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Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites.

Tran TM, Bijker EM, Haks MC, Ottenhoff THM, Visser L, Schats R, Venepally P, Lorenzi H, Crompton PD, Sauerwein RW.

Sci Rep. 2019 Jun 10;9(1):8386. doi: 10.1038/s41598-019-44924-7.


Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.

Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.

J Exp Med. 2019 Jun 3;216(6):1280-1290. doi: 10.1084/jem.20181681. Epub 2019 Apr 12.


Does Atelectasis Cause Fever After Surgery? Putting a Damper on Dogma.

Crompton JG, Crompton PD, Matzinger P.

JAMA Surg. 2019 Mar 6. doi: 10.1001/jamasurg.2018.5645. [Epub ahead of print] No abstract available.


[Dynamics of Egg Excretion of Schistosoma haematobium in a Longitudinal Cohort Under Treatment with Praziquantel over a Five-Year Period in Kalifabougou, Mali].

Niaré DS, Doumtabe D, Ongoiba A, Sidibé K, Traoré A, Sangala J, Kayentao K, Tran TM, Crompton PD, Traoré B, Doumbo OK.

Bull Soc Pathol Exot. 2018;111(2):114-120. doi: 10.3166/bspe-2018-0018. French.


NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity.

Arora G, Hart GT, Manzella-Lapeira J, Doritchamou JY, Narum DL, Thomas LM, Brzostowski J, Rajagopalan S, Doumbo OK, Traore B, Miller LH, Pierce SK, Duffy PE, Crompton PD, Desai SA, Long EO.

Elife. 2018 Jun 26;7. pii: e36806. doi: 10.7554/eLife.36806.


Extent and Dynamics of Polymorphism in the Malaria Vaccine Candidate Plasmodium falciparum Reticulocyte-Binding Protein Homologue-5 in Kalifabougou, Mali.

Ouattara A, Tran TM, Doumbo S, Adams M, Agrawal S, Niangaly A, Nelson-Owens S, Doumtabé D, Tolo Y, Ongoiba A, Takala-Harrison S, Traoré B, Silva JC, Crompton PD, Doumbo OK, Plowe CV.

Am J Trop Med Hyg. 2018 Jul;99(1):43-50. doi: 10.4269/ajtmh.17-0737. Epub 2018 May 24.


What goes around comes around: modeling malaria transmission from humans back to mosquitos.

Miura K, Crompton PD.

J Clin Invest. 2018 Apr 2;128(4):1264-1266. doi: 10.1172/JCI120260. Epub 2018 Mar 12.


Atypical activation of dendritic cells by Plasmodium falciparum.

Götz A, Tang MS, Ty MC, Arama C, Ongoiba A, Doumtabe D, Traore B, Crompton PD, Loke P, Rodriguez A.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10568-E10577. doi: 10.1073/pnas.1708383114. Epub 2017 Nov 21.


Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens.

Liu EW, Skinner J, Tran TM, Kumar K, Narum DL, Jain A, Ongoiba A, Traoré B, Felgner PL, Crompton PD.

Am J Trop Med Hyg. 2018 Jan;98(1):57-66. doi: 10.4269/ajtmh.17-0437. Erratum in: Am J Trop Med Hyg. 2018 Feb;98(2):636.


Synergistic malaria vaccine combinations identified by systematic antigen screening.

Bustamante LY, Powell GT, Lin YC, Macklin MD, Cross N, Kemp A, Cawkill P, Sanderson T, Crosnier C, Muller-Sienerth N, Doumbo OK, Traore B, Crompton PD, Cicuta P, Tran TM, Wright GJ, Rayner JC.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12045-12050. doi: 10.1073/pnas.1702944114. Epub 2017 Oct 23.


Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells.

Obeng-Adjei N, Portugal S, Holla P, Li S, Sohn H, Ambegaonkar A, Skinner J, Bowyer G, Doumbo OK, Traore B, Pierce SK, Crompton PD.

PLoS Pathog. 2017 Sep 27;13(9):e1006576. doi: 10.1371/journal.ppat.1006576. eCollection 2017 Sep.


A Streamlined Approach to Antibody Novel Germline Allele Prediction and Validation.

Wendel BS, He C, Crompton PD, Pierce SK, Jiang N.

Front Immunol. 2017 Sep 4;8:1072. doi: 10.3389/fimmu.2017.01072. eCollection 2017.


Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children.

Wendel BS, He C, Qu M, Wu D, Hernandez SM, Ma KY, Liu EW, Xiao J, Crompton PD, Pierce SK, Ren P, Chen K, Jiang N.

Nat Commun. 2017 Sep 14;8(1):531. doi: 10.1038/s41467-017-00645-x.


Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.

