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A novel synthesis of trans-unsaturated fatty acids by the Gram-positive commensal bacterium Enterococcus faecalis FA2-2.

Kondakova T, Kumar S, Cronan JE.

Chem Phys Lipids. 2019 Aug;222:23-35. doi: 10.1016/j.chemphyslip.2019.04.010. Epub 2019 May 2.


Escherichia coli vectors having stringently repressible replication origins allow a streamlining of Crispr/Cas9 gene editing.

Srinivas S, Hu Z, Cronan JE.

Plasmid. 2019 May;103:53-62. doi: 10.1016/j.plasmid.2019.04.004. Epub 2019 Apr 29.


Coping with inadvertent lysis of Escherichia coli cultures: Strains resistant to lysogeny and infection by the stealthy lysogenic phage Φ80.

Srinivas S, Cronan JE.

Biotechnol Bioeng. 2019 Jul;116(7):1820-1826. doi: 10.1002/bit.26971. Epub 2019 Apr 2.


Transcriptional regulation of fatty acid cis-trans isomerization in the solvent-tolerant soil bacterium, Pseudomonas putida F1.

Kondakova T, Cronan JE.

Environ Microbiol. 2019 May;21(5):1659-1676. doi: 10.1111/1462-2920.14546. Epub 2019 Mar 12.


Advances in synthesis of biotin and assembly of lipoic acid.

Cronan JE.

Curr Opin Chem Biol. 2018 Dec;47:60-66. doi: 10.1016/j.cbpa.2018.08.004. Epub 2018 Sep 17. Review.


Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor.

Cao X, Koch T, Steffens L, Finkensieper J, Zigann R, Cronan JE, Dahl C.

Elife. 2018 Jul 13;7. pii: e37439. doi: 10.7554/eLife.37439.


Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes.

Cao X, Zhu L, Song X, Hu Z, Cronan JE.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7063-E7072. doi: 10.1073/pnas.1805862115. Epub 2018 Jul 9.


Novel Xanthomonas campestris Long-Chain-Specific 3-Oxoacyl-Acyl Carrier Protein Reductase Involved in Diffusible Signal Factor Synthesis.

Hu Z, Dong H, Ma JC, Yu Y, Li KH, Guo QQ, Zhang C, Zhang WB, Cao X, Cronan JE, Wang H.

MBio. 2018 May 8;9(3). pii: e00596-18. doi: 10.1128/mBio.00596-18.


Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle.

Cao X, Hong Y, Zhu L, Hu Y, Cronan JE.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):647-655. doi: 10.1073/pnas.1718653115. Epub 2018 Jan 16.


A Canonical Biotin Synthesis Enzyme, 8-Amino-7-Oxononanoate Synthase (BioF), Utilizes Different Acyl Chain Donors in Bacillus subtilis and Escherichia coli.

Manandhar M, Cronan JE.

Appl Environ Microbiol. 2017 Dec 15;84(1). pii: e02084-17. doi: 10.1128/AEM.02084-17. Print 2018 Jan 1.


Expression and Activity of the BioH Esterase of Biotin Synthesis is Independent of Genome Context.

Cao X, Zhu L, Hu Z, Cronan JE.

Sci Rep. 2017 May 19;7(1):2141. doi: 10.1038/s41598-017-01490-0.


The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes.

Estrada P, Manandhar M, Dong SH, Deveryshetty J, Agarwal V, Cronan JE, Nair SK.

Nat Chem Biol. 2017 Jun;13(6):668-674. doi: 10.1038/nchembio.2359. Epub 2017 Apr 17.


An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae.

Shi J, Cao X, Chen Y, Cronan JE, Guo Z.

Biochemistry. 2016 Dec 6;55(48):6705-6717. Epub 2016 Nov 21.


Unsaturated Fatty Acid Synthesis in the Gastric Pathogen Helicobacter pylori Proceeds via a Backtracking Mechanism.

Bi H, Zhu L, Jia J, Zeng L, Cronan JE.

