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Items: 1 to 50 of 51

1.

Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits.

Martínez Allo VC, Hauk V, Sarbia N, Pinto NA, Croci DO, Dalotto-Moreno T, Morales RM, Gatto SG, Manselle Cocco MN, Stupirski JC, Deladoey Á, Maronna E, Marcaida P, Durigan V, Secco A, Mamani M, Dos Santos A, Catalán Pellet A, Pérez Leiros C, Rabinovich GA, Toscano MA.

Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6630-6639. doi: 10.1073/pnas.1922778117. Epub 2020 Mar 11.

PMID:
32161138
2.

Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin.

Dusoswa SA, Verhoeff J, Abels E, Méndez-Huergo SP, Croci DO, Kuijper LH, de Miguel E, Wouters VMCJ, Best MG, Rodriguez E, Cornelissen LAM, van Vliet SJ, Wesseling P, Breakefield XO, Noske DP, Würdinger T, Broekman MLD, Rabinovich GA, van Kooyk Y, Garcia-Vallejo JJ.

Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3693-3703. doi: 10.1073/pnas.1907921117. Epub 2020 Feb 4.

PMID:
32019882
3.

Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia.

Podaza E, Palacios F, Croci DO, Risnik D, Yan XJ, Almejún MB, Colado A, Elías EE, Borge M, Morande PE, Bezares R, Fernández-Grecco H, Rabinovich GA, Gamberale R, Chiorazzi N, Giordano M.

Haematologica. 2020 Jan 16. pii: haematol.2019.227975. doi: 10.3324/haematol.2019.227975. [Epub ahead of print] No abstract available.

4.

An adipose tissue galectin controls endothelial cell function via preferential recognition of 3-fucosylated glycans.

Maller SM, Cagnoni AJ, Bannoud N, Sigaut L, Pérez Sáez JM, Pietrasanta LI, Yang RY, Liu FT, Croci DO, Di Lella S, Sundblad V, Rabinovich GA, Mariño KV.

FASEB J. 2020 Jan;34(1):735-753. doi: 10.1096/fj.201901817R. Epub 2019 Nov 26.

PMID:
31914594
5.

Glycosylation-dependent galectin-receptor interactions promote Chlamydia trachomatis infection.

Lujan AL, Croci DO, Gambarte Tudela JA, Losinno AD, Cagnoni AJ, Mariño KV, Damiani MT, Rabinovich GA.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E6000-E6009. doi: 10.1073/pnas.1802188115. Epub 2018 Jun 11.

6.

Galectins: Multitask signaling molecules linking fibroblast, endothelial and immune cell programs in the tumor microenvironment.

Elola MT, Ferragut F, Méndez-Huergo SP, Croci DO, Bracalente C, Rabinovich GA.

Cell Immunol. 2018 Nov;333:34-45. doi: 10.1016/j.cellimm.2018.03.008. Epub 2018 Mar 21. Review.

PMID:
29602445
7.

Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF.

Ridano ME, Subirada PV, Paz MC, Lorenc VE, Stupirski JC, Gramajo AL, Luna JD, Croci DO, Rabinovich GA, Sánchez MC.

Oncotarget. 2017 May 16;8(20):32505-32522. doi: 10.18632/oncotarget.17129.

8.

Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies.

Croci DO, Mendez-Huergo SP, Cerliani JP, Rabinovich GA.

Handb Exp Pharmacol. 2018;249:31-61. doi: 10.1007/164_2017_29.

PMID:
28405776
9.

Translating the 'Sugar Code' into Immune and Vascular Signaling Programs.

Cerliani JP, Blidner AG, Toscano MA, Croci DO, Rabinovich GA.

Trends Biochem Sci. 2017 Apr;42(4):255-273. doi: 10.1016/j.tibs.2016.11.003. Epub 2016 Dec 13. Review.

PMID:
27986367
10.

Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet.

Hockl PF, Wolosiuk A, Pérez-Sáez JM, Bordoni AV, Croci DO, Toum-Terrones Y, Soler-Illia GJ, Rabinovich GA.

Pharmacol Res. 2016 Jul;109:45-54. doi: 10.1016/j.phrs.2016.02.005. Epub 2016 Feb 4. Review.

PMID:
26855319
11.

The galectin-1-glycan axis controls sperm fertilizing capacity by regulating sperm motility and membrane hyperpolarization.

Vasen G, Battistone MA, Croci DO, Brukman NG, Weigel Muñoz M, Stupirski JC, Rabinovich GA, Cuasnicú PS.

