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Items: 48


Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.

Speir M, Nowell CJ, Chen AA, O'Donnell JA, Shamie IS, Lakin PR, D'Cruz AA, Braun RO, Babon JJ, Lewis RS, Bliss-Moreau M, Shlomovitz I, Wang S, Cengia LH, Stoica AI, Hakem R, Kelliher MA, O'Reilly LA, Patsiouras H, Lawlor KE, Weller E, Lewis NE, Roberts AW, Gerlic M, Croker BA.

Nat Immunol. 2020 Jan;21(1):54-64. doi: 10.1038/s41590-019-0550-7. Epub 2019 Dec 9.


β-glucan-dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment.

Pazhakh V, Ellett F, Croker BA, O'Donnell JA, Pase L, Schulze KE, Greulich RS, Gupta A, Reyes-Aldasoro CC, Andrianopoulos A, Lieschke GJ.

PLoS Biol. 2019 Sep 4;17(9):e3000113. doi: 10.1371/journal.pbio.3000113. eCollection 2019 Sep.


Single-cell cloning of human T-cell lines reveals clonal variation in cell death responses to chemotherapeutics.

Hanlon K, Thompson A, Pantano L, Hutchinson JN, Al-Obeidi A, Wang S, Bliss-Moreau M, Helble J, Alexe G, Stegmaier K, Bauer DE, Croker BA.

Cancer Genet. 2019 Sep;237:69-77. doi: 10.1016/j.cancergen.2019.06.003. Epub 2019 Jun 12.


Mutations in topoisomerase IIβ result in a B cell immunodeficiency.

Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM.

Nat Commun. 2019 Aug 13;10(1):3644. doi: 10.1038/s41467-019-11570-6.


Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.

McKenzie MD, Ghisi M, Oxley EP, Ngo S, Cimmino L, Esnault C, Liu R, Salmon JM, Bell CC, Ahmed N, Erlichster M, Witkowski MT, Liu GJ, Chopin M, Dakic A, Simankowicz E, Pomilio G, Vu T, Krsmanovic P, Su S, Tian L, Baldwin TM, Zalcenstein DA, DiRago L, Wang S, Metcalf D, Johnstone RW, Croker BA, Lancaster GI, Murphy AJ, Naik SH, Nutt SL, Pospisil V, Schroeder T, Wall M, Dawson MA, Wei AH, de Thé H, Ritchie ME, Zuber J, Dickins RA.

Cell Stem Cell. 2019 Aug 1;25(2):258-272.e9. doi: 10.1016/j.stem.2019.07.001.


Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling.

Liu X, D'Cruz AA, Hansen J, Croker BA, Lawlor KE, Sims NA, Wicks IP.

Osteoarthritis Cartilage. 2019 Oct;27(10):1557-1563. doi: 10.1016/j.joca.2019.05.018. Epub 2019 Jun 5.


BID-ding on necroptosis in MDS.

Croker BA, Kelliher MA.

Blood. 2019 Jan 10;133(2):103-104. doi: 10.1182/blood-2018-11-886242. No abstract available.


Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model.

Shlomovitz I, Erlich Z, Speir M, Zargarian S, Baram N, Engler M, Edry-Botzer L, Munitz A, Croker BA, Gerlic M.

FEBS J. 2019 Feb;286(3):507-522. doi: 10.1111/febs.14738. Epub 2019 Jan 4.


The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.

D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, Croker BA.

Sci Signal. 2018 Sep 4;11(546). pii: eaao1716. doi: 10.1126/scisignal.aao1716.


Vestibular Sclerosis: Is This a New, Distinct Clinicopathological Entity?

Croker BA, Scurry JP, Petry FM, Fischer G.

J Low Genit Tract Dis. 2018 Jul;22(3):260-263. doi: 10.1097/LGT.0000000000000404.


Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens.

Waight JD, Chand D, Dietrich S, Gombos R, Horn T, Gonzalez AM, Manrique M, Swiech L, Morin B, Brittsan C, Tanne A, Akpeng B, Croker BA, Buell JS, Stein R, Savitsky DA, Wilson NS.

Cancer Cell. 2018 Jun 11;33(6):1033-1047.e5. doi: 10.1016/j.ccell.2018.05.005.


Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica JS, Vince JE, Schroder K.

J Immunol. 2018 May 15;200(10):3341-3346. doi: 10.4049/jimmunol.1701620. Epub 2018 Apr 16.


Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia.

McArthur K, D'Cruz AA, Segal D, Lackovic K, Wilks AF, O'Donnell JA, Nowell CJ, Gerlic M, Huang DCS, Burns CJ, Croker BA.

