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Progress towards the development of Klebsiella vaccines.

Choi M, Tennant SM, Simon R, Cross AS.

Expert Rev Vaccines. 2019 Jul;18(7):681-691. doi: 10.1080/14760584.2019.1635460. Epub 2019 Jun 28.


Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection.

Lillehoj EP, Guang W, Hyun SW, Liu A, Hegerle N, Simon R, Cross AS, Ishida H, Luzina IG, Atamas SP, Goldblum SE.

J Biol Chem. 2019 Jan 11;294(2):662-678. doi: 10.1074/jbc.RA118.006022. Epub 2018 Nov 14.


Development of a broad spectrum glycoconjugate vaccine to prevent wound and disseminated infections with Klebsiella pneumoniae and Pseudomonas aeruginosa.

Hegerle N, Choi M, Sinclair J, Amin MN, Ollivault-Shiflett M, Curtis B, Laufer RS, Shridhar S, Brammer J, Toapanta FR, Holder IA, Pasetti MF, Lees A, Tennant SM, Cross AS, Simon R.

PLoS One. 2018 Sep 6;13(9):e0203143. doi: 10.1371/journal.pone.0203143. eCollection 2018.


Effect of hypobaria and hyperoxia during sepsis on survival and energy metabolism.

Choi M, Tamrakar P, Schuck PF, Proctor JL, Moore A, Asbury K, Fiskum G, Coksaygan T, Cross AS.

J Trauma Acute Care Surg. 2018 Jul;85(1S Suppl 2):S68-S76. doi: 10.1097/TA.0000000000001909.


Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1230. doi: 10.1007/s13361-018-1960-8.


Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1221-1229. doi: 10.1007/s13361-018-1897-y. Epub 2018 Feb 20. Erratum in: J Am Soc Mass Spectrom. 2018 Apr 23;:.


International survey on high- and low-dose synacthen test and assessment of accuracy in preparing low-dose synacthen.

Cross AS, Helen Kemp E, White A, Walker L, Meredith S, Sachdev P, Krone NP, Ross RJ, Wright NP, Elder CJ.

Clin Endocrinol (Oxf). 2018 May;88(5):744-751. doi: 10.1111/cen.13559. Epub 2018 Feb 22.


Use of salivary cortisol and cortisone in the high- and low-dose synacthen test.

Elder CJ, Harrison RF, Cross AS, Vilela R, Keevil BG, Wright NP, Ross RJ.

Clin Endocrinol (Oxf). 2018 Jun;88(6):772-778. doi: 10.1111/cen.13509. Epub 2017 Nov 29.


Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited.

Feng C, Li J, Snyder G, Huang W, Goldblum SE, Chen WH, Wang LX, McClane BA, Cross AS.

mBio. 2017 Jun 27;8(3). pii: e00078-17. doi: 10.1128/mBio.00078-17.


IL-18/IL-1/IL-17A axis: A novel therapeutic target for neonatal sepsis?

Cross AS.

Cytokine. 2016 Oct;86:1-3. doi: 10.1016/j.cyto.2016.07.001. Epub 2016 Jul 17.


The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.

Hyun SW, Liu A, Liu Z, Cross AS, Verceles AC, Magesh S, Kommagalla Y, Kona C, Ando H, Luzina IG, Atamas SP, Piepenbrink KH, Sundberg EJ, Guang W, Ishida H, Lillehoj EP, Goldblum SE.

Glycobiology. 2016 Aug;26(8):834-49. doi: 10.1093/glycob/cww060. Epub 2016 May 25.


Phase 1 testing of detoxified LPS/group B meningococcal outer membrane protein vaccine with and without synthetic CPG 7909 adjuvant for the prevention and treatment of sepsis.

Cross AS, Greenberg N, Billington M, Zhang L, DeFilippi C, May RC, Bajwa KK.

Vaccine. 2015 Nov 27;33(48):6719-26. doi: 10.1016/j.vaccine.2015.10.072. Epub 2015 Oct 26.


Potential role of autophagy in the bactericidal activity of human PMNs for Bacillus anthracis.

Ramachandran G, Gade P, Tsai P, Lu W, Kalvakolanu DV, Rosen GM, Cross AS.

Pathog Dis. 2015 Dec;73(9):ftv080. doi: 10.1093/femspd/ftv080. Epub 2015 Sep 30.


Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding.

