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Items: 1 to 50 of 96


Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model.

Britto DD, Wyroba B, Chen W, Lockwood RA, Tran KB, Shepherd PR, Hall CJ, Crosier KE, Crosier PS, Astin JW.

Dis Model Mech. 2018 Nov 5. pii: dmm.035998. doi: 10.1242/dmm.035998. [Epub ahead of print]


Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation.

Hall CJ, Sanderson LE, Lawrence LM, Pool B, van der Kroef M, Ashimbayeva E, Britto D, Harper JL, Lieschke GJ, Astin JW, Crosier KE, Dalbeth N, Crosier PS.

J Clin Invest. 2018 May 1;128(5):1752-1771. doi: 10.1172/JCI94584. Epub 2018 Mar 26.


The innate immune cell response to bacterial infection in larval zebrafish is light-regulated.

Du LY, Darroch H, Keerthisinghe P, Ashimbayeva E, Astin JW, Crosier KE, Crosier PS, Warman G, Cheeseman J, Hall CJ.

Sci Rep. 2017 Oct 4;7(1):12657. doi: 10.1038/s41598-017-12842-1.


Transient inflammatory response mediated by interleukin-1β is required for proper regeneration in zebrafish fin fold.

Hasegawa T, Hall CJ, Crosier PS, Abe G, Kawakami K, Kudo A, Kawakami A.

Elife. 2017 Feb 23;6. pii: e22716. doi: 10.7554/eLife.22716.


Innate immune cells and bacterial infection in zebrafish.

Astin JW, Keerthisinghe P, Du L, Sanderson LE, Crosier KE, Crosier PS, Hall CJ.

Methods Cell Biol. 2017;138:31-60. doi: 10.1016/bs.mcb.2016.08.002. Epub 2016 Oct 8. Review.


A Zebrafish Model for Chlamydia Infection with the Obligate Intracellular Pathogen Waddlia chondrophila.

Fehr AG, Ruetten M, Seth-Smith HM, Nufer L, Voegtlin A, Lehner A, Greub G, Crosier PS, Neuhauss SC, Vaughan L.

Front Microbiol. 2016 Nov 18;7:1829. eCollection 2016.


A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.

Oehlers SH, Flores MV, Hall CJ, Wang L, Ko DC, Crosier KE, Crosier PS.

FEBS J. 2017 Feb;284(3):402-413. doi: 10.1111/febs.13976. Epub 2017 Jan 9.


Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model.

Dalton JP, Uy B, Okuda KS, Hall CJ, Denny WA, Crosier PS, Swift S, Wiles S.

J Antimicrob Chemother. 2017 Feb;72(2):421-427. doi: 10.1093/jac/dkw421. Epub 2016 Oct 24.


Inflammatory pathway network-based drug repositioning and molecular phenomics.

Gu J, Crosier PS, Hall CJ, Chen L, Xu X.

Mol Biosyst. 2016 Aug 16;12(9):2777-84. doi: 10.1039/c6mb00222f.


Lymphatics, Cancer and Zebrafish.

Astin JW, Crosier PS.

Adv Exp Med Biol. 2016;916:199-218. doi: 10.1007/978-3-319-30654-4_9. Review.


A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions.

Oliver VF, van Bysterveldt KA, Cadzow M, Steger B, Romano V, Markie D, Hewitt AW, Mackey DA, Willoughby CE, Sherwin T, Crosier PS, McGhee CN, Vincent AL.

Ophthalmology. 2016 Apr;123(4):709-22. doi: 10.1016/j.ophtha.2015.12.008. Epub 2016 Jan 16.


Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays.

Macdonald NP, Zhu F, Hall CJ, Reboud J, Crosier PS, Patton EE, Wlodkowic D, Cooper JM.

Lab Chip. 2016 Jan 21;16(2):291-7. doi: 10.1039/c5lc01374g.


A zebrafish model of inflammatory lymphangiogenesis.

Okuda KS, Misa JP, Oehlers SH, Hall CJ, Ellett F, Alasmari S, Lieschke GJ, Crosier KE, Crosier PS, Astin JW.

