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Come from away: Best practices in mini-sabbaticals for the development of young investigators: a White Paper by the SEQUIN (mini-Sabbatical Evaluation and QUality ImprovemeNt) Group.

Pillinger MH, Lemon SC, Zand MS, Foster PJ Jr, Merchant JS, Kimberly R, Allison J, Cronstein BN, Galeano C, Holden-Wiltse J, Trayhan M, White RJ, Davin A, Saag KG.

J Clin Transl Sci. 2019 Feb;3(1):37-44. doi: 10.1017/cts.2019.369. Review.


Regeneration of a Pediatric Alveolar Cleft Model Using Three-Dimensionally Printed Bioceramic Scaffolds and Osteogenic Agents: Comparison of Dipyridamole and rhBMP-2.

Lopez CD, Coelho PG, Witek L, Torroni A, Greenberg MI, Cuadrado DL, Guarino AM, Bekisz JM, Cronstein BN, Flores RL.

Plast Reconstr Surg. 2019 Aug;144(2):358-370. doi: 10.1097/PRS.0000000000005840.


Repair of Critical-Sized Long Bone Defects Using Dipyridamole-Augmented 3D-Printed Bioactive Ceramic Scaffolds.

Witek L, Alifarag AM, Tovar N, Lopez CD, Cronstein BN, Rodriguez ED, Coelho PG.

J Orthop Res. 2019 Jul 23. doi: 10.1002/jor.24424. [Epub ahead of print]


Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats.

Liu X, Corciulo C, Arabagian S, Ulman A, Cronstein BN.

Sci Rep. 2019 May 15;9(1):7430. doi: 10.1038/s41598-019-43834-y.


Dipyridamole Augments Three-Dimensionally Printed Bioactive Ceramic Scaffolds to Regenerate Craniofacial Bone.

Lopez CD, Diaz-Siso JR, Witek L, Bekisz JM, Gil LF, Cronstein BN, Flores RL, Torroni A, Rodriguez ED, Coelho PG.

Plast Reconstr Surg. 2019 May;143(5):1408-1419. doi: 10.1097/PRS.0000000000005531.


Adenosine A2A receptor (A2AR) activation triggers Akt signaling and enhances nuclear localization of β-catenin in osteoblasts.

Borhani S, Corciulo C, Larranaga-Vera A, Cronstein BN.

FASEB J. 2019 Jun;33(6):7555-7562. doi: 10.1096/fj.201900014R. Epub 2019 Mar 13.


Unmet need in rheumatology: reports from the Targeted Therapies meeting 2018.

Winthrop KL, Weinblatt ME, Crow MK, Burmester GR, Mease PJ, So AK, Bykerk V, Van Vollenhoven RF, Dougados M, Kay J, Mariette X, Sieper J, Melchers F, Cronstein BN, Shevach E, Breedfeld FC, Kalden J, Smolen JS, Furst DE.

Ann Rheum Dis. 2019 Jul;78(7):872-878. doi: 10.1136/annrheumdis-2018-214280. Epub 2019 Feb 2. Review.


Methotrexate BAFFles anti-drug antibodies.

Cronstein BN.

Nat Rev Rheumatol. 2018 Sep;14(9):505-506. doi: 10.1038/s41584-018-0064-y. No abstract available.


Form and functional repair of long bone using 3D-printed bioactive scaffolds.

Tovar N, Witek L, Atria P, Sobieraj M, Bowers M, Lopez CD, Cronstein BN, Coelho PG.

J Tissue Eng Regen Med. 2018 Sep;12(9):1986-1999. doi: 10.1002/term.2733. Epub 2018 Aug 24.


Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing.

Lopez CD, Bekisz JM, Corciulo C, Mediero A, Coelho PG, Witek L, Flores RL, Cronstein BN.

Adv Drug Deliv Rev. 2018 Jun 18. pii: S0169-409X(18)30149-2. doi: 10.1016/j.addr.2018.06.010. [Epub ahead of print]


The role of 3D printing in treating craniomaxillofacial congenital anomalies.

Lopez CD, Witek L, Torroni A, Flores RL, Demissie DB, Young S, Cronstein BN, Coelho PG.

Birth Defects Res. 2018 Aug 1;110(13):1055-1064. doi: 10.1002/bdr2.1345. Epub 2018 May 20. Review.


The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation.

Bekisz JM, Lopez CD, Corciulo C, Mediero A, Coelho PG, Witek L, Flores RL, Cronstein BN.

Inflammation. 2018 Aug;41(4):1135-1141. doi: 10.1007/s10753-018-0781-z. Review.


Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis.

Yang L, Fanok MH, Mediero-Munoz A, Fogli LK, Corciulo C, Abdollahi S, Cronstein BN, Scher JU, Koralov SB.

Arthritis Rheumatol. 2018 Jun;70(6):855-867. doi: 10.1002/art.40447. Epub 2018 Apr 18.


Three dimensionally printed bioactive ceramic scaffold osseoconduction across critical-sized mandibular defects.