Oncotarget. 2017 Jul 28;8(35):57948-57963. doi: 10.18632/oncotarget.19678. eCollection 2017 Aug 29.


Myelopoiesis embraces its inner weakness.

Gerlic M, Croker BA.

Nat Immunol. 2017 Aug 22;18(9):953-954. doi: 10.1038/ni.3814. No abstract available.


Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis.

Zargarian S, Shlomovitz I, Erlich Z, Hourizadeh A, Ofir-Birin Y, Croker BA, Regev-Rudzki N, Edry-Botzer L, Gerlic M.

PLoS Biol. 2017 Jun 26;15(6):e2002711. doi: 10.1371/journal.pbio.2002711. eCollection 2017 Jun.


A Helicobacter pylori Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization.

Hutton ML, D'Costa K, Rossiter AE, Wang L, Turner L, Steer DL, Masters SL, Croker BA, Kaparakis-Liaskos M, Ferrero RL.

Front Cell Infect Microbiol. 2017 Jun 6;7:219. doi: 10.3389/fcimb.2017.00219. eCollection 2017.


A motive for killing: effector functions of regulated lytic cell death.

Bliss-Moreau M, Chen AA, D'Cruz AA, Croker BA.

Immunol Cell Biol. 2017 Feb;95(2):146-151. doi: 10.1038/icb.2016.113. Epub 2016 Nov 9. Review.


IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.


Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis.

Croker BA, Silke J, Gerlic M.

Curr Opin Hematol. 2015 Jul;22(4):293-301. doi: 10.1097/MOH.0000000000000148. Review.


Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3.

Liu X, Liu R, Croker BA, Lawlor KE, Smyth GK, Wicks IP.

Osteoarthritis Cartilage. 2015 Oct;23(10):1743-54. doi: 10.1016/j.joca.2015.05.011. Epub 2015 Jun 2.


Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts AW, Kastner DL, Lew AM, Lyras D, Kile BT, Croker BA, Masters SL.

J Exp Med. 2015 Jun 1;212(6):927-38. doi: 10.1084/jem.20142384. Epub 2015 May 25.


RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.

Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282.


Fas regulates neutrophil lifespan during viral and bacterial infection.

O'Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Zhang JG, O'Reilly LA, Cengia L, Dias S, Masters SL, Hartland EL, Roberts AW, Gerlic M, Croker BA.

J Leukoc Biol. 2015 Feb;97(2):321-6. doi: 10.1189/jlb.3AB1113-594RR. Epub 2014 Dec 3.


Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.

Liu X, Croker BA, Campbell IK, Gauci SJ, Alexander WS, Tonkin BA, Walsh NC, Linossi EM, Nicholson SE, Lawlor KE, Wicks IP.

Arthritis Rheumatol. 2014 Sep;66(9):2391-402. doi: 10.1002/art.38701.


RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J.

Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8.


NLRP1a expression in Srebp-1a-deficient mice.

Gerlic M, Croker BA, Cengia LH, Moayeri M, Kile BT, Masters SL.

Cell Metab. 2014 Mar 4;19(3):345-6. doi: 10.1016/j.cmet.2014.02.002. No abstract available.


Pyroptotic death storms and cytopenia.

Croker BA, O'Donnell JA, Gerlic M.

Curr Opin Immunol. 2014 Feb;26:128-37. doi: 10.1016/j.coi.2013.12.002. Epub 2013 Dec 22. Review.


Neutrophil survival in the death zone.

Croker BA.

Blood. 2014 Jan 16;123(3):307-8. doi: 10.1182/blood-2013-11-538298.


NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.

Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O'Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker BA.

Immunity. 2012 Dec 14;37(6):1009-23. doi: 10.1016/j.immuni.2012.08.027. Epub 2012 Dec 6.


Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor.

Lindqvist LM, Vikström I, Chambers JM, McArthur K, Ann Anderson M, Henley KJ, Happo L, Cluse L, Johnstone RW, Roberts AW, Kile BT, Croker BA, Burns CJ, Rizzacasa MA, Strasser A, Huang DC.

Cell Death Dis. 2012 Oct 11;3:e409. doi: 10.1038/cddis.2012.149.


Towards a four-dimensional view of neutrophils.

Croker BA, Roberts AW, Nicola NA.

Methods Mol Biol. 2012;844:87-99. doi: 10.1007/978-1-61779-527-5_6. Review.


Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.

Croker BA, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts AW.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13135-40. doi: 10.1073/pnas.1110358108. Epub 2011 Jul 18.


IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.