Cell Chem Biol. 2016 Dec 22;23(12):1480-1489. doi: 10.1016/j.chembiol.2016.10.007. Epub 2016 Nov 17.


Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.

Cronan JE.

Microbiol Mol Biol Rev. 2016 Apr 13;80(2):429-50. doi: 10.1128/MMBR.00073-15. Print 2016 Jun. Review.


pBR322 vectors having tetracycline-dependent replication.

Cronan JE.

Plasmid. 2016 Mar-May;84-85:20-6. doi: 10.1016/j.plasmid.2016.02.004. Epub 2016 Feb 11.


A Biotin Biosynthesis Gene Restricted to Helicobacter.

Bi H, Zhu L, Jia J, Cronan JE.

Sci Rep. 2016 Feb 12;6:21162. doi: 10.1038/srep21162.


Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.

Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD.

ACS Cent Sci. 2015;1(2):77-82.


The Atypical Occurrence of Two Biotin Protein Ligases in Francisella novicida Is Due to Distinct Roles in Virulence and Biotin Metabolism.

Feng Y, Chin CY, Chakravartty V, Gao R, Crispell EK, Weiss DS, Cronan JE.

MBio. 2015 Jun 9;6(3):e00591. doi: 10.1128/mBio.00591-15.


A series of medium and high copy number arabinose-inducible Escherichia coli expression vectors compatible with pBR322 and pACYC184.

Chakravartty V, Cronan JE.

Plasmid. 2015 Sep;81:21-6. doi: 10.1016/j.plasmid.2015.03.001. Epub 2015 May 27.


The conserved modular elements of the acyl carrier proteins of lipid synthesis are only partially interchangeable.

Zhu L, Cronan JE.

J Biol Chem. 2015 May 29;290(22):13791-9. doi: 10.1074/jbc.M115.648402. Epub 2015 Apr 10.


Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.

Vetting MW, Al-Obaidi N, Zhao S, San Francisco B, Kim J, Wichelecki DJ, Bouvier JT, Solbiati JO, Vu H, Zhang X, Rodionov DA, Love JD, Hillerich BS, Seidel RD, Quinn RJ, Osterman AL, Cronan JE, Jacobson MP, Gerlt JA, Almo SC.

Biochemistry. 2015 Jan 27;54(3):909-31. doi: 10.1021/bi501388y. Epub 2015 Jan 16.


Evidence against translational repression by the carboxyltransferase component of Escherichia coli acetyl coenzyme A carboxylase.

Smith AC, Cronan JE.

J Bacteriol. 2014 Nov;196(21):3768-75. doi: 10.1128/JB.02091-14. Epub 2014 Aug 25.


Roles of small laccases from Streptomyces in lignin degradation.

Majumdar S, Lukk T, Solbiati JO, Bauer S, Nair SK, Cronan JE, Gerlt JA.

Biochemistry. 2014 Jun 24;53(24):4047-58.


Xanthomonas campestris RpfB is a fatty Acyl-CoA ligase required to counteract the thioesterase activity of the RpfF diffusible signal factor (DSF) synthase.

Bi H, Yu Y, Dong H, Wang H, Cronan JE.

Mol Microbiol. 2014 Jul;93(2):262-75. doi: 10.1111/mmi.12657. Epub 2014 Jun 18.


The chain-flipping mechanism of ACP (acyl carrier protein)-dependent enzymes appears universal.

Cronan JE.

Biochem J. 2014 Jun 1;460(2):157-63. doi: 10.1042/BJ20140239. Review.


Successful conversion of the Bacillus subtilis BirA Group II biotin protein ligase into a Group I ligase.

Henke SK, Cronan JE.

PLoS One. 2014 May 9;9(5):e96757. doi: 10.1371/journal.pone.0096757. eCollection 2014.


PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis.

Feng Y, Cronan JE.

Res Microbiol. 2014 Jul-Aug;165(6):429-38. doi: 10.1016/j.resmic.2014.04.005. Epub 2014 May 9.


Biotin and Lipoic Acid: Synthesis, Attachment, and Regulation.

