Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 22

1.

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.

Gomes B, Driessens G, Bartlett D, Cai D, Cauwenberghs S, Crosignani S, Dalvie D, Denies S, Dillon CP, Fantin VR, Guo J, Letellier MC, Li W, Maegley K, Marillier R, Miller N, Pirson R, Rabolli V, Ray C, Streiner N, Torti VR, Tsaparikos K, Van den Eynde BJ, Wythes M, Yao LC, Zheng X, Tumang J, Kraus M.

Mol Cancer Ther. 2018 Dec;17(12):2530-2542. doi: 10.1158/1535-7163.MCT-17-1104. Epub 2018 Sep 19.

PMID:
30232146
2.

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.

Crosignani S, Bingham P, Bottemanne P, Cannelle H, Cauwenberghs S, Cordonnier M, Dalvie D, Deroose F, Feng JL, Gomes B, Greasley S, Kaiser SE, Kraus M, Négrerie M, Maegley K, Miller N, Murray BW, Schneider M, Soloweij J, Stewart AE, Tumang J, Torti VR, Van Den Eynde B, Wythes M.

J Med Chem. 2017 Dec 14;60(23):9617-9629. doi: 10.1021/acs.jmedchem.7b00974. Epub 2017 Nov 21.

PMID:
29111717
3.

Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy.

Quattropani A, Sauer WH, Crosignani S, Dorbais J, Gerber P, Gonzalez J, Marin D, Muzerelle M, Beltran F, Nichols A, Georgi K, Schneider M, Vitte PA, Eligert V, Novo-Perez L, Hantson J, Nock S, Carboni S, de Souza AL, Arrighi JF, Boschert U, Bombrun A.

ChemMedChem. 2015 Apr;10(4):688-714. doi: 10.1002/cmdc.201402557. Epub 2015 Mar 3.

PMID:
25735812
4.

Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids.

Crosignani S, Jorand-Lebrun C, Campbell G, Prêtre A, Grippi-Vallotton T, Quattropani A, Bouscary-Desforges G, Bombrun A, Missotten M, Humbert Y, Frémaux C, Pâquet M, El Harkani K, Bradshaw CG, Cleva C, Abla N, Daff H, Schott O, Pittet PA, Arrighi JF, Gaudet M, Johnson Z.

ACS Med Chem Lett. 2011 Oct 10;2(12):938-42. doi: 10.1021/ml200223s. eCollection 2011 Dec 8.

5.

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

Crosignani S, Prêtre A, Jorand-Lebrun C, Fraboulet G, Seenisamy J, Augustine JK, Missotten M, Humbert Y, Cleva C, Abla N, Daff H, Schott O, Schneider M, Burgat-Charvillon F, Rivron D, Hamernig I, Arrighi JF, Gaudet M, Zimmerli SC, Juillard P, Johnson Z.

J Med Chem. 2011 Oct 27;54(20):7299-317. doi: 10.1021/jm200866y. Epub 2011 Oct 3.

PMID:
21916510
6.

Optimization of the Central Core of Indolinone-Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists.

Crosignani S, Jorand-Lebrun C, Page P, Campbell G, Colovray V, Missotten M, Humbert Y, Cleva C, Arrighi JF, Gaudet M, Johnson Z, Ferro P, Chollet A.

ACS Med Chem Lett. 2011 Jun 9;2(8):644-9. doi: 10.1021/ml2001196. eCollection 2011 Aug 11.

7.

Novel application of α-azido aldehydes in multicomponent reactions: synthesis of triazolo-fused dihydrooxazinones via a Passerini reaction-dipolar cycloaddition strategy.

De Moliner F, Crosignani S, Galatini A, Riva R, Basso A.

ACS Comb Sci. 2011 Sep 12;13(5):453-7. doi: 10.1021/co200072z. Epub 2011 Jun 27.

PMID:
21627306
8.

Synthesis of 5-carboxamide-oxazolines with a Passerini-Zhu/Staudinger-Aza-Wittig two-step protocol.

De Moliner F, Crosignani S, Banfi L, Riva R, Basso A.

J Comb Chem. 2010 Sep 13;12(5):613-6. doi: 10.1021/cc100122n. No abstract available.

PMID:
20831261
9.