Lopez CD, Diaz-Siso JR, Witek L, Bekisz JM, Cronstein BN, Torroni A, Flores RL, Rodriguez ED, Coelho PG.

J Surg Res. 2018 Mar;223:115-122. doi: 10.1016/j.jss.2017.10.027. Epub 2017 Nov 17.


Adenosine metabolism, immunity and joint health.

Haskó G, Antonioli L, Cronstein BN.

Biochem Pharmacol. 2018 May;151:307-313. doi: 10.1016/j.bcp.2018.02.002. Epub 2018 Feb 7. Review.


Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis.

Mediero A, Wilder T, Shah L, Cronstein BN.

FASEB J. 2018 Jul;32(7):3487-3501. doi: 10.1096/fj.201700217R. Epub 2018 Feb 2.


Dipyridamole enhances osteogenesis of three-dimensionally printed bioactive ceramic scaffolds in calvarial defects.

Bekisz JM, Flores RL, Witek L, Lopez CD, Runyan CM, Torroni A, Cronstein BN, Coelho PG.

J Craniomaxillofac Surg. 2018 Feb;46(2):237-244. doi: 10.1016/j.jcms.2017.11.011. Epub 2017 Nov 21.


Teaching Targeted Drug Discovery and Development to Healthcare Professionals.

Fruchter R, Ahmad M, Pillinger M, Galeano C, Cronstein BN, Gold-von Simson G.

Clin Transl Sci. 2018 May;11(3):277-282. doi: 10.1111/cts.12523. Epub 2017 Nov 28. No abstract available.


Ecto-5'-nucleotidase (CD73) regulates bone formation and remodeling during intramembranous bone repair in aging mice.

Bradaschia-Correa V, Josephson AM, Egol AJ, Mizrahi MM, Leclerc K, Huo J, Cronstein BN, Leucht P.

Tissue Cell. 2017 Oct;49(5):545-551. doi: 10.1016/j.tice.2017.07.001. Epub 2017 Jul 4.


Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression.

Corciulo C, Lendhey M, Wilder T, Schoen H, Cornelissen AS, Chang G, Kennedy OD, Cronstein BN.

Nat Commun. 2017 May 11;8:15019. doi: 10.1038/ncomms15019.


Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases.

Cronstein BN, Sitkovsky M.

Nat Rev Rheumatol. 2017 Jan;13(1):41-51. doi: 10.1038/nrrheum.2016.178. Epub 2016 Nov 10. Review.


Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism.

Mediero A, Wilder T, Reddy VS, Cheng Q, Tovar N, Coelho PG, Witek L, Whatling C, Cronstein BN.

FASEB J. 2016 Nov;30(11):3887-3900. Epub 2016 Aug 10.


Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis.

Mediero A, Wilder T, Ramkhelawon B, Moore KJ, Cronstein BN.

FASEB J. 2016 Nov;30(11):3835-3844. Epub 2016 Aug 8.


Growth Hormone Control of Hepatic Lipid Metabolism.

Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S.

Diabetes. 2016 Dec;65(12):3598-3609. Epub 2016 Sep 27.


Regulation of bone and cartilage by adenosine signaling.

Strazzulla LC, Cronstein BN.

Purinergic Signal. 2016 Dec;12(4):583-593. Epub 2016 Jul 29. Review.


Adenosine A2B receptors play an important role in bone homeostasis.

Corciulo C, Wilder T, Cronstein BN.

Purinergic Signal. 2016 Sep;12(3):537-47. doi: 10.1007/s11302-016-9519-2. Epub 2016 Jun 11.


The benefits and drawbacks of biosimilars.

Cronstein BN.

Clin Adv Hematol Oncol. 2015 Oct;13(10):639-41. Review. No abstract available.


Bone regeneration in critical bone defects using three-dimensionally printed β-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2.

Ishack S, Mediero A, Wilder T, Ricci JL, Cronstein BN.

J Biomed Mater Res B Appl Biomater. 2017 Feb;105(2):366-375. doi: 10.1002/jbm.b.33561. Epub 2015 Oct 29.


Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis.

Mediero A, Ramkhelawon B, Wilder T, Purdue PE, Goldring SR, Dewan MZ, Loomis C, Moore KJ, Cronstein BN.

Ann Rheum Dis. 2016 Sep;75(9):1706-13. doi: 10.1136/annrheumdis-2015-207593. Epub 2015 Oct 9.


Adenosine A2A receptor plays an important role in radiation-induced dermal injury.

Perez-Aso M, Mediero A, Low YC, Levine J, Cronstein BN.

FASEB J. 2016 Jan;30(1):457-65. doi: 10.1096/fj.15-280388. Epub 2015 Sep 28.


Teaching Translational Research to Medical Students: The New York University School of Medicine's Master's of Science in Clinical Investigation Dual-Degree Program.

Gillman J, Pillinger M, Plottel CS, Galeano C, Maddalo S, Hochman JS, Cronstein BN, Gold-von Simson G.