Kurup SP, Obeng-Adjei N, Anthony SM, Traore B, Doumbo OK, Butler NS, Crompton PD, Harty JT.

Nat Med. 2017 Oct;23(10):1220-1225. doi: 10.1038/nm.4395. Epub 2017 Sep 11.


Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.

Pieper K, Tan J, Piccoli L, Foglierini M, Barbieri S, Chen Y, Silacci-Fregni C, Wolf T, Jarrossay D, Anderle M, Abdi A, Ndungu FM, Doumbo OK, Traore B, Tran TM, Jongo S, Zenklusen I, Crompton PD, Daubenberger C, Bull PC, Sallusto F, Lanzavecchia A.

Nature. 2017 Aug 31;548(7669):597-601. doi: 10.1038/nature23670. Epub 2017 Aug 23.


Atypical memory B cells in human chronic infectious diseases: An interim report.

Portugal S, Obeng-Adjei N, Moir S, Crompton PD, Pierce SK.

Cell Immunol. 2017 Nov;321:18-25. doi: 10.1016/j.cellimm.2017.07.003. Epub 2017 Jul 11. Review.


Treatment of Chronic Asymptomatic Plasmodium falciparum Infection Does Not Increase the Risk of Clinical Malaria Upon Reinfection.

Portugal S, Tran TM, Ongoiba A, Bathily A, Li S, Doumbo S, Skinner J, Doumtabe D, Kone Y, Sangala J, Jain A, Davies DH, Hung C, Liang L, Ricklefs S, Homann MV, Felgner PL, Porcella SF, Färnert A, Doumbo OK, Kayentao K, Greenwood BM, Traore B, Crompton PD.

Clin Infect Dis. 2017 Mar 1;64(5):645-653. doi: 10.1093/cid/ciw849.


Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice.

Dotsey E, Ushach I, Pone E, Nakajima R, Jasinskas A, Argueta DA, Dillon A, DiPatrizio N, Davies H, Zlotnik A, Crompton PD, Felgner PL.

Sci Rep. 2017 Feb 17;7:42584. doi: 10.1038/srep42584.


Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) Web-Server.

Proietti C, Zakrzewski M, Watkins TS, Berger B, Hasan S, Ratnatunga CN, Brion MJ, Crompton PD, Miles JJ, Doolan DL, Krause L.

Sci Rep. 2016 Dec 6;6:38178. doi: 10.1038/srep38178.


Emerging concepts in T follicular helper cell responses to malaria.

Hansen DS, Obeng-Adjei N, Ly A, Ioannidis LJ, Crompton PD.

Int J Parasitol. 2017 Feb;47(2-3):105-110. doi: 10.1016/j.ijpara.2016.09.004. Epub 2016 Nov 17. Review.


The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.

Hart GT, Akkaya M, Chida AS, Wei C, Jenks SA, Tipton C, He C, Wendel BS, Skinner J, Arora G, Kayentao K, Ongoiba A, Doumbo O, Traore B, Narum DL, Jiang N, Crompton PD, Sanz I, Pierce SK.

J Immunol. 2016 Nov 15;197(10):3841-3849. Epub 2016 Oct 19.


PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria.

Crompton PD, Pierce SK.

Immunity. 2016 Aug 16;45(2):231-3. doi: 10.1016/j.immuni.2016.08.001.


Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria.

Tran TM, Jones MB, Ongoiba A, Bijker EM, Schats R, Venepally P, Skinner J, Doumbo S, Quinten E, Visser LG, Whalen E, Presnell S, O'Connell EM, Kayentao K, Doumbo OK, Chaussabel D, Lorenzi H, Nutman TB, Ottenhoff TH, Haks MC, Traore B, Kirkness EF, Sauerwein RW, Crompton PD.

Sci Rep. 2016 Aug 10;6:31291. doi: 10.1038/srep31291.


Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge.

Krishnamurty AT, Thouvenel CD, Portugal S, Keitany GJ, Kim KS, Holder A, Crompton PD, Rawlings DJ, Pepper M.

Immunity. 2016 Aug 16;45(2):402-14. doi: 10.1016/j.immuni.2016.06.014. Epub 2016 Jul 26.


Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children.

Obeng-Adjei N, Portugal S, Tran TM, Yazew TB, Skinner J, Li S, Jain A, Felgner PL, Doumbo OK, Kayentao K, Ongoiba A, Traore B, Crompton PD.

Cell Rep. 2015 Oct 13;13(2):425-39. doi: 10.1016/j.celrep.2015.09.004. Epub 2015 Oct 1.


Genetic Resistance to Malaria Is Associated With Greater Enhancement of Immunoglobulin (Ig)M Than IgG Responses to a Broad Array of Plasmodium falciparum Antigens.

