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Items: 26


A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma.

Birch JL, Strathdee K, Gilmour L, Vallatos A, McDonald L, Kouzeli A, Vasan R, Qaisi AH, Croft DR, Crighton D, Gill K, Gray CH, Konczal J, Mezna M, McArthur D, Schüttelkopf AW, McConnell P, Sime M, Holmes WM, Bower J, McKinnon HJ, Drysdale M, Olson MF, Chalmers AJ.

Cancer Res. 2018 Nov 15;78(22):6509-6522. doi: 10.1158/0008-5472.CAN-18-1697. Epub 2018 Oct 2.


Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.

Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, McKinnon H, McMenemy C, Mezna M, Morrice NA, Munro J, Naylor G, Rath N, Schüttelkopf AW, Sime M, Olson MF.

Cancer Res. 2018 Apr 15;78(8):2096-2114. doi: 10.1158/0008-5472.CAN-17-2870. Epub 2018 Jan 30.


LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.

Mardilovich K, Baugh M, Crighton D, Kowalczyk D, Gabrielsen M, Munro J, Croft DR, Lourenco F, James D, Kalna G, McGarry L, Rath O, Shanks E, Garnett MJ, McDermott U, Brookfield J, Charles M, Hammonds T, Olson MF.

Oncotarget. 2015 Nov 17;6(36):38469-86. doi: 10.18632/oncotarget.6288.


Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, Long JS, O'Prey M, Croft DR, Beaumatin F, Baudot AD, Mrschtik M, Rosenfeldt M, Zhang Y, Gillespie DA, Ryan KM.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):773-8. doi: 10.1073/pnas.1409563112. Epub 2015 Jan 7.


A novel small-molecule MRCK inhibitor blocks cancer cell invasion.

Unbekandt M, Croft DR, Crighton D, Mezna M, McArthur D, McConnell P, Schüttelkopf AW, Belshaw S, Pannifer A, Sime M, Bower J, Drysdale M, Olson MF.

Cell Commun Signal. 2014 Oct 5;12:54. doi: 10.1186/s12964-014-0054-x.


Transcriptional regulation of Rho GTPase signaling.

Croft DR, Olson MF.

Transcription. 2011 Sep-Oct;2(5):211-5. doi: 10.4161/trns.2.5.16904.


Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system.

Lemarié F, Croft DR, Tate RJ, Ryan KM, Dufès C.

Biomaterials. 2012 Mar;33(9):2701-9. doi: 10.1016/j.biomaterials.2011.12.019. Epub 2011 Dec 24.


The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy.

Wilkinson S, Croft DR, O'Prey J, Meedendorp A, O'Prey M, Dufès C, Ryan KM.

Autophagy. 2011 Nov;7(11):1295-301. doi: 10.4161/auto.7.11.16646. Epub 2011 Nov 1.


Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.

Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF.

Cancer Cell. 2011 Jun 14;19(6):776-91. doi: 10.1016/j.ccr.2011.05.008.


p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.

Croft DR, Crighton D, Samuel MS, Lourenco FC, Munro J, Wood J, Bensaad K, Vousden KH, Sansom OJ, Ryan KM, Olson MF.

Cell Res. 2011 Apr;21(4):666-82. doi: 10.1038/cr.2010.154. Epub 2010 Nov 16.


LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

Scott RW, Hooper S, Crighton D, Li A, König I, Munro J, Trivier E, Wickman G, Morin P, Croft DR, Dawson J, Machesky L, Anderson KI, Sahai EA, Olson MF.

J Cell Biol. 2010 Oct 4;191(1):169-85. doi: 10.1083/jcb.201002041. Epub 2010 Sep 27.


Regulating the conversion between rounded and elongated modes of cancer cell movement.

Croft DR, Olson MF.

Cancer Cell. 2008 Nov 4;14(5):349-51. doi: 10.1016/j.ccr.2008.10.009.


Spectrum of infection and risk factors for human monkeypox, United States, 2003.

Reynolds MG, Davidson WB, Curns AT, Conover CS, Huhn G, Davis JP, Wegner M, Croft DR, Newman A, Obiesie NN, Hansen GR, Hays PL, Pontones P, Beard B, Teclaw R, Howell JF, Braden Z, Holman RC, Karem KL, Damon IK.

Emerg Infect Dis. 2007 Sep;13(9):1332-9. doi: 10.3201/eid1309.070175.


Occupational risks during a monkeypox outbreak, Wisconsin, 2003.

Croft DR, Sotir MJ, Williams CJ, Kazmierczak JJ, Wegner MV, Rausch D, Graham MB, Foldy SL, Wolters M, Damon IK, Karem KL, Davis JP.

Emerg Infect Dis. 2007 Aug;13(8):1150-7.


Impact of a child care educational intervention on parent knowledge about appropriate antibiotic use.

Croft DR, Knobloch MJ, Chyou PH, Ellen DV, Janette C, Davis JP, Besser RE, Belongia EA.

WMJ. 2007 Apr;106(2):78-84.


Conditional regulation of a ROCK-estrogen receptor fusion protein.

Croft DR, Olson MF.

Methods Enzymol. 2006;406:541-53.


AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.

Spence HJ, McGarry L, Chew CS, Carragher NO, Scott-Carragher LA, Yuan Z, Croft DR, Olson MF, Frame M, Ozanne BW.

Mol Cell Biol. 2006 Feb;26(4):1480-95.


Stability of p21Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton.

Coleman ML, Densham RM, Croft DR, Olson MF.

Oncogene. 2006 May 4;25(19):2708-16.


Meningococcal disease incidence and mortality in Wisconsin, 1993-2002.

Sotir MJ, Ahrabi-Fard S, Croft DR, Kazmierczak J, Monson TA, Wegner MV, Davis JP.

WMJ. 2005 Apr;104(3):38-44.


Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.

Croft DR, Coleman ML, Li S, Robertson D, Sullivan T, Stewart CL, Olson MF.

J Cell Biol. 2005 Jan 17;168(2):245-55.


Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis.

Croft DR, Sahai E, Mavria G, Li S, Tsai J, Lee WM, Marshall CJ, Olson MF.

Cancer Res. 2004 Dec 15;64(24):8994-9001.


Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway.

McMullan R, Lax S, Robertson VH, Radford DJ, Broad S, Watt FM, Rowles A, Croft DR, Olson MF, Hotchin NA.

Curr Biol. 2003 Dec 16;13(24):2185-9.


FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence.

Croft DR, Trapp J, Kernstine K, Kirchner P, Mullan B, Galvin J, Peterson MW, Gross T, McLennan G, Kern JA.

Lung Cancer. 2002 Jun;36(3):297-301.


An evaluation of the quality and contents of asthma education on the World Wide Web.

Croft DR, Peterson MW.

Chest. 2002 Apr;121(4):1301-7.


Complex CD44 splicing combinations in synovial fibroblasts from arthritic joints.

Croft DR, Dall P, Davies D, Jackson DG, McIntyre P, Kramer IM.

Eur J Immunol. 1997 Jul;27(7):1680-4.


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