Biol Open. 2015 Sep 14;4(10):1270-80. doi: 10.1242/bio.013540.


mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish.

Koltowska K, Paterson S, Bower NI, Baillie GJ, Lagendijk AK, Astin JW, Chen H, Francois M, Crosier PS, Taft RJ, Simons C, Smith KA, Hogan BM.

Genes Dev. 2015 Aug 1;29(15):1618-30. doi: 10.1101/gad.263210.115.


Interfacing Lab-on-a-Chip Embryo Technology with High-Definition Imaging Cytometry.

Zhu F, Hall CJ, Crosier PS, Wlodkowic D.

Zebrafish. 2015 Aug;12(4):315-8. doi: 10.1089/zeb.2015.1105. Epub 2015 Jul 1.


An inducible transgene reports activation of macrophages in live zebrafish larvae.

Sanderson LE, Chien AT, Astin JW, Crosier KE, Crosier PS, Hall CJ.

Dev Comp Immunol. 2015 Nov;53(1):63-9. doi: 10.1016/j.dci.2015.06.013. Epub 2015 Jun 26.


Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis.

Chew TS, O'Shea NR, Sewell GW, Oehlers SH, Mulvey CM, Crosier PS, Godovac-Zimmermann J, Bloom SL, Smith AM, Segal AW.

Dis Model Mech. 2015 Aug 1;8(8):817-29. doi: 10.1242/dmm.020362. Epub 2015 Jun 4.


Lymphatic vessels arise from specialized angioblasts within a venous niche.

Nicenboim J, Malkinson G, Lupo T, Asaf L, Sela Y, Mayseless O, Gibbs-Bar L, Senderovich N, Hashimshony T, Shin M, Jerafi-Vider A, Avraham-Davidi I, Krupalnik V, Hofi R, Almog G, Astin JW, Golani O, Ben-Dor S, Crosier PS, Herzog W, Lawson ND, Hanna JH, Yanai I, Yaniv K.

Nature. 2015 Jun 4;522(7554):56-61.


Microfluidic device for a rapid immobilization of zebrafish larvae in environmental scanning electron microscopy.

Akagi J, Zhu F, Skommer J, Hall CJ, Crosier PS, Cialkowski M, Wlodkowic D.

Cytometry A. 2015 Mar;87(3):190-4. doi: 10.1002/cyto.a.22603. Epub 2014 Dec 5.


Interception of host angiogenic signalling limits mycobacterial growth.

Oehlers SH, Cronan MR, Scott NR, Thomas MI, Okuda KS, Walton EM, Beerman RW, Crosier PS, Tobin DM.

Nature. 2015 Jan 29;517(7536):612-5. doi: 10.1038/nature13967. Epub 2014 Nov 24.


Fishing on chips: up-and-coming technological advances in analysis of zebrafish and Xenopus embryos.

Zhu F, Skommer J, Huang Y, Akagi J, Adams D, Levin M, Hall CJ, Crosier PS, Wlodkowic D.

Cytometry A. 2014 Nov;85(11):921-32. doi: 10.1002/cyto.a.22571. Epub 2014 Oct 6. Review.


An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis.

Astin JW, Jamieson SM, Eng TC, Flores MV, Misa JP, Chien A, Crosier KE, Crosier PS.

Mol Cancer Ther. 2014 Oct;13(10):2450-62. doi: 10.1158/1535-7163.MCT-14-0469-T. Epub 2014 Jul 22.


Repositioning drugs for inflammatory disease - fishing for new anti-inflammatory agents.

Hall CJ, Wicker SM, Chien AT, Tromp A, Lawrence LM, Sun X, Krissansen GW, Crosier KE, Crosier PS.

Dis Model Mech. 2014 Sep;7(9):1069-81. doi: 10.1242/dmm.016873. Epub 2014 Jul 18.


Mitochondrial metabolism, reactive oxygen species, and macrophage function-fishing for insights.

Hall CJ, Sanderson LE, Crosier KE, Crosier PS.

J Mol Med (Berl). 2014 Nov;92(11):1119-28. doi: 10.1007/s00109-014-1186-6. Epub 2014 Jun 25. Review.


Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting.