FASEB J. 2015 Oct;29(10):4189-200. doi: 10.1096/fj.15-270975. Epub 2015 Jul 1.

PMID:
26136479
12.

Regulation of galectins by hypoxia and their relevance in angiogenesis: strategies and methods.

Salatino M, Croci DO, Laderach DJ, Compagno D, Gentilini L, Dalotto-Moreno T, Dergan-Dylon LS, Méndez-Huergo SP, Toscano MA, Cerliani JP, Rabinovich GA.

Methods Mol Biol. 2015;1207:293-304. doi: 10.1007/978-1-4939-1396-1_19.

PMID:
25253148
13.

Study of galectins in tumor immunity: strategies and methods.

Cerliani JP, Dalotto-Moreno T, Compagno D, Dergan-Dylon LS, Laderach DJ, Gentilini L, Croci DO, Méndez-Huergo SP, Toscano MA, Salatino M, Rabinovich GA.

Methods Mol Biol. 2015;1207:249-68. doi: 10.1007/978-1-4939-1396-1_16.

PMID:
25253145
14.

Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment.

Croci DO, Cerliani JP, Pinto NA, Morosi LG, Rabinovich GA.

Glycobiology. 2014 Dec;24(12):1283-90. doi: 10.1093/glycob/cwu083. Epub 2014 Aug 12. Review.

PMID:
25117007
15.

Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference.

Croci DO, Rabinovich GA.

Oncoimmunology. 2014 Jun 25;3:e29380. eCollection 2014.

16.

Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis.

Bastón JI, Barañao RI, Ricci AG, Bilotas MA, Olivares CN, Singla JJ, Gonzalez AM, Stupirski JC, Croci DO, Rabinovich GA, Meresman GF.

J Pathol. 2014 Nov;234(3):329-37. doi: 10.1002/path.4397. Epub 2014 Aug 8.

PMID:
24979200
17.

Control of angiogenesis by galectins involves the release of platelet-derived proangiogenic factors.

Etulain J, Negrotto S, Tribulatti MV, Croci DO, Carabelli J, Campetella O, Rabinovich GA, Schattner M.

PLoS One. 2014 Apr 30;9(4):e96402. doi: 10.1371/journal.pone.0096402. eCollection 2014.

18.

Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors.

Croci DO, Cerliani JP, Dalotto-Moreno T, Méndez-Huergo SP, Mascanfroni ID, Dergan-Dylon S, Toscano MA, Caramelo JJ, García-Vallejo JJ, Ouyang J, Mesri EA, Junttila MR, Bais C, Shipp MA, Salatino M, Rabinovich GA.

Cell. 2014 Feb 13;156(4):744-58. doi: 10.1016/j.cell.2014.01.043.

19.

Galectins in hematological malignancies.

Giordano M, Croci DO, Rabinovich GA.

Curr Opin Hematol. 2013 Jul;20(4):327-35. doi: 10.1097/MOH.0b013e328362370f. Review.

PMID:
23695449
20.

Nurse-like cells control the activity of chronic lymphocytic leukemia B cells via galectin-1.

Croci DO, Morande PE, Dergan-Dylon S, Borge M, Toscano MA, Stupirski JC, Bezares RF, Avalos JS, Narbaitz M, Gamberale R, Rabinovich GA, Giordano M.

Leukemia. 2013 Jun;27(6):1413-6. doi: 10.1038/leu.2012.315. Epub 2012 Nov 7. No abstract available.

PMID:
23257714
21.

Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease.

Dalotto-Moreno T, Croci DO, Cerliani JP, Martinez-Allo VC, Dergan-Dylon S, Méndez-Huergo SP, Stupirski JC, Mazal D, Osinaga E, Toscano MA, Sundblad V, Rabinovich GA, Salatino M.

Cancer Res. 2013 Feb 1;73(3):1107-17. doi: 10.1158/0008-5472.CAN-12-2418. Epub 2012 Nov 29.

22.

A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease.

Laderach DJ, Gentilini LD, Giribaldi L, Delgado VC, Nugnes L, Croci DO, Al Nakouzi N, Sacca P, Casas G, Mazza O, Shipp MA, Vazquez E, Chauchereau A, Kutok JL, Rodig SJ, Elola MT, Compagno D, Rabinovich GA.

Cancer Res. 2013 Jan 1;73(1):86-96. doi: 10.1158/0008-5472.CAN-12-1260. Epub 2012 Oct 29.

