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Items: 1 to 50 of 467

1.

Epilepsy and cannabidiol: a guide to treatment.

Arzimanoglou A, Brandl U, Cross JH, Gil-Nagel A, Lagae L, Landmark CJ, Specchio N, Nabbout R, Thiele EA, Gubbay O.

Epileptic Disord. 2020 Feb 1;22(1):1-14. doi: 10.1684/epd.2020.1141.

PMID:
32096470
2.

MRI profiling of focal cortical dysplasia using multi-compartment diffusion models.

Lorio S, Adler S, Gunny R, D'Arco F, Kaden E, Wagstyl K, Jacques TS, Clark CA, Cross JH, Baldeweg T, Carmichael DW.

Epilepsia. 2020 Feb 17. doi: 10.1111/epi.16451. [Epub ahead of print]

PMID:
32065673
3.

Early postnatal hypoferremia in low birthweight and preterm babies: A prospective cohort study in hospital-delivered Gambian neonates.

Cross JH, Jarjou O, Mohammed NI, Rayment Gomez S, Touray BJB, Prentice AM, Cerami C.

EBioMedicine. 2020 Feb;52:102613. doi: 10.1016/j.ebiom.2019.102613. Epub 2020 Jan 22.

4.

Genetics in the epilepsies - A broadening concept.

Cross JH.

Eur J Paediatr Neurol. 2020 Jan;24:8. doi: 10.1016/j.ejpn.2020.01.009. Epub 2020 Jan 10. No abstract available.

PMID:
31973986
5.

Optimising Evidence-Based Psychological Treatment for the Mental Health Needs of Children with Epilepsy: Principles and Methods.

Shafran R, Bennett S, Coughtrey A, Welch A, Walji F, Cross JH, Heyman I, Sibelli A, Smith J, Ross J, Dalrymple E, Varadkar S; MICE Research Study Team, Moss-Morris R.

Clin Child Fam Psychol Rev. 2020 Jan 21. doi: 10.1007/s10567-019-00310-3. [Epub ahead of print] Review.

PMID:
31965422
6.

Dravet syndrome: Treatment options and management of prolonged seizures.

Cross JH, Caraballo RH, Nabbout R, Vigevano F, Guerrini R, Lagae L.

Epilepsia. 2019 Dec;60 Suppl 3:S39-S48. doi: 10.1111/epi.16334.

PMID:
31904119
7.

The concept of disease modification.

Cross JH, Lagae L.

Eur J Paediatr Neurol. 2020 Jan;24:43-46. doi: 10.1016/j.ejpn.2019.12.005. Epub 2019 Dec 17. Review.

PMID:
31879224
8.

Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation.

Barba C, Cross JH, Braun K, Cossu M, Klotz KA, De Masi S, Perez Jiménez MA, Gaily E, Specchio N, Cabral P, Toulouse J, Dimova P, Battaglia D, Freri E, Consales A, Cesaroni E, Tarta-Arsene O, Gil-Nagel A, Mindruta I, Di Gennaro G, Giulioni M, Tisdall MM, Eltze C, Tahir MZ, Jansen F, van Rijen P, Sanders M, Tassi L, Francione S, Lo Russo G, Jacobs J, Bast T, Matta G, Budke M, Fournier Del Castillo C, Metsahonkala EL, Karppinen A, Ferreira JC, Minkin K, Marras CE; European Survey Group, Arzimanoglou A, Guerrini R.

Epilepsia. 2020 Feb;61(2):216-227. doi: 10.1111/epi.16414. Epub 2019 Dec 26.

PMID:
31876960
9.

Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial.

Lagae L, Sullivan J, Knupp K, Laux L, Polster T, Nikanorova M, Devinsky O, Cross JH, Guerrini R, Talwar D, Miller I, Farfel G, Galer BS, Gammaitoni A, Mistry A, Morrison G, Lock M, Agarwal A, Lai WW, Ceulemans B; FAiRE DS Study Group.