Astin JW, Haggerty MJ, Okuda KS, Le Guen L, Misa JP, Tromp A, Hogan BM, Crosier KE, Crosier PS.

Development. 2014 Jul;141(13):2680-90. doi: 10.1242/dev.106591. Epub 2014 Jun 5.


Epidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fuelled matrix metalloproteinase production.

Hall CJ, Boyle RH, Sun X, Wicker SM, Misa JP, Krissansen GW, Print CG, Crosier KE, Crosier PS.

Nat Commun. 2014 May 23;5:3880. doi: 10.1038/ncomms4880.


Pkd1 regulates lymphatic vascular morphogenesis during development.

Coxam B, Sabine A, Bower NI, Smith KA, Pichol-Thievend C, Skoczylas R, Astin JW, Frampton E, Jaquet M, Crosier PS, Parton RG, Harvey NL, Petrova TV, Schulte-Merker S, Francois M, Hogan BM.

Cell Rep. 2014 May 8;7(3):623-33. doi: 10.1016/j.celrep.2014.03.063. Epub 2014 Apr 24.


Integrated chip-based physiometer for automated fish embryo toxicity biotests in pharmaceutical screening and ecotoxicology.

Akagi J, Zhu F, Hall CJ, Crosier KE, Crosier PS, Wlodkowic D.

Cytometry A. 2014 Jun;85(6):537-47. doi: 10.1002/cyto.a.22464. Epub 2014 Mar 24.


OpenSource lab-on-a-chip physiometer for accelerated zebrafish embryo biotests.

Akagi J, Hall CJ, Crosier KE, Cooper JM, Crosier PS, Wlodkowic D.

Curr Protoc Cytom. 2014 Jan 2;67:Unit 9.44.. doi: 10.1002/0471142956.cy0944s67.


Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production.

Hall CJ, Boyle RH, Astin JW, Flores MV, Oehlers SH, Sanderson LE, Ellett F, Lieschke GJ, Crosier KE, Crosier PS.

Cell Metab. 2013 Aug 6;18(2):265-78. doi: 10.1016/j.cmet.2013.06.018.


Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling.

Wilson CW, Parker LH, Hall CJ, Smyczek T, Mak J, Crow A, Posthuma G, De Mazière A, Sagolla M, Chalouni C, Vitorino P, Roose-Girma M, Warming S, Klumperman J, Crosier PS, Ye W.

Blood. 2013 Nov 21;122(22):3678-90. doi: 10.1182/blood-2013-02-483156. Epub 2013 Jul 25.


Toward embedded laboratory automation for smart Lab-on-a-Chip embryo arrays.

Wang KI, Salcic Z, Yeh J, Akagi J, Zhu F, Hall CJ, Crosier KE, Crosier PS, Wlodkowic D.

Biosens Bioelectron. 2013 Oct 15;48:188-96. doi: 10.1016/j.bios.2013.04.033. Epub 2013 Apr 30.


Chemically induced intestinal damage models in zebrafish larvae.

Oehlers SH, Flores MV, Hall CJ, Okuda KS, Sison JO, Crosier KE, Crosier PS.

Zebrafish. 2013 Jun;10(2):184-93. doi: 10.1089/zeb.2012.0824. Epub 2013 Feb 28.


Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages.

Yang CT, Cambier CJ, Davis JM, Hall CJ, Crosier PS, Ramakrishnan L.

Cell Host Microbe. 2012 Sep 13;12(3):301-12. doi: 10.1016/j.chom.2012.07.009.


Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish.

Pase L, Layton JE, Wittmann C, Ellett F, Nowell CJ, Reyes-Aldasoro CC, Varma S, Rogers KL, Hall CJ, Keightley MC, Crosier PS, Grabher C, Heath JK, Renshaw SA, Lieschke GJ.

Curr Biol. 2012 Oct 9;22(19):1818-24. doi: 10.1016/j.cub.2012.07.060. Epub 2012 Aug 30.


New rationale for large metazoan embryo manipulations on chip-based devices.

Khoshmanesh K, Akagi J, Hall CJ, Crosier KE, Crosier PS, Cooper JM, Wlodkowic D.