Arama C, Skinner J, Doumtabe D, Portugal S, Tran TM, Jain A, Traore B, Doumbo OK, Davies DH, Troye-Blomberg M, Dolo A, Felgner PL, Crompton PD.

Open Forum Infect Dis. 2015 Aug 26;2(3):ofv118. doi: 10.1093/ofid/ofv118. eCollection 2015 Sep.


Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection.

Yooseph S, Kirkness EF, Tran TM, Harkins DM, Jones MB, Torralba MG, O'Connell E, Nutman TB, Doumbo S, Doumbo OK, Traore B, Crompton PD, Nelson KE.

BMC Genomics. 2015 Aug 22;16:631. doi: 10.1186/s12864-015-1819-3.


Plasmodium falciparum Gametocyte-Specific Antibody Profiling Reveals Boosting through Natural Infection and Identifies Potential Markers of Gametocyte Exposure.

Skinner J, Huang CY, Waisberg M, Felgner PL, Doumbo OK, Ongoiba A, Kayentao K, Traore B, Crompton PD, Williamson KC.

Infect Immun. 2015 Nov;83(11):4229-36. doi: 10.1128/IAI.00644-15. Epub 2015 Aug 17.


Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities.

Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse B.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4438-47. doi: 10.1073/pnas.1501705112. Epub 2015 Jul 27.


Malaria Vaccines: Moving Forward After Encouraging First Steps.

Tran TM, Portugal S, Draper SJ, Crompton PD.

Curr Trop Med Rep. 2015 Mar;2(1):1-3.


Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function.

Portugal S, Tipton CM, Sohn H, Kone Y, Wang J, Li S, Skinner J, Virtaneva K, Sturdevant DE, Porcella SF, Doumbo OK, Doumbo S, Kayentao K, Ongoiba A, Traore B, Sanz I, Pierce SK, Crompton PD.

Elife. 2015 May 8;4. doi: 10.7554/eLife.07218.


HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults.

Subramaniam KS, Skinner J, Ivan E, Mutimura E, Kim RS, Feintuch CM, Portugal S, Anastos K, Crompton PD, Daily JP.

PLoS One. 2015 Apr 30;10(4):e0124412. doi: 10.1371/journal.pone.0124412. eCollection 2015.


Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans.

Banga S, Coursen JD, Portugal S, Tran TM, Hancox L, Ongoiba A, Traore B, Doumbo OK, Huang CY, Harty JT, Crompton PD.

PLoS One. 2015 Apr 28;10(4):e0125090. doi: 10.1371/journal.pone.0125090. eCollection 2015.


PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity.

Zander RA, Obeng-Adjei N, Guthmiller JJ, Kulu DI, Li J, Ongoiba A, Traore B, Crompton PD, Butler NS.

Cell Host Microbe. 2015 May 13;17(5):628-41. doi: 10.1016/j.chom.2015.03.007. Epub 2015 Apr 16.


Ethnic differences in susceptibility to malaria: what have we learned from immuno-epidemiological studies in West Africa?

Arama C, Maiga B, Dolo A, Kouriba B, Traoré B, Crompton PD, Pierce SK, Troye-Blomberg M, Miller LH, Doumbo OK.

Acta Trop. 2015 Jun;146:152-6. doi: 10.1016/j.actatropica.2015.03.023. Epub 2015 Mar 27. Review.


Asymptomatic Multiclonal Plasmodium falciparum Infections Carried Through the Dry Season Predict Protection Against Subsequent Clinical Malaria.

Sondén K, Doumbo S, Hammar U, Vafa Homann M, Ongoiba A, Traoré B, Bottai M, Crompton PD, Färnert A.

J Infect Dis. 2015 Aug 15;212(4):608-16. doi: 10.1093/infdis/jiv088. Epub 2015 Feb 23.


RTS,S vaccination is associated with serologic evidence of decreased exposure to Plasmodium falciparum liver- and blood-stage parasites.

Campo JJ, Aponte JJ, Skinner J, Nakajima R, Molina DM, Liang L, Sacarlal J, Alonso PL, Crompton PD, Felgner PL, Dobaño C.

Mol Cell Proteomics. 2015 Mar;14(3):519-31. doi: 10.1074/mcp.M114.044677. Epub 2014 Dec 29.


Gut microbiota elicits a protective immune response against malaria transmission.

Yilmaz B, Portugal S, Tran TM, Gozzelino R, Ramos S, Gomes J, Regalado A, Cowan PJ, d'Apice AJ, Chong AS, Doumbo OK, Traore B, Crompton PD, Silveira H, Soares MP.

Cell. 2014 Dec 4;159(6):1277-89. doi: 10.1016/j.cell.2014.10.053.


