J Biol Chem. 2013 Feb 8;288(6):3804-15. doi: 10.1074/jbc.M112.435495. Epub 2012 Dec 21.

36.

What is your diagnosis? Intracranial parasitic migration.

Ward AB, Cross JR, Glass EN, de Lahunta A.

J Am Vet Med Assoc. 2012 Sep 15;241(6):693-5. doi: 10.2460/javma.241.6.693. No abstract available.

PMID:
22947150
37.

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.

Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19611-6. doi: 10.1073/pnas.1117773108. Epub 2011 Nov 21.

38.

Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production.

Ward PS, Cross JR, Lu C, Weigert O, Abel-Wahab O, Levine RL, Weinstock DM, Sharp KA, Thompson CB.

Oncogene. 2012 May 10;31(19):2491-8. doi: 10.1038/onc.2011.416. Epub 2011 Sep 26.

39.

Suspected epidural morphine analgesia induced chronic urinary and bowel dysfunction in a cat.

Song RB, Cross JR, Golder FJ, Callan MB.

J Feline Med Surg. 2011 Aug;13(8):602-5. doi: 10.1016/j.jfms.2011.03.014. Epub 2011 May 14.

PMID:
21571562
40.

Correlating magnetic resonance findings with neuropathology and clinical signs in dogs and cats.

Vite CH, Cross JR.

Vet Radiol Ultrasound. 2011 Mar-Apr;52(1 Suppl 1):S23-31. doi: 10.1111/j.1740-8261.2010.01782.x.

41.

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.

Vento MT, Zazzu V, Loffreda A, Cross JR, Downward J, Stoppelli MP, Iaccarino I.

PLoS One. 2010 Dec 20;5(12):e15636. doi: 10.1371/journal.pone.0015636.

42.

Associations of parental and peer characteristics with adolescents' social dominance orientation.

Cross JR, Fletcher KL.

J Youth Adolesc. 2011 Jun;40(6):694-706. doi: 10.1007/s10964-010-9585-7. Epub 2010 Sep 5.

PMID:
20820895
43.

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.

Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ.

Blood. 2010 Jun 10;115(23):4742-9. doi: 10.1182/blood-2009-10-249540. Epub 2010 Mar 29.

44.

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.

Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB.

Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18.

45.

The challenge of adolescent crowd research: defining the crowd.

Cross JR, Fletcher KL.

J Youth Adolesc. 2009 Jul;38(6):747-64. doi: 10.1007/s10964-008-9307-6. Epub 2008 Jul 15.

PMID:
19636778
46.

ATP-citrate lyase links cellular metabolism to histone acetylation.

Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB.

Science. 2009 May 22;324(5930):1076-80. doi: 10.1126/science.1164097.

47.

Bartonella-associated meningoradiculoneuritis and dermatitis or panniculitis in 3 dogs.

Cross JR, Rossmeisl JH, Maggi RG, Breitschwerdt EB, Duncan RB.

J Vet Intern Med. 2008 May-Jun;22(3):674-8. doi: 10.1111/j.1939-1676.2008.0087.x. Epub 2008 May 2. No abstract available.

48.

Ryan White notification law repealed. The deletion of emergency-response provisions demands attention.

Cross JR.

JEMS. 2008 Mar;33(3):136-7. doi: 10.1016/S0197-2510(08)70091-3. No abstract available.

PMID:
18328405
49.

Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur.

Cross JR, Postigo A, Blight K, Downward J.

Cell Death Differ. 2008 Jun;15(6):997-1008. doi: 10.1038/cdd.2008.14. Epub 2008 Feb 15.

50.

What is your diagnosis? Osteochondroma, extraskeletal osteosarcoma, or tumor calcinosis.

Cross JR, Tromblee TC, Miller JM.

J Am Vet Med Assoc. 2007 Jun 15;230(12):1807-8. No abstract available.

PMID:
17571979

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