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Items: 49


Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.

Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10488-10493. doi: 10.1073/pnas.1816911116. Epub 2019 May 8.


Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis.

Nicaise AM, Wagstaff LJ, Willis CM, Paisie C, Chandok H, Robson P, Fossati V, Williams A, Crocker SJ.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9030-9039. doi: 10.1073/pnas.1818348116. Epub 2019 Mar 25.


TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling.

Nicaise AM, Johnson KM, Willis CM, Guzzo RM, Crocker SJ.

Mol Neurobiol. 2019 May;56(5):3380-3392. doi: 10.1007/s12035-018-1310-7. Epub 2018 Aug 18.


Long-Term Improvement of Neurological Signs and Metabolic Dysfunction in a Mouse Model of Krabbe's Disease after Global Gene Therapy.

Marshall MS, Issa Y, Jakubauskas B, Stoskute M, Elackattu V, Marshall JN, Bogue W, Nguyen D, Hauck Z, Rue E, Karumuthil-Melethil S, Zaric V, Bosland M, van Breemen RB, Givogri MI, Gray SJ, Crocker SJ, Bongarzone ER.

Mol Ther. 2018 Mar 7;26(3):874-889. doi: 10.1016/j.ymthe.2018.01.009. Epub 2018 Jan 17.


A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma.

Willis CM, Ménoret A, Jellison ER, Nicaise AM, Vella AT, Crocker SJ.

Front Neurosci. 2017 Jun 15;11:335. doi: 10.3389/fnins.2017.00335. eCollection 2017.


iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response.

Nicaise AM, Banda E, Guzzo RM, Russomanno K, Castro-Borrero W, Willis CM, Johnson KM, Lo AC, Crocker SJ.

Exp Neurol. 2017 Feb;288:114-121. doi: 10.1016/j.expneurol.2016.11.012. Epub 2016 Nov 16.


A microglial hypothesis of globoid cell leukodystrophy pathology.

Nicaise AM, Bongarzone ER, Crocker SJ.

J Neurosci Res. 2016 Nov;94(11):1049-61. doi: 10.1002/jnr.23773. Review.


TIMP-1 couples RhoK activation to IL-1β-induced astrocyte responses.

Johnson KM, Crocker SJ.

Neurosci Lett. 2015 Nov 16;609:165-70. doi: 10.1016/j.neulet.2015.10.038. Epub 2015 Oct 17.


Transition from identity to bioactivity-guided proteomics for biomarker discovery with focus on the PF2D platform.

Ménoret A, Crocker SJ, Rodriguez A, Rathinam VA, Clark RB, Vella AT.

Proteomics Clin Appl. 2016 Jan;10(1):8-24. doi: 10.1002/prca.201500029. Epub 2015 Sep 16. Review.


Extracellular matrix composition determines astrocyte responses to mechanical and inflammatory stimuli.

Johnson KM, Milner R, Crocker SJ.

Neurosci Lett. 2015 Jul 23;600:104-9. doi: 10.1016/j.neulet.2015.06.013. Epub 2015 Jun 9.


An in vitro model for the study of cellular pathophysiology in globoid cell leukodystrophy.

Claycomb KI, Johnson KM, Bongarzone ER, Crocker SJ.

J Vis Exp. 2014 Oct 21;(92):e51903. doi: 10.3791/51903.


Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions.

Claycomb KI, Winokur PN, Johnson KM, Nicaise AM, Giampetruzzi AW, Sacino AV, Snyder EY, Barbarese E, Bongarzone ER, Crocker SJ.

J Neuropathol Exp Neurol. 2014 Oct;73(10):964-74. doi: 10.1097/NEN.0000000000000117.


Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis.

Wang X, Kimbrel EA, Ijichi K, Paul D, Lazorchak AS, Chu J, Kouris NA, Yavanian GJ, Lu SJ, Pachter JS, Crocker SJ, Lanza R, Xu RH.

Stem Cell Reports. 2014 Jun 6;3(1):115-30. doi: 10.1016/j.stemcr.2014.04.020. eCollection 2014 Jul 8.


Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease.

Smith BR, Santos MB, Marshall MS, Cantuti-Castelvetri L, Lopez-Rosas A, Li G, van Breemen R, Claycomb KI, Gallea JI, Celej MS, Crocker SJ, Givogri MI, Bongarzone ER.