23.

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.

Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, Leung HJ, Ouyang J, Ilarregui JM, Toscano MA, Domaica CI, Croci MC, Shipp MA, Mesri EA, Albini A, Rabinovich GA.

J Exp Med. 2012 Oct 22;209(11):1985-2000. doi: 10.1084/jem.20111665. Epub 2012 Oct 1.

24.

Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration.

Starossom SC, Mascanfroni ID, Imitola J, Cao L, Raddassi K, Hernandez SF, Bassil R, Croci DO, Cerliani JP, Delacour D, Wang Y, Elyaman W, Khoury SJ, Rabinovich GA.

Immunity. 2012 Aug 24;37(2):249-63. doi: 10.1016/j.immuni.2012.05.023. Epub 2012 Aug 9.

25.

Binding of galectin-1 to αIIbβ₃ integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis.

Romaniuk MA, Croci DO, Lapponi MJ, Tribulatti MV, Negrotto S, Poirier F, Campetella O, Rabinovich GA, Schattner M.

FASEB J. 2012 Jul;26(7):2788-98. doi: 10.1096/fj.11-197541. Epub 2012 Mar 27.

PMID:
22456341
26.

Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer.

Rabinovich GA, Croci DO.

Immunity. 2012 Mar 23;36(3):322-35. doi: 10.1016/j.immuni.2012.03.004. Review.

27.

Integrating structure and function of 'tandem-repeat' galectins.

Troncoso MF, Elola MT, Croci DO, Rabinovich GA.

Front Biosci (Schol Ed). 2012 Jan 1;4:864-87. Review.

PMID:
22202096
28.

Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.

Rossi LE, Avila DE, Spallanzani RG, Ziblat A, Fuertes MB, Lapyckyj L, Croci DO, Rabinovich GA, Domaica CI, Zwirner NW.

J Leukoc Biol. 2012 Feb;91(2):321-31. doi: 10.1189/jlb.0711339. Epub 2011 Nov 28.

PMID:
22124136
29.

The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide.

Zacarías Fluck MF, Hess L, Salatino M, Croci DO, Stupirski JC, Di Masso RJ, Roggero E, Rabinovich GA, Scharovsky OG.

Cancer Immunol Immunother. 2012 Apr;61(4):469-80. doi: 10.1007/s00262-011-1114-3. Epub 2011 Sep 27.

PMID:
21947259
30.

Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1.

Toscano MA, Campagna L, Molinero LL, Cerliani JP, Croci DO, Ilarregui JM, Fuertes MB, Nojek IM, Fededa JP, Zwirner NW, Costas MA, Rabinovich GA.

Mol Immunol. 2011 Sep;48(15-16):1940-9. doi: 10.1016/j.molimm.2011.05.021.

PMID:
21689853
31.

Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function.

Pasquini LA, Millet V, Hoyos HC, Giannoni JP, Croci DO, Marder M, Liu FT, Rabinovich GA, Pasquini JM.

Cell Death Differ. 2011 Nov;18(11):1746-56. doi: 10.1038/cdd.2011.40. Epub 2011 May 13.

32.

Cell-type specific regulation of galectin-3 expression by glucocorticoids in lung Clara cells and macrophages.

Maldonado CA, Sundblad V, Salatino M, Elia J, García LN, Leimgruber C, Croci DO, Rabinovich GA.

Histol Histopathol. 2011 Jun;26(6):747-59. doi: 10.14670/HH-26.747.

PMID:
21472689
33.

Tumor immune escape mechanisms that operate during metastasis.

Croci DO, Salatino M.

Curr Pharm Biotechnol. 2011 Nov;12(11):1923-36. Review.

PMID:
21470132
34.

Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth.

Espelt MV, Croci DO, Bacigalupo ML, Carabias P, Manzi M, Elola MT, Muñoz MC, Dominici FP, Wolfenstein-Todel C, Rabinovich GA, Troncoso MF.

Hepatology. 2011 Jun;53(6):2097-106. doi: 10.1002/hep.24294.

PMID:
21391228
35.

Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed.

Croci DO, Cumashi A, Ushakova NA, Preobrazhenskaya ME, Piccoli A, Totani L, Ustyuzhanina NE, Bilan MI, Usov AI, Grachev AA, Morozevich GE, Berman AE, Sanderson CJ, Kelly M, Di Gregorio P, Rossi C, Tinari N, Iacobelli S, Rabinovich GA, Nifantiev NE; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO), Italy.