Nita-Lazar M, Banerjee A, Feng C, Amin MN, Frieman MB, Chen WH, Cross AS, Wang LX, Vasta GR.

Mol Immunol. 2015 May;65(1):1-16. doi: 10.1016/j.molimm.2014.12.010. Epub 2015 Jan 16.


CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis.

Ramachandran G, Kaempfer R, Chung CS, Shirvan A, Chahin AB, Palardy JE, Parejo NA, Chen Y, Whitford M, Arad G, Hillman D, Shemesh R, Blackwelder W, Ayala A, Cross AS, Opal SM.

J Infect Dis. 2015 Mar 15;211(6):995-1003. doi: 10.1093/infdis/jiu556. Epub 2014 Oct 9.


Immunization of cows with novel core glycolipid vaccine induces anti-endotoxin antibodies in bovine colostrum.

Cross AS, Karreman HJ, Zhang L, Rosenberg Z, Opal SM, Lees A.

Vaccine. 2014 Oct 21;32(46):6107-14. doi: 10.1016/j.vaccine.2014.08.083. Epub 2014 Sep 19.


Regulation of the death-associated protein kinase 1 expression and autophagy via ATF6 requires apoptosis signal-regulating kinase 1.

Gade P, Manjegowda SB, Nallar SC, Maachani UB, Cross AS, Kalvakolanu DV.

Mol Cell Biol. 2014 Nov;34(21):4033-48. doi: 10.1128/MCB.00397-14. Epub 2014 Aug 18.


Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: role in phagocytosis.

Stamatos NM, Zhang L, Jokilammi A, Finne J, Chen WH, El-Maarouf A, Cross AS, Hankey KG.

Glycobiology. 2014 Sep;24(9):864-79. doi: 10.1093/glycob/cwu050. Epub 2014 May 27.


Human airway epithelia express catalytically active NEU3 sialidase.

Lillehoj EP, Hyun SW, Feng C, Zhang L, Liu A, Guang W, Nguyen C, Sun W, Luzina IG, Webb TJ, Atamas SP, Passaniti A, Twaddell WS, Puché AC, Wang LX, Cross AS, Goldblum SE.

Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L876-86. doi: 10.1152/ajplung.00322.2013. Epub 2014 Mar 21.


The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans.

Harris KM, Ramachandran G, Basu S, Rollins S, Mann D, Cross AS.

Eur J Immunol. 2014 Mar;44(3):752-62. doi: 10.1002/eji.201343784. Epub 2014 Jan 2.


Serum bactericidal assays to evaluate typhoidal and nontyphoidal Salmonella vaccines.

Boyd MA, Tennant SM, Saague VA, Simon R, Muhsen K, Ramachandran G, Cross AS, Galen JE, Pasetti MF, Levine MM.

Clin Vaccine Immunol. 2014 May;21(5):712-21. doi: 10.1128/CVI.00115-14. Epub 2014 Mar 12.


NEU1 sialidase regulates the sialylation state of CD31 and disrupts CD31-driven capillary-like tube formation in human lung microvascular endothelia.

Lee C, Liu A, Miranda-Ribera A, Hyun SW, Lillehoj EP, Cross AS, Passaniti A, Grimm PR, Kim BY, Welling PA, Madri JA, DeLisser HM, Goldblum SE.

J Biol Chem. 2014 Mar 28;289(13):9121-35. doi: 10.1074/jbc.M114.555888. Epub 2014 Feb 18.


InP-based waveguide photodiodes heterogeneously integrated on silicon-on-insulator for photonic microwave generation.

Beling A, Cross AS, Piels M, Peters J, Zhou Q, Bowers JE, Campbell JC.

Opt Express. 2013 Nov 4;21(22):25901-6. doi: 10.1364/OE.21.025901.


Neuraminidase reprograms lung tissue and potentiates lipopolysaccharide-induced acute lung injury in mice.

Feng C, Zhang L, Nguyen C, Vogel SN, Goldblum SE, Blackwelder WC, Cross AS.

J Immunol. 2013 Nov 1;191(9):4828-37. doi: 10.4049/jimmunol.1202673. Epub 2013 Sep 25.


Anti-endotoxin vaccines: back to the future.

Cross AS.

Virulence. 2014 Jan 1;5(1):219-25. doi: 10.4161/viru.25965. Epub 2013 Aug 13. Review.


High-power flip-chip mounted photodiode array.

Cross AS, Zhou Q, Beling A, Fu Y, Campbell JC.