A nested real-time PCR assay for the quantification of Plasmodium falciparum DNA extracted from dried blood spots.

Tran TM, Aghili A, Li S, Ongoiba A, Kayentao K, Doumbo S, Traore B, Crompton PD.

Malar J. 2014 Oct 4;13:393. doi: 10.1186/1475-2875-13-393.


Co-infection of long-term carriers of Plasmodium falciparum with Schistosoma haematobium enhances protection from febrile malaria: a prospective cohort study in Mali.

Doumbo S, Tran TM, Sangala J, Li S, Doumtabe D, Kone Y, Traoré A, Bathily A, Sogoba N, Coulibaly ME, Huang CY, Ongoiba A, Kayentao K, Diallo M, Dramane Z, Nutman TB, Crompton PD, Doumbo O, Traore B.

PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3154. doi: 10.1371/journal.pntd.0003154. eCollection 2014 Sep.


Exposure-dependent control of malaria-induced inflammation in children.

Portugal S, Moebius J, Skinner J, Doumbo S, Doumtabe D, Kone Y, Dia S, Kanakabandi K, Sturdevant DE, Virtaneva K, Porcella SF, Li S, Doumbo OK, Kayentao K, Ongoiba A, Traore B, Crompton PD.

PLoS Pathog. 2014 Apr 17;10(4):e1004079. doi: 10.1371/journal.ppat.1004079. eCollection 2014 Apr.


Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease.

Crompton PD, Moebius J, Portugal S, Waisberg M, Hart G, Garver LS, Miller LH, Barillas-Mury C, Pierce SK.

Annu Rev Immunol. 2014;32:157-87. doi: 10.1146/annurev-immunol-032713-120220. Review.


Naturally acquired antibodies specific for Plasmodium falciparum reticulocyte-binding protein homologue 5 inhibit parasite growth and predict protection from malaria.

Tran TM, Ongoiba A, Coursen J, Crosnier C, Diouf A, Huang CY, Li S, Doumbo S, Doumtabe D, Kone Y, Bathily A, Dia S, Niangaly M, Dara C, Sangala J, Miller LH, Doumbo OK, Kayentao K, Long CA, Miura K, Wright GJ, Traore B, Crompton PD.

J Infect Dis. 2014 Mar 1;209(5):789-98. doi: 10.1093/infdis/jit553. Epub 2013 Oct 16.


Young lives lost as B cells falter: what we are learning about antibody responses in malaria.

Portugal S, Pierce SK, Crompton PD.

J Immunol. 2013 Apr 1;190(7):3039-46. doi: 10.4049/jimmunol.1203067. Review.


An intensive longitudinal cohort study of Malian children and adults reveals no evidence of acquired immunity to Plasmodium falciparum infection.

Tran TM, Li S, Doumbo S, Doumtabe D, Huang CY, Dia S, Bathily A, Sangala J, Kone Y, Traore A, Niangaly M, Dara C, Kayentao K, Ongoiba A, Doumbo OK, Traore B, Crompton PD.

Clin Infect Dis. 2013 Jul;57(1):40-7. doi: 10.1093/cid/cit174. Epub 2013 Mar 13.


Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion.

Illingworth J, Butler NS, Roetynck S, Mwacharo J, Pierce SK, Bejon P, Crompton PD, Marsh K, Ndungu FM.

J Immunol. 2013 Feb 1;190(3):1038-47. doi: 10.4049/jimmunol.1202438. Epub 2012 Dec 21.


Systems immunology of human malaria.

Tran TM, Samal B, Kirkness E, Crompton PD.

Trends Parasitol. 2012 Jun;28(6):248-57. doi: 10.1016/ Epub 2012 May 15. Review.


B cell analysis of ethnic groups in Mali with differential susceptibility to malaria.

Portugal S, Doumtabe D, Traore B, Miller LH, Troye-Blomberg M, Doumbo OK, Dolo A, Pierce SK, Crompton PD.

Malar J. 2012 May 11;11:162. doi: 10.1186/1475-2875-11-162.


Plasmodium falciparum malaria in the Peruvian Amazon, a region of low transmission, is associated with immunologic memory.

Clark EH, Silva CJ, Weiss GE, Li S, Padilla C, Crompton PD, Hernandez JN, Branch OH.

Infect Immun. 2012 Apr;80(4):1583-92. doi: 10.1128/IAI.05961-11. Epub 2012 Jan 17.


Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection.

Butler NS, Moebius J, Pewe LL, Traore B, Doumbo OK, Tygrett LT, Waldschmidt TJ, Crompton PD, Harty JT.

Nat Immunol. 2011 Dec 11;13(2):188-95. doi: 10.1038/ni.2180.

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