Clin Transl Sci. 2015 Dec;8(6):734-9. doi: 10.1111/cts.12328. Epub 2015 Sep 13.


Clinical trial development for biosimilars.

Alten R, Cronstein BN.

Semin Arthritis Rheum. 2015 Jun;44(6 Suppl):S2-8. doi: 10.1016/j.semarthrit.2015.04.002. Review.


Promotion of Wound Healing by an Agonist of Adenosine A2A Receptor Is Dependent on Tissue Plasminogen Activator.

Montesinos MC, Desai-Merchant A, Cronstein BN.

Inflammation. 2015 Dec;38(6):2036-41. doi: 10.1007/s10753-015-0184-3.


Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2.

Mediero A, Wilder T, Perez-Aso M, Cronstein BN.

FASEB J. 2015 Apr;29(4):1577-90. doi: 10.1096/fj.14-265066. Epub 2015 Jan 8.


Outcomes related to methotrexate dose and route of administration in patients with rheumatoid arthritis: a systematic literature review.

Goodman SM, Cronstein BN, Bykerk VP.

Clin Exp Rheumatol. 2015 Mar-Apr;33(2):272-8. Epub 2014 Dec 23. Review.


Brief Report: Methotrexate Prevents Wear Particle-Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A2A Receptor.

Mediero A, Perez-Aso M, Wilder T, Cronstein BN.

Arthritis Rheumatol. 2015 Mar;67(3):849-55. doi: 10.1002/art.38971.


Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation.

Mediero A, Ramkhelawon B, Perez-Aso M, Moore KJ, Cronstein BN.

J Bone Miner Res. 2015 May;30(5):837-54. doi: 10.1002/jbmr.2421.


Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements.

Mediero A, Perez-Aso M, Cronstein BN.

FASEB J. 2014 Nov;28(11):4901-13. doi: 10.1096/fj.14-255703. Epub 2014 Aug 13.


Designing and implementing INTREPID, an intensive program in translational research methodologies for new investigators.

Plottel CS, Aphinyanaphongs Y, Shao Y, Micoli KJ, Fang Y, Goldberg JD, Galeano CR, Stangel JH, Chavis-Keeling D, Hochman JS, Cronstein BN, Pillinger MH.

Clin Transl Sci. 2014 Dec;7(6):493-9. doi: 10.1111/cts.12198. Epub 2014 Jul 28.


Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway.

Ouyang X, Ghani A, Malik A, Wilder T, Colegio OR, Flavell RA, Cronstein BN, Mehal WZ.

Nat Commun. 2013;4:2909. doi: 10.1038/ncomms3909.


Mechanisms of action of methotrexate.

Chan ES, Cronstein BN.

Bull Hosp Jt Dis (2013). 2013;71 Suppl 1:S5-8. Review.


Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis.

Fernández P, Perez-Aso M, Smith G, Wilder T, Trzaska S, Chiriboga L, Franks A Jr, Robson SC, Cronstein BN, Chan ESL.

Am J Pathol. 2013 Dec;183(6):1740-1746. doi: 10.1016/j.ajpath.2013.08.024.


Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3.

Perez-Aso M, Fernandez P, Mediero A, Chan ES, Cronstein BN.

FASEB J. 2014 Feb;28(2):802-12. doi: 10.1096/fj.13-241646. Epub 2013 Nov 7.


Rolofylline, an adenosine A1 receptor antagonist, inhibits osteoclast differentiation as an inverse agonist.

He W, Wilder T, Cronstein BN.

Br J Pharmacol. 2013 Nov;170(6):1167-76. doi: 10.1111/bph.12342.


Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance.

Perez-Aso M, Mediero A, Cronstein BN.

Purinergic Signal. 2013 Dec;9(4):573-83. doi: 10.1007/s11302-013-9368-1. Epub 2013 Jun 8.


Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.

He W, Mazumder A, Wilder T, Cronstein BN.

FASEB J. 2013 Sep;27(9):3446-54. doi: 10.1096/fj.13-231233. Epub 2013 May 16.


Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism.

Chan ES, Liu H, Fernandez P, Luna A, Perez-Aso M, Bujor AM, Trojanowska M, Cronstein BN.

Arthritis Res Ther. 2013;15(3):R58.


Activation of adenosine A(2A) receptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation.

Mediero A, Perez-Aso M, Cronstein BN.

Br J Pharmacol. 2013 Jul;169(6):1372-88. doi: 10.1111/bph.12227.


The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4Rα) signaling.

Ferrante CJ, Pinhal-Enfield G, Elson G, Cronstein BN, Hasko G, Outram S, Leibovich SJ.

Inflammation. 2013 Aug;36(4):921-31. doi: 10.1007/s10753-013-9621-3.


Adenosine and bone metabolism.

Mediero A, Cronstein BN.

Trends Endocrinol Metab. 2013 Jun;24(6):290-300. doi: 10.1016/j.tem.2013.02.001. Epub 2013 Mar 14. Review.

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