Opt Express. 2013 Apr 22;21(8):9967-73. doi: 10.1364/OE.21.009967.


A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes.

Ramachandran G, Tulapurkar ME, Harris KM, Arad G, Shirvan A, Shemesh R, Detolla LJ, Benazzi C, Opal SM, Kaempfer R, Cross AS.

J Infect Dis. 2013 Jun 15;207(12):1869-77. doi: 10.1093/infdis/jit104. Epub 2013 Mar 14.


A mixture of functionally oligoclonal humanized monoclonal antibodies that neutralize Clostridium difficile TcdA and TcdB with high levels of in vitro potency shows in vivo protection in a hamster infection model.

Davies NL, Compson JE, Mackenzie B, O'Dowd VL, Oxbrow AK, Heads JT, Turner A, Sarkar K, Dugdale SL, Jairaj M, Christodoulou L, Knight DE, Cross AS, Hervé KJ, Tyson KL, Hailu H, Doyle CB, Ellis M, Kriek M, Cox M, Page MJ, Moore AR, Lightwood DJ, Humphreys DP.

Clin Vaccine Immunol. 2013 Mar;20(3):377-90. doi: 10.1128/CVI.00625-12. Epub 2013 Jan 16.


Mechanisms of triglyceride accumulation in activated macrophages.

Feingold KR, Shigenaga JK, Kazemi MR, McDonald CM, Patzek SM, Cross AS, Moser A, Grunfeld C.

J Leukoc Biol. 2012 Oct;92(4):829-39. doi: 10.1189/jlb.1111537. Epub 2012 Jun 29.


An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy.

Gade P, Ramachandran G, Maachani UB, Rizzo MA, Okada T, Prywes R, Cross AS, Mori K, Kalvakolanu DV.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10316-21. doi: 10.1073/pnas.1119273109. Epub 2012 Jun 13.


Angiopoietin like protein 4 expression is decreased in activated macrophages.

Feingold KR, Shigenaga JK, Cross AS, Moser A, Grunfeld C.

Biochem Biophys Res Commun. 2012 May 11;421(3):612-5. doi: 10.1016/j.bbrc.2012.04.055. Epub 2012 Apr 19.


Sialyl residues modulate LPS-mediated signaling through the Toll-like receptor 4 complex.

Feng C, Stamatos NM, Dragan AI, Medvedev A, Whitford M, Zhang L, Song C, Rallabhandi P, Cole L, Nhu QM, Vogel SN, Geddes CD, Cross AS.

PLoS One. 2012;7(4):e32359. doi: 10.1371/journal.pone.0032359. Epub 2012 Apr 9.


NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not.

Cross AS, Hyun SW, Miranda-Ribera A, Feng C, Liu A, Nguyen C, Zhang L, Luzina IG, Atamas SP, Twaddell WS, Guang W, Lillehoj EP, Puché AC, Huang W, Wang LX, Passaniti A, Goldblum SE.

J Biol Chem. 2012 May 4;287(19):15966-80. doi: 10.1074/jbc.M112.346817. Epub 2012 Mar 8.


Effect of the mammalian arginase inhibitor 2(S)-amino-6-boronohexanoic acid on Bacillus anthracis arginase.

Tsai P, Cao GL, Tomczuk B, Suzdak PD, Cross AS, Shapiro P, Rosen GM.

Curr Microbiol. 2012 Apr;64(4):379-84. doi: 10.1007/s00284-012-0084-9. Epub 2012 Jan 24.


NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling.

Lillehoj EP, Hyun SW, Feng C, Zhang L, Liu A, Guang W, Nguyen C, Luzina IG, Atamas SP, Passaniti A, Twaddell WS, Puché AC, Wang LX, Cross AS, Goldblum SE.

J Biol Chem. 2012 Mar 9;287(11):8214-31. doi: 10.1074/jbc.M111.292888. Epub 2012 Jan 13.


Bacillus anthracis-derived edema toxin (ET) counter-regulates movement of neutrophils and macromolecules through the endothelial paracellular pathway.

Nguyen C, Feng C, Zhan M, Cross AS, Goldblum SE.

BMC Microbiol. 2012 Jan 9;12:2. doi: 10.1186/1471-2180-12-2.


Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza.

Chen WH, Toapanta FR, Shirey KA, Zhang L, Giannelou A, Page C, Frieman MB, Vogel SN, Cross AS.