Discovery of a novel series of CXCR3 antagonists.

Crosignani S, Missotten M, Cleva C, Dondi R, Ratinaud Y, Humbert Y, Mandal AB, Bombrun A, Power C, Chollet A, Proudfoot A.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3614-7. doi: 10.1016/j.bmcl.2010.04.113. Epub 2010 Apr 28.

PMID:
20483605
10.

Discovery of a novel series of potent S1P1 agonists.

Crosignani S, Bombrun A, Covini D, Maio M, Marin D, Quattropani A, Swinnen D, Simpson D, Sauer W, Françon B, Martin T, Cambet Y, Nichols A, Martinou I, Burgat-Charvillon F, Rivron D, Donini C, Schott O, Eligert V, Novo-Perez L, Vitte PA, Arrighi JF.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1516-9. doi: 10.1016/j.bmcl.2010.01.102. Epub 2010 Jan 25.

PMID:
20149651
11.

Microwave-assisted ester formation using O-alkylisoureas: a convenient method for the synthesis of esters with inversion of configuration.

Chighine A, Crosignani S, Arnal MC, Bradley M, Linclau B.

J Org Chem. 2009 Jul 3;74(13):4753-62. doi: 10.1021/jo900476y.

PMID:
19462991
12.

Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

Crosignani S, Page P, Missotten M, Colovray V, Cleva C, Arrighi JF, Atherall J, Macritchie J, Martin T, Humbert Y, Gaudet M, Pupowicz D, Maio M, Pittet PA, Golzio L, Giachetti C, Rocha C, Bernardinelli G, Filinchuk Y, Scheer A, Schwarz MK, Chollet A.

J Med Chem. 2008 Apr 10;51(7):2227-43. doi: 10.1021/jm701383e. Epub 2008 Mar 5.

PMID:
18318469
13.

A practical synthesis of a high-loading solid-supported IBX amide for the oxidation of alcohols.

Lecarpentier P, Crosignani S, Linclau B.

Mol Divers. 2005;9(4):341-51.

PMID:
16311811
14.

A straightforward, one-pot protocol for the preparation of libraries of 2-oxazolines.

Crosignani S, Swinnen D.

J Comb Chem. 2005 Sep-Oct;7(5):688-96.

PMID:
16153063
15.

Polymer-supported Mukaiyama reagent: a useful coupling reagent for the synthesis of esters and amides.

Crosignani S, Gonzalez J, Swinnen D.

Org Lett. 2004 Nov 25;6(24):4579-82.

PMID:
15548080
16.

Polymer-supported O-alkylisoureas: useful reagents for the O-alkylation of carboxylic acids.

Crosignani S, White PD, Linclau B.

J Org Chem. 2004 Sep 3;69(18):5897-905.

PMID:
15373475
17.

Microwaves, supported-reagents and parallel synthesis: isocyanide and ester synthesis.

Crosignani S, Launay D, Linclau B, Bradley M.

Mol Divers. 2003;7(2-4):203-10.

PMID:
14870852
18.

Polymer-supported o-benzyl and o-allylisoureas: convenient preparation and use in ester synthesis from carboxylic acids.

Crosignani S, White PD, Steinauer R, Linclau B.

Org Lett. 2003 Mar 20;5(6):853-6.

PMID:
12633089
19.

A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N'-diisopropylcarbodiimide.

Crosignani S, Nadal B, Li Z, Linclau B.

Chem Commun (Camb). 2003 Jan 21;(2):260-1.

PMID:
12585420
20.

Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas.

Crosignani S, White PD, Linclau B.

Org Lett. 2002 Aug 22;4(17):2961-3.

PMID:
12182599
21.

Polymer-supported O-methylisourea: a new reagent for the O-methylation of carboxylic acids.

Crosignani S, White PD, Linclau B.

Org Lett. 2002 Mar 21;4(6):1035-7.

PMID:
11893215
22.

The treatment of malignant effusions with radioactive colloidal gold (Au198); a review of sixty-six cases.

SEAL SH, CROSIGNANI S, VALVASSORI G, NICKSON JJ, AGOSTINO D.

Am J Obstet Gynecol. 1958 May;75(5):1027-33. No abstract available.

PMID:
13520824

Supplemental Content

Loading ...
Support Center