Cronan JE.

EcoSal Plus. 2014 May;6(1). doi: 10.1128/ecosalplus.ESP-0001-2012.


A new pathway of exogenous fatty acid incorporation proceeds by a classical phosphoryl transfer reaction.

Cronan JE.

Mol Microbiol. 2014 Apr;92(2):217-21. doi: 10.1111/mmi.12558. Epub 2014 Mar 3.


Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.

Kumar R, Zhao S, Vetting MW, Wood BM, Sakai A, Cho K, Solbiati J, Almo SC, Sweedler JV, Jacobson MP, Gerlt JA, Cronan JE.

MBio. 2014 Feb 11;5(1):e00933-13. doi: 10.1128/mBio.00933-13.


A Francisella virulence factor catalyses an essential reaction of biotin synthesis.

Feng Y, Napier BA, Manandhar M, Henke SK, Weiss DS, Cronan JE.

Mol Microbiol. 2014 Jan;91(2):300-14. doi: 10.1111/mmi.12460. Epub 2013 Dec 9.


Proofreading of noncognate acyl adenylates by an acyl-coenzyme a ligase.

Manandhar M, Cronan JE.

Chem Biol. 2013 Dec 19;20(12):1441-6. doi: 10.1016/j.chembiol.2013.10.010. Epub 2013 Nov 21.


The wing of a winged helix-turn-helix transcription factor organizes the active site of BirA, a bifunctional repressor/ligase.

Chakravartty V, Cronan JE.

J Biol Chem. 2013 Dec 13;288(50):36029-39. doi: 10.1074/jbc.M113.525618. Epub 2013 Nov 4.


Inefficient translation renders the Enterococcus faecalis fabK enoyl-acyl carrier protein reductase phenotypically cryptic.

Bi H, Zhu L, Wang H, Cronan JE.

J Bacteriol. 2014 Jan;196(1):170-9. doi: 10.1128/JB.01148-13. Epub 2013 Oct 25.


The two functional enoyl-acyl carrier protein reductases of Enterococcus faecalis do not mediate triclosan resistance.

Zhu L, Bi H, Ma J, Hu Z, Zhang W, Cronan JE, Wang H.

MBio. 2013 Oct 1;4(5):e00613-13. doi: 10.1128/mBio.00613-13.


Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation.

Goble AM, Feng Y, Raushel FM, Cronan JE.

ACS Chem Biol. 2013 Dec 20;8(12):2622-9. doi: 10.1021/cb4004628. Epub 2013 Oct 8.


Discovery of new enzymes and metabolic pathways by using structure and genome context.

Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP.

Nature. 2013 Oct 31;502(7473):698-702. doi: 10.1038/nature12576. Epub 2013 Sep 22.


FabQ, a dual-function dehydratase/isomerase, circumvents the last step of the classical fatty acid synthesis cycle.

Bi H, Wang H, Cronan JE.

Chem Biol. 2013 Sep 19;20(9):1157-67. doi: 10.1016/j.chembiol.2013.07.007. Epub 2013 Aug 22.


The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis.

Hermes FA, Cronan JE.

Yeast. 2013 Oct;30(10):415-27. doi: 10.1002/yea.2979. Epub 2013 Sep 2.


Profligate biotin synthesis in α-proteobacteria - a developing or degenerating regulatory system?

Feng Y, Zhang H, Cronan JE.

Mol Microbiol. 2013 Apr;88(1):77-92. doi: 10.1111/mmi.12170. Epub 2013 Mar 12.


Remarkable diversity in the enzymes catalyzing the last step in synthesis of the pimelate moiety of biotin.

Shapiro MM, Chakravartty V, Cronan JE.

PLoS One. 2012;7(11):e49440. doi: 10.1371/journal.pone.0049440. Epub 2012 Nov 9.


Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis.

Agarwal V, Lin S, Lukk T, Nair SK, Cronan JE.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17406-11. doi: 10.1073/pnas.1207028109. Epub 2012 Oct 8.

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