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Items: 1 to 50 of 85


Impact of a borderless sample transport network for scaling up viral load monitoring: results of a geospatial optimization model for Zambia.

Nichols BE, Girdwood SJ, Crompton T, Stewart-Isherwood L, Berrie L, Chimhamhiwa D, Moyo C, Kuehnle J, Stevens W, Rosen S; EQUIP Health.

J Int AIDS Soc. 2018 Dec;21(12):e25206. doi: 10.1002/jia2.25206.


IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.

Yánez DC, Sahni H, Ross S, Solanki A, Lau CI, Papaioannou E, Barbarulo A, Powell R, Lange UC, Adams DJ, Barenco M, Ono M, D'Acquisto F, Furmanski AL, Crompton T.

Eur J Immunol. 2018 Oct 26. doi: 10.1002/eji.201847692. [Epub ahead of print]


Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation.

Lau CI, Yánez DC, Solanki A, Papaioannou E, Saldaña JI, Crompton T.

J Autoimmun. 2018 Sep;93:131-138. doi: 10.1016/j.jaut.2018.07.009. Epub 2018 Jul 27.


A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme.

Bending D, Paduraru A, Ducker CB, Prieto Martín P, Crompton T, Ono M.

EMBO J. 2018 Aug 15;37(16). pii: e99013. doi: 10.15252/embj.201899013. Epub 2018 Jul 10.


A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo.

Bending D, Martín PP, Paduraru A, Ducker C, Marzaganov E, Laviron M, Kitano S, Miyachi H, Crompton T, Ono M.

J Cell Biol. 2018 Aug 6;217(8):2931-2950. doi: 10.1083/jcb.201711048. Epub 2018 Jun 25.


Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh.

Solanki A, Yanez DC, Ross S, Lau CI, Papaioannou E, Li J, Saldaña JI, Crompton T.

Development. 2018 Jan 31;145(3). pii: dev146910. doi: 10.1242/dev.146910.


Transplanted human thymus slices induce and support T-cell development in mice after cryopreservation.

Ross S, Cheung M, Lau CI, Sebire N, Burch M, Kilbride P, Fuller B, Morris GJ, Davies EG, Crompton T.

Eur J Immunol. 2018 Apr;48(4):716-719. doi: 10.1002/eji.201747193. Epub 2018 Feb 1.


The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh.

Solanki A, Lau CI, Saldaña JI, Ross S, Crompton T.

J Exp Med. 2017 Jul 3;214(7):2041-2058. doi: 10.1084/jem.20160852. Epub 2017 May 22.


The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus.

Lau CI, Barbarulo A, Solanki A, Saldaña JI, Crompton T.

Oncotarget. 2017 Apr 11;8(15):24163-24176. doi: 10.18632/oncotarget.15241.


Thymus transplantation for complete DiGeorge syndrome: European experience.

Davies EG, Cheung M, Gilmour K, Maimaris J, Curry J, Furmanski A, Sebire N, Halliday N, Mengrelis K, Adams S, Bernatoniene J, Bremner R, Browning M, Devlin B, Erichsen HC, Gaspar HB, Hutchison L, Ip W, Ifversen M, Leahy TR, McCarthy E, Moshous D, Neuling K, Pac M, Papadopol A, Parsley KL, Poliani L, Ricciardelli I, Sansom DM, Voor T, Worth A, Crompton T, Markert ML, Thrasher AJ.

J Allergy Clin Immunol. 2017 Dec;140(6):1660-1670.e16. doi: 10.1016/j.jaci.2017.03.020. Epub 2017 Apr 8.


Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma.

Standing ASI, Yánez DC, Ross R, Crompton T, Furmanski AL.

J Leukoc Biol. 2017 Oct;102(4):965-976. doi: 10.1189/jlb.3HI1016-438RR. Epub 2017 Feb 24.


Hedgehog Signalling in the Embryonic Mouse Thymus.

Barbarulo A, Lau CI, Mengrelis K, Ross S, Solanki A, Saldaña JI, Crompton T.

J Dev Biol. 2016 Jul 16;4(3):22. doi: 10.3390/jdb4030022.


Sonic Hedgehog regulates thymic epithelial cell differentiation.

Saldaña JI, Solanki A, Lau CI, Sahni H, Ross S, Furmanski AL, Ono M, Holländer G, Crompton T.

J Autoimmun. 2016 Apr;68:86-97. doi: 10.1016/j.jaut.2015.12.004. Epub 2016 Jan 6.


A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation.

Sahni H, Ross S, Barbarulo A, Solanki A, Lau CI, Furmanski A, Saldaña JI, Ono M, Hubank M, Barenco M, Crompton T.

Oncotarget. 2015 Oct 6;6(30):28646-60. doi: 10.18632/oncotarget.5796.