Lancet. 2020 Dec 21;394(10216):2243-2254. doi: 10.1016/S0140-6736(19)32500-0. Epub 2019 Dec 17.

PMID:
31862249
10.

A perspective on cannabinoids for treating epilepsy: Do they really change the landscape?

Cross JH, Cock H.

Neuropharmacology. 2019 Nov 23:107861. doi: 10.1016/j.neuropharm.2019.107861. [Epub ahead of print] Review.

PMID:
31770546
11.

Drug Development for Rare Paediatric Epilepsies: Current State and Future Directions.

Auvin S, Avbersek A, Bast T, Chiron C, Guerrini R, Kaminski RM, Lagae L, Muglia P, Cross JH.

Drugs. 2019 Dec;79(18):1917-1935. doi: 10.1007/s40265-019-01223-9. Review.

PMID:
31734883
12.

Neonatal iron distribution and infection susceptibility in full term, preterm and low birthweight babies in urban Gambia: study protocol for an observational study.

Cross JH, Jarjou O, Mohammed NI, Prentice AM, Cerami C.

Version 2. Gates Open Res. 2019 Oct 15 [revised 2019 Jan 1];3:1469. doi: 10.12688/gatesopenres.12963.2. eCollection 2019.

13.

Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia.

Bah A, Muhammad AK, Wegmuller R, Verhoef H, Goheen MM, Sanyang S, Danso E, Sise EA, Pasricha SR, Armitage AE, Drakesmith H, Cross JH, Moore SE, Cerami C, Prentice AM.

Lancet Glob Health. 2019 Nov;7(11):e1564-e1574. doi: 10.1016/S2214-109X(19)30393-6.

14.

Centromedian thalamic nuclei deep brain stimulation and Anakinra treatment for FIRES - Two different outcomes.

Sa M, Singh R, Pujar S, D'Arco F, Desai N, Eltze C, Hughes E, Al Obaidi M, Eleftheriou D, Tisdall M, Selway R, Cross JH, Kaliakatsos M, Valentin A.

Eur J Paediatr Neurol. 2019 Sep;23(5):749-754. doi: 10.1016/j.ejpn.2019.08.001. Epub 2019 Aug 8.

PMID:
31446001
15.

Optimal clinical management of children receiving ketogenic parenteral nutrition: a clinical practice guide.

van der Louw E, Aldaz V, Harvey J, Roan M, van den Hurk D, Cross JH, Auvin S; Review Group.

Dev Med Child Neurol. 2020 Jan;62(1):48-56. doi: 10.1111/dmcn.14306. Epub 2019 Jul 16.

16.

Association of quality of paediatric epilepsy care with mortality and unplanned hospital admissions among children and young people with epilepsy in England: a national longitudinal data linkage study.

Hargreaves DS, Arora S, Viveiro C, Hale DR, Ward JL, Sherlaw-Johnson C, Viner RM, Dunkley C, Cross JH.

Lancet Child Adolesc Health. 2019 Sep;3(9):627-635. doi: 10.1016/S2352-4642(19)30201-9. Epub 2019 Jul 4.

17.

Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy.

Pitkänen A, Henshall DC, Cross JH, Guerrini R, Jozwiak S, Kokaia M, Simonato M, Sisodiya S, Mifsud J.

Epilepsia. 2019 Jul;60(7):1281-1292. doi: 10.1111/epi.16091. Epub 2019 Jun 18. Review.

PMID:
31211425
18.

Severity Assessment in CDKL5 Deficiency Disorder.

Demarest S, Pestana-Knight EM, Olson HE, Downs J, Marsh ED, Kaufmann WE, Partridge CA, Leonard H, Gwadry-Sridhar F, Frame KE, Cross JH, Chin RFM, Parikh S, Panzer A, Weisenberg J, Utley K, Jaksha A, Amin S, Khwaja O, Devinsky O, Neul JL, Percy AK, Benke TA.