Biomicrofluidics. 2012 Jun;6(2):24102-2410214. doi: 10.1063/1.3699971. Epub 2012 Apr 3.


lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish.

Okuda KS, Astin JW, Misa JP, Flores MV, Crosier KE, Crosier PS.

Development. 2012 Jul;139(13):2381-91. doi: 10.1242/dev.077701. Epub 2012 May 23.


Miniaturized embryo array for automated trapping, immobilization and microperfusion of zebrafish embryos.

Akagi J, Khoshmanesh K, Evans B, Hall CJ, Crosier KE, Cooper JM, Crosier PS, Wlodkowic D.

PLoS One. 2012;7(5):e36630. doi: 10.1371/journal.pone.0036630. Epub 2012 May 14.


Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis.

Oehlers SH, Flores MV, Hall CJ, Crosier KE, Crosier PS.

Dis Model Mech. 2012 Jul;5(4):457-67. doi: 10.1242/dmm.009365. Epub 2012 Apr 19.


Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide.

Hall CJ, Flores MV, Oehlers SH, Sanderson LE, Lam EY, Crosier KE, Crosier PS.

Cell Stem Cell. 2012 Feb 3;10(2):198-209. doi: 10.1016/j.stem.2012.01.007.


DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.

Buchanan CM, Shih JH, Astin JW, Rewcastle GW, Flanagan JU, Crosier PS, Shepherd PR.

Clin Sci (Lond). 2012 May 1;122(10):449-57. doi: 10.1042/CS20110412.


The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish.

Oehlers SH, Flores MV, Hall CJ, Swift S, Crosier KE, Crosier PS.

Dis Model Mech. 2011 Nov;4(6):832-41. doi: 10.1242/dmm.006122. Epub 2011 Jul 4.


Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation.

Crawford KC, Vega Flores M, Oehlers SH, Hall CJ, Crosier KE, Crosier PS.

Genesis. 2011 Dec;49(12):905-11. doi: 10.1002/dvg.20767. Epub 2011 Oct 13.


A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents.

Oehlers SH, Flores MV, Okuda KS, Hall CJ, Crosier KE, Crosier PS.

Dev Dyn. 2011 Jan;240(1):288-98. doi: 10.1002/dvdy.22519.


Topographical distribution of antimicrobial genes in the zebrafish intestine.

Oehlers SH, Flores MV, Chen T, Hall CJ, Crosier KE, Crosier PS.

Dev Comp Immunol. 2011 Mar;35(3):385-91. doi: 10.1016/j.dci.2010.11.008. Epub 2010 Nov 25.


Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties.

Flores MV, Crawford KC, Pullin LM, Hall CJ, Crosier KE, Crosier PS.

Biochem Biophys Res Commun. 2010 Sep 10;400(1):164-8. doi: 10.1016/j.bbrc.2010.08.037. Epub 2010 Aug 13.


Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved.

Rhodes JM, Bentley FK, Print CG, Dorsett D, Misulovin Z, Dickinson EJ, Crosier KE, Crosier PS, Horsfield JA.

Dev Biol. 2010 Aug 15;344(2):637-49. doi: 10.1016/j.ydbio.2010.05.493. Epub 2010 May 27.


Visualization of embryonic lymphangiogenesis advances the use of the zebrafish model for research in cancer and lymphatic pathologies.

Flores MV, Hall CJ, Crosier KE, Crosier PS.

Dev Dyn. 2010 Jul;239(7):2128-35. doi: 10.1002/dvdy.22328.


Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells.

Lam EY, Hall CJ, Crosier PS, Crosier KE, Flores MV.

Blood. 2010 Aug 12;116(6):909-14. doi: 10.1182/blood-2010-01-264382. Epub 2010 May 7.


Expression of zebrafish cxcl8 (interleukin-8) and its receptors during development and in response to immune stimulation.

Oehlers SH, Flores MV, Hall CJ, O'Toole R, Swift S, Crosier KE, Crosier PS.

Dev Comp Immunol. 2010 Mar;34(3):352-9. doi: 10.1016/j.dci.2009.11.007. Epub 2009 Dec 1.


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