Gli2, Hedgehog and TCR signalling.

Furmanski AL, Crompton T.

Oncotarget. 2015 Sep 22;6(28):24592-3. doi: 10.18632/oncotarget.5017. No abstract available.


The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity.

Furmanski AL, Barbarulo A, Solanki A, Lau CI, Sahni H, Saldana JI, D'Acquisto F, Crompton T.

J Cell Sci. 2015 Jun 1;128(11):2085-95. doi: 10.1242/jcs.165803. Epub 2015 Apr 23.


The prevalence of bifid iliopsoas tendon on MRI in children.

Crompton T, Lloyd C, Kokkinakis M, Norman-Taylor F.

J Child Orthop. 2014 Aug;8(4):333-6. doi: 10.1007/s11832-014-0596-x. Epub 2014 Jun 1.


Direct BMP2/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4+CD8+ double-positive cell.

Hager-Theodorides AL, Ross SE, Sahni H, Mishina Y, Furmanski AL, Crompton T.

Cell Cycle. 2014;13(2):324-33. doi: 10.4161/cc.27118. Epub 2013 Nov 18.


Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: a potential novel prognostic marker for breast cancer.

Youssef G, Gillett C, Agbaje O, Crompton T, Montano X.

Mod Pathol. 2014 Mar;27(3):361-74. doi: 10.1038/modpathol.2013.129. Epub 2013 Aug 16.


Ankle osteomyelitis: an unusual presentation.

Robati S, Porter K, Shahid M, Crompton T, Sandiford N.

JRSM Short Rep. 2013 May 29;4(6):35. doi: 10.1177/2042533313476682. Print 2013 Jun. No abstract available.


Routine microbiologic culture of kidney transport fluid: a single-center retrospective study.

Robati S, Froghi S, Kemal KI, Porter KJ, Crompton T, Sharma A.

Transplant Proc. 2013 May;45(4):1618-21. doi: 10.1016/j.transproceed.2013.01.033.


Tissue-derived hedgehog proteins modulate Th differentiation and disease.

Furmanski AL, Saldana JI, Ono M, Sahni H, Paschalidis N, D'Acquisto F, Crompton T.

J Immunol. 2013 Mar 15;190(6):2641-9. doi: 10.4049/jimmunol.1202541. Epub 2013 Feb 13.


T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss.

Furmanski AL, O'Shaughnessy RF, Saldana JI, Blundell MP, Thrasher AJ, Sebire NJ, Davies EG, Crompton T.

J Invest Dermatol. 2013 May;133(5):1221-30. doi: 10.1038/jid.2012.492. Epub 2013 Jan 10.


Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog.

Lau CI, Outram SV, Saldaña JI, Furmanski AL, Dessens JT, Crompton T.

Blood. 2012 May 17;119(20):4741-51. doi: 10.1182/blood-2011-10-387266. Epub 2012 Mar 28.


Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte.

Furmanski AL, Saldana JI, Rowbotham NJ, Ross SE, Crompton T.

Eur J Immunol. 2012 Feb;42(2):489-99. doi: 10.1002/eji.201141758. Epub 2011 Dec 16.


CD3+CD4-CD8- (double negative) T cells: saviours or villains of the immune response?

D'Acquisto F, Crompton T.

Biochem Pharmacol. 2011 Aug 15;82(4):333-40. doi: 10.1016/j.bcp.2011.05.019. Epub 2011 May 27. Review.


Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development.

Drakopoulou E, Outram SV, Rowbotham NJ, Ross SE, Furmanski AL, Saldana JI, Hager-Theodorides AL, Crompton T.

Cell Cycle. 2010 Oct 15;9(20):4144-52. Epub 2010 Oct 27.


Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells.

Maione F, Paschalidis N, Iqbal AJ, Crompton T, Perretti M, D'Acquisto F.

Autoimmunity. 2010 Dec;43(8):672-81. doi: 10.3109/08916931003678296. Epub 2010 Apr 7.


Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection.

Paschalidis N, Huggins A, Rowbotham NJ, Furmanski AL, Crompton T, Flower RJ, Perretti M, D'Acquisto F.

Cell Cycle. 2010 Feb 15;9(4):784-93. Epub 2010 Feb 17.


Peptide-specific, TCR-alpha-driven, coreceptor-independent negative selection in TCR alpha-chain transgenic mice.

Furmanski AL, Bartok I, Chai JG, Singh Y, Ferreira C, Scott D, Holland SJ, Bourdeaux C, Crompton T, Dyson J.

J Immunol. 2010 Jan 15;184(2):650-7. doi: 10.4049/jimmunol.0902291. Epub 2009 Dec 7.


Shh, BMP4 and IL-7 in the maintenance and differentiation of human CD34+ progenitor cells in the thymus.