Pediatr Neurol. 2019 Aug;97:38-42. doi: 10.1016/j.pediatrneurol.2019.03.017. Epub 2019 Mar 27.

PMID:
31147226
19.

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E, Reich A, Schneider AL, Pressler RM, Simpson MA, Debelle GD, Wassmer E, Morton J, Sieciechowicz D, Jan-Kamsteeg E, Paciorkowski AR, King MD, Cross JH, Poduri A, Mefford HC, Scheffer IE, Haack TB, McCullagh G; Deciphering Developmental Disorders Study; UK10K Consortium; NIHR BioResource, Millichap JJ, Carvill GL, Clayton-Smith J, Maher ER, Raymond FL, Kurian MA.

Am J Hum Genet. 2019 May 2;104(5):948-956. doi: 10.1016/j.ajhg.2019.03.005. Epub 2019 Apr 11.

20.

Neuropsychiatric profile of paediatric hypothalamic hamartoma: systematic review and case series.

Corbet Burcher G, Liang H, Lancaster R, Cross JH, Tisdall M, Varadkar S, Spoudeas HA, Caredda E, Bennett S, Heyman I.

Dev Med Child Neurol. 2019 Dec;61(12):1377-1385. doi: 10.1111/dmcn.14241. Epub 2019 Apr 11. Review.

PMID:
30977116
21.

Determinants of IQ outcome after focal epilepsy surgery in childhood: A longitudinal case-control neuroimaging study.

Skirrow C, Cross JH, Owens R, Weiss-Croft L, Martin-Sanfilippo P, Banks T, Shah E, Harkness W, Vargha-Khadem F, Baldeweg T.

Epilepsia. 2019 May;60(5):872-884. doi: 10.1111/epi.14707. Epub 2019 Apr 10.

PMID:
30968956
22.

Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Clinical Review.

Olson HE, Demarest ST, Pestana-Knight EM, Swanson LC, Iqbal S, Lal D, Leonard H, Cross JH, Devinsky O, Benke TA.

Pediatr Neurol. 2019 Aug;97:18-25. doi: 10.1016/j.pediatrneurol.2019.02.015. Epub 2019 Feb 23. Review.

PMID:
30928302
23.

MEG Assessment of Expressive Language in Children Evaluated for Epilepsy Surgery.

Foley E, Cross JH, Thai NJ, Walsh AR, Bill P, Furlong P, Wood AG, Cerquiglini A, Seri S.

Brain Topogr. 2019 May;32(3):492-503. doi: 10.1007/s10548-019-00703-1. Epub 2019 Mar 20.

24.

Diagnostic and prognostic value of noninvasive long-term video-electroencephalographic monitoring in epilepsy surgery: A systematic review and meta-analysis from the E-PILEPSY consortium.

Kobulashvili T, Kuchukhidze G, Brigo F, Zimmermann G, Höfler J, Leitinger M, Dobesberger J, Kalss G, Rohracher A, Neuray C, Wakonig A, Ernst F, Braun KPJ, Mouthaan BE, Van Eijsden P, Ryvlin P, Cross JH, Trinka E; E-PILEPSY consortium.

Epilepsia. 2018 Dec;59(12):2272-2283. doi: 10.1111/epi.14598. Epub 2018 Nov 22.

25.

Experiences and needs of parents of young children with active epilepsy: A population-based study.

Jones C, Atkinson P, Memon A, Dabydeen L, Das KB, Cross JH, Gillberg C, Neville BGR, Scott RC, Reilly C.

Epilepsy Behav. 2019 Jan;90:37-44. doi: 10.1016/j.yebeh.2018.10.031. Epub 2018 Nov 27.

PMID:
30500487
26.

Neurologic phenotypes associated with COL4A1/2 mutations: Expanding the spectrum of disease.