Immunol Lett. 2012 Jan 30;141(2):227-34. doi: 10.1016/j.imlet.2011.10.009. Epub 2011 Oct 20.


Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1.

Feng C, Zhang L, Almulki L, Faez S, Whitford M, Hafezi-Moghadam A, Cross AS.

J Leukoc Biol. 2011 Aug;90(2):313-21. doi: 10.1189/jlb.1210708. Epub 2011 May 6.


The early humoral immune response to Bacillus anthracis toxins in patients infected with cutaneous anthrax.

Brenneman KE, Doganay M, Akmal A, Goldman S, Galloway DR, Mateczun AJ, Cross AS, Baillie LW.

FEMS Immunol Med Microbiol. 2011 Jul;62(2):164-72. doi: 10.1111/j.1574-695X.2011.00800.x. Epub 2011 Apr 15.


Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine.

Chen WH, Cross AS, Edelman R, Sztein MB, Blackwelder WC, Pasetti MF.

Vaccine. 2011 Apr 5;29(16):2865-73. doi: 10.1016/j.vaccine.2011.02.017. Epub 2011 Feb 23.


LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity.

Stamatos NM, Carubelli I, van de Vlekkert D, Bonten EJ, Papini N, Feng C, Venerando B, d'Azzo A, Cross AS, Wang LX, Gomatos PJ.

J Leukoc Biol. 2010 Dec;88(6):1227-39. doi: 10.1189/jlb.1209776. Epub 2010 Sep 8.


Development of an anti-endotoxin vaccine for sepsis.

Cross AS.

Subcell Biochem. 2010;53:285-302. doi: 10.1007/978-90-481-9078-2_13.


Bacillus anthracis endospores regulate ornithine decarboxylase and inducible nitric oxide synthase through ERK1/2 and p38 mitogen-activated protein kinases.

Porasuphatana S, Cao GL, Tsai P, Tavakkoli F, Huwar T, Baillie L, Cross AS, Shapiro P, Rosen GM.

Curr Microbiol. 2010 Dec;61(6):567-73. doi: 10.1007/s00284-010-9654-x. Epub 2010 May 4.


Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4.

Gregory SH, Chen WH, Mott S, Palardy JE, Parejo NA, Heninger S, Anderson CA, Artenstein AW, Opal SM, Cross AS.

Vaccine. 2010 Apr 1;28(16):2908-15. doi: 10.1016/j.vaccine.2010.01.067. Epub 2010 Feb 17.


Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors.

Chen WH, Basu S, Bhattacharjee AK, Cross AS.

Innate Immun. 2010 Oct;16(5):322-32. doi: 10.1177/1753425909346973. Epub 2009 Oct 12.


What is a virulence factor?

Cross AS.

Crit Care. 2008;12(6):196. doi: 10.1186/cc7127. Epub 2008 Dec 2.


An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity.

Li XL, Ezelle HJ, Kang TJ, Zhang L, Shirey KA, Harro J, Hasday JD, Mohapatra SK, Crasta OR, Vogel SN, Cross AS, Hassel BA.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20816-21. doi: 10.1073/pnas.0807265105. Epub 2008 Dec 15.


In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes.

Berry LM, Adams R, Airey M, Bracher MG, Bourne T, Carrington B, Cross AS, Davies GC, Finney HM, Foulkes R, Gozzard N, Griffin RA, Hailu H, Lamour SD, Lawson AD, Lightwood DJ, McKnight AJ, O'Dowd VL, Oxbrow AK, Popplewell AG, Shaw S, Stephens PE, Sweeney B, Tomlinson KL, Uhe C, Palframan RT.

Int Immunopharmacol. 2009 Feb;9(2):201-6. doi: 10.1016/j.intimp.2008.11.001. Epub 2008 Nov 27.


Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia.

Chen WH, Kang TJ, Bhattacharjee AK, Cross AS.

Innate Immun. 2008 Oct;14(5):269-78. doi: 10.1177/1753425908095959.


Differential expression of toll-like receptor genes: sepsis compared with sterile inflammation 1 day before sepsis diagnosis.

Lissauer ME, Johnson SB, Bochicchio GV, Feild CJ, Cross AS, Hasday JD, Whiteford CC, Nussbaumer WA, Towns M, Scalea TM.

Shock. 2009 Mar;31(3):238-44. doi: 10.1097/SHK.0b013e3181834991.


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