Croker BA, Kiu H, Pellegrini M, Toe J, Preston S, Metcalf D, O'Donnell JA, Cengia LH, McArthur K, Nicola NA, Alexander WS, Roberts AW.

Immunol Cell Biol. 2012 Jan;90(1):124-9. doi: 10.1038/icb.2011.29. Epub 2011 Apr 26.


Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease.

Croker BA, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts AW.

J Immunol. 2011 Jan 15;186(2):1131-9. doi: 10.4049/jimmunol.1002702. Epub 2010 Dec 15.


Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways.

Zhan Y, Xu Y, Seah S, Brady JL, Carrington EM, Cheers C, Croker BA, Wu L, Villadangos JA, Lew AM.

J Immunol. 2010 Aug 15;185(4):2125-33. doi: 10.4049/jimmunol.0903793. Epub 2010 Jul 19.


Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production.

Masters SL, Mielke LA, Cornish AL, Sutton CE, O'Donnell J, Cengia LH, Roberts AW, Wicks IP, Mills KH, Croker BA.

EMBO Rep. 2010 Aug;11(8):640-6. doi: 10.1038/embor.2010.93. Epub 2010 Jul 2.


An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Berger M, Krebs P, Crozat K, Li X, Croker BA, Siggs OM, Popkin D, Du X, Lawson BR, Theofilopoulos AN, Xia Y, Khovananth K, Moresco EM, Satoh T, Takeuchi O, Akira S, Beutler B.

Nat Immunol. 2010 Apr;11(4):335-43. doi: 10.1038/ni.1847. Epub 2010 Feb 28.


A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis.

Eyles JL, Hickey MJ, Norman MU, Croker BA, Roberts AW, Drake SF, James WG, Metcalf D, Campbell IK, Wicks IP.

Blood. 2008 Dec 15;112(13):5193-201. doi: 10.1182/blood-2008-02-139535. Epub 2008 Sep 29.


Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.

Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15028-33. doi: 10.1073/pnas.0806619105. Epub 2008 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19561. Rutschmann, Sophie [added].


SOCS regulation of the JAK/STAT signalling pathway.

Croker BA, Kiu H, Nicholson SE.

Semin Cell Dev Biol. 2008 Aug;19(4):414-22. doi: 10.1016/j.semcdb.2008.07.010. Epub 2008 Jul 30. Review.


Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.

Croker BA, Mielke LA, Wormald S, Metcalf D, Kiu H, Alexander WS, Hilton DJ, Roberts AW.

Exp Hematol. 2008 Jul;36(7):786-98. doi: 10.1016/j.exphem.2008.02.008. Epub 2008 Apr 8.


Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.

Alexander WS, Viney EM, Zhang JG, Metcalf D, Kauppi M, Hyland CD, Carpinelli MR, Stevenson W, Croker BA, Hilton AA, Ellis S, Selan C, Nandurkar HH, Goodnow CC, Kile BT, Nicola NA, Roberts AW, Hilton DJ.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16442-7. Epub 2006 Oct 24.


SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.

Wong PK, Egan PJ, Croker BA, O'Donnell K, Sims NA, Drake S, Kiu H, McManus EJ, Alexander WS, Roberts AW, Wicks IP.

J Clin Invest. 2006 Jun;116(6):1571-81. Epub 2006 May 18.


SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.

Croker BA, Metcalf D, Robb L, Wei W, Mifsud S, DiRago L, Cluse LA, Sutherland KD, Hartley L, Williams E, Zhang JG, Hilton DJ, Nicola NA, Alexander WS, Roberts AW.

Immunity. 2004 Feb;20(2):153-65.


SOCS3 negatively regulates IL-6 signaling in vivo.

Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, Robb L, Greenhalgh CJ, Förster I, Clausen BE, Nicola NA, Metcalf D, Hilton DJ, Roberts AW, Alexander WS.

Nat Immunol. 2003 Jun;4(6):540-5. Epub 2003 May 18.


Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses.

Croker BA, Handman E, Hayball JD, Baldwin TM, Voigt V, Cluse LA, Yang FC, Williams DA, Roberts AW.

Immunol Cell Biol. 2002 Jun;80(3):231-40.


The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.

Croker BA, Tarlinton DM, Cluse LA, Tuxen AJ, Light A, Yang FC, Williams DA, Roberts AW.

J Immunol. 2002 Apr 1;168(7):3376-86.


Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.

Kile BT, Viney EM, Willson TA, Brodnicki TC, Cancilla MR, Herlihy AS, Croker BA, Baca M, Nicola NA, Hilton DJ, Alexander WS.

Gene. 2000 Nov 27;258(1-2):31-41.


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