Zagaglia S, Selch C, Nisevic JR, Mei D, Michalak Z, Hernandez-Hernandez L, Krithika S, Vezyroglou K, Varadkar SM, Pepler A, Biskup S, Leão M, Gärtner J, Merkenschlager A, Jaksch M, Møller RS, Gardella E, Kristiansen BS, Hansen LK, Vari MS, Helbig KL, Desai S, Smith-Hicks CL, Hino-Fukuyo N, Talvik T, Laugesaar R, Ilves P, Õunap K, Körber I, Hartlieb T, Kudernatsch M, Winkler P, Schimmel M, Hasse A, Knuf M, Heinemeyer J, Makowski C, Ghedia S, Subramanian GM, Striano P, Thomas RH, Micallef C, Thom M, Werring DJ, Kluger GJ, Cross JH, Guerrini R, Balestrini S, Sisodiya SM.

Neurology. 2018 Nov 27;91(22):e2078-e2088. doi: 10.1212/WNL.0000000000006567. Epub 2018 Nov 9. Erratum in: Neurology. 2020 Feb 18;94(7):332.

27.

Parenting stress and perceived stigma in mothers of young children with epilepsy: A case-control study.

Reilly C, Atkinson P, Memon A, Jones C, Dabydeen L, Das KB, Cross JH, Neville BGR, Gillberg C, Scott RC.

Epilepsy Behav. 2018 Dec;89:112-117. doi: 10.1016/j.yebeh.2018.10.016. Epub 2018 Nov 6.

PMID:
30412923
28.

A web-based diagnostic reference centre for the European Reference Network "EpiCare": recommendations of the eNeuropathology working group.

Kölble K, Cross JH, Becker A, Blümcke I.

Epileptic Disord. 2018 Oct 1;20(5):339-345. doi: 10.1684/epd.2018.1002. Review.

29.

Multimodal computational neocortical anatomy in pediatric hippocampal sclerosis.

Adler S, Blackwood M, Northam GB, Gunny R, Hong SJ, Bernhardt BC, Bernasconi A, Bernasconi N, Jacques T, Tisdall M, Carmichael DW, Cross JH, Baldeweg T.

Ann Clin Transl Neurol. 2018 Sep 27;5(10):1200-1210. doi: 10.1002/acn3.634. eCollection 2018 Oct.

30.

Correction: The clinical spectrum and natural history of early-onset diseases due to DNA polymerase gamma mutations.

Hikmat O, Tzoulis C, Chong WK, Chentouf L, Klingenberg C, Fratter C, Carr LJ, Prabhakar P, Kumaraguru N, Gissen P, Cross JH, Jacques TS, Taanman JW, Bindoff LA, Rahman S.

Genet Med. 2019 Apr;21(4):1027. doi: 10.1038/s41436-018-0098-1.

PMID:
30228318
31.

Child and parental sleep in young children with epilepsy: A population-based case-control study.

Reilly C, Atkinson P, Memon A, Jones C, Dabydeen L, Cross JH, Das KB, Gillberg C, Neville BGR, Scott RC.

Epilepsia Open. 2018 Jul 8;3(3):383-391. doi: 10.1002/epi4.12241. eCollection 2018 Sep.

32.

Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission.

Auvin S, Wirrell E, Donald KA, Berl M, Hartmann H, Valente KD, Van Bogaert P, Cross JH, Osawa M, Kanemura H, Aihara M, Guerreiro MM, Samia P, Vinayan KP, Smith ML, Carmant L, Kerr M, Hermann B, Dunn D, Wilmshurst JM.

Epilepsia. 2018 Oct;59(10):1867-1880. doi: 10.1111/epi.14549. Epub 2018 Sep 3.

33.

Epilepsy surgery near or in eloquent cortex in children-Practice patterns and recommendations for minimizing and reporting deficits.