PLoS One. 2011 Feb 28;6(2):e17283. doi: 10.1371/journal.pone.0017283.

36.

Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications.

Mascanfroni ID, Cerliani JP, Dergan-Dylon S, Croci DO, Ilarregui JM, Rabinovich GA.

Int Immunopharmacol. 2011 Jul;11(7):833-41. doi: 10.1016/j.intimp.2011.01.021. Epub 2011 Feb 4. Review.

PMID:
21296197
37.

Regulated expression of galectin-3, a multifunctional glycan-binding protein, in haematopoietic and non-haematopoietic tissues.

Sundblad V, Croci DO, Rabinovich GA.

Histol Histopathol. 2011 Feb;26(2):247-65. doi: 10.14670/HH-26.247. Review.

PMID:
21154238
38.

Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8.

Delgado VM, Nugnes LG, Colombo LL, Troncoso MF, Fernández MM, Malchiodi EL, Frahm I, Croci DO, Compagno D, Rabinovich GA, Wolfenstein-Todel C, Elola MT.

FASEB J. 2011 Jan;25(1):242-54. doi: 10.1096/fj.09-144907. Epub 2010 Sep 27.

PMID:
20876211
39.

Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate.

Cooper D, Ilarregui JM, Pesoa SA, Croci DO, Perretti M, Rabinovich GA.

Methods Enzymol. 2010;480:199-244. doi: 10.1016/S0076-6879(10)80011-4. Review.

PMID:
20816212
40.

Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria.

Di Lella S, Martí MA, Croci DO, Guardia CM, Díaz-Ricci JC, Rabinovich GA, Caramelo JJ, Estrin DA.

Biochemistry. 2010 Sep 7;49(35):7652-8. doi: 10.1021/bi100356g.

PMID:
20666428
41.

"Time sweet time": circadian characterization of galectin-1 null mice.

Casiraghi LP, Croci DO, Poirier F, Rabinovich GA, Golombek DA.

J Circadian Rhythms. 2010 Apr 19;8:4. doi: 10.1186/1740-3391-8-4.

42.

Overcoming the hurdles of tumor immunity by targeting regulatory pathways in innate and adaptive immune cells.

Zwirner NW, Croci DO, Domaica CI, Rabinovich GA.

Curr Pharm Des. 2010 Jan;16(3):255-67. Review.

PMID:
20109135
43.

Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings.

Laderach DJ, Compagno D, Toscano MA, Croci DO, Dergan-Dylon S, Salatino M, Rabinovich GA.

IUBMB Life. 2010 Jan;62(1):1-13. doi: 10.1002/iub.281. Review.

44.

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.

Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA.

Nat Immunol. 2009 Sep;10(9):981-91. doi: 10.1038/ni.1772. Epub 2009 Aug 9.

PMID:
19668220
45.

Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway.

Croci DO, Cogno IS, Vittar NB, Salvatierra E, Trajtenberg F, Podhajcer OL, Osinaga E, Rabinovich GA, Rivarola VA.

J Cell Biochem. 2008 Oct 1;105(2):381-90. doi: 10.1002/jcb.21836.

PMID:
18553460
46.

Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway.

Fernández Larrosa PN, Croci DO, Riva DA, Bibini M, Luzzi R, Saracco M, Mersich SE, Rabinovich GA, Martínez Peralta L.

Retrovirology. 2008 Feb 8;5:19. doi: 10.1186/1742-4690-5-19.

47.

Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer.

Salatino M, Croci DO, Bianco GA, Ilarregui JM, Toscano MA, Rabinovich GA.

Expert Opin Biol Ther. 2008 Jan;8(1):45-57. Review.

PMID:
18081536
48.

The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation.

Pacienza N, Pozner RG, Bianco GA, D'Atri LP, Croci DO, Negrotto S, Malaver E, Gómez RM, Rabinovich GA, Schattner M.

FASEB J. 2008 Apr;22(4):1113-23. Epub 2007 Nov 5.

PMID:
17984174
49.

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.

Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA.

Nat Immunol. 2007 Aug;8(8):825-34. Epub 2007 Jun 24.

PMID:
17589510
50.

Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment.

Croci DO, Zacarías Fluck MF, Rico MJ, Matar P, Rabinovich GA, Scharovsky OG.

Cancer Immunol Immunother. 2007 Nov;56(11):1687-700. Epub 2007 Jun 15. Review.

PMID:
17571260

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