J Pathol. 2014 Apr;232(5):509-21. doi: 10.1002/path.4328. Epub 2014 Feb 20.


A framework for assessing global change risks to forest carbon stocks in the United States.

Woodall CW, Domke GM, Riley KL, Oswalt CM, Crocker SJ, Yohe GW.

PLoS One. 2013 Sep 10;8(9):e73222. doi: 10.1371/journal.pone.0073222. eCollection 2013.


MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology.

Ijichi K, Brown GD, Moore CS, Lee JP, Winokur PN, Pagarigan R, Snyder EY, Bongarzone ER, Crocker SJ.

Glia. 2013 May;61(5):765-77. doi: 10.1002/glia.22471. Epub 2013 Feb 13.


Astrocyte regulation of CNS inflammation and remyelination.

Claycomb KI, Johnson KM, Winokur PN, Sacino AV, Crocker SJ.

Brain Sci. 2013 Jul 22;3(3):1109-27. doi: 10.3390/brainsci3031109.


Effect of garlic-derived organosulfur compounds on mitochondrial function and integrity in isolated mouse liver mitochondria.

Caro AA, Adlong LW, Crocker SJ, Gardner MW, Luikart EF, Gron LU.

Toxicol Lett. 2012 Oct 17;214(2):166-74. doi: 10.1016/j.toxlet.2012.08.017. Epub 2012 Aug 29.


Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal.

Zhan H, Moore CS, Chen B, Zhou X, Ma XM, Ijichi K, Bennett MV, Li XJ, Crocker SJ, Wang ZW.

PLoS One. 2012;7(6):e39489. doi: 10.1371/journal.pone.0039489. Epub 2012 Jun 29.


An alternate perspective on the roles of TIMPs and MMPs in pathology.

Moore CS, Crocker SJ.

Am J Pathol. 2012 Jan;180(1):12-6. doi: 10.1016/j.ajpath.2011.09.008. Epub 2011 Oct 25. Review.


Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination.

Moore CS, Milner R, Nishiyama A, Frausto RF, Serwanski DR, Pagarigan RR, Whitton JL, Miller RH, Crocker SJ.

J Neurosci. 2011 Apr 20;31(16):6247-54. doi: 10.1523/JNEUROSCI.5474-10.2011.


Coxsackievirus preferentially replicates and induces cytopathic effects in undifferentiated neural progenitor cells.

Tsueng G, Tabor-Godwin JM, Gopal A, Ruller CM, Deline S, An N, Frausto RF, Milner R, Crocker SJ, Whitton JL, Feuer R.

J Virol. 2011 Jun;85(12):5718-32. doi: 10.1128/JVI.02261-10. Epub 2011 Apr 6.


Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination.

Crocker SJ, Bajpai R, Moore CS, Frausto RF, Brown GD, Pagarigan RR, Whitton JL, Terskikh AV.

Neuropathol Appl Neurobiol. 2011 Oct;37(6):643-53. doi: 10.1111/j.1365-2990.2011.01165.x.


How factors secreted from astrocytes impact myelin repair.

Moore CS, Abdullah SL, Brown A, Arulpragasam A, Crocker SJ.

J Neurosci Res. 2011 Jan;89(1):13-21. doi: 10.1002/jnr.22482. Review.


Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period.

Feuer R, Ruller CM, An N, Tabor-Godwin JM, Rhoades RE, Maciejewski S, Pagarigan RR, Cornell CT, Crocker SJ, Kiosses WB, Pham-Mitchell N, Campbell IL, Whitton JL.

J Virol. 2009 Sep;83(18):9356-69. doi: 10.1128/JVI.02382-07. Epub 2009 Jul 1.


Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis.

Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ.

Autophagy. 2009 Feb;5(2):152-8. Epub 2009 Feb 5.


Effects of calpain inhibition on dopaminergic markers and motor function following intrastriatal 6-hydroxydopamine administration in rats.

Grant RJ, Sellings LH, Crocker SJ, Melloni E, Park DS, Clarke PB.

Neuroscience. 2009 Jan 23;158(2):558-69. doi: 10.1016/j.neuroscience.2008.10.023. Epub 2008 Nov 1.


Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination.

Hebb AL, Moore CS, Bhan V, Campbell T, Fisk JD, Robertson HA, Thorne M, Lacasse E, Holcik M, Gillard J, Crocker SJ, Robertson GS.

Mult Scler. 2008 Jun;14(5):577-94. doi: 10.1177/1352458507087468.


Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1.

Crocker SJ, Frausto RF, Whitmire JK, Benning N, Milner R, Whitton JL.

Am J Pathol. 2007 Dec;171(6):1762-73. Epub 2007 Nov 30.


Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency.

Frausto RF, Crocker SJ, Eam B, Whitmire JK, Whitton JL.

J Neuroimmunol. 2007 Dec;192(1-2):124-33. Epub 2007 Oct 26.


Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice.

Crocker SJ, Whitmire JK, Frausto RF, Chertboonmuang P, Soloway PD, Whitton JL, Campbell IL.

Am J Pathol. 2006 Dec;169(6):2104-16.


Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.

Crocker SJ, Hayley SP, Smith PD, Mount MP, Lamba WR, Callaghan SM, Slack RS, Park DS.

J Neurochem. 2006 Jan;96(2):489-99. Epub 2005 Nov 29.


BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.

Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM.

Neuron. 2004 Dec 16;44(6):931-45.


Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

Hayley S, Crocker SJ, Smith PD, Shree T, Jackson-Lewis V, Przedborski S, Mount M, Slack R, Anisman H, Park DS.

J Neurosci. 2004 Feb 25;24(8):2045-53.


The TIMPs tango with MMPs and more in the central nervous system.

Crocker SJ, Pagenstecher A, Campbell IL.

J Neurosci Res. 2004 Jan 1;75(1):1-11. Review.


Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.

Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13650-5. Epub 2003 Oct 31.


Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.

Crocker SJ, Smith PD, Jackson-Lewis V, Lamba WR, Hayley SP, Grimm E, Callaghan SM, Slack RS, Melloni E, Przedborski S, Robertson GS, Anisman H, Merali Z, Park DS.

J Neurosci. 2003 May 15;23(10):4081-91.


Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice.

Crocker SJ, Liston P, Anisman H, Lee CJ, Smith PD, Earl N, Thompson CS, Park DS, Korneluk RG, Robertson GS.

Neurobiol Dis. 2003 Mar;12(2):150-61.


Endogenous expression of inhibitor of apoptosis proteins in facial motoneurons of neonatal and adult rats following axotomy.

McPhail LT, Vanderluit JL, McBride CB, Oschipok LW, Crocker SJ, Xu D, Thompson CS, Liston P, Holcik M, Robertson GS, Tetzlaff W.

Neuroscience. 2003;117(3):567-75.


c-Jun mediates axotomy-induced dopamine neuron death in vivo.

Crocker SJ, Lamba WR, Smith PD, Callaghan SM, Slack RS, Anisman H, Park DS.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13385-90. Epub 2001 Oct 30.


NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease.

Crocker SJ, Wigle N, Liston P, Thompson CS, Lee CJ, Xu D, Roy S, Nicholson DW, Park DS, MacKenzie A, Korneluk RG, Robertson GS.

Eur J Neurosci. 2001 Jul;14(2):391-400.


Neuroprotection by the inhibition of apoptosis.

Robertson GS, Crocker SJ, Nicholson DW, Schulz JB.

Brain Pathol. 2000 Apr;10(2):283-92. Review.


Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus.

Xu D, Bureau Y, McIntyre DC, Nicholson DW, Liston P, Zhu Y, Fong WG, Crocker SJ, Korneluk RG, Robertson GS.

J Neurosci. 1999 Jun 15;19(12):5026-33.


D1-Receptor-related priming is attenuated by antisense-meditated 'knockdown' of fosB expression.

Crocker SJ, Morelli M, Wigle N, Nakabeppu Y, Robertson GS.

Brain Res Mol Brain Res. 1998 Jan;53(1-2):69-77.


Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus.

Xu DG, Crocker SJ, Doucet JP, St-Jean M, Tamai K, Hakim AM, Ikeda JE, Liston P, Thompson CS, Korneluk RG, MacKenzie A, Robertson GS.

Nat Med. 1997 Sep;3(9):997-1004.


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