Jayakar P, Jayakar A, Libenson M, Arzimanoglou A, Rydenhag B, Cross JH, Bhatia S, Tassi L, Lachhwani D, Gaillard WD; Pediatric Epilepsy Surgery Task Force; International League Against Epilepsy.

Epilepsia. 2018 Aug;59(8):1484-1491. doi: 10.1111/epi.14510. Epub 2018 Jul 22.

34.

Genome-wide association study: Exploring the genetic basis for responsiveness to ketogenic dietary therapies for drug-resistant epilepsy.

Schoeler NE, Leu C, Balestrini S, Mudge JM, Steward CA, Frankish A, Leung MA, Mackay M, Scheffer I, Williams R, Sander JW, Cross JH, Sisodiya SM.

Epilepsia. 2018 Aug;59(8):1557-1566. doi: 10.1111/epi.14516. Epub 2018 Jul 16.

35.

European trends in epilepsy surgery.

Baud MO, Perneger T, Rácz A, Pensel MC, Elger C, Rydenhag B, Malmgren K, Cross JH, McKenna G, Tisdall M, Lamberink HJ, Rheims S, Ryvlin P, Isnard J, Mauguière F, Arzimanoglou A, Akkol S, Deniz K, Ozkara C, Lossius M, Rektor I, Kälviäinen R, Vanhatalo LM, Dimova P, Minkin K, Staack AM, Steinhoff BJ, Kalina A, Krsek P, Marusic P, Jordan Z, Fabo D, Carrette E, Boon P, Rocka S, Mameniškienė R, Vulliemoz S, Pittau F, Braun KPJ, Seeck M.

Neurology. 2018 Jul 10;91(2):e96-e106. doi: 10.1212/WNL.0000000000005776. Epub 2018 Jun 13.

PMID:
29898967
36.

Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group.

Kossoff EH, Zupec-Kania BA, Auvin S, Ballaban-Gil KR, Christina Bergqvist AG, Blackford R, Buchhalter JR, Caraballo RH, Cross JH, Dahlin MG, Donner EJ, Guzel O, Jehle RS, Klepper J, Kang HC, Lambrechts DA, Liu YMC, Nathan JK, Nordli DR Jr, Pfeifer HH, Rho JM, Scheffer IE, Sharma S, Stafstrom CE, Thiele EA, Turner Z, Vaccarezza MM, van der Louw EJTM, Veggiotti P, Wheless JW, Wirrell EC; Charlie Foundation; Matthew's Friends; Practice Committee of the Child Neurology Society.

Epilepsia Open. 2018 May 21;3(2):175-192. doi: 10.1002/epi4.12225. eCollection 2018 Jun.

37.

Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome.

Devinsky O, Patel AD, Cross JH, Villanueva V, Wirrell EC, Privitera M, Greenwood SM, Roberts C, Checketts D, VanLandingham KE, Zuberi SM; GWPCARE3 Study Group.

N Engl J Med. 2018 May 17;378(20):1888-1897. doi: 10.1056/NEJMoa1714631.

38.

Pre- and postsurgical cognitive trajectories and quantitative MRI changes in Rasmussen syndrome.

Rudebeck SR, Shavel-Jessop S, Varadkar S, Owen T, Cross JH, Vargha-Khadem F, Baldeweg T.

Epilepsia. 2018 Jun;59(6):1210-1219. doi: 10.1111/epi.14192. Epub 2018 May 11.

39.

Pediatric epilepsy surgery: the earlier the better.

Braun KPJ, Cross JH.

Expert Rev Neurother. 2018 Apr;18(4):261-263. doi: 10.1080/14737175.2018.1455503. Epub 2018 Mar 23. No abstract available.

PMID:
29560752
40.

Stiripentol efficacy and safety in Dravet syndrome: a 12-year observational study.

Myers KA, Lightfoot P, Patil SG, Cross JH, Scheffer IE.