Furmanski AL, Crompton T.

Cell Cycle. 2009 Dec;8(23):3810. Epub 2009 Dec 1. No abstract available.


The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms.

Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Rowbotham NJ, Crompton T.

J Immunol. 2009 Sep 1;183(5):3023-32. doi: 10.4049/jimmunol.0900152. Epub 2009 Aug 10.


Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism.

Rowbotham NJ, Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Dessens JT, Crompton T.

Blood. 2009 May 21;113(21):5144-56. doi: 10.1182/blood-2008-10-185751. Epub 2009 Mar 9.


Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation.

Outram SV, Hager-Theodorides AL, Shah DK, Rowbotham NJ, Drakopoulou E, Ross SE, Lanske B, Dessens JT, Crompton T.

Blood. 2009 Mar 5;113(10):2217-28. doi: 10.1182/blood-2008-03-144840. Epub 2008 Dec 23.


KLF13 influences multiple stages of both B and T cell development.

Outram SV, Gordon AR, Hager-Theodorides AL, Metcalfe J, Crompton T, Kemp P.

Cell Cycle. 2008 Jul 1;7(13):2047-55. Epub 2008 May 5.


Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation.

Rowbotham NJ, Furmanski AL, Hager-Theodorides AL, Ross SE, Drakopoulou E, Koufaris C, Outram SV, Crompton T.

Cell Cycle. 2008 Apr 1;7(7):904-8. Epub 2008 Jan 18.


Splenomegaly and modified erythropoiesis in KLF13-/- mice.

Gordon AR, Outram SV, Keramatipour M, Goddard CA, Colledge WH, Metcalfe JC, Hager-Theodorides AL, Crompton T, Kemp PR.

J Biol Chem. 2008 May 2;283(18):11897-904. doi: 10.1074/jbc.M709569200. Epub 2008 Feb 19.


A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity.

Rowbotham NJ, Hager-Theodorides AL, Furmanski AL, Crompton T.

Cell Cycle. 2007 Sep 1;6(17):2138-42. Epub 2007 Jun 27.


Sonic hedgehog signalling in T-cell development and activation.

Crompton T, Outram SV, Hager-Theodorides AL.

Nat Rev Immunol. 2007 Sep;7(9):726-35. Epub 2007 Aug 10. Review.


Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus.

Hager-Theodorides AL, Rowbotham NJ, Outram SV, Dessens JT, Crompton T.

Eur J Immunol. 2007 Feb;37(2):487-500.


Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation.

Rowbotham NJ, Hager-Theodorides AL, Cebecauer M, Shah DK, Drakopoulou E, Dyson J, Outram SV, Crompton T.

Blood. 2007 May 1;109(9):3757-66. Epub 2007 Jan 16.


The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.

Hager-Theodorides AL, Dessens JT, Outram SV, Crompton T.

Blood. 2005 Aug 15;106(4):1296-304. Epub 2005 Apr 26.


Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis.

Sacedón R, Díez B, Nuñez V, Hernández-López C, Gutierrez-Frías C, Cejalvo T, Outram SV, Crompton T, Zapata AG, Vicente A, Varas A.

J Immunol. 2005 Feb 1;174(3):1456-61.


OLIN: optimized normalization, visualization and quality testing of two-channel microarray data.

Futschik ME, Crompton T.

Bioinformatics. 2005 Apr 15;21(8):1724-6. Epub 2004 Dec 7.


Deranged smooth muscle alpha-actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series.

Knowles CH, Silk DB, Darzi A, Veress B, Feakins R, Raimundo AH, Crompton T, Browning EC, Lindberg G, Martin JE.

Gut. 2004 Nov;53(11):1583-9.


Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cells.

Gutiérrez-Frías C, Sacedón R, Hernández-López C, Cejalvo T, Crompton T, Zapata AG, Varas A, Vicente A.

J Immunol. 2004 Oct 15;173(8):5046-53.


Model selection and efficiency testing for normalization of cDNA microarray data.

Futschik M, Crompton T.

Genome Biol. 2004;5(8):R60. Epub 2004 Jul 30.


Reduced thymocyte development in sonic hedgehog knockout embryos.

Shah DK, Hager-Theodorides AL, Outram SV, Ross SE, Varas A, Crompton T.

J Immunol. 2004 Feb 15;172(4):2296-306.


Expression of hedgehog proteins in the human thymus.

Sacedón R, Varas A, Hernández-López C, Gutiérrez-deFrías C, Crompton T, Zapata AG, Vicente A.

J Histochem Cytochem. 2003 Nov;51(11):1557-66.


The role of morphogens in T-cell development.

Varas A, Hager-Theodorides AL, Sacedón R, Vicente A, Zapata AG, Crompton T.

Trends Immunol. 2003 Apr;24(4):197-206. Review.


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