Dev Med Child Neurol. 2018 Jun;60(6):574-578. doi: 10.1111/dmcn.13704. Epub 2018 Feb 23.

41.

The ketogenic diet is effective for refractory epilepsy associated with acquired structural epileptic encephalopathy.

Villaluz MM, Lomax LB, Jadhav T, Cross JH, Scheffer IE.

Dev Med Child Neurol. 2018 Jul;60(7):718-723. doi: 10.1111/dmcn.13687. Epub 2018 Feb 16.

42.

Topographic principles of cortical fluid-attenuated inversion recovery signal in temporal lobe epilepsy.

Adler S, Hong SJ, Liu M, Baldeweg T, Cross JH, Bernasconi A, Bernhardt BC, Bernasconi N.

Epilepsia. 2018 Mar;59(3):627-635. doi: 10.1111/epi.14017. Epub 2018 Jan 31.

43.

The epileptic encephalopathy jungle - from Dr West to the concepts of aetiology-related and developmental encephalopathies.

Kalser J, Cross JH.

Curr Opin Neurol. 2018 Apr;31(2):216-222. doi: 10.1097/WCO.0000000000000535. Review.

PMID:
29356691
44.

Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders.

Augustin K, Khabbush A, Williams S, Eaton S, Orford M, Cross JH, Heales SJR, Walker MC, Williams RSB.

Lancet Neurol. 2018 Jan;17(1):84-93. doi: 10.1016/S1474-4422(17)30408-8. Epub 2017 Dec 16. Review.

PMID:
29263011
45.

Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy.

McTague A, Nair U, Malhotra S, Meyer E, Trump N, Gazina EV, Papandreou A, Ngoh A, Ackermann S, Ambegaonkar G, Appleton R, Desurkar A, Eltze C, Kneen R, Kumar AV, Lascelles K, Montgomery T, Ramesh V, Samanta R, Scott RH, Tan J, Whitehouse W, Poduri A, Scheffer IE, Chong WKK, Cross JH, Topf M, Petrou S, Kurian MA.

Neurology. 2018 Jan 2;90(1):e55-e66. doi: 10.1212/WNL.0000000000004762. Epub 2017 Dec 1.

46.

Crossing the lines between epilepsy syndromes: a myoclonic epilepsy variant with prominent eyelid myoclonia and atonic components.

Dragoumi P, Emery J, Chivers F, Brady M, Desurkar A, Cross JH, Das KB.

Epileptic Disord. 2018 Feb 1;20(1):35-41. doi: 10.1684/epd.2017.0937.

47.

Prevalence and risk factors for autism spectrum disorder in epilepsy: a systematic review and meta-analysis.

Strasser L, Downes M, Kung J, Cross JH, De Haan M.

Dev Med Child Neurol. 2018 Jan;60(1):19-29. doi: 10.1111/dmcn.13598. Epub 2017 Nov 9. Review.

48.

Expert Opinion on the Management of Lennox-Gastaut Syndrome: Treatment Algorithms and Practical Considerations.

Cross JH, Auvin S, Falip M, Striano P, Arzimanoglou A.

Front Neurol. 2017 Sep 29;8:505. doi: 10.3389/fneur.2017.00505. eCollection 2017. Review.

49.

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery.

Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G; EEBB Consortium.

N Engl J Med. 2017 Oct 26;377(17):1648-1656. doi: 10.1056/NEJMoa1703784.

50.

Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours.

Stone TJ, Keeley A, Virasami A, Harkness W, Tisdall M, Izquierdo Delgado E, Gutteridge A, Brooks T, Kristiansen M, Chalker J, Wilkhu L, Mifsud W, Apps J, Thom M, Hubank M, Forshew T, Cross JH, Hargrave D, Ham J, Jacques TS.

Acta Neuropathol. 2018 Jan;135(1):115-129. doi: 10.1007/s00401-017-1773-z. Epub 2